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X-WR-CALNAME:Institute for Bioengineering of Catalonia
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DTSTART;TZID=Europe/Madrid:20230118T120000
DTEND;TZID=Europe/Madrid:20230118T140000
DTSTAMP:20260506T205534
CREATED:20230112T111150Z
LAST-MODIFIED:20230112T111309Z
UID:103534-1674043200-1674050400@ibecbarcelona.eu
SUMMARY:IRB Research Node/IBEC Joint Seminar:  Jolanda van Leeuwen
DESCRIPTION:Date: Wednesday 18 January 2023\, 12:00h\nPlace: Audiorium Room\, PCB \nSpeaker: Jolanda van Leeuwen\, University of Lausanne\, Lausanne\, Switzerland \nTitle:  Systematic analysis of genetic suppression interactions \nHost: Patrick Aloy (IRB) & Benedetta Bolognesi (IBEC) \nAbstract: \nRecent genome sequencing efforts have identified people that are healthy despite carrying mutations that have been directly associated with severe early-onset Mendelian diseases. These resilient individuals may carry secondary mutations elsewhere in the genome that can compensate for the deleterious effect of the disease-associated mutation\, a phenomenon referred to as genetic suppression. Identification of the protective mutations could highlight strategies for therapeutic intervention\, but we currently lack the expertise to identify the suppressor mutations among the millions of variants scattered across the genomes of resilient individuals. \nI will discuss how we use systematic genetic suppression interaction screens in the budding yeast and cultured human cells to dissect gene function and pathway connectivity\, and to define conserved properties of genetic suppression that we can use to predict suppression interactions between genomic variants across species.
URL:https://ibecbarcelona.eu/ca/event/irb-research-node-ibec-joint-seminar-systematic-analysis-of-genetic-suppression-interactions/
LOCATION:Auditori Antoni Caparrós\, PCB\, Tower D\, c/Baldiri Reixac 4-8\, Barcelona\, Spain
CATEGORIES:Joint seminar / workshop / symposium
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DTSTART;TZID=Europe/Madrid:20230119T093000
DTEND;TZID=Europe/Madrid:20230119T113000
DTSTAMP:20260506T205534
CREATED:20230112T111707Z
LAST-MODIFIED:20230112T111707Z
UID:103539-1674120600-1674127800@ibecbarcelona.eu
SUMMARY:IRB Research Node/IBEC Joint Seminar: Nunilo Cremades
DESCRIPTION:Date: Thursday 19 January 2023\, 9:30h\nPlace: Felix Serratosa Hall\, PCB \nSpeaker: Nunilo Cremades\, PhD – Associate Professor at Dept. Biochemistry and Molecular and Cellular Biology and Group Leader at Institute for Biocomputation and Physics of Complex Systems (BIFI)\, University of Zaragoza\, Spain \nTitle:  Liquid-liquid phase separation and co-aggregation of neurodegenerative disease-related alpha-synuclein and Tau proteins \nHost: Xavier Salvatella (IRB) & Benedetta Bolognesi (IBEC) \nAbstract: \nSpatial segregation in the cell can be achieved through the formation of protein-rich liquid-like dense bodies\, termed biomolecular condensates or liquid droplets\, through a process known as liquid-liquid phase separation (LLPS). Emerging evidence supports the hypothesis that aberrant protein-driven LLPS and the transition of the liquid droplets to solid-like structures might be a relevant cellular pathway leading to the formation of amyloid\, toxic aggregates that are often a hallmark of relevant neurodegenerative diseases. A number of experimental studies have highlighted the flexible\, typically disordered and ‘multivalent’ nature of the constituent proteins in these liquid-like condensates\, although less is known about the particular molecular determinants governing the growth and maturation of these condensates into more solid-like states. While the LLPS process of Tau\, the protein that is generally associated with Alzheimer´s disease\, has been recently clarified\, that of alpha-synuclein (αS)\, the protein linked to Parkinson´s disease\, remains obscure. In this talk\, I will show our recent findings that demonstrate that αS actively phase-separates into liquid condensates by electrostatic complex coacervation with positively charged polypeptides such as Tau. By combining a set of advanced biophysical techniques\, we have been able to characterize αS/Tau LLPS and identified key factors leading to the co-aggregation of both proteins inside the coacervates. The mechanism of co-aggregation between αS and Tau that we have identified could be the basis for the in vivo formation of αS/Tau hetero-aggregates observed in the brains of patients suffering from synucleinopathies.
URL:https://ibecbarcelona.eu/ca/event/irb-research-node-ibec-joint-seminar-nunilo-cremades/
LOCATION:Sala Félix Serratosa – PCB\, c/ Baldiri i reixac 10-12\, Barcelona\, Spain\, 08028\, Spain
CATEGORIES:Joint seminar / workshop / symposium
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