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DTSTART;TZID=Europe/Madrid:20260605T100000
DTEND;TZID=Europe/Madrid:20260605T110000
DTSTAMP:20260604T110103
CREATED:20260529T062937Z
LAST-MODIFIED:20260602T100143Z
UID:133841-1780653600-1780657200@ibecbarcelona.eu
SUMMARY:PhD Discussion. Margherita Gallano and Carles Prado Morales
DESCRIPTION:Nuclear Envelope Remodelling under Mechanical Perturbation\nMargherita Gallano\, predoctoral researcher in the Cellular and Molecular Mechanobiology Group \nCells experience mechanical loads during many fundamental processes\, including growth\, differentiation\, and migration. These forces are transmitted to the nucleus and can influence gene expression\, ultimately modulating cell behaviour and determining cell fate. The Nuclear Envelope (NE) plays a critical role in this process\, as it has been shown to sense cell size variations and activate mechanosensitive signalling pathways. Yet\, the phenomenology of NE responses to mechanical stimuli remains largely unexplored. In this project\, we aim to characterize the dynamic response of the NE under both stretch and compression\, and to unravel the associated mechanosensing mechanisms. To do so\, we employ a custom-made microfluidic device to apply controlled stretch to HeLa cells nuclei and a nanoindenter to subject cells to compressive loads. Using single cells and isolated nuclei as model systems\, we aim to distinguish active from passive processes of NE remodelling. Our results demonstrate that isolated nuclei undergo NE remodelling upon strain application\, characterised by flattening of nuclear envelope wrinkles and increase in nuclear volume. In indentation experiments on intact HeLa cells\, we observe rapid NE wrinkling upon release of the compressive load\, followed by a gradual restoration of the original nuclear morphology. \n  \nTopical enzyme-powered nano-mRNA vaccines\nCarles Prado\, Smart Nano-Bio-Devices group \nThe skin constitutes the body’s primary defensive barrier\, a function attributed to its complex and highly dense architecture. Beyond its protective role\, the skin also represents a promising route for drug delivery and vaccination. Current vaccination strategies primarily rely on injectable administration\, which targets tissues with relatively low densities of antigen-presenting cells (APCs). This approach can result in limited efficiency\, reduced patient compliance\, increased infection risk\, and higher healthcare costs. In contrast\, skin contains a dense network of resident APCs\, making it an attractive target for immunization. However\, most topical delivery approaches require physical disruption of the stratum corneum (SC) to overcome the barrier\, causing adverse effects and local tissue damage. To address these limitations\, we have developed a novel needle-free delivery platform based on enzymatically powered nanomotors capable of actively and non-disruptively penetrating the skin barrier. Through self-propulsion and local modulation of the lipid organization of the SC\, these nanomotors enhance transport into the viable epidermis and dermis. Our goal is to employ this technology to topically deliver mRNA to epidermal Langerhans cells and dermal dendritic cells and to evaluate its performance in a human relevant model.
URL:https://ibecbarcelona.eu/ca/event/phd-discussion-margherita-gallano-and-carles-prado-morales/
LOCATION:Baobab room\, Floor 11\, Tower 1
CATEGORIES:IBEC Seminar
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DTSTART;TZID=Europe/Madrid:20260612T100000
DTEND;TZID=Europe/Madrid:20260612T110000
DTSTAMP:20260604T110103
CREATED:20260529T063846Z
LAST-MODIFIED:20260529T063846Z
UID:133845-1781258400-1781262000@ibecbarcelona.eu
SUMMARY:Ibec Seminar. Santiago A. Rodríguez-Seguí
DESCRIPTION:Epigenomic Control of Pancreatic β-Cell Development and Fate: Toward Engineering a Vascularized Organoid-on-Chip Platform\nSantiago A. Rodríguez-Seguí1\,2 \n1 Instituto de Fisiología\, Biología Molecular y Neurociencias (IFIBYNE-UBA-CONICET)\, Universidad de Buenos Aires\, Facultad de Ciencias Exactas y Naturales\, Buenos Aires\, Argentina. \n2 Departamento de Fisiología\, Biología Molecular y Celular\, Universidad de Buenos Aires\, Facultad de Ciencias Exactas y Naturales\, Ciudad Universitaria\, Buenos Aires\, Argentina. \nThe human genome encodes the instructions for the vast cellular differentiation required for embryonic development and adult homeostasis. Some developmental programs are reactivated during regeneration upon tissue damage. Decoding this regulatory logic demands integrated approaches: the development of suitable human tissue models\, genomic characterization of transcriptional and epigenetic programs\, and experimental validation. State-of-the-art bioengineering technologies — including microfluidic and biomaterial platforms that recapitulate tissue microenvironments — are enabling insights into human biology that would otherwise be difficult to achieve. \nDiabetes is associated with malfunction of pancreatic β-cells. Our work\, based on pioneering ChIP-seq and scRNA-seq studies in human and mouse pancreatic samples — adult islets\, embryonic pancreas\, and iPSC-derived progenitors — has identified regulatory mechanisms controlling β-cell development and fate. We mapped the enhancer landscape of human islets\, uncovered enhancer mutations causing pancreatic agenesis\, and demonstrated that TEAD and YAP regulate key enhancers during pancreatic development. More recently\, we showed that glucocorticoid receptor activation modulates early differentiation in pancreatic progenitors\, and that HNF1B mutations disrupt this process in iPSC-derived models. From the regenerative angle\, we reported that the peptide INGAP-PP signals to multiple islet cell types\, including β-cells and endothelial cells\, suggesting that its effects depend on multicellular crosstalk poorly captured by conventional culture. \nBuilding on this foundation\, we are now developing a vascularized pancreatic endocrine organoid-on-chip platform that recapitulates the β-cell vascular niche. This platform\, developed in collaboration with the University of Barcelona and IBEC\, integrates human β-cells\, endothelial cells\, and stromal cells in a perfusable microfluidic device. It will enable epigenomic dissection of how vascular niche signals modulate the enhancer landscape underlying β-cell fate in a controlled human microenvironment. Our long-term vision is to translate this mechanistic understanding into precision medicine approaches for diabetes. \nSantiago Rodríguez Seguí is a Principal Investigator at the Institute for Physiology\, Molecular Biology\, and Neurosciences (IFIBYNE)\, affiliated with the National Scientific and Technical Research Council of Argentina (CONICET) and the University of Buenos Aires. He holds a degree in Bioengineering from the University of Entre Ríos\, Argentina\, and a PhD in Biomedicine from the University of Barcelona\, Spain. \nHis research focuses on pancreatic beta cell development and regeneration. He has authored more than 20 publications\, with significant contributions to the field published in high-impact journals such as Nature Genetics\, Nature Cell Biology\, and Development. His work has been recognized with awards from the National Academy of Medicine of Argentina and the Honorable Senate of the Argentine Nation.
URL:https://ibecbarcelona.eu/ca/event/ibec-seminar-santiago-a-rodriguez-segui/
LOCATION:Baobab room\, Floor 11\, Tower 1
CATEGORIES:IBEC Seminar
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DTSTART;TZID=Europe/Madrid:20260618T090000
DTEND;TZID=Europe/Madrid:20260618T150000
DTSTAMP:20260604T110103
CREATED:20260529T061827Z
LAST-MODIFIED:20260529T061827Z
UID:133836-1781773200-1781794800@ibecbarcelona.eu
SUMMARY:IBEC Day
DESCRIPTION:IBEC Day brings together the entire IBEC community for a day of exchange and connection\, designed to share\, connect and celebrate together. \nThis year’s edition is particularly meaningful\, as it forms part of the celebration of IBEC’s 20th anniversary\, marking an important milestone for the institute and offering an opportunity to look back\, recognise the journey so far\, and continue building the future in a shared way. \nThroughout the day\, we will present relevant updates and developments across the institution\, learn about ongoing initiatives\, and create spaces for conversation in an informal setting. \nIBEC Day aims to strengthen our sense of belonging\, foster dialogue\, and offer an opportunity to experience a day that helps us feel more connected as an institution.
URL:https://ibecbarcelona.eu/ca/event/ibec-day/
LOCATION:Auditori Vèrtex – UPC
CATEGORIES:IBEC Symposium / Conference / Congress
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DTSTART;TZID=Europe/Madrid:20260618T173000
DTEND;TZID=Europe/Madrid:20260618T210000
DTSTAMP:20260604T110103
CREATED:20260515T062616Z
LAST-MODIFIED:20260515T062730Z
UID:133602-1781803800-1781816400@ibecbarcelona.eu
SUMMARY:Alumni IBEC - 20 Years of Community
DESCRIPTION:On the occasion of the 20th anniversary of IBEC\, we are pleased to invite the entire Alumni community to a special event taking place on June 18th at 5:30 pm at the Auditori Antoni Caparrós (PCB).  \nThis gathering aims to reconnect all those who have been part of IBEC over the past 20 years\, share professional journeys\, exchange experiences and strengthen a diverse and active Alumni network with impact across many fields.  \nIt will be an afternoon to meet again\, enjoy meaningful networking\, discover new professional stories shaped by IBEC\, and collectively celebrate the path travelled and the talent that has grown within the institute.  \nThe event will conclude with a cocktail reception from 7:00 pm\, offering a relaxed environment to continue conversations and build connections. 
URL:https://ibecbarcelona.eu/ca/event/alumni-ibec-20-years-of-community/
LOCATION:Auditori Antoni Caparrós\, PCB\, Tower D\, c/Baldiri Reixac 4-8\, Barcelona\, Spain
CATEGORIES:IBEC Symposium / Conference / Congress
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