{"id":135109,"date":"2015-09-08T14:10:47","date_gmt":"2015-09-08T14:10:47","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/research-groups\/former-groups\/nanoscopy-for-nanomedicine\/"},"modified":"2015-09-08T14:10:47","modified_gmt":"2015-09-08T14:10:47","slug":"nanoscopy-for-nanomedicine","status":"publish","type":"page","link":"https:\/\/ibecbarcelona.eu\/ca\/research-groups\/former-groups\/nanoscopy-for-nanomedicine\/","title":{"rendered":"Nanoscopy for Nanomedicine"},"content":{"rendered":"
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About<\/h2>\n
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The main goal of our group is to use Super Resolution Microscopy (nanoscopy) to visualize and track in living cells and tissues self-assembled nanomaterials with therapeutic potential (nanomedicine). <\/h4>\n\n\n\n

The understanding of materials-cell interactions is the key towards the development of novel nanotechnology-based therapies for treatment of cancer and infectious diseases.<\/strong><\/p>\n\n\n\n

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Our group aims to use a multidisciplinary approach, at the interface of chemistry, physics and biology, to develop novel nanomaterials for the treatment of cancer and infectious diseases.<\/p>\n<\/blockquote>\n\n\n\n

We aim at the development of novel nanocarriers for drug delivery based on self-assembly, i.e. able to build themselves. Molecular self-organization is ubiquitous in the biological world and represents for us a source of inspiration for the design of nanostructures with biomedical potential. In particular we focus on the development of self-assembled nanoparticles and nanofibers able to selectively target diseased cells and deliver locally therapeutic moieties such as drugs and genetic material (e.g. DNA, siRNA, mRNA).<\/p>\n\n\n\n

A key point towards the development of novel nanotechnology-based therapies is the understanding of the behavior of nanomaterials in the complex biological environment. Here we use super resolution microscopy to track nanomaterials during their voyage in the biological environment and to visualize the interactions with blood components, immune system and target cells. <\/h6>\n\n\n\n
We make use of a variety of super resolution techniques based on single molecule detection such a stochastic optical reconstruction microscopy (STORM), photoactivated localization microscopy (PALM), point accumulation for imaging in nanoscale topography (PAINT), and single particle tracking (SPT). These methods allow to achieve a resolution down to few nanometers and are therefore ideal to visualize nanosized synthetic objects in the biological environment. Super resolution microscopy provides a molecular picture of structure-activity relations and represent a guide towards the design of innovative materials for nanomedicine.<\/h6>\n\n\n\n
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TEM image of novel self-assembled nanofibers synthesized in the group.<\/figcaption><\/figure>\n\n\n\n
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Nanoparticles interactions with blood components imaged with conventional optical microscopy<\/figcaption><\/figure>\n\n\n\n
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Super resolution STORM microscopy<\/figcaption><\/figure>\n<\/figure>\n\n\n\n<\/div>

Projects<\/h2>\n
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INTERNATIONAL GRANTS<\/th>FINANCER<\/th>PI<\/th><\/tr><\/thead>
NANOSTORM<\/strong> Design of Nanomaterials for Targeted Therapies Guided by Super Resolution Imaging (2018-2023)<\/td>ERC, European Commission<\/td>Lorenzo Albertazzi<\/td><\/tr>
THERACAT BIO-orthogonal catalysis for cancer therapy (2018-2022)<\/td>MARIE CURIE, European Commission<\/td>Lorenzo Albertazzi<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

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NATIONAL GRANTS<\/th>FINANCER<\/th>PI<\/th><\/tr><\/thead>
STROMATARGET \u00b7<\/strong> Pol\u00edmeros supramoleculares dirigidos al microambiente tumoral: validaci\u00f3n mediante t\u00e9cnicas de microscop\u00eda avanzada (2020-2023)<\/td>MINECO: Retos investigaci\u00f3n: Proyectos I+D<\/td>Silvia Pujals<\/td><\/tr>
Collaborative Research Projects AOM-BIST<\/td>BIST<\/td>Lorenzo Albertazzi<\/td><\/tr>
Understanding and measuring mechanical tumor properties to improve cancer  diagnosis, treatment, and survival: Application to liquid biopsies
(2017-2021)<\/td>		Obra Social La Caixa<\/td>Lorenzo Albertazzi<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

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FINISHED PROJECTS<\/th>FINANCER<\/th>PI<\/th><\/tr><\/thead>
NANOVAX<\/strong> Nanovacunas dise\u00f1adas para inmunoterapia antitumoral (2016-2020)<\/td>Acciones de Programaci\u00f3n Conjunta Internacional, MINECO<\/td>Lorenzo Albertazzi
Josep Samitier<\/td><\/tr>
TARGETSTORM <\/strong>Nanomateriales para terapias dirigidas contra el c\u00e1ncer visualizados con microscopia de s\u00faper resoluci\u00f3n STORM (2016-2019)<\/td>Retos investigaci\u00f3n: Proyectos I+D, MINECO<\/td>Silvia Pujals<\/td><\/tr>
SGR Grups de recerca consolidats (2017-2019)<\/td>SGR, AGAUR<\/td>Silvia Pujals<\/td><\/tr>
Novel approaches for Pandemic Virus Targeting Using Adaptive Polymers (2015-2017)<\/td>AXA Research Fund<\/td>Lorenzo Albertazzi<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

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Publications<\/h2>\n
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(See full publication list in ORCID<\/a>)<\/p>\n\n\n

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