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DTSTART;TZID=Europe/Madrid:20230413T150000
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DTSTAMP:20260430T132939
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SUMMARY:IBEC Seminar: David Caballero
DESCRIPTION:Engineering the cancer: from biomaterials to on-chip solutions\nDavid Caballero; Research Institute on Biomaterials\, Biodegradables and Biomimetics\, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine\, University of Minho\, Portugal. \nCancer is a complex and multifaceted pathology\, which is influenced by numerous factors\, including the tumor microenvironment (TME). This environment is composed of various of components that interact in a tightly regulated manner\, affecting cancer cell behavior and response to treatment. Building realistic models of the TME is therefore essential for improving our knowledge of cancer pathophysiology and developing more effective therapies. In recent years\, there has been growing interest in using precisely-engineered biomaterials and microphysiological systems to create accurate 3D in vitro models of the TME. These models can provide a more physiologically-relevant habitat for studying fundamental aspects of cancer biology and for performing drug screening. Additionally\, when combined with organ-on-a-chip technology\, these models offer a high degree of biomimicry and control\, allowing for a precise recreation and better understanding of key biological functions of the native TME\, surpassing what traditional platforms can achieve. In this lecture\, I will present our latest works utilizing biomimetic materials and on-chip systems as powerful preclinical tools for engineering realistic in vitro models of the TME to study key aspects of tumorigenesis\, for drug screening/discovery purposes\, and for disease diagnosis applications.
URL:https://ibecbarcelona.eu/ca/event/ibec-seminar-david-caballero/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
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DTSTART;TZID=Europe/Madrid:20230426T110000
DTEND;TZID=Europe/Madrid:20230426T110000
DTSTAMP:20260430T132939
CREATED:20230412T131424Z
LAST-MODIFIED:20230412T131618Z
UID:107088-1682506800-1682506800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Dr. Ubaka Ogbogu
DESCRIPTION:Foregrounding justice\, equity and inclusion as determinants of access to precision medicine: an ethical case study of patient-derived tissue organoids.\nDr. Ubaka Ogbogu\, Professor and the Associate Dean Research in the Faculty of Law from the University of Alberta\, Canada.  \nUbaka Ogbogu is a Professor and the Associate Dean Research in the Faculty of Law. He is also the Chair of the University of Alberta Research Ethics Board 2 and the Katz Research Fellow in Health Law and Science Policy. Dr. Ogbogu is a recipient of the Confederation of Alberta Faculty Associations Distinguished Academic Early Career Award. He holds a doctorate in law from the University of Toronto\, a Master of Laws degree from the University of Alberta and undergraduate degrees in law from the University of Benin\, Nigeria and the Nigerian Law School. \nOgbogu’s scholarly work is focused broadly on the ethical\, legal and societal implications of novel and emerging biotechnologies and associated research. His publications have explored a diverse range of issues in this field\, including the ethical and legal issues associated with stem cell research\, gene and engineered cell therapies\, biobanks\, germline gene editing. In his talk\, Prof. Obgobu will reflect about these issues and also discuss how foregrounding justice\, equity and inclusion are elements that impact on access to precise medicine. \nHe has been invited to IBEC by Nuria Montserrat. \n  \n 
URL:https://ibecbarcelona.eu/ca/event/ibec-seminar-dr-ubaka-ogbogu/
LOCATION:Sala Dolors Aleu\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:IBEC Seminar
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DTSTART;TZID=Europe/Madrid:20230428T120000
DTEND;TZID=Europe/Madrid:20230428T133000
DTSTAMP:20260430T132939
CREATED:20230309T155632Z
LAST-MODIFIED:20230426T104601Z
UID:105698-1682683200-1682688600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Charles Baroud
DESCRIPTION:Modeling immune-cancer interactions using a microfluidic 3D culture approach\nCharles Baroud\, Professor at Ecole Polytechnique\, France\nLab head at Institut Pasteur\, Paris\, France \nCancer immunotherapy is emerging as a transformative approach for treating cancer patients. This approach\, which has shown some remarkable successes\, leverages the patient’s own immune cells to locate and attack the tumor cells. However the method suffers from large heterogeneities in outcomes between different patients\, in part due to the the number\, phenotype\, and distribution of cytotoxic T cells (CTLs) around the tumor cells. For this reason decoding the collective behavior of CTLs\, as they recognize and attack cancer cells\, is a major challenge that requires advanced in vitro models. This seminar will present a microfluidic platform that enables quantitative measurements of the spatiotemporal dynamics of individual CTLs as they migrate in three-dimensional (3D) environments and attack cancer spheroids. The method provides access to the trajectories of thousands of cells around hundreds of spheroids\, which in turn enables probabilistic modeling of the trajectories. Analysis of the migration and killing events allows us to dissect the different phases of interactions and to identify limiting steps for different conditions. The talk will present the microfluidics and then shift focus to different biological models\, with implications for both fundamental biology and for personalized medicine. \n\n 
URL:https://ibecbarcelona.eu/ca/event/ibec-seminar-charles-baroud/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
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