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DTSTART;TZID=Europe/Madrid:20160708T100000
DTEND;TZID=Europe/Madrid:20160708T110000
DTSTAMP:20260506T023841
CREATED:20160705T171136Z
LAST-MODIFIED:20160705T171136Z
UID:23873-1467972000-1467975600@ibecbarcelona.eu
SUMMARY:PhD Discussion Session: Pilar Rodríguez and Montserrat López
DESCRIPTION:Long-ranged force patterns and waves during the formation and maintenance of repulsive epithelial barriers\nPilar Rodríguez Franco\, Integrative cell and tissue dynamics group\nFor an organism to develop and maintain homeostasis\, cell types with distinct functions must often be separated by physical boundaries. A prevalent mechanism for the formation and maintenance of such boundaries is the repulsive interaction between Eph receptor tyrosine kinases and their ligands Ephrins. Upon contact\, cells expressing Eph and Ephrin trigger diverse local mechanisms that prevent intercellular adhesion\, including receptor endocytosis\, extracellular cadherin cleavage\, and local contractility. Here we show that\, besides these local subcellular mechanisms\, Eph/Ephrin boundary formation involves cooperative physical forces generated by cells located many rows behind the boundary. Contact between two epithelial monolayers\, one expressing Eph and one expressing Ephrin\, results in the buildup of two supracellular acto-myosin cables that line epithelial edges at both sides of the boundary. Besides these cables\, both monolayers exhibit long-lived periodic patterns of traction forces that expand several cell rows and tend to pull the monolayer away from the boundary\, thereby contributing to sustain tissue segregation. The formation of these patterns is paralleled by the generation of soliton-like deformation waves that propagate away from the boundary. Finally\, we show that periodic traction patterns and mechanical waves are observed not only during Eph/Ephrin repulsion but also during formation of diverse types of barriers. Our findings thus unveil a global physical mechanism that sustains tissue separation. \n  \nNanoscale Conductance mapping of redox proteins\nMontserrat López Martínez\, Nanoprobes and nanoswitches group\nElectron Transfer (ET) plays essential roles in crucial biological processes such as cell respiration and photosynthesis. It takes place between redox proteins and in protein complexes that display an outstanding efficiency and environmental adaptability. Although the fundamental aspects of ET processes are well understood\, more experimental methods are needed to determine electronic pathways in these redox protein structures. Understanding how ET works is important not only for fundamental reasons\, but also for the potential technological applications of these redox-active nanoscale systems.\nElectrochemical Scanning Tunneling Microscopy (ECSTM) is an excellent tool to study redox molecules including proteins. It offers single molecule resolution and allows working in nearly physiological conditions\, with full electrochemical control. Beyond imaging\, ECSTM allows performing current-voltage and current-distance tunneling spectroscopy. We adapted the current-voltage spectroscopy mode of ECSTM to obtain simultaneous topographic and differential conductance images under potentiostatic control. After validation of the method we applied it to the study of the redox protein Azurin immobilized on to a Au  surface\, a model system to study biological ET processes.
URL:https://ibecbarcelona.eu/ca/event/phd-discussion-session-pilar-rodriguez-and-montserrat-lopez/
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20160708T100000
DTEND;TZID=Europe/Madrid:20160708T110000
DTSTAMP:20260506T023841
CREATED:20160705T171136Z
LAST-MODIFIED:20160705T171136Z
UID:95915-1467972000-1467975600@ibecbarcelona.eu
SUMMARY:PhD Discussion Session: Pilar Rodríguez and Montserrat López
DESCRIPTION:Long-ranged force patterns and waves during the formation and maintenance of repulsive epithelial barriers\nPilar Rodríguez Franco\, Integrative cell and tissue dynamics group\nFor an organism to develop and maintain homeostasis\, cell types with distinct functions must often be separated by physical boundaries. A prevalent mechanism for the formation and maintenance of such boundaries is the repulsive interaction between Eph receptor tyrosine kinases and their ligands Ephrins. Upon contact\, cells expressing Eph and Ephrin trigger diverse local mechanisms that prevent intercellular adhesion\, including receptor endocytosis\, extracellular cadherin cleavage\, and local contractility. Here we show that\, besides these local subcellular mechanisms\, Eph/Ephrin boundary formation involves cooperative physical forces generated by cells located many rows behind the boundary. Contact between two epithelial monolayers\, one expressing Eph and one expressing Ephrin\, results in the buildup of two supracellular acto-myosin cables that line epithelial edges at both sides of the boundary. Besides these cables\, both monolayers exhibit long-lived periodic patterns of traction forces that expand several cell rows and tend to pull the monolayer away from the boundary\, thereby contributing to sustain tissue segregation. The formation of these patterns is paralleled by the generation of soliton-like deformation waves that propagate away from the boundary. Finally\, we show that periodic traction patterns and mechanical waves are observed not only during Eph/Ephrin repulsion but also during formation of diverse types of barriers. Our findings thus unveil a global physical mechanism that sustains tissue separation. \n  \nNanoscale Conductance mapping of redox proteins\nMontserrat López Martínez\, Nanoprobes and nanoswitches group\nElectron Transfer (ET) plays essential roles in crucial biological processes such as cell respiration and photosynthesis. It takes place between redox proteins and in protein complexes that display an outstanding efficiency and environmental adaptability. Although the fundamental aspects of ET processes are well understood\, more experimental methods are needed to determine electronic pathways in these redox protein structures. Understanding how ET works is important not only for fundamental reasons\, but also for the potential technological applications of these redox-active nanoscale systems.\nElectrochemical Scanning Tunneling Microscopy (ECSTM) is an excellent tool to study redox molecules including proteins. It offers single molecule resolution and allows working in nearly physiological conditions\, with full electrochemical control. Beyond imaging\, ECSTM allows performing current-voltage and current-distance tunneling spectroscopy. We adapted the current-voltage spectroscopy mode of ECSTM to obtain simultaneous topographic and differential conductance images under potentiostatic control. After validation of the method we applied it to the study of the redox protein Azurin immobilized on to a Au  surface\, a model system to study biological ET processes.
URL:https://ibecbarcelona.eu/ca/event/phd-discussion-session-pilar-rodriguez-and-montserrat-lopez-2/
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160712T100000
DTEND;TZID=UTC:20160712T230000
DTSTAMP:20260506T023841
CREATED:20160510T055158Z
LAST-MODIFIED:20160510T055158Z
UID:95913-1468317600-1468364400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Prof. Shulamit Levenberg
DESCRIPTION:Engineering Vascularized Tissue Constructs\nProf. Shulamit Levenberg\, Faculty of Biomedical Engineering\, Technion\, Haifa\, Israel\nVascularization continues to represent a major challenge in the successful implementation of regenerative strategies. Cell organization into 3D tissue vascularized structures involves cell-matrix and cell-cell interactions\, some of which occur between the different tissue cell types. During this process\, cells further differentiate and assemble into structures resembling the final tissue architecture. We have established that vessel network assembly yielding vascularized 3D tissue structures can be induced in-vitro by means of coculturing endothelial cells\, fibroblasts and tissue-specific cells. We have also shown that in vitro pre-vascularization of engineered tissues can promote tissue survival and further vascularization upon implantation\, via anastomosis of the engineered vessels with host vasculature\, forming functional blood vessels in vivo. Vascularization of engineered tissues can be enhanced through coordinated application of improved biomaterial systems with relevant cell types. Moreover\, we have shown that vessel network maturity and morphology can be highly regulated by both matrix composition and by external mechanical stimulations. Our recent studies have focused on investigation of the degree of the in vitro prevascularization required to achieve best postimplantation vascularization of tissue constructs\, as well as on understanding the mechanisms underlying host-implant vessel integration and anastomosis. New co-culture approaches for inducing pre-defined vessel structures in vitro will also be discussed\, as will novel studies on vascularized muscle flaps engineered to reconstruct large soft tissue defects.
URL:https://ibecbarcelona.eu/ca/event/ibec-seminar-prof-shulamit-levenberg-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160712T100000
DTEND;TZID=UTC:20160712T230000
DTSTAMP:20260506T023841
CREATED:20160510T055158Z
LAST-MODIFIED:20160510T055158Z
UID:22777-1468317600-1468364400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Prof. Shulamit Levenberg
DESCRIPTION:Engineering Vascularized Tissue Constructs\nProf. Shulamit Levenberg\, Faculty of Biomedical Engineering\, Technion\, Haifa\, Israel\nVascularization continues to represent a major challenge in the successful implementation of regenerative strategies. Cell organization into 3D tissue vascularized structures involves cell-matrix and cell-cell interactions\, some of which occur between the different tissue cell types. During this process\, cells further differentiate and assemble into structures resembling the final tissue architecture. We have established that vessel network assembly yielding vascularized 3D tissue structures can be induced in-vitro by means of coculturing endothelial cells\, fibroblasts and tissue-specific cells. We have also shown that in vitro pre-vascularization of engineered tissues can promote tissue survival and further vascularization upon implantation\, via anastomosis of the engineered vessels with host vasculature\, forming functional blood vessels in vivo. Vascularization of engineered tissues can be enhanced through coordinated application of improved biomaterial systems with relevant cell types. Moreover\, we have shown that vessel network maturity and morphology can be highly regulated by both matrix composition and by external mechanical stimulations. Our recent studies have focused on investigation of the degree of the in vitro prevascularization required to achieve best postimplantation vascularization of tissue constructs\, as well as on understanding the mechanisms underlying host-implant vessel integration and anastomosis. New co-culture approaches for inducing pre-defined vessel structures in vitro will also be discussed\, as will novel studies on vascularized muscle flaps engineered to reconstruct large soft tissue defects.
URL:https://ibecbarcelona.eu/ca/event/ibec-seminar-prof-shulamit-levenberg/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20160715T110000
DTEND;TZID=Europe/Madrid:20160715T130000
DTSTAMP:20260506T023841
CREATED:20160711T161150Z
LAST-MODIFIED:20160711T161150Z
UID:95916-1468580400-1468587600@ibecbarcelona.eu
SUMMARY:IBEC PhD Thesis Defence: Manuel Lozano
DESCRIPTION:“Multichannel analysis of normal and continuous adventitious respiratory sounds for the assessment of pulmonary function in respiratory diseases”\nManuel Lozano\, Biomedical Signal Processing and Interpretation group\nManuel will be defending his PhD thesis on Friday 15th July at 11:00 at the Facultat de Matemàtiques i Estadística (Sala d’Actes) of the UPC (c. Pau Gargallo\, 5 08028 Barcelona). \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/ca/event/ibec-phd-thesis-defence-manuel-lozano-2/
LOCATION:Sala d’Actes de la Facultat de Matemàtiques i Estadística\, c. Pau Gargallo 5\, 08028 Barcelona\, Spain
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20160715T110000
DTEND;TZID=Europe/Madrid:20160715T130000
DTSTAMP:20260506T023841
CREATED:20160711T161150Z
LAST-MODIFIED:20160711T161150Z
UID:23969-1468580400-1468587600@ibecbarcelona.eu
SUMMARY:IBEC PhD Thesis Defence: Manuel Lozano
DESCRIPTION:“Multichannel analysis of normal and continuous adventitious respiratory sounds for the assessment of pulmonary function in respiratory diseases”\nManuel Lozano\, Biomedical Signal Processing and Interpretation group\nManuel will be defending his PhD thesis on Friday 15th July at 11:00 at the Facultat de Matemàtiques i Estadística (Sala d’Actes) of the UPC (c. Pau Gargallo\, 5 08028 Barcelona). \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/ca/event/ibec-phd-thesis-defence-manuel-lozano/
LOCATION:Sala d’Actes de la Facultat de Matemàtiques i Estadística\, c. Pau Gargallo 5\, 08028 Barcelona\, Spain
CATEGORIES:PhD Thesis Defence
END:VEVENT
END:VCALENDAR