Staff member


Xavier Fernàndez-Busquets
Group Leader
Nanomalaria
xfernandez@ibecbarcelona.eu
+34 932 275 707
Staff member publications

Marques, J., Valle-Delgado, J. J., Urbán, P., Baró, E., Prohens, R., Mayor, A., Cisteró, P., Delves, M., Sinden, R. E., Grandfils, C., de Paz, J. L., García-Salcedo, J. A., Fernàndez-Busquets, X., (2017). Adaptation of targeted nanocarriers to changing requirements in antimalarial drug delivery Nanomedicine: Nanotechnology, Biology, and Medicine 13, (2), 515-525

Caddeo, C., Manca, M. L., Matos, M., Gutierrez, G., Díez-Sales, O., Peris, J. E., Usach, I., Fernàndez-Busquets, X., Fadda, A. M., Manconi, M., (2017). Functional response of novel bioprotective poloxamer-structured vesicles on inflamed skin Nanomedicine: Nanotechnology, Biology, and Medicine 13, (3), 1127-1136

Caddeo, C., Pons, R., Carbone, C., Fernàndez-Busquets, X., Cardia, M. C., Maccioni, A. M., Fadda, A. M., Manconi, M., (2017). Physico-chemical characterization of succinyl chitosan-stabilized liposomes for the oral co-delivery of quercetin and resveratrol Carbohydrate Polymers 157, 1853-1861

Moles, E., Marcos, J., Imperial, S., Pozo, O. J., Fernàndez-Busquets, X., (2017). 2-picolylamine derivatization for high sensitivity detection of abscisic acid in apicomplexan blood-infecting parasites Talanta 168, 130-135

Vitonyte, J., Manca, M. L., Caddeo, C., Valenti, D., Peris, J. E., Usach, I., Nacher, A., Matos, M., Gutiérrez, G., Orrù, G., Fernàndez-Busquets, X., Fadda, A. M., Manconi, M., (2017). Bifunctional viscous nanovesicles co-loaded with resveratrol and gallic acid for skin protection against microbial and oxidative injuries European Journal of Pharmaceutics and Biopharmaceutics 114, 278-287

Moles, E., Moll, K., Ch'ng, J. H., Parini, P., Wahlgren, M., Fernàndez-Busquets, X., (2016). Development of drug-loaded immunoliposomes for the selective targeting and elimination of rosetting Plasmodium falciparum-infected red blood cells Journal of Controlled Release 241, 57-67

Guivernau, B., Bonet, J., Valls-Comamala, V., Bosch-Morató, M., Godoy, J. A., Inestrosa, N. C., Perálvarez-Marín, A., Fernàndez-Busquets, X., Andreu, D., Oliva, B., Muñoz, F. J., (2016). Amyloid- Journal of Neuroscience 36, (46), 11693-11703

Marques, J., Vilanova, Eduardo, Mourão, Paulo A. S., Fernàndez-Busquets, Xavier, (2016). Marine organism sulfated polysaccharides exhibiting significant antimalarial activity and inhibition of red blood cell invasion by Plasmodium Scientific Reports 6, 24368 [Open Access]

Fernàndez-Busquets, X., (2016). Novel strategies for Plasmodium-targeted drug delivery Expert Opinion on Drug Delivery 13, (7), 919-922

Vilanova, Eduardo, Santos, Gustavo R. C., Aquino, Rafael S., Valle-Delgado, Juan J., Anselmetti, Dario, Fernàndez-Busquets, Xavier, Mourão, Paulo A. S., (2016). Carbohydrate-carbohydrate interactions mediated by sulfate esters and calcium provide the cell adhesion required for the emergence of early metazoans Journal of Biological Chemistry 291, (18), 9425-9437

Caddeo, C., Nacher, A., Vassallo, A., Armentano, M. F., Pons, R., Fernàndez-Busquets, X., Carbone, C., Valenti, D., Fadda, A. M., Manconi, M., (2016). Effect of quercetin and resveratrol co-incorporated in liposomes against inflammatory/oxidative response associated with skin cancer International Journal of Pharmaceutics 513, (1-2), 153-163

Credi, C., De Marco, C., Molena, E., Pla Roca, M., Samitier, J., Marques, J., Fernàndez-Busquets, X., Levi, M., Turri, S., (2016). Heparin micropatterning onto fouling-release perfluoropolyether-based polymers via photobiotin activation Colloids and Surfaces B: Biointerfaces 146, 250-259

Valle-Delgado, J. J., Fernàndez-Busquets, X., (2016). Rapid diagnostic tests for malaria: Past, present and future Future Microbiology 11, (11), 1379-1382

Moles, Ernest, Valle-Delgado, Juan José, Urbán, Patricia, Azcárate, Isabel G., Bautista, José M., Selva, Javier, Egea, Gustavo, Ventura, Salvador, Fernàndez-Busquets, Xavier, (2015). Possible roles of amyloids in malaria pathophysiology Future Science OA 1, (2), FSO43

Manca, M. L., Castangia, I., Zaru, M., Nácher, A., Valenti, D., Fernàndez-Busquets, X., Fadda, A. M., Manconi, M., (2015). Development of curcumin loaded sodium hyaluronate immobilized vesicles (hyalurosomes) and their potential on skin inflammation and wound restoring Biomaterials 71, 100-109

Moles, E., Urbán, P., Jiménez-Díaz, M. B., Viera-Morilla, S., Angulo-Barturen, I., Busquets, M. A., Fernàndez-Busquets, X., (2015). Immunoliposome-mediated drug delivery to Plasmodium-infected and non-infected red blood cells as a dual therapeutic/prophylactic antimalarial strategy Journal of Controlled Release 210, 217-229

Castangia, I., Nácher, A., Caddeo, C., Merino, V., Díez-Sales, O., Catalán-Latorre, A., Fernàndez-Busquets, X., Fadda, A. M., Manconi, M., (2015). Therapeutic efficacy of quercetin enzyme-responsive nanovesicles for the treatment of experimental colitis in rats Acta Biomaterialia 13, 216-227

Urbán, Patricia, Ranucci, Elisabetta, Fernàndez-Busquets, Xavier, (2015). Polyamidoamine nanoparticles as nanocarriers for the drug delivery to malaria parasite stages in the mosquito vector Nanomedicine 10, (22), 3401-3414

Moles, E., Fernàndez-Busquets, X., (2015). Loading antimalarial drugs into noninfected red blood cells: An undesirable roommate for Plasmodium Future Medicinal Chemistry 7, (7), 837-840

Castangia, I., Manca, M. L., Matricardi, P., Catalán-Latorre, A., Nácher, A., Diez-Sales, O., Fernàndez-Busquets, X., Fadda, A. M., Manconi, M., (2015). Effects of ethanol and diclofenac on the organization of hydrogenated phosphatidylcholine bilayer vesicles and their ability as skin carriers Journal of Materials Science: Materials in Medicine 26, 137

Fernàndez-Busquets, X., de Groot, N.S., Ventura, S., (2015). Structural and computational insights into conformational diseases: A review Bentham Science Publishers 7, 134-182

Pujol, A., Urbán, P., Riera, C., Fisa, R., Molina, I., Salvador, F., Estelrich, J., Fernàndez-Busquets, X., (2014). Application of quantum dots to the study of liposome targeting in leishmaniasis and malaria International Journal of Theoretical and Applied Nanotechnology 2, (1), 1-8

Fernàndez-Busquets, X., (2014). Toy kit against malaria: Magic bullets, LEGO, Trojan horses and Russian dolls Therapeutic Delivery 5, (10), 1049-1052

Movellan, J., Urbán, P., Moles, E., de la Fuente, J. M., Sierra, T., Serrano, J. L., Fernàndez-Busquets, X., (2014). Amphiphilic dendritic derivatives as nanocarriers for the targeted delivery of antimalarial drugs Biomaterials 35, (27), 7940-7950

Urbán, P., Valle-Delgado, J. J., Mauro, N., Marques, J., Manfredi, A., Rottmann, M., Ranucci, E., Ferruti, P., Fernàndez-Busquets, X., (2014). Use of poly(amidoamine) drug conjugates for the delivery of antimalarials to Journal of Controlled Release 177, (1), 84-95

Marques, J., Moles, E., Urbán, P., Prohens, R., Busquets, M. A., Sevrin, C., Grandfils, C., Fernàndez-Busquets, X., (2014). Application of heparin as a dual agent with antimalarial and liposome targeting activities toward Plasmodium-infected red blood cells Nanomedicine: Nanotechnology, Biology, and Medicine 10, (8), 1719-1728

Paaijmans, Krijn, Fernàndez-Busquets, Xavier, (2014). Antimalarial drug delivery to the mosquito: an option worth exploring? Future Microbiology 9, (5), 579-582

Manca, M. L., Castangia, I., Matricardi, P., Lampis, S., Fernàndez-Busquets, X., Fadda, A. M., Manconi, M., (2014). Molecular arrangements and interconnected bilayer formation induced by alcohol or polyalcohol in phospholipid vesicles Colloids and Surfaces B: Biointerfaces 117, 360-367

Ramos-Fernández, E., Tajes, M., Palomer, E., Ill-Raga, G., Bosch-Morató, M., Guivernau, B., Román-Dégano, I., Eraso-Pichot, A., Alcolea, D., Fortea, J., Nuñez, L., Paez, A., Alameda, F., Fernàndez-Busquets, X., Lleó, A., Elosúa, R., Boada, M., Valverde, M. A., Muñoz, F. J., (2014). Posttranslational nitro-glycative modifications of albumin in Alzheimer's disease: Implications in cytotoxicity and amyloid- Journal of Alzheimer's Disease 40, (3), 643-657

Urbán, P., Fernàndez-Busquets, X., (2014). Nanomedicine against malaria Current Medicinal Chemistry 21, (5), 605-629

Caddeo, C., Díez-Sales, O., Pons, R., Fernàndez-Busquets, X., Fadda, A. M., Manconi, M., (2014). Topical anti-inflammatory potential of quercetin in lipid-based nanosystems: In vivo and in vitro evaluation Pharmaceutical Research 31, (4), 959-968

Le Roux, D., Burger, P. B., Niemand, J., Grobler, A., Urbán, P., Fernàndez-Busquets, X., Barker, R. H., Serrano, A. E., I. Louw, A., Birkholtz, L. M., (2014). Novel S-adenosyl-L-methionine decarboxylase inhibitors as potent antiproliferative agents against intraerythrocytic International Journal for Parasitology: Drugs and Drug Resistance 4, (1), 28-36

Tajes, M., Ramos-Fernández, E., Weng-Jiang, X., Bosch-Morató, M., Guivernau, B., Eraso-Pichot, A., Salvador, B., Fernàndez-Busquets, X., Roquer, J., Muñoz, F. J., (2014). The blood-brain barrier: Structure, function and therapeutic approaches to cross it Molecular Membrane Biology 31, (5), 152-167

Valle-Delgado, J. J., Urbán, P., Fernàndez-Busquets, X., (2013). Demonstration of specific binding of heparin to Plasmodium falciparum-infected vs. non-infected red blood cells by single-molecule force spectroscopy Nanoscale 5, (9), 3673-3680

Fernàndez-Busquets, X., (2013). Amyloid fibrils in neurodegenerative diseases: villains or heroes? Future Medicinal Chemistry 5, (16), 1903-1906

Fernàndez-Busquets, X., (2013). Heparin-functionalized nanocapsules: Enabling targeted delivery of antimalarial drugs Future Medicinal Chemistry 5, (7), 737-739

Castangia, I., Manca, M. L., Matricardi, P., Sinico, C., Lampis, S., Fernàndez-Busquets, X., Fadda, A. M., Manconi, M., (2013). Effect of diclofenac and glycol intercalation on structural assembly of phospholipid lamellar vesicles International Journal of Pharmaceutics 456, (1), 1-9

Pujol, A., Riera, C., Fisa, R., Molina, I., Salvador, F., Estelrich, J., Urbán, P., Fernàndez-Busquets, X., (2013). Nanomedicine for infectious diseases: Application of quantum dots encapsulated in immunoliposomes to the study of targeted drug delivery against leishmaniasis and malaria Proceedings of the 4th International Conference on Nanotechnology: Fundamentals and Applications. International ASET Inc. , 1-8

Mir, Mònica , Tahirbegi, Islam Bogachan , Valle-Delgado, Juan José , Fernàndez-Busquets, X., Samitier, Josep , (2012). In vitro study of magnetite-amyloid Nanomedicine: Nanotechnology, Biology and Medicine 8, (6), 974-980

Valle-Delgado, J. J., Liepina, I., Lapidus, D., Sabaté, R., Ventura, S., Samitier, J., Fernàndez-Busquets, X., (2012). Self-assembly of human amylin-derived peptides studied by atomic force microscopy and single molecule force spectroscopy Soft Matter 8, (4), 1234-1242

Villar-Pique, A., De Groot, N. S., Sabaté, R., Acebrón, S. P., Celaya, G., Fernàndez-Busquets, X., Muga, A., Ventura, S., (2012). The effect of amyloidogenic peptides on bacterial aging correlates with their intrinsic aggregation propensity Journal of Molecular Biology 421, (2-3), 270-281

Urban, P., Valle-Delgado, J. J., Moles, E., Marques, J., Diez, C., Fernàndez-Busquets, X., (2012). Nanotools for the delivery of antimicrobial peptides Current Drug Targets 13, (9), 1158-1172

Urban, Patricia, Estelrich, Joan, Cortés, Alfred, Fernàndez-Busquets, X., (2011). A nanovector with complete discrimination for targeted delivery to Plasmodium falciparum-infected versus non-infected red blood cells in vitro Journal of Controlled Release 151, (2), 202-211

Urban, Patricia, Estelrich, Joan, Adeva, Alberto, Cortes, Alfred, Fernàndez-Busquets, X., (2011). Study of the efficacy of antimalarial drugs delivered inside targeted immunoliposomal nanovectors Nanoscale Research Letters 6, (1), 620

Valle-Delgado, J. J., Alfonso-Prieto, M., de Groot, N. S., Ventura, S., Samitier, J., Rovira, C., Fernàndez-Busquets, X., (2010). Modulation of A beta(42) fibrillogenesis by glycosaminoglycan structure FASEB Journal 24, (11), 4250-4261

Sisquella, X., de Pourcq, K., Alguacil, J., Robles, J., Sanz, F., Anselmetti, D., Imperial, S., Fernàndez-Busquets, X., (2010). A single-molecule force spectroscopy nanosensor for the identification of new antibiotics and antimalarials FASEB Journal 24, (11), 4203-4217

Valente, T., Gella, A., Fernàndez-Busquets, X., Unzeta, M., Durany, N., (2010). Immunohistochemical analysis of human brain suggests pathological synergism of Alzheimer's disease and diabetes mellitus Neurobiology of Disease 37, (1), 67-76

Fernàndez-Busquets, X., Ponce, J., Bravo, R., Arimon, M., Martianez, T., Gella, A., Cladera, J., Durany, N., (2010). Modulation of amyloid beta peptide(1-42) cytotoxicity and aggregation in vitro by glucose and chondroitin sulfate Current Alzheimer Research 7, (5), 428-438

Gallego, I., Oncins, G., Sisquella, X., Fernàndez-Busquets, X., Daban, J. R., (2010). Nanotribology results show that DNA forms a mechanically resistant 2D network in metaphase chromatin plates Biophysical Journal 99, (12), 3951-3958

Harder, A., Walhorn, V., Dierks, T., Fernàndez-Busquets, X., Anselmetti, D., (2010). Single-molecule force spectroscopy of cartilage aggrecan self-adhesion Biophysical Journal 99, (10), 3498-3504

Sabaté, R., Espargaró, A., de Groot, N. S., Valle-Delgado, J. J., Fernàndez-Busquets, X., Ventura, S., (2010). The role of protein sequence and amino acid composition in amyloid formation: Scrambling and backward reading of IAPP amyloid fibrils Journal of Molecular Biology 404, (2), 337-352

Fernàndez-Busquets, X., Körnig, A., Bucior, I., Burger, M. M., Anselmetti, D., (2009). Self-recognition and Ca2+-dependent carbohydrate-carbohydrate cell adhesion provide clues to the cambrian explosion Molecular Biology and Evolution 26, (11), 2551-2561

Guix, F. X., Ill-Raga, G., Bravo, R., Nakaya, T., de Fabritiis, G., Coma, M., Miscione, G. P., Villa-Freixa, J., Suzuki, T., Fernàndez-Busquets, X., Valverde, M. A., de Strooper, B., Munoz, F. J., (2009). Amyloid-dependent triosephosphate isomerase nitrotyrosination induces glycation and tau fibrillation Brain 132, (5), 1335-1345

Pla, D., Sischka, A., Albericio, F., Alvarez, M., Fernàndez-Busquets, X., Anselmetti, D., (2009). Optical-tweezers study of topoisomerase inhibition Small 5, (11), 1269-1272

Gimenez-Oya, V., Villacanas, O., Fernàndez-Busquets, X., Rubio-Martinez, J., Imperial, S., (2009). Mimicking direct protein-protein and solvent-mediated interactions in the CDP-methylerythritol kinase homodimer: a pharmacophore-directed virtual screening approach Journal of Molecular Modeling 15, (8), 997-1007

Rodriguez-Segui, S. A., Bucior, I., Burger, M. M., Errachid, A., Fernàndez-Busquets, X., (2009). Application of the quartz crystal microbalance to the study of multivalent carbohydrate-carbohydrate adhesion Sensor Letters AMER SCIENTIFIC PUBLISHERS 7, (5), 782-787

Bravo, R., Arimon, M., Valle-Delgado, J. J., Garcia, R., Durany, N., Castel, S., Cruz, M., Ventura, S., Fernàndez-Busquets, X., (2008). Sulfated polysaccharides promote the assembly of amyloid beta(1-42) peptide into stable fibrils of reduced cytotoxicity Journal of Biological Chemistry 283, (47), 32471-32483

Morell, M., Bravo, R., Espargaro, A., Sisquella, X., Aviles, F. X., Fernàndez-Busquets, X., Ventura, S., (2008). Inclusion bodies: Specificity in their aggregation process and amyloid-like structure Biochimica et Biophysica Acta - Molecular Cell Research 1783, (10), 1815-1825

Sabella, C., Faszewski, E., Himic, L., Colpitts, K. M., Kaltenbach, J., Burger, M. M., Fernàndez-Busquets, X., (2007). Cyclosporin A suspends transplantation reactions in the marine sponge Microciona prolifera Journal of Immunology 179, (9), 5927-5935

Rodriguez, Segui, Bucior, I., Burger, M. M., Samitier, J., Errachid, A., Fernàndez-Busquets, X., (2007). Application of a bio-QCM to study carbohydrates self-interaction in presence of calcium Transducers '07 & Eurosensors Xxi, Digest of Technical Papers IEEE 1-2, 1995-1998

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