Staff member


Xavier Fernàndez-Busquets

Group Leader
Nanomalaria
xfernandez@ibecbarcelona.eu
+34 932 275 707
CV Summary

Xavier Fernàndez-Busquets is Head of the Nanomalaria Joint Unit at the Institute for Bioengineering of Catalonia and the Barcelona Centre for International Health Research. He got his PhD in Biochemistry at the Universitat Autònoma de Barcelona. He has been a visiting scientist at CIBA-GEIGY AG (Basel, Switzerland) and a postdoctoral fellow at the Friedrich Miescher Institute (Basel) and the Marine Biological Laboratory (Woods Hole, US) from 1993 to 1999, and at the Universitat de Barcelona until 2001, when he obtained a Ramón y Cajal grant to start his research on Nanomedicine.

Staff member publications

Marques, J., Valle-Delgado, J. J., Urbán, P., Baró, E., Prohens, R., Mayor, A., Cisteró, P., Delves, M., Sinden, R. E., Grandfils, C., de Paz, J. L., García-Salcedo, J. A., Fernàndez-Busquets, X., (2017). Adaptation of targeted nanocarriers to changing requirements in antimalarial drug delivery Nanomedicine: Nanotechnology, Biology, and Medicine 13, (2), 515-525

Caddeo, C., Manca, M. L., Matos, M., Gutierrez, G., Díez-Sales, O., Peris, J. E., Usach, I., Fernàndez-Busquets, X., Fadda, A. M., Manconi, M., (2017). Functional response of novel bioprotective poloxamer-structured vesicles on inflamed skin Nanomedicine: Nanotechnology, Biology, and Medicine 13, (3), 1127-1136

Caddeo, C., Pons, R., Carbone, C., Fernàndez-Busquets, X., Cardia, M. C., Maccioni, A. M., Fadda, A. M., Manconi, M., (2017). Physico-chemical characterization of succinyl chitosan-stabilized liposomes for the oral co-delivery of quercetin and resveratrol Carbohydrate Polymers 157, 1853-1861

Moles, E., Marcos, J., Imperial, S., Pozo, O. J., Fernàndez-Busquets, X., (2017). 2-picolylamine derivatization for high sensitivity detection of abscisic acid in apicomplexan blood-infecting parasites Talanta 168, 130-135

Vitonyte, J., Manca, M. L., Caddeo, C., Valenti, D., Peris, J. E., Usach, I., Nacher, A., Matos, M., Gutiérrez, G., Orrù, G., Fernàndez-Busquets, X., Fadda, A. M., Manconi, M., (2017). Bifunctional viscous nanovesicles co-loaded with resveratrol and gallic acid for skin protection against microbial and oxidative injuries European Journal of Pharmaceutics and Biopharmaceutics 114, 278-287

Moles, E., Moll, K., Ch'ng, J. H., Parini, P., Wahlgren, M., Fernàndez-Busquets, X., (2016). Development of drug-loaded immunoliposomes for the selective targeting and elimination of rosetting Plasmodium falciparum-infected red blood cells Journal of Controlled Release 241, 57-67

Guivernau, B., Bonet, J., Valls-Comamala, V., Bosch-Morató, M., Godoy, J. A., Inestrosa, N. C., Perálvarez-Marín, A., Fernàndez-Busquets, X., Andreu, D., Oliva, B., Muñoz, F. J., (2016). Amyloid- Journal of Neuroscience 36, (46), 11693-11703

Marques, J., Vilanova, Eduardo, Mourão, Paulo A. S., Fernàndez-Busquets, Xavier, (2016). Marine organism sulfated polysaccharides exhibiting significant antimalarial activity and inhibition of red blood cell invasion by Plasmodium Scientific Reports 6, 24368 [Open Access]

Fernàndez-Busquets, X., (2016). Novel strategies for Plasmodium-targeted drug delivery Expert Opinion on Drug Delivery 13, (7), 919-922

Vilanova, Eduardo, Santos, Gustavo R. C., Aquino, Rafael S., Valle-Delgado, Juan J., Anselmetti, Dario, Fernàndez-Busquets, Xavier, Mourão, Paulo A. S., (2016). Carbohydrate-carbohydrate interactions mediated by sulfate esters and calcium provide the cell adhesion required for the emergence of early metazoans Journal of Biological Chemistry 291, (18), 9425-9437

Caddeo, C., Nacher, A., Vassallo, A., Armentano, M. F., Pons, R., Fernàndez-Busquets, X., Carbone, C., Valenti, D., Fadda, A. M., Manconi, M., (2016). Effect of quercetin and resveratrol co-incorporated in liposomes against inflammatory/oxidative response associated with skin cancer International Journal of Pharmaceutics 513, (1-2), 153-163

Credi, C., De Marco, C., Molena, E., Pla Roca, M., Samitier, J., Marques, J., Fernàndez-Busquets, X., Levi, M., Turri, S., (2016). Heparin micropatterning onto fouling-release perfluoropolyether-based polymers via photobiotin activation Colloids and Surfaces B: Biointerfaces 146, 250-259

Valle-Delgado, J. J., Fernàndez-Busquets, X., (2016). Rapid diagnostic tests for malaria: Past, present and future Future Microbiology 11, (11), 1379-1382

Moles, Ernest, Valle-Delgado, Juan José, Urbán, Patricia, Azcárate, Isabel G., Bautista, José M., Selva, Javier, Egea, Gustavo, Ventura, Salvador, Fernàndez-Busquets, Xavier, (2015). Possible roles of amyloids in malaria pathophysiology Future Science OA 1, (2), FSO43

Manca, M. L., Castangia, I., Zaru, M., Nácher, A., Valenti, D., Fernàndez-Busquets, X., Fadda, A. M., Manconi, M., (2015). Development of curcumin loaded sodium hyaluronate immobilized vesicles (hyalurosomes) and their potential on skin inflammation and wound restoring Biomaterials 71, 100-109

Moles, E., Urbán, P., Jiménez-Díaz, M. B., Viera-Morilla, S., Angulo-Barturen, I., Busquets, M. A., Fernàndez-Busquets, X., (2015). Immunoliposome-mediated drug delivery to Plasmodium-infected and non-infected red blood cells as a dual therapeutic/prophylactic antimalarial strategy Journal of Controlled Release 210, 217-229

Castangia, I., Nácher, A., Caddeo, C., Merino, V., Díez-Sales, O., Catalán-Latorre, A., Fernàndez-Busquets, X., Fadda, A. M., Manconi, M., (2015). Therapeutic efficacy of quercetin enzyme-responsive nanovesicles for the treatment of experimental colitis in rats Acta Biomaterialia 13, 216-227

Urbán, Patricia, Ranucci, Elisabetta, Fernàndez-Busquets, Xavier, (2015). Polyamidoamine nanoparticles as nanocarriers for the drug delivery to malaria parasite stages in the mosquito vector Nanomedicine 10, (22), 3401-3414

Moles, E., Fernàndez-Busquets, X., (2015). Loading antimalarial drugs into noninfected red blood cells: An undesirable roommate for Plasmodium Future Medicinal Chemistry 7, (7), 837-840

Castangia, I., Manca, M. L., Matricardi, P., Catalán-Latorre, A., Nácher, A., Diez-Sales, O., Fernàndez-Busquets, X., Fadda, A. M., Manconi, M., (2015). Effects of ethanol and diclofenac on the organization of hydrogenated phosphatidylcholine bilayer vesicles and their ability as skin carriers Journal of Materials Science: Materials in Medicine 26, 137

Fernàndez-Busquets, X., de Groot, N.S., Ventura, S., (2015). Structural and computational insights into conformational diseases: A review Bentham Science Publishers 7, 134-182

Pujol, A., Urbán, P., Riera, C., Fisa, R., Molina, I., Salvador, F., Estelrich, J., Fernàndez-Busquets, X., (2014). Application of quantum dots to the study of liposome targeting in leishmaniasis and malaria International Journal of Theoretical and Applied Nanotechnology 2, (1), 1-8

Fernàndez-Busquets, X., (2014). Toy kit against malaria: Magic bullets, LEGO, Trojan horses and Russian dolls Therapeutic Delivery 5, (10), 1049-1052

Movellan, J., Urbán, P., Moles, E., de la Fuente, J. M., Sierra, T., Serrano, J. L., Fernàndez-Busquets, X., (2014). Amphiphilic dendritic derivatives as nanocarriers for the targeted delivery of antimalarial drugs Biomaterials 35, (27), 7940-7950

Urbán, P., Valle-Delgado, J. J., Mauro, N., Marques, J., Manfredi, A., Rottmann, M., Ranucci, E., Ferruti, P., Fernàndez-Busquets, X., (2014). Use of poly(amidoamine) drug conjugates for the delivery of antimalarials to Journal of Controlled Release 177, (1), 84-95

Marques, J., Moles, E., Urbán, P., Prohens, R., Busquets, M. A., Sevrin, C., Grandfils, C., Fernàndez-Busquets, X., (2014). Application of heparin as a dual agent with antimalarial and liposome targeting activities toward Plasmodium-infected red blood cells Nanomedicine: Nanotechnology, Biology, and Medicine 10, (8), 1719-1728

Paaijmans, Krijn, Fernàndez-Busquets, Xavier, (2014). Antimalarial drug delivery to the mosquito: an option worth exploring? Future Microbiology 9, (5), 579-582

Manca, M. L., Castangia, I., Matricardi, P., Lampis, S., Fernàndez-Busquets, X., Fadda, A. M., Manconi, M., (2014). Molecular arrangements and interconnected bilayer formation induced by alcohol or polyalcohol in phospholipid vesicles Colloids and Surfaces B: Biointerfaces 117, 360-367

Ramos-Fernández, E., Tajes, M., Palomer, E., Ill-Raga, G., Bosch-Morató, M., Guivernau, B., Román-Dégano, I., Eraso-Pichot, A., Alcolea, D., Fortea, J., Nuñez, L., Paez, A., Alameda, F., Fernàndez-Busquets, X., Lleó, A., Elosúa, R., Boada, M., Valverde, M. A., Muñoz, F. J., (2014). Posttranslational nitro-glycative modifications of albumin in Alzheimer's disease: Implications in cytotoxicity and amyloid- Journal of Alzheimer's Disease 40, (3), 643-657

Urbán, P., Fernàndez-Busquets, X., (2014). Nanomedicine against malaria Current Medicinal Chemistry 21, (5), 605-629

Caddeo, C., Díez-Sales, O., Pons, R., Fernàndez-Busquets, X., Fadda, A. M., Manconi, M., (2014). Topical anti-inflammatory potential of quercetin in lipid-based nanosystems: In vivo and in vitro evaluation Pharmaceutical Research 31, (4), 959-968

Le Roux, D., Burger, P. B., Niemand, J., Grobler, A., Urbán, P., Fernàndez-Busquets, X., Barker, R. H., Serrano, A. E., I. Louw, A., Birkholtz, L. M., (2014). Novel S-adenosyl-L-methionine decarboxylase inhibitors as potent antiproliferative agents against intraerythrocytic International Journal for Parasitology: Drugs and Drug Resistance 4, (1), 28-36

Tajes, M., Ramos-Fernández, E., Weng-Jiang, X., Bosch-Morató, M., Guivernau, B., Eraso-Pichot, A., Salvador, B., Fernàndez-Busquets, X., Roquer, J., Muñoz, F. J., (2014). The blood-brain barrier: Structure, function and therapeutic approaches to cross it Molecular Membrane Biology 31, (5), 152-167

Valle-Delgado, J. J., Urbán, P., Fernàndez-Busquets, X., (2013). Demonstration of specific binding of heparin to Plasmodium falciparum-infected vs. non-infected red blood cells by single-molecule force spectroscopy Nanoscale 5, (9), 3673-3680

Fernàndez-Busquets, X., (2013). Amyloid fibrils in neurodegenerative diseases: villains or heroes? Future Medicinal Chemistry 5, (16), 1903-1906

Fernàndez-Busquets, X., (2013). Heparin-functionalized nanocapsules: Enabling targeted delivery of antimalarial drugs Future Medicinal Chemistry 5, (7), 737-739

Castangia, I., Manca, M. L., Matricardi, P., Sinico, C., Lampis, S., Fernàndez-Busquets, X., Fadda, A. M., Manconi, M., (2013). Effect of diclofenac and glycol intercalation on structural assembly of phospholipid lamellar vesicles International Journal of Pharmaceutics 456, (1), 1-9

Pujol, A., Riera, C., Fisa, R., Molina, I., Salvador, F., Estelrich, J., Urbán, P., Fernàndez-Busquets, X., (2013). Nanomedicine for infectious diseases: Application of quantum dots encapsulated in immunoliposomes to the study of targeted drug delivery against leishmaniasis and malaria Proceedings of the 4th International Conference on Nanotechnology: Fundamentals and Applications. International ASET Inc. , 1-8

Mir, Mònica , Tahirbegi, Islam Bogachan , Valle-Delgado, Juan José , Fernàndez-Busquets, X., Samitier, Josep , (2012). In vitro study of magnetite-amyloid Nanomedicine: Nanotechnology, Biology and Medicine 8, (6), 974-980

Valle-Delgado, J. J., Liepina, I., Lapidus, D., Sabaté, R., Ventura, S., Samitier, J., Fernàndez-Busquets, X., (2012). Self-assembly of human amylin-derived peptides studied by atomic force microscopy and single molecule force spectroscopy Soft Matter 8, (4), 1234-1242

Villar-Pique, A., De Groot, N. S., Sabaté, R., Acebrón, S. P., Celaya, G., Fernàndez-Busquets, X., Muga, A., Ventura, S., (2012). The effect of amyloidogenic peptides on bacterial aging correlates with their intrinsic aggregation propensity Journal of Molecular Biology 421, (2-3), 270-281

Urban, P., Valle-Delgado, J. J., Moles, E., Marques, J., Diez, C., Fernàndez-Busquets, X., (2012). Nanotools for the delivery of antimicrobial peptides Current Drug Targets 13, (9), 1158-1172

Urban, Patricia, Estelrich, Joan, Cortés, Alfred, Fernàndez-Busquets, X., (2011). A nanovector with complete discrimination for targeted delivery to Plasmodium falciparum-infected versus non-infected red blood cells in vitro Journal of Controlled Release 151, (2), 202-211

Urban, Patricia, Estelrich, Joan, Adeva, Alberto, Cortes, Alfred, Fernàndez-Busquets, X., (2011). Study of the efficacy of antimalarial drugs delivered inside targeted immunoliposomal nanovectors Nanoscale Research Letters 6, (1), 620

Valle-Delgado, J. J., Alfonso-Prieto, M., de Groot, N. S., Ventura, S., Samitier, J., Rovira, C., Fernàndez-Busquets, X., (2010). Modulation of A beta(42) fibrillogenesis by glycosaminoglycan structure FASEB Journal 24, (11), 4250-4261

Sisquella, X., de Pourcq, K., Alguacil, J., Robles, J., Sanz, F., Anselmetti, D., Imperial, S., Fernàndez-Busquets, X., (2010). A single-molecule force spectroscopy nanosensor for the identification of new antibiotics and antimalarials FASEB Journal 24, (11), 4203-4217

Valente, T., Gella, A., Fernàndez-Busquets, X., Unzeta, M., Durany, N., (2010). Immunohistochemical analysis of human brain suggests pathological synergism of Alzheimer's disease and diabetes mellitus Neurobiology of Disease 37, (1), 67-76

Fernàndez-Busquets, X., Ponce, J., Bravo, R., Arimon, M., Martianez, T., Gella, A., Cladera, J., Durany, N., (2010). Modulation of amyloid beta peptide(1-42) cytotoxicity and aggregation in vitro by glucose and chondroitin sulfate Current Alzheimer Research 7, (5), 428-438

Gallego, I., Oncins, G., Sisquella, X., Fernàndez-Busquets, X., Daban, J. R., (2010). Nanotribology results show that DNA forms a mechanically resistant 2D network in metaphase chromatin plates Biophysical Journal 99, (12), 3951-3958

Harder, A., Walhorn, V., Dierks, T., Fernàndez-Busquets, X., Anselmetti, D., (2010). Single-molecule force spectroscopy of cartilage aggrecan self-adhesion Biophysical Journal 99, (10), 3498-3504

Sabaté, R., Espargaró, A., de Groot, N. S., Valle-Delgado, J. J., Fernàndez-Busquets, X., Ventura, S., (2010). The role of protein sequence and amino acid composition in amyloid formation: Scrambling and backward reading of IAPP amyloid fibrils Journal of Molecular Biology 404, (2), 337-352

Fernàndez-Busquets, X., Körnig, A., Bucior, I., Burger, M. M., Anselmetti, D., (2009). Self-recognition and Ca2+-dependent carbohydrate-carbohydrate cell adhesion provide clues to the cambrian explosion Molecular Biology and Evolution 26, (11), 2551-2561

Guix, F. X., Ill-Raga, G., Bravo, R., Nakaya, T., de Fabritiis, G., Coma, M., Miscione, G. P., Villa-Freixa, J., Suzuki, T., Fernàndez-Busquets, X., Valverde, M. A., de Strooper, B., Munoz, F. J., (2009). Amyloid-dependent triosephosphate isomerase nitrotyrosination induces glycation and tau fibrillation Brain 132, (5), 1335-1345

Pla, D., Sischka, A., Albericio, F., Alvarez, M., Fernàndez-Busquets, X., Anselmetti, D., (2009). Optical-tweezers study of topoisomerase inhibition Small 5, (11), 1269-1272

Gimenez-Oya, V., Villacanas, O., Fernàndez-Busquets, X., Rubio-Martinez, J., Imperial, S., (2009). Mimicking direct protein-protein and solvent-mediated interactions in the CDP-methylerythritol kinase homodimer: a pharmacophore-directed virtual screening approach Journal of Molecular Modeling 15, (8), 997-1007

Rodriguez-Segui, S. A., Bucior, I., Burger, M. M., Errachid, A., Fernàndez-Busquets, X., (2009). Application of the quartz crystal microbalance to the study of multivalent carbohydrate-carbohydrate adhesion Sensor Letters AMER SCIENTIFIC PUBLISHERS 7, (5), 782-787

Bravo, R., Arimon, M., Valle-Delgado, J. J., Garcia, R., Durany, N., Castel, S., Cruz, M., Ventura, S., Fernàndez-Busquets, X., (2008). Sulfated polysaccharides promote the assembly of amyloid beta(1-42) peptide into stable fibrils of reduced cytotoxicity Journal of Biological Chemistry 283, (47), 32471-32483

Morell, M., Bravo, R., Espargaro, A., Sisquella, X., Aviles, F. X., Fernàndez-Busquets, X., Ventura, S., (2008). Inclusion bodies: Specificity in their aggregation process and amyloid-like structure Biochimica et Biophysica Acta - Molecular Cell Research 1783, (10), 1815-1825

Sabella, C., Faszewski, E., Himic, L., Colpitts, K. M., Kaltenbach, J., Burger, M. M., Fernàndez-Busquets, X., (2007). Cyclosporin A suspends transplantation reactions in the marine sponge Microciona prolifera Journal of Immunology 179, (9), 5927-5935

Rodriguez, Segui, Bucior, I., Burger, M. M., Samitier, J., Errachid, A., Fernàndez-Busquets, X., (2007). Application of a bio-QCM to study carbohydrates self-interaction in presence of calcium Transducers '07 & Eurosensors Xxi, Digest of Technical Papers IEEE 1-2, 1995-1998

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