BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Institute for Bioengineering of Catalonia - ECPv6.15.18//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-ORIGINAL-URL:https://ibecbarcelona.eu/ca/
X-WR-CALDESC:Esdeveniments per Institute for Bioengineering of Catalonia
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:Europe/Madrid
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20200329T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20201025T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20210328T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20211031T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20220327T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20221030T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210310T090000
DTEND;TZID=Europe/Madrid:20210310T230000
DTSTAMP:20260406T122020
CREATED:20210301T090512Z
LAST-MODIFIED:20210308T082802Z
UID:82193-1615366800-1615417200@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Maider Badiola
DESCRIPTION:Compartmentalised microfluidic culture systems for in vitro modelling of neurological and neuromuscular microenvironments\nMaider Badiola\, Nanobioengineering group \nMovement of skeletal-muscle fibres is generated by the locomotion circuit. Failures in any part of the circuit can cause or define the severity of neuromuscular diseases (NMD)\, such as amyotrophic lateral sclerosis (ALS). Conventional in vitro study models coculturing motoneurons and skeletal muscle cells are not physiologically relevant. Moreover\, studying fragments of the circuit cannot provide a comprehensive and complete view of the pathological process. \nThis thesis aims to study the neuromuscular context in vitro through compartmentalised microfluidic culture systems (cµFCS) and to create physiologically relevant study models. It offers an evolving prospective of in vitro models\, moving from mice to human cells\, from 2D to 3D cell cultures\, from primary cells to human induced pluripotent stem cells (hiPSC)\, and analysing both healthy and diseased cells. \nThis thesis gathers many technological innovations from a Bioengineering point of view\, paving the way for future studies in the neuromuscular field. It shows that the integration of the entire neuromuscular circuit components in the developed in vitro systems provides a wider view of the neuromuscular physiology and the pathological processes. These results show first steps towards future 3D physiological neuromuscular circuit models on a chip for NMD studies. \nThe defence will take place online using the Microsoft Teams Platform
URL:https://ibecbarcelona.eu/ca/event/phd-thesis-defence-maider-badiola/
CATEGORIES:PhD Thesis Defence
END:VEVENT
END:VCALENDAR