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DTSTART;TZID=Europe/Madrid:20260116T103000
DTEND;TZID=Europe/Madrid:20260116T113000
DTSTAMP:20260405T144453
CREATED:20260114T090528Z
LAST-MODIFIED:20260120T103235Z
UID:131284-1768559400-1768563000@ibecbarcelona.eu
SUMMARY:Ibec Seminar. Ulrich Schwarz.
DESCRIPTION:Modelling optogenetic control of cell contractility\nUlrich Schwarz\, Heidelberg University \nAnimal cells are highly dynamic and continuously generate force\, for example for mechanosensing\, cell division\, cell migration\, morphogenesis and regeneration. Their main force generators are non-muscle myosin II molecular motors that slide actin filaments past one another. We first discuss how myosin II minifilaments dynamically assemble on demand and how this system can be controlled by optogenetics. The resulting deformations and forces can be predicted with continuum models for active solids\, which are solved with the finite element method and verified experimentally with traction force microscopy. Next\, we use active gel theory combined with van der Waals theory for myosin II molecules to demonstrate that cell contractility is sufficient to explain cell migration and that optogenetics can be used to initiate\, revert and stop migration. We then turn to multiple cells and show for a cell doublet how the neighboring cell actively responds to the contraction of an optogenetically activated cell. We finally introduce a finite element framework for cellularized active solids that allows us to study mechanosensitive wave propagation in optogenetically activated cell layers.
URL:https://ibecbarcelona.eu/ca/event/ibec-seminar-ulrich-schwarz/
LOCATION:Baobab room\, Floor 11\, Tower 1
CATEGORIES:IBEC Seminar
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20260122T100000
DTEND;TZID=Europe/Madrid:20260122T110000
DTSTAMP:20260405T144453
CREATED:20260116T071926Z
LAST-MODIFIED:20260116T071926Z
UID:131312-1769076000-1769079600@ibecbarcelona.eu
SUMMARY:Ibec Seminar. Barbara di Ventura
DESCRIPTION:Splice it into action! Inteins for controlling and probing biology\nBarbara di Ventura\, Universität Freiburg \nInteins are unusual proteins that perform a self-catalyzed protein splicing reaction. They have become valuable tools in synthetic and cell biology. In this talk\, I will introduce the basic principles of intein function and present recent work from my lab on exploiting inteins and engineering light-controlled intein activity.
URL:https://ibecbarcelona.eu/ca/event/ibec-seminar-barbara-di-ventura/
LOCATION:Torres I\, Floor -1\, Room 3
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20260123T103000
DTEND;TZID=Europe/Madrid:20260123T113000
DTSTAMP:20260405T144453
CREATED:20251212T131817Z
LAST-MODIFIED:20260120T122733Z
UID:130859-1769164200-1769167800@ibecbarcelona.eu
SUMMARY:Transversal skills.  Begonya Nafria Escalera
DESCRIPTION:Involucrar als pacients\, no és una moda passatjera\n Begonya Nafria Escalera\, Patient Engagement in Research Head of Department at Sant Joan de Déu Chidren’s Hospital (Spain) \nLa recerca i la innovació que respongui a les necessitats dels pacients\, requereix involucrar-los en les fases inicials i durant la vida d’un projecte. En aquesta sessió parlarem sobre la nova ciència que és el “patient involvement”\, aportant també projectes inscpiradors que demostrin els beneficis d’involucrar als pacients en l’àmbit de les ciències de la salut. \n  \n 
URL:https://ibecbarcelona.eu/ca/event/transversal-skills-begonya-nafria-escalera/
LOCATION:Baobab room\, Floor 11\, Tower 1
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20260126T160000
DTEND;TZID=Europe/Madrid:20260126T170000
DTSTAMP:20260405T144453
CREATED:20260108T111446Z
LAST-MODIFIED:20260108T111446Z
UID:131221-1769443200-1769446800@ibecbarcelona.eu
SUMMARY:Ibec Seminar. Silke Henkes
DESCRIPTION:Mechanochemical feedback in model epithelial tissues\nSilke Henkes\, Leiden Institute of Physics\, Leiden University \nIn the development of animals\, tissues self-organise starting from a single cell into layers\, shapes and patterns. This active mechanical process operates beyond the theoretical framework of reaction-diffusion equations such as Turing patterns. At the same time\, combining active driving with careful mechanical design of a system is distinct route to pattern formation and artificial functionality. \nHere I will show how two types of active driving interacts with mechanics: First\, for polar active materials where cells crawl on a substrate\, even with only uncorrelated activity\, elasticity leads to\nthe emergence of mesoscopic space-time correlations. I will show how this explains the ‘fingering instability’ at the edge of MDCK epithelial cell sheets as long lived active correlations. If we add alignment to generate a flocking state\, and cell division and death\, we model corneal epithelial cells well. We are then able to simulate the whole curved corneal epithelium\, and show that an inflow of cells from the limbus generates a stable spiral flow pattern with a +1 topological defect at the centre. \nSecond\, mechanochemical stress feedback in cell-cell junctions arises from the catch bond dynamics of the actomyosin cortex. It allows a junction to generate a contractile force that can overcome external pulling and thus allow for an active rearrangement or T1. In vertex and continuum models\, for strong enough feedback this gives rise to convergence-extension flows where the flow is opposite the direction of mechanical polarisation\, effectively generating a negative viscosity state.
URL:https://ibecbarcelona.eu/ca/event/ibec-seminar-silke-henkes/
LOCATION:Baobab room\, Floor 11\, Tower 1
CATEGORIES:IBEC Seminar
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20260130T093000
DTEND;TZID=Europe/Madrid:20260130T103000
DTSTAMP:20260405T144453
CREATED:20251211T145452Z
LAST-MODIFIED:20251211T145452Z
UID:130855-1769765400-1769769000@ibecbarcelona.eu
SUMMARY:Ibec Seminar. Francisco Lorenzo-Martín
DESCRIPTION:Next-generation organoid models for colorectal cancer research\nFrancisco Lorenzo-Martín\, University of Salamanca \n\nThree-dimensional organoid culture technologies have revolutionized cancer research by allowing for more realistic and scalable reproductions of tumor structures. This has enabled better modelling of low-complexity cancer cell behaviors that occur over short periods of time. However\, the currently available organoid systems lack the requisite multi-cellular diversity\, tissue-level organization\, biological durability\, and experimental flexibility that are needed to capture complex oncological processes. Consequently\, the study of many multifactorial cancer mechanisms is still not possible in vitro and instead requires the extensive use of animal models\, which provide limited spatiotemporal resolution of cellular dynamics and come at a substantial ethical cost. To overcome these limitations\, we have implemented tissue engineering and microfabrication technologies to develop topobiologically complex ex vivo cancer avatars. Focusing on colorectal cancer\, we have generated miniature tissues consisting of long-lived gut-shaped colon epithelia (‘mini-colons’) that are able to undergo tumorigenesis in vitro and stably integrate cancer cells with their native tumor microenvironment. This system provides an unprecedented repertoire of experimental possibilities\, which we illustrate through diverse applications. Altogether\, these next-generation organoid models push the boundaries of ex vivo cancer research.
URL:https://ibecbarcelona.eu/ca/event/ibec-seminar-francisco-lorenzo-martin/
LOCATION:Baobab room\, Floor 11\, Tower 1
CATEGORIES:IBEC Seminar
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