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X-WR-CALDESC:Esdeveniments per Institute for Bioengineering of Catalonia
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170714T100000
DTEND;TZID=Europe/Madrid:20170714T110000
DTSTAMP:20260509T120114
CREATED:20170630T073735Z
LAST-MODIFIED:20170630T073735Z
UID:30516-1500026400-1500030000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Maria Vinaixa
DESCRIPTION:Mass spectrometry and metabolomics data analysis for synthetic biology\n Maria Vinaixa\, Synthetic Biology for Fine and Speciality Chemicals (SYNBIOCHEM)\, Manchester Institute of Biotechnology\nSynthetic biology builds upon the creation of new biologically inspired standardized parts that can be put together using design or simulations tools to build circuits that will create de-novo biological functions or modify existing ones. Using synthetic biology\, microbial cell factories can be engineered to provide new sustainable bio-routes for the production of fuels\, biopharmaceuticals\, fragrances\, and food flavors among others. In this regard\, the SYNBIOCHEM Centre (www.synbiochem.co.uk) has set-up an automated Design/Build/Test/Learn pipeline designed to provide access to target fine chemicals through iterative\, rapid and predictable engineering of production pathways and microbial strains. This pipeline moves from Design of new parts (e.g. enzymes\, regulatory circuits\, metabolic pathways)\, through to combinatorial high-throughput Build approaches (directed evolution\, components\, pathways and strain assembly) and high-throughput analytics in Test (product extraction\, instrumental analysis\, data analysis and sharing) feeding back to improved designs via an active Learning stage at each cycle iteration. This pipeline allows unprecedented possibilities for retro biosynthesis of non-natural products and for the expansion of natural products chemical diversity. Screening for the small-molecule structure diversity emanating from such pipeline is an analytically daunting challenge. In this regard\, mass spectrometry (MS) is a key analytical technology offering the high throughput screening capabilities as well as the versatility needed to cope with such chemical diversity. However\, curating MS data and merging it with all other types of data generated through iterative D/B/T/L cycle so that it can be used to learn and redesign remains a challenge. Despite Metabolomics has powered computational solutions for MS data analysis; such solutions do only partially cover the needs within a synthetic biology context. Thus\, we are building the next generation computational toolbox for MS data analysis and storage so it can be harvested across the entire pipeline. In this seminar\, main capabilities and functionalities on such toolbox are going to be discussed.
URL:https://ibecbarcelona.eu/ca/event/ibec-seminar-maria-vinaixa/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170714T100000
DTEND;TZID=Europe/Madrid:20170714T110000
DTSTAMP:20260509T120114
CREATED:20170630T073735Z
LAST-MODIFIED:20170630T073735Z
UID:96077-1500026400-1500030000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Maria Vinaixa
DESCRIPTION:Mass spectrometry and metabolomics data analysis for synthetic biology\n Maria Vinaixa\, Synthetic Biology for Fine and Speciality Chemicals (SYNBIOCHEM)\, Manchester Institute of Biotechnology\nSynthetic biology builds upon the creation of new biologically inspired standardized parts that can be put together using design or simulations tools to build circuits that will create de-novo biological functions or modify existing ones. Using synthetic biology\, microbial cell factories can be engineered to provide new sustainable bio-routes for the production of fuels\, biopharmaceuticals\, fragrances\, and food flavors among others. In this regard\, the SYNBIOCHEM Centre (www.synbiochem.co.uk) has set-up an automated Design/Build/Test/Learn pipeline designed to provide access to target fine chemicals through iterative\, rapid and predictable engineering of production pathways and microbial strains. This pipeline moves from Design of new parts (e.g. enzymes\, regulatory circuits\, metabolic pathways)\, through to combinatorial high-throughput Build approaches (directed evolution\, components\, pathways and strain assembly) and high-throughput analytics in Test (product extraction\, instrumental analysis\, data analysis and sharing) feeding back to improved designs via an active Learning stage at each cycle iteration. This pipeline allows unprecedented possibilities for retro biosynthesis of non-natural products and for the expansion of natural products chemical diversity. Screening for the small-molecule structure diversity emanating from such pipeline is an analytically daunting challenge. In this regard\, mass spectrometry (MS) is a key analytical technology offering the high throughput screening capabilities as well as the versatility needed to cope with such chemical diversity. However\, curating MS data and merging it with all other types of data generated through iterative D/B/T/L cycle so that it can be used to learn and redesign remains a challenge. Despite Metabolomics has powered computational solutions for MS data analysis; such solutions do only partially cover the needs within a synthetic biology context. Thus\, we are building the next generation computational toolbox for MS data analysis and storage so it can be harvested across the entire pipeline. In this seminar\, main capabilities and functionalities on such toolbox are going to be discussed.
URL:https://ibecbarcelona.eu/ca/event/ibec-seminar-maria-vinaixa-3/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170714T100000
DTEND;TZID=Europe/Madrid:20170714T110000
DTSTAMP:20260509T120114
CREATED:20170630T073735Z
LAST-MODIFIED:20170630T073735Z
UID:96075-1500026400-1500030000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Maria Vinaixa
DESCRIPTION:Mass spectrometry and metabolomics data analysis for synthetic biology\n Maria Vinaixa\, Synthetic Biology for Fine and Speciality Chemicals (SYNBIOCHEM)\, Manchester Institute of Biotechnology\nSynthetic biology builds upon the creation of new biologically inspired standardized parts that can be put together using design or simulations tools to build circuits that will create de-novo biological functions or modify existing ones. Using synthetic biology\, microbial cell factories can be engineered to provide new sustainable bio-routes for the production of fuels\, biopharmaceuticals\, fragrances\, and food flavors among others. In this regard\, the SYNBIOCHEM Centre (www.synbiochem.co.uk) has set-up an automated Design/Build/Test/Learn pipeline designed to provide access to target fine chemicals through iterative\, rapid and predictable engineering of production pathways and microbial strains. This pipeline moves from Design of new parts (e.g. enzymes\, regulatory circuits\, metabolic pathways)\, through to combinatorial high-throughput Build approaches (directed evolution\, components\, pathways and strain assembly) and high-throughput analytics in Test (product extraction\, instrumental analysis\, data analysis and sharing) feeding back to improved designs via an active Learning stage at each cycle iteration. This pipeline allows unprecedented possibilities for retro biosynthesis of non-natural products and for the expansion of natural products chemical diversity. Screening for the small-molecule structure diversity emanating from such pipeline is an analytically daunting challenge. In this regard\, mass spectrometry (MS) is a key analytical technology offering the high throughput screening capabilities as well as the versatility needed to cope with such chemical diversity. However\, curating MS data and merging it with all other types of data generated through iterative D/B/T/L cycle so that it can be used to learn and redesign remains a challenge. Despite Metabolomics has powered computational solutions for MS data analysis; such solutions do only partially cover the needs within a synthetic biology context. Thus\, we are building the next generation computational toolbox for MS data analysis and storage so it can be harvested across the entire pipeline. In this seminar\, main capabilities and functionalities on such toolbox are going to be discussed.
URL:https://ibecbarcelona.eu/ca/event/ibec-seminar-maria-vinaixa-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170725T100000
DTEND;TZID=Europe/Madrid:20170725T110000
DTSTAMP:20260509T120114
CREATED:20170717T120502Z
LAST-MODIFIED:20170717T120502Z
UID:96085-1500976800-1500980400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Ronen Zaidel-Bar
DESCRIPTION:Regulation of actomyosin contractility in C. elegans\nRonen Zaidel-Bar\, Mechanobiology Institute Singapore and Tel-Aviv University Medical School\nThe actomyosin cortex is responsible for cell shape and for dynamic processes such as cell polarization and cytokinesis. We are studying the regulation of cortical contractility in the C. elegans zygote\, using genetic loss of function and live-imaging. In my talk\, I will discuss recent findings regarding two proteins: the actin cross-linking protein plastin (PLST-1) and the transmembrane receptor E-cadherin (HMR-1). Consistent with previous in-vitro reconstitution studies\, we show that an optimal level of cross-linking by plastin is required for the generation of coordinated long-range contractions in the cortex; without the connectivity afforded by plastin\, zygote polarization and cytokinesis are severely perturbed. E-cadherin is well known for its role as a cell-cell adhesion receptor. \nSurprisingly\, we discovered a role for non-junctional E-cadherin clusters in regulating cortical contractility. E-cadherin clusters inhibit RhoA and non-muscle myosin II activity at the cortex and form a physical barrier that slows actin flows. In the absence of non-junctional E-cadherin cytokinesis proceeds faster\, but the cortex is also at a risk of detaching from the plasma membrane. Thus\, our studies in the C. elegans zygote are shedding light on structural and regulatory mechanisms underlying cortex function.
URL:https://ibecbarcelona.eu/ca/event/ibec-seminar-ronen-zaidel-bar-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170725T100000
DTEND;TZID=Europe/Madrid:20170725T110000
DTSTAMP:20260509T120114
CREATED:20170717T120502Z
LAST-MODIFIED:20170717T120502Z
UID:30584-1500976800-1500980400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Ronen Zaidel-Bar
DESCRIPTION:Regulation of actomyosin contractility in C. elegans\nRonen Zaidel-Bar\, Mechanobiology Institute Singapore and Tel-Aviv University Medical School\nThe actomyosin cortex is responsible for cell shape and for dynamic processes such as cell polarization and cytokinesis. We are studying the regulation of cortical contractility in the C. elegans zygote\, using genetic loss of function and live-imaging. In my talk\, I will discuss recent findings regarding two proteins: the actin cross-linking protein plastin (PLST-1) and the transmembrane receptor E-cadherin (HMR-1). Consistent with previous in-vitro reconstitution studies\, we show that an optimal level of cross-linking by plastin is required for the generation of coordinated long-range contractions in the cortex; without the connectivity afforded by plastin\, zygote polarization and cytokinesis are severely perturbed. E-cadherin is well known for its role as a cell-cell adhesion receptor. \nSurprisingly\, we discovered a role for non-junctional E-cadherin clusters in regulating cortical contractility. E-cadherin clusters inhibit RhoA and non-muscle myosin II activity at the cortex and form a physical barrier that slows actin flows. In the absence of non-junctional E-cadherin cytokinesis proceeds faster\, but the cortex is also at a risk of detaching from the plasma membrane. Thus\, our studies in the C. elegans zygote are shedding light on structural and regulatory mechanisms underlying cortex function.
URL:https://ibecbarcelona.eu/ca/event/ibec-seminar-ronen-zaidel-bar/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170725T100000
DTEND;TZID=Europe/Madrid:20170725T110000
DTSTAMP:20260509T120114
CREATED:20170717T120502Z
LAST-MODIFIED:20170717T120502Z
UID:96086-1500976800-1500980400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Ronen Zaidel-Bar
DESCRIPTION:Regulation of actomyosin contractility in C. elegans\nRonen Zaidel-Bar\, Mechanobiology Institute Singapore and Tel-Aviv University Medical School\nThe actomyosin cortex is responsible for cell shape and for dynamic processes such as cell polarization and cytokinesis. We are studying the regulation of cortical contractility in the C. elegans zygote\, using genetic loss of function and live-imaging. In my talk\, I will discuss recent findings regarding two proteins: the actin cross-linking protein plastin (PLST-1) and the transmembrane receptor E-cadherin (HMR-1). Consistent with previous in-vitro reconstitution studies\, we show that an optimal level of cross-linking by plastin is required for the generation of coordinated long-range contractions in the cortex; without the connectivity afforded by plastin\, zygote polarization and cytokinesis are severely perturbed. E-cadherin is well known for its role as a cell-cell adhesion receptor. \nSurprisingly\, we discovered a role for non-junctional E-cadherin clusters in regulating cortical contractility. E-cadherin clusters inhibit RhoA and non-muscle myosin II activity at the cortex and form a physical barrier that slows actin flows. In the absence of non-junctional E-cadherin cytokinesis proceeds faster\, but the cortex is also at a risk of detaching from the plasma membrane. Thus\, our studies in the C. elegans zygote are shedding light on structural and regulatory mechanisms underlying cortex function.
URL:https://ibecbarcelona.eu/ca/event/ibec-seminar-ronen-zaidel-bar-3/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
END:VCALENDAR