Staff member


Xavier Trepat
Group Leader / ICREA Research Professor
Integrative Cell and Tissue Dynamics
xtrepat@ibecbarcelona.eu
+34 934 020 265
Staff member publications

Castellanos, M. I., Mas-Moruno, C., Grau, A., Serra-Picamal, X., Trepat, X., Albericio, F., Joner, M., Gil, F. J., Ginebra, M. P., Manero, J. M., Pegueroles, M., (2017). Functionalization of CoCr surfaces with cell adhesive peptides to promote HUVECs adhesion and proliferation Applied Surface Science 393, 82-92

Blanch-Mercader, C., Vincent, R., Bazellières, E., Serra-Picamal, X., Trepat, X., Casademunt, J., (2017). Effective viscosity and dynamics of spreading epithelia: a solvable model Soft Matter 13, (6), 1235-1243

Malinverno, C., Corallino, S., Giavazzi, F., Bergert, M., Li, Q., Leoni, M., Disanza, A., Frittoli, E., Oldani, A., Martini, E., Lendenmann, T., Deflorian, G., Beznoussenko, G. V., Poulikakos, D., Ong, K. H., Uroz, M., Trepat, X., Parazzoli, D., Maiuri, P., Yu, W., Ferrari, A., Cerbino, R., Scita, G., (2017). Endocytic reawakening of motility in jammed epithelia Nature Materials ,

Arroyo, M., Trepat, X., (2017). Hydraulic fracturing in cells and tissues: fracking meets cell biology Current Opinion in Cell Biology 44, 1-6

Valon, L., Marín-Llauradó, A., Wyatt, T., Charras, G., Trepat, X., (2017). Optogenetic control of cellular forces and mechanotransduction Nature Communications 8, 14396 [Open Access]

Sunyer, R., Conte, V., Escribano, J., Elosegui-Artola, A., Labernadie, A., Valon, L., Navajas, D., García-Aznar, J. M., Muñoz, J. J., Roca-Cusachs, P., Trepat, X., (2016). Collective cell durotaxis emerges from long-range intercellular force transmission Science 353, (6304), 1157-1161

Elosegui, Alberto, Oria, Roger, Chen, Yunfeng, Kosmalska, Anita, Perez-Gonzalez, Carlos, Castro, Natalia, Zhu, Cheng, Trepat, Xavier, Roca-Cusachs, Pere, (2016). Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity Nature Cell Biology 18, (5), 540-548

Tekeli, I., Aujard, I., Trepat, X., Jullien, L., Raya, A., Zalvidea, D., (2016). Long-term in vivo single-cell lineage tracing of deep structures using three-photon activation Light: Science and Applications 5, (6), e16084 [Open Access]

Ladoux, B., Mège, R. M., Trepat, X., (2016). Front-rear polarization by mechanical cues: From single cells to tissues Trends in Cell Biology 26, (6), 420-433

Plutoni, C., Bazellieres, E., Le Borgne-Rochet, M., Comunale, F., Brugues, A., Séveno, M., Planchon, D., Thuault, S., Morin, N., Bodin, S., Trepat, X., Gauthier-Rouvière, C., (2016). P-cadherin promotes collective cell migration via a Cdc42-mediated increase in mechanical forces Journal of Cell Biology 212, (2), 199-217 [Open Access]

Asadipour, N., Trepat, X., Muñoz, J. J., (2016). Porous-based rheological model for tissue fluidisation Journal of the Mechanics and Physics of Solids 96, 535-549

Alencar, A. M., Ferraz, M. S. A., Park, C. Y., Millet, E., Trepat, X., Fredberg, J. J., Butler, J. P., (2016). Non-equilibrium cytoquake dynamics in cytoskeletal remodeling and stabilization Soft Matter 12, (41), 8506-8511

Przybyla, L., Lakins, J. N., Sunyer, R., Trepat, X., Weaver, V. M., (2016). Monitoring developmental force distributions in reconstituted embryonic epithelia Methods 94, 101-113

Casares, L., Vincent, R., Zalvidea, D., Campillo, N., Navajas, D., Arroyo, M., Trepat, X., (2015). Hydraulic fracture during epithelial stretching Nature Materials 14, (3), 343-351

Bazellières, Elsa, Conte, Vito, Elosegui, Alberto, Serra-Picamal, Xavier, Bintanel-Morcillo, María, Roca-Cusachs, Pere, Muñoz, José J., Sales-Pardo, Marta, Guimerà, Roger, Trepat, Xavier, (2015). Control of cell-cell forces and collective cell dynamics by the intercellular adhesome Nature Cell Biology 17, (4), 409-420

Ravasio, Andrea, Cheddadi, Ibrahim, Chen, Tianchi, Pereira, Telmo, Ong, Hui Ting, Bertocchi, Cristina, Brugues, Agusti, Jacinto, Antonio, Kabla, Alexandre J., Toyama, Yusuke, Trepat, Xavier, Gov, Nir, Neves de Almeida, Luis, Ladoux, Benoit, (2015). Gap geometry dictates epithelial closure efficiency Nature Communications 6, 7683

Vedula, Sri Ram Krishna, Peyret, Grégoire, Cheddadi, Ibrahim, Chen, Tianchi, Brugués, Agustí, Hirata, Hiroaki, Lopez-Menendez, Horacio, Toyama, Yusuke, Neves de Almeida, Luis, Trepat, Xavier, Lim, Chwee Teck, Ladoux, Benoit, (2015). Mechanics of epithelial closure over non-adherent environments Nature Communications 6, 6111

Kosmalska, A. J., Casares, L., Elosegui, A., Thottacherry, J. J., Moreno-Vicente, R., González-Tarragó, V., Del Pozo, M. Á, Mayor, S., Arroyo, M., Navajas, D., Trepat, X., Gauthier, N. C., Roca-Cusachs, P., (2015). Physical principles of membrane remodelling during cell mechanoadaptation Nature Communications 6, 7292

Vincent, Romaric, Bazellières, Elsa, Pérez-González, Carlos, Uroz, Marina, Serra-Picamal, Xavier, Trepat, Xavier, (2015). Active tensile modulus of an epithelial monolayer Physical Review Letters 115, (24), 248103

Lucantonio, Alessandro, Noselli, Giovanni, Trepat, Xavier, DeSimone, Antonio, Arroyo, Marino, (2015). Hydraulic fracture and toughening of a brittle layer bonded to a hydrogel Physical Review Letters 115, (18), 188105

Brask, J. B., Singla-Buxarrais, G., Uroz, M., Vincent, R., Trepat, X., (2015). Compressed sensing traction force microscopy Acta Biomaterialia 26, 286-294

Reginensi, Diego, Carulla, Patricia, Nocentini, Sara, Seira, Oscar, Serra-Picamal, Xavier, Torres-Espín, Abel, Matamoros-Angles, Andreu, Gavín, Rosalina, Moreno-Flores, María Teresa, Wandosell, Francisco, Samitier, Josep, Trepat, Xavier, Navarro, Xavier, del Río, José Antonio, (2015). Increased migration of olfactory ensheathing cells secreting the Nogo receptor ectodomain over inhibitory substrates and lesioned spinal cord Cellular and Molecular Life Sciences 72, (14), 2719-2737

García, S., Sunyer, R., Olivares, A., Noailly, J., Atencia, J., Trepat, X., (2015). Generation of stable orthogonal gradients of chemical concentration and substrate stiffness in a microfluidic device Lab on a Chip 15, (12), 2606-2614

Vizoso, Miguel, Puig, Marta, Carmona, F. Javier, Maqueda, Maria, Velásquez, Adriana, Gomez, Antonio, Labernadie, Anna, Lugo, Roberto, Gabasa, Marta, Rigat-Brugarolas, Luis G., Trepat, Xavier, Ramírez, Jose, Reguart, Noemí, Moran, Sebastian, Vidal, Enrique, Perera, Alexandre, Esteller, Manel, Alcaraz, Jordi, (2015). Aberrant DNA methylation in Non Small Cell Lung Cancer associated fibroblasts Carcinogenesis 32, (12), 1453-1463

Mrkonji, Garcia-Elias, A., Pardo-Pastor, C., Bazellières, E., Trepat, X., Vriens, J., Ghosh, D., Voets, T., Vicente, R., Valverde, M. A., (2015). TRPV4 participates in the establishment of trailing adhesions and directional persistence of migrating cells Pflugers Archiv European Journal of Physiology 467, (10), 2107-2119

Zaritsky, Assaf, Welf, Erik S., Tseng, Yun-Yu, Angeles Rabadán, M., Serra-Picamal, Xavier, Trepat, Xavier, Danuser, Gaudenz, (2015). Seeds of locally aligned motion and stress coordinate a collective cell migration Biophysical Journal 109, (12), 2492-2500

Perrault, Cecile, Brugues, Agusti, Bazellieres, Elsa, Ricco, Pierre, Lacroix, Damien, Trepat, Xavier, (2015). Traction forces of endothelial cells under slow shear flow Biophysical Journal 109, (8), 1533-1536

Serra-Picamal, Xavier, Conte, Vito, Sunyer, Raimon, Muñoz, José J., Trepat, Xavier, (2015). Mapping forces and kinematics during collective cell migration Academic Press 125, 309-330

Vedula, S. R. K., Hirata, H., Nai, M. H., Brugués, A., Toyama, Y., Trepat, X., Lim, C. T., Ladoux, B., (2014). Epithelial bridges maintain tissue integrity during collective cell migration Nature Materials 13, (1), 87-96

Elosegui, A., Bazellières, E., Allen, M. D., Andreu, I., Oria, R., Sunyer, R., Gomm, J. J., Marshall, J. F., Jones, J. L., Trepat, X., Roca-Cusachs, P., (2014). Rigidity sensing and adaptation through regulation of integrin types Nature Materials 13, (6), 631-637

Brugués, A., Anon, E., Conte, V., Veldhuis, J. H., Gupta, M., Colombelli, J., Muñoz, J. J., Brodland, G. W., Ladoux, B., Trepat, X., (2014). Forces driving epithelial wound healing Nature Physics 10, (9), 683–690

Kim, Jae Hun, Serra-Picamal, Xavier, Tambe, Dhananjay T., Zhou, Enhua H., Park, Chan Young, Sadati, Monirosadat, Park, Jin-Ah, Krishnan, Ramaswamy, Gweon, Bomi, Millet, Emil, Butler, James P., Trepat, Xavier, Fredberg, Jeffrey J., (2013). Propulsion and navigation within the advancing monolayer sheet Nature Materials 12, (9), 856-863

Theveneau, E., Steventon, B., Scarpa, E., Garcia, S., Trepat, X., Streit, A., Mayor, R., (2013). Chase-and-run between adjacent cell populations promotes directional collective migration Nature Cell Biology 15, (7), 763-772

Roca-Cusachs, P., Sunyer, R., Trepat, X., (2013). Mechanical guidance of cell migration: lessons from chemotaxis Current Opinion in Cell Biology 25, (5), 543-549

Chen, Zaozao, Lessey, Elizabeth, Berginski, Matthew E., Cao, Li, Li, Jonathan, Trepat, Xavier, Itano, Michelle, Gomez, Shawn M., Kapustina, Maryna, Huang, Cai, Burridge, Keith, Truskey, George, Jacobson, Ken, (2013). Gleevec, an Abl family inhibitor, produces a profound change in cell shape and migration PLoS ONE 8, (1), e52233

Tambe, D. T., Croutelle, U., Trepat, X., Park, C. Y., Kim, J. H., Millet, E., Butler, J. P., Fredberg, J. J., (2013). Monolayer stress microscopy: Limitations, artifacts, and accuracy of recovered intercellular stresses PLoS ONE 8, (2), e55172

Serra-Picamal, Xavier, Conte, Vito, Vincent, Romaric, Anon, Ester, Tambe, Dhananjay T., Bazellieres, Elsa, Butler, James P., Fredberg, Jeffrey J., Trepat, Xavier, (2012). Mechanical waves during tissue expansion Nature Physics Nature Publishing Group 8, (8), 628-634

Anon, Ester, Serra-Picamal, Xavier, Hersen, Pascal, Gauthier, Nils C., Sheetz, Michael P., Trepat, Xavier, Ladoux, Benoît, (2012). Cell crawling mediates collective cell migration to close undamaged epithelial gaps Proceedings of the National Academy of Sciences of the United States of America 109, (27), 10891-10896

Nocentini, S., Reginensi, D., Garcia, S., Carulla, P., Moreno-Flores, Wandosell, F., Trepat, X., Bribian, A., Del Rí, (2012). Myelin-associated proteins block the migration of olfactory ensheathing cells: an in vitro study using single-cell tracking and traction force microscopy Cellular and Molecular Life Sciences 69, (10), 1689-1703

Trepat, Xavier, Chen, Zaozao, Jacobson, Ken, (2012). Cell Migration John Wiley & Sons, Inc. 2, 2369–2392

Trepat, X., (2011). Forcing tumor arrest Physics 4, 85

Tambe, Dhananjay T., Corey Hardin, C., Angelini, Thomas E., Rajendran, Kavitha, Park, Chan Young, Serra-Picamal, Xavier, Zhou, Enhua H., Zaman, Muhammad H., Butler, James P., Weitz, David A., Fredberg, Jeffrey J., Trepat, X., (2011). Collective cell guidance by cooperative intercellular forces Nature Materials 10, (6), 469-475

Trepat, X., Fredberg, J. J., (2011). Plithotaxis and emergent dynamics in collective cellular migration Trends in Cell Biology 21, (11), 638-646

Angelini, Thomas E., Hannezo, Edouard, Trepat, Xavier, Marquez, Manuel, Fredberg, Jeffrey J., Weitz, David A., (2011). Glass-like dynamics of collective cell migration Proceedings of the National Academy of Sciences 108, (12), 4714-4719

Krishnan, Ramaswamy, Klumpers, Darinka D., Park, Chan Y., Rajendran, Kavitha, Trepat, Xavier, van Bezu, Jan, van Hinsbergh, Victor W. M., Carman, Christopher V., Brain, Joseph D., Fredberg, Jeffrey J., Butler, James P., van Nieuw Amerongen, Geerten P., (2011). Substrate stiffening promotes endothelial monolayer disruption through enhanced physical forces American Journal of Physiology - Cell Physiology 300, (1), C146-C154

Trepat, X., Fabry, B., Fredberg, J. J., (2010). Pulling it together in three dimensions Nature Methods 7, (12), 963-965

Angelini, T. E., Hannezo, E., Trepat, X., Fredberg, J. J., Weitz, D. A., (2010). Cell migration driven by cooperative substrate deformation patterns Physical Review Letters 104, (16), 168104

Park, C. Y., Tambe, D., Alencar, A. M., Trepat, X., Zhou, E. H., Millet, E., Butler, J. P., Fredberg, J. J., (2010). Mapping the cytoskeletal prestress The American Journal of Physiology - Cell Physiology 298, (5), C1245-C1252

Trepat, X., Wasserman, M. R., Angelini, T. E., Millet, E., Weitz, D. A., Butler, J. P., Fredberg, J. J., (2009). Physical forces during collective cell migration Nature Physics 5, (6), 426-430

Zhou, E. H., Trepat, X., Park, C. Y., Lenormand, G., Oliver, M. N., Mijailovich, S. M., Hardin, C., Weitz, D. A., Butler, J. P., Fredberg, J. J., (2009). Universal behavior of the osmotically compressed cell and its analogy to the colloidal glass transition Proceedings of the National Academy of Sciences of the United States of America 106, (26), 10632-10637

Krishnan, R., Park, C. Y., Lin, Y. C., Mead, J., Jaspers, R. T., Trepat, X., Lenormand, G., Tambe, D., Smolensky, A. V., Knoll, A. H., Butler, J. P., Fredberg, J. J., (2009). Reinforcement versus fluidization in cytoskeletal mechanoresponsiveness PLoS ONE 4, (5), e5486

Sunyer, R., Trepat, X., Fredberg, J. J., Farre, R., Navajas, D., (2009). The temperature dependence of cell mechanics measured by atomic force microscopy Physical Biology 6, (2), 25009

Trepat, X., Farré, R., (2008). Alveolar permeability and stretch: Too far, too fast European Respiratory Journal 32, (4), 826-828

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