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X-WR-CALNAME:Institute for Bioengineering of Catalonia
X-ORIGINAL-URL:https://ibecbarcelona.eu/ca/
X-WR-CALDESC:Esdeveniments per Institute for Bioengineering of Catalonia
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20231201T120000
DTEND;TZID=Europe/Madrid:20231201T130000
DTSTAMP:20260428T084136
CREATED:20231122T092220Z
LAST-MODIFIED:20231122T105201Z
UID:112738-1701432000-1701435600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Dr. Neil Lin
DESCRIPTION:Epithelial Cell Variability is Governed by Physics Principles and Has Mechanobiology Impacts\nDr. Neil Lin\,  Assistant Professor of Mechanical Engineering and Bioengineering at University of California\, Los Angeles (UCLA). \nBiological systems inherently exhibit variability\, seen in diverse cell shapes\, sizes\, and mechanical properties. Despite its prevalence\, our understanding of the role of phenotypic heterogeneity in cell biology is incomplete. This talk explores how basic physics governs cell-to-cell variability in epithelial monolayers and its impact on biological processes. The first part covers how cell shape heterogeneity influences chromatin organization during crowding. The second part demonstrates that in deformed epithelial layers\, nucleo-cytoskeleton coupling regulates intracellular strain distribution\, influencing cellular mechanoresponse and gene expression. Overall\, cell-cell variability significantly shapes tissue development and remodeling. \n\nDr. Neil Lin is an Assistant Professor of Mechanical Engineering and Bioengineering at University of California\, Los Angeles (UCLA). He obtained his Ph.D. in physics at Cornell University\, studying the microscopic mechanisms that underlie the non-Newtonian suspension flow property. From there\, he went on to do a postdoctoral fellowship at Harvard University\, studying approaches to recreate microenvironment cues for recapitulating kidney functions in vitro. He joined UCLA in 2019\, and his research is to utilize mechanobiology principles to engineer epithelial tissues. His honors include an NIH MIRA\, Prostate Cancer Foundation Young Investigator Award\, and BMES CMBE Rising Star Award.
URL:https://ibecbarcelona.eu/ca/event/ibec-seminar-dr-neil-lin/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20231214T103000
DTEND;TZID=Europe/Madrid:20231214T140000
DTSTAMP:20260428T084136
CREATED:20231128T140435Z
LAST-MODIFIED:20231128T140435Z
UID:112919-1702549800-1702562400@ibecbarcelona.eu
SUMMARY:Nanomed Spain: JORNADA SOBRE PROYECTOS DE COLABORACIÓN PÚBLICO-PRIVADA 2023 (Spanish)
DESCRIPTION:NANOMEDSPAIN organizes together with the Leitat technology center a conference on the call for Public-Private Collaboration Projects that will open at the beginning of 2024. \nMª Estefanía Freitas\, Deputy Head of the Scientific-Technical Thematic Programs Branch of the State Research Agency\, Ministry of Science and Innovation\, will present the most important aspects and main novelties of the call. \nThe day will also have the possibility of holding meetings between interested parties and Mª Estefanía Freitas\, and B2B meetings between those attending the day. \nThis event will be in Spanish.
URL:https://ibecbarcelona.eu/ca/event/nanomed-spain-jornada-sobre-proyectos-de-colaboracion-publico-privada-2023-spanish/
LOCATION:Cambra de Comerç\, Av. Diagonal\, 452 – 454\, Barcelona
CATEGORIES:External seminar,Professional and Personal Development
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20231215T100000
DTEND;TZID=Europe/Madrid:20231215T110000
DTSTAMP:20260428T084136
CREATED:20231127T122753Z
LAST-MODIFIED:20231204T154540Z
UID:112845-1702634400-1702638000@ibecbarcelona.eu
SUMMARY:PhD Discussions: Zhendong Xie and Júlia Alcàcer
DESCRIPTION:Integrating phenotypic targeting in physiologically-based pharmacokinetics modeling.\nZhendong Xie\, Molecular Bionics group \nSelective drugging\, also known as the “magic bullet\,” is the concept that drugs can target specific molecules\, cells\, or targets while minimising interactions with other parts of the body. Nanoparticles (NPs) with functioned ligands target cells with a certain range of receptors due to the multivalent effect. To develop precision drugs\, it is crucial to understand how NPs are distributed in different organs and interact with different cell types in vivo. Our focus is on investigating the distribution of poly(2-(methacryloyloxy)ethylphosphorylcholine)-poly(2-(diisopropyl-amino)ethyl methacrylate) (PMPC-PDPA) polymersome. We use the PMPC polymersome’s interactions with different receptors to target specific cell groups based on phenotypic association theory (PAT)\, a statistical model based on the description between nanocarriers and cell phenotype (receptor density and glycocalyx). \nWe integrate phenotypic targeting in physiologically-based pharmacokinetics modeling (PBPK) to mimic the distribution of NPs in organs in silico to identify the most selective combination of parameters for precision drugs. The PBPK is built based on the circulation system\, anatomy data\, and cell protein atlas to predict the distribution of NPs among different organs\, considering the advection among various biological fluids\, diffusion of NPs in different organs\, and NPs’ interaction with different cells. A non-Langmiur differential rate equation (NLDRE) is applied to extrapolate the PMPC-cell interaction kinetics based on single-cell level uptake experiments. The association constant/affinity kA/j is derived from the PAT to reveal the selectivity of NPs to different cells. We propose that the difference in kA/j results in a larger distribution and cell targeting discrimination. \nThrough experiments in vivo\, we obtained information about drug distribution among different organs\, the selectivity of NPs to different cells\, and some undetectable parameters such as glycocalyx density. Based on these parameters\, we change the injected dose\, the NP radius\, and the polymerization of the PMPC ligand to simulate the distribution of PMPC in silico and develop a better administration strategy. \n\nExploring host-pathogen interactions: Unraveling the dynamics of Pseudomonas aeruginosa and Burkholderia cenocepacia infection in Galleria mellonella\nJúlia Alcàcer\, Bacterial infections: antimicrobial therapies group \nPseudomonas aeruginosa and Burkholderia cenocepacia are two multidrug-resistant opportunistic pathogens often isolated from the lungs of cystic fibrosis patients. It is known that the presence of more than one species in an infection promotes the appearance of a network of interactions that can lead to an increase in their antimicrobial tolerance or to the evasion of the host immune system. Galleria mellonella has been used as an animal model throughout this study\, as its immune system is comparable to that of mammals\, and it presents practical advantages such as their easy maintenance. With the aim of understanding bacterial and host behaviors after infection\, the survival rate of Galleria mellonella after a P. aeruginosa and B. cenocepacia single and dual-species infection was monitored\, as well as the efficacy of antibiotic treatment to such infections. In order to characterize the infection evolution\, the tissue-specific infection dissemination and hemocyte phagocytosis were evaluated through confocal microscopy.
URL:https://ibecbarcelona.eu/ca/event/phd-discussions-zhendong-xie-and-julia-alcacer/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20231215T140000
DTEND;TZID=Europe/Madrid:20231215T150000
DTSTAMP:20260428T084136
CREATED:20231211T113708Z
LAST-MODIFIED:20231211T113913Z
UID:113211-1702648800-1702652400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Pavan Kumar Bosukonda
DESCRIPTION:Smart artificial microcompartments: motility and communication\nPavan Kumar Bosukonda\, Assistant Professor at the Department of Chemistry\, Indian Institute of Technology Roorkee \n  \nNature is a continuous source of inspiration for the design of smart and intelligent materials. In particular\, cells which are the building blocks of life display a complex symphony of various chemical/physical processes which make “life” possible and give it the characteristics which enable life to flourish and sustain. The topology of control systems in place within living cells offer many lessons in design of smart artificial microcompartments or microbots. In this talk\, I will be discussing examples of microcompartments which are capable of smart adaptive motility\, self-assembly and chemical-mediated communication with each other. We use simple buoyancy forces to regulate movement of our microcapsules and use antagonistic control to design relatively complex autonomous behavior by employing stratified chemical environments. The motile microcapsules can turn on/off chemical reactions and carry out logistics of molecular cargo. Also\, I will discuss how we can use the combination of a stimuli responsive hydrogel and stratified environments to design a chemo-mechanical oscillator.  Another focus will be our results on multiphase coacervates and how they formulate a pathway for self-assembly of microdroplets into clusters or tissue-like structures and trigger chemical communication between them. \n\nBrief Bio: Dr. Pavan Kumar Bosukonda is an Assistant Professor at the Department of Chemistry\, Indian Institute of Technology Roorkee. He carried out his doctoral studies at Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR)\, Bangalore\, in the field of porous materials wherein his specific interest was to use supramolecular strategies for pore engineering in mesoporous silica. After completing his Ph.D. in 2015\, he moved to the University of Bristol\, UK\, to work with Prof. Stephen Mann as a Marie-Sklodowska-Curie Postdoctoral Fellow in the field of protocells. His current research interests are focused on developing strategies to fabricate motile microcompartments\, study of multiphase dynamics in liquid-liquid phase separation and designing strategies for regulating chemical communication between microcompartments.
URL:https://ibecbarcelona.eu/ca/event/ibec-seminar-pavan-kumar-bosukonda/
LOCATION:Sala Olivera\, Tower I\, Floor 11
CATEGORIES:IBEC Seminar
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20231219T100000
DTEND;TZID=Europe/Madrid:20231219T110000
DTSTAMP:20260428T084136
CREATED:20231212T123816Z
LAST-MODIFIED:20231215T121923Z
UID:113273-1702980000-1702983600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Prof. Aitor Aguirre
DESCRIPTION:Reverse engineering human heart  development with pluripotent stem cells\nProf. Aitor Aguirre\, Institute for Quantitative Health Science and Engineering (IQ) and the Department of Biomedical Engineering at Michigan State University  \nDuring development\, an exquisitely orchestrated series of biological processes lay down the map for the entirety of our bodies and carry it out to perfection. However\, occasional errors occur (due to mutations\, environmental factors\, and other causes) and lead to congenital defects\, the most common birth defect in humans affecting 1% of all newborns. Certain conditions such as obesity\, diabetes\, infections or drug use can increase this risk much further.\nTo tackle CHDs\, we are reverse engineering human heart development on a dish with the use of pluripotent stem cells\, creating heart organoids or synthetic mini-hearts. By recapitulating  aspects of heart development in vitro\, under fully controlled conditions\, we can dissect gene networks and morphological changes that give rise to specific parts of the heart to understand and prevent CHD\, such as single ventricle defects. Furthermore\, we can also use these mini-hearts as models to study the exposure to environmental conditions and other factors that are very poorly known. \n\nDr. Aguirre obtained his B.S. in Biology and M.S. in Biochemistry and Molecular Biology at the University of the Basque Country and his Ph.D. in Material Science at the Institute for Bioengineering of Catalonia (IBEC). For his postdoctoral training Dr. Aguirre joined The Salk Institute under the supervision of J.C. Izpisua-Belmonte\, where he explored in vivo reprogramming applied to cardiac regeneration\, making significant contributions to non-coding RNA biology in human cardiac development (Cell Stem Cell\, 2014; Circulation\, 2015). Dr. Aguirre became Assistant Professor of Medicine at the University of California\, San Diego in 2017 and joined the Institute for Quantitative Health Science and Engineering (IQ) and the Department of Biomedical Engineering at Michigan State University one year later. He became associate professor in 2023 and is currently the Chief of IQ’s Developmental and Stem Cell Biology Division and the Director of MSU’s Stem Cell Core Facility. Dr. Aguirre has extensive experience in cardiac development\, cardiovascular disease\, tissue engineering and -omic approaches. Dr. Aguirre has received numerous awards and nominations including the Hispanic Center of Excellence award at the University of California\, a career development NHLBI K01 award and frequently serves in grant review panels for the NIH and European Commission\, among others.
URL:https://ibecbarcelona.eu/ca/event/ibec-seminar-prof-aitor-aguirre/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20231219T200000
DTEND;TZID=Europe/Madrid:20231219T220000
DTSTAMP:20260428T084136
CREATED:20231212T131916Z
LAST-MODIFIED:20231212T131928Z
UID:113275-1703016000-1703023200@ibecbarcelona.eu
SUMMARY:Christmas Party 2023
DESCRIPTION:There’ll be food\, drink\, music and some fun surprises at this most wonderful time of the year!\n\n\nVenue \n\n\n\nFifteen restaurant (PCB) \n\n\nProgramme \n\n\n20:00 – 21:00 · Sale of raffle tickets\n20:00 – 22:00 · Christmas appetizer\n22:00 · Raffle and party\n00:30 · End \n\n\n\nWhen you register\, you’ll have a chance to choose a charity to be a beneficiary of our annual raffle. Tickets will be sold at the beginning of the event(€1 each) to support the chosen charity. \nIBEC Christmas celebration \n \n 
URL:https://ibecbarcelona.eu/ca/event/christmas-party-2023/
LOCATION:Fifteen Restaurant\, PCB
CATEGORIES:Social / Internal / PhD Committee
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20231220T163000
DTEND;TZID=Europe/Madrid:20231220T183000
DTSTAMP:20260428T084136
CREATED:20231122T105131Z
LAST-MODIFIED:20231122T110757Z
UID:112763-1703089800-1703097000@ibecbarcelona.eu
SUMMARY:PhD Thesis Defense: Marina Martínez Hernández
DESCRIPTION:Promoting cardiac regeneration by biomimetic microenvironments\n\n\n\n\nAuthor: Marina Martínez Hernández\, Biomaterials for Regenerative Therapies\n\n\nReading date: 20/12/2023\nReading time: 16:30 \n\n\nReading place: School of Mathematics and Statistics of UPC (Sala d’actes\, carrer Pau Gargallo)
URL:https://ibecbarcelona.eu/ca/event/phd-thesis-defense-marina-martinez-hernandez/
CATEGORIES:PhD Thesis Defence
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