{"id":116270,"date":"2024-03-04T16:36:07","date_gmt":"2024-03-04T15:36:07","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/industry-and-hospitals\/capabilities\/biological-models\/"},"modified":"2024-07-10T12:00:03","modified_gmt":"2024-07-10T10:00:03","slug":"building-biological-models","status":"publish","type":"page","link":"https:\/\/ibecbarcelona.eu\/ca\/industry-and-hospitals\/capabilities\/building-biological-models\/","title":{"rendered":"Biological models\u00a0"},"content":{"rendered":"\n<h4 class=\"wp-block-heading\">IBEC is a leader in developing innovative biological models to study human diseases and treatment responses. These models provide a powerful toolset for researchers and industry, offering:<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Reduced reliance on animal testing<\/strong>: IBEC&#8217;s models allow for earlier and more efficient disease research stages, minimizing the need for animal models.<\/li>\n\n\n\n<li><strong>Enhanced understanding of human diseases:<\/strong> These models closely mimic human biology, providing a more accurate representation of disease processes compared to traditional methods.<\/li>\n\n\n\n<li><strong>Development of new therapeutic strategies:<\/strong> The ability to effectively test potential treatments on these models accelerates drug discovery and development.<\/li>\n<\/ul>\n\n\n<div class=\"responsive-tabs\">\n<h2 class=\"tabtitle\">KEY MODEL TYPES<\/h2>\n<div class=\"tabcontent\">\n\n\n\n\n<p><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong><em>In vitro<\/em> models:<\/strong>\n<ul class=\"wp-block-list\">\n<li>Platforms: primary cultures, cortical stem cells, cortical organoids.<\/li>\n\n\n\n<li>Ex vivo implantation platform:\n<ul class=\"wp-block-list\">\n<li>3DEX: Mimics in utero implantation for direct imaging.<\/li>\n\n\n\n<li>IMPLATFORM: Microfluidic platform for ex vivo embryo culture.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>Cell and Tissue Models:\n<ul class=\"wp-block-list\">\n<li>Human Plasma-Derived Protein Supplement for embryo culture and implantation.<\/li>\n\n\n\n<li>Cardiac tissue models from induced pluripotent stem cells (iPSCs).<\/li>\n\n\n\n<li>3D cultured myoblasts for studying muscle formation.<\/li>\n\n\n\n<li>Microencapsulated beta-cells for diabetes research.<\/li>\n\n\n\n<li>3D micro liver models for drug testing (NAFL, NAFLD, NASH).<\/li>\n\n\n\n<li>Biomaterials for cell encapsulation and scaffolds (pancreatic beta cells, hepatocytes, retinal cells).<\/li>\n\n\n\n<li>Epithelial dynamics, cell mechanics, tissue growth, wound healing, and cancer cell invasion.<\/li>\n\n\n\n<li>Cancer cell interaction with Cancer-Associated Fibroblasts (CAFs).<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Organ-on-a-chip models:<\/strong>\n<ul class=\"wp-block-list\">\n<li>Microfluidic platform for modeling: Heart, Skin, Vessels, Bone, Angiogenesis, Muscle, NAFL, NAFLD, NASH, and Progenitor cell recruitment.<\/li>\n\n\n\n<li>Standardized approaches using patient-derived organoids for personalized cancer treatment.<\/li>\n\n\n\n<li>Human skeletal muscle integrated with biosensors for studying muscle function Organoids.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Organoids:<\/strong>\n<ul class=\"wp-block-list\">\n<li>Available Organoids: Cortical, Kidney, Retina, Muscle, Heart, Skin, Liver, Pancreas, Intestine, Spinal Cord, Bladder cancer and colorectal cancer.<\/li>\n\n\n\n<li>Studies on organoid mechanics and function (validated on kidney organoids), and genome editing.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong><em>In vivo<\/em> models:<\/strong>\n<ul class=\"wp-block-list\">\n<li>Mouse models of Parkinson\u00b4s, Alzheimer\u00b4s diseases (male and female).<\/li>\n\n\n\n<li>Development of Parkinson&#8217;s and tauopathy models using adenoviral delivery.<\/li>\n\n\n\n<li>Plasmodium-infected mice for malaria studies.<\/li>\n\n\n\n<li>Zebrafish model for visual function studies.<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n\n\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>IBEC is a leader in developing innovative biological models to study human diseases and treatment responses. These models provide a powerful toolset for researchers and industry, offering:<\/p>\n","protected":false},"author":4,"featured_media":116232,"parent":115865,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"tags":[],"class_list":["post-116270","page","type-page","status-publish","has-post-thumbnail"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Biological models\u00a0 - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"description\" content=\"Building biological models to study human diseases and the response to treatments, what increases our understanding of the disease before progressing to animal testing.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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