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X-WR-CALNAME:Institute for Bioengineering of Catalonia
X-ORIGINAL-URL:https://ibecbarcelona.eu/ca/
X-WR-CALDESC:Esdeveniments per Institute for Bioengineering of Catalonia
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DTSTART;TZID=Europe/Madrid:20260203T100000
DTEND;TZID=Europe/Madrid:20260203T150000
DTSTAMP:20260426T203129
CREATED:20260119T133250Z
LAST-MODIFIED:20260128T132855Z
UID:131531-1770112800-1770130800@ibecbarcelona.eu
SUMMARY:Ibec Seminar. Prof. Pierangelo Gobbo
DESCRIPTION:A search for the right scientific question: can we fabricate cells and tissues from scratch?\nProf. Pierangelo Gobbo\, University of Trieste \nBottom-up synthetic biology is an emerging research field whose objectives is to design and fabricate existing biological systems from inanimate molecules\, materials\, and chemical reactions.[1] One of the key biological systems that bottom-up synthetic biology is trying to re-design and fabricate is the living cell. This research led to the concept of “protocell” and “prototissues”.[2] A protocell is a micro-compartmentalised system capable of imitating at least one of the key features of a living cell (e.g.\, enzyme catalysis\, communication based on diffusible chemical signals\, information storage etc.). A prototissue is instead a free-standing and covalently interconnected network of communicating protocell units that can display synergistic functions.[3\, 4] \nWhile thus far efforts have been placed in the development of methods to fabricate PCMs with complex 3D architectures and demonstrate their chemical communication properties\, in this contribution I will show how I used the knowledge acquired during my entire scientific journey to move beyond the state-of-the-art in bottom-up synthetic biology\, and develop the first prototissues capable of photo-mechano-chemical transduction.[5] These are prototissues capable of converting a light stimulus into complex mechanical movements that in turn can influence the biocatalysis hosted within the protocell units composing the material itself. In order to achieve this\, we have designed and assembled a covalent and thermoresponsive poly(N-isopropylacrylamide) (P(NIPAM)) polymer network directly inside the lumen of the protocells composing the PCM\, where we also placed poly(ethylene oxide) (PEG) stabilised gold nanoparticles (AuNPs)\, amyloglucosidase (AGx)\, and glucose oxidase (GOx). By exploiting the photo-thermal effect of AuNPs and the thermoresponsive properties of the PNIPAM network in a synergistic manner\, we were able to achieve reversible light-induced contractions of the PCM. Most importantly\, the contraction caused the material to become hydrophobic. This made the contracted protocell membranes impermeable to small hydrophilic substrate molecules for enzyme catalysis\, and effectively shut off the hosted enzyme cascade. \nThe fabrication of tissue-like materials with increasingly advanced biomimetic properties will not only help us to understand the physicochemical basis of the emerging behaviours of living tissues\, but will also find important applications in tissue engineering\, pharmacokinetics\, mechanobiology\, personalised therapy\, in the development of micro-bioreactors and soft robotics. \nPierangelo Gobbo received his BSc (2008) and MSc (2010) in Chemistry at the University of Padua (Italy) and his PhD in 2016 at the University of Western Ontario (Canada). In 2016 he joined the research group of Prof. Stephen Mann\, FRS at the University of Bristol (UK) as an NSERC of Canada Postdoctoral Fellow first\, and then as an EU Marie Curie Postdoctoral Fellow. In 2019 Pierangelo started his independent research career at the School of Chemistry of the University of Bristol under a Vice-Chancellor’s Fellowship (Assistant Professorship). In October 2021 Pierangelo moved to the Department of Chemical and Pharmaceutical Sciences of the University of Trieste (Italy) where he is pioneering the first strategies to use synthetic cells (or “protocells”) as foundational units to assemble free-standing tissue-like materials with complex 3D architectures and programmable bio-inspired emergent behaviours such as contractility\, phototropism\, and biochemical sensing. During his academic career Pierangelo was awarded numerous awards for excellence in research. The most recent are Italy’s Giacomo Ciamician Medal for Organic Chemistry (2021)\, UK’s EPSRC New Investigator Award (2020)\, and the Canada’s Governor General’s Gold Medal (2017). He is currently PI on an ERC Starting Grant 2021\, co-coordinator of an EIC Pathfinder Open 2022\, and the coordinator of other National research projects.
URL:https://ibecbarcelona.eu/ca/event/ibec-seminar-prof-pierangelo-gobbo/
LOCATION:Baobab room\, Floor 11\, Tower 1
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20260203T123000
DTEND;TZID=Europe/Madrid:20260203T170000
DTSTAMP:20260426T203129
CREATED:20260114T142056Z
LAST-MODIFIED:20260119T141340Z
UID:131306-1770121800-1770138000@ibecbarcelona.eu
SUMMARY:Nano Cancer Day
DESCRIPTION:El Nanodía Mundial Contra el Cáncer es un evento organizado en el marco del Día Mundial contra el Cáncer donde se darán a conocer las últimas innovaciones en materia de NANOMEDICINA contra el CÁNCER\, con temas que van desde el diagnóstico precoz\, la liberación controlada de fármacos o la radioterapia con nanopartículas. \nUn año más\, expertos en NANOMEDICINA de diferentes campos -investigadores\, empresarios\, médicos oncólogos\, pacientes\, etc.\,  expondrán los últimos avances y nos darán la oportunidad de descubrir el generador de progreso que la NANOMEDICINA significa para la salud como creador de nuevas oportunidades en el diagnóstico y el tratamiento del cáncer y como podemos contribuir en la misión Europea contra el cáncer. \nNANOMED Spain organiza la edición de este año con el Hospital del Mar Research Institute Barcelona \n  \n\n\n\n09:30\nBienvenida e Inauguración · \nJosep Samitier · Coordinador Científico de NANOMED Spain\nJoaquín Arribas · Director del Hospital del Mar Research Institute Barcelona (HMRIB)\n\n\n09:40\nNanomedicina y cáncer \nJosep Samitier · Coordinador Científico de NANOMED Spain\n\n\n10:00\nIniciativa en terapias avanzadas: Programa de Terapia Celular y sustancias de Origen Humano\nLuís Álvarez Vallina · Director del Programa de Terapia Celular y Sustancias de Origen Humano del Hospital del Mar Research Institute Barcelona (HMRIB) y director de Investigación del Banco de Sangre y Tejidos (BST)\n\n\n10:25\nTBC\n\n\n10:50\nCafé\n\n\n11:25\nPlataformas y Capacidades para la fabricación de Terapias avanzadas de uso clínico \nNúria Gavalda · Directora de Estrategia e Innovación del Banco de Sangre y Tejidos (BST)\n\n\n11:45\nTBC\nGiuseppe Battaglia · Institut de Bioenginyeria de Catalunya (IBEC)\n\n\n12:10\nApoyando la Investigación e Innovación en Cáncer\nSofía Cabezudo  · Gestora de Proyectos Asociación Española contra el Cáncer (AECC)\n\n\n12:30\nClausura\n\n\n\n  \nPara registrarse hacer click aquí.
URL:https://ibecbarcelona.eu/ca/event/nano-cancer-day/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:External symposium / conference / congress
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20260216T113000
DTEND;TZID=Europe/Madrid:20260216T123000
DTSTAMP:20260426T203129
CREATED:20260128T102059Z
LAST-MODIFIED:20260128T102059Z
UID:131754-1771241400-1771245000@ibecbarcelona.eu
SUMMARY:Ibec Seminar. Monika E. Dolega
DESCRIPTION:Nucleolar mechano-adaptation and its role in epithelial homeostasis\nMonika E. Dolega\, Institute for Advanced Biosciences IAB\, INSERM U1209\, CNRS UMR5309\, University Grenoble-Alpes\, Grenoble\, France \n  \nEpithelial tissues experience constant mechanical stimuli tied to normal physiological functions\, but how they maintain homeostasis under such dynamic conditions remains unclear. Our previous RNAseq study on in-plane compressed epithelial monolayers revealed altered transcripts of ribosomal proteins essential for ribosome biogenesis in nucleoli—membrane-less\, sub-nuclear biocondensates that challenge classical mechanotransduction concepts. Although few studies confirm nucleolar sensitivity to external cues\, detailed mechanisms are lacking. Using advanced microscopy\, omics\, and biophysical approaches\, we uncover a new mechanism of nucleolar mechano-adaptation. Mechanical confinement over minutes reorganizes nucleolar structure and downregulates pre-rRNA transcription. Central to this process is the nucleolar protein Nucleolin\, which translocates to perform two roles: it leaves the rDNA promoter region to down-regulate ribosome biogenesis and participates in DNA repair at damage sites caused by compression. This study introduces the nucleolus as a mechano-sensitive organelle\, advancing mechanobiology and cancer research by revealing a new potential therapeutic target
URL:https://ibecbarcelona.eu/ca/event/ibec-seminar-monika-e-dolega/
LOCATION:Baobab room\, Floor 11\, Tower 1
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20260217T090000
DTEND;TZID=Europe/Madrid:20260217T153000
DTSTAMP:20260426T203129
CREATED:20260122T111927Z
LAST-MODIFIED:20260122T111956Z
UID:131633-1771318800-1771342200@ibecbarcelona.eu
SUMMARY:Innovació científica i tecnològica en salut: transferència de resultats per a la medicina del futur
DESCRIPTION:i millorar la qualitat de vida de la ciutadana\, però sense transferència no hi ha impacte. Catalunya és un referent en recerca biomèdica i biotecnològica\, però el gran repte és transformar aquest coneixement en solucions reals que arribin a la clínica i al pacient. \nEn el marc de la Barcelona Health Innovation Week 2026\, des de l’Institut de Bioenginyeria de Catalunya (IBEC) organitzem aquesta jornada per demostrar que és possible connectar l’ecosistema de recerca amb el sistema de sanitari i empreses per impulsar la medicina personalitzada\, les teràpies avançades i les tecnologies que milloren el diagnòstic i el tractament. \nAquesta sessió posa el focus en la transferència tecnològica i en l’impacte real de la recerca. Presentarem els resultats del Pla Complementari de Biotecnologia aplicada a la salut a Catalunya\, un programa que ha fomentat la col·laboració entre centres de recerca i instituts sanitaris per desenvolupar solucions disruptives en salut. A més\, comptarem amb experts i expertes en transferència tecnològica\, inversió i gestió de la innovació que compartiran estratègies per accelerar la translació de coneixement cap al mercat i la clínica així com casos d’èxit que ja estan marcant el camí de la medicina del futur. \nSi vols conèixer de prop les claus de l’èxit en la translació de la medicina personalitzada\, connectar amb agents de l’ecosistema d’innovació i formar part de la conversa sobre el futur de la nostra salut\, no et perdis aquesta oportunitat única per entendre com la col·laboració i la inversió en innovació poden generar valor per a la societat. \nActivitat gratuïta. Registre obligatori aquí.
URL:https://ibecbarcelona.eu/ca/event/innovacio-cientifica-i-tecnologica-en-salut-transferencia-de-resultats-per-a-la-medicina-del-futur/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:External symposium / conference / congress,IBEC Symposium / Conference / Congress
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20260227T090000
DTEND;TZID=Europe/Madrid:20260227T130000
DTSTAMP:20260426T203129
CREATED:20260128T091847Z
LAST-MODIFIED:20260204T141925Z
UID:131743-1772182800-1772197200@ibecbarcelona.eu
SUMMARY:Thematic Network. NET-CNS Workshop 3: Overcoming Therapeutic Barriers in CNS
DESCRIPTION:This third workshop will focus on overcoming therapeutic barriers in CNS disorders\, with particular emphasis on delivery strategies\, biological interfaces\, and translational challenges. \nSchedule \n09:00 – Registration\n09:20 – Welcome from Network Coordinator\n09:30 – IBEC speaker: Daniel Gonzalez-Carter\, Molecular Bionics group Group. “Exploiting the physiology of the BBB to target therapies to the brain.”Daniel Gonzalez-Carter\, IBEC Molecular Bionics Group\,\n10:00 – Invited speaker: Cristina Fornaguera\, NanoTherapies Lab\, Institut Químic de Sarrià (IQS)\, Universitat Ramon Llull (URL). “From Bench to Brain: Polymeric Nanoparticles for Controlled Brain Delivery”\n10:40 – Coffee Break and Networking\n11:10 – Invited speaker: Meritxell Teixidó\, Gate2Brain. “Gate2Brain blood-brain barrier shuttle peptides: From discovery to applications and going beyond small molecules”\n11:50 – Invited speaker: Eloi Montañez\, IDIBELL Department of Physiological Sciences .Faculty of Medicine and Health Sciences\, University of Barcelona. “Linking TDP-43 to Vascular Degeneration and Neuroinflammation”\n12:30 – IBEC speaker: Anna Lagunas\, IBEC Nanobioengineering Group\, “A BBB-on-a-chip (BBB-oC) with integrated micro-TEER to evaluate brain drug delivery”\n13:00 – End of the Workshop \nTo register\, click here.
URL:https://ibecbarcelona.eu/ca/event/thematic-network-net-cns-workshop-3-overcoming-therapeutic-barriers-in-cns/
LOCATION:Baobab room\, Floor 11\, Tower 1
CATEGORIES:IBEC Seminar
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