{"id":17098,"date":"2014-12-05T15:45:24","date_gmt":"2014-12-05T14:45:24","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?page_id=17098"},"modified":"2023-12-27T15:41:46","modified_gmt":"2023-12-27T14:41:46","slug":"cellular-and-respiratory-biomechanics","status":"publish","type":"page","link":"https:\/\/ibecbarcelona.eu\/ca\/cellmech","title":{"rendered":"Cellular and respiratory biomechanics"},"content":{"rendered":"
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About<\/h2>\n
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The goal of our research is to gain a deeper understanding of cellular and <\/strong>respiratory biomechanics to improve the diagnosis and treatment of respiratory diseases.
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The work is organized in two interrelated areas, focused on respiratory mechanics at both the systemic and the cellular level. We use basic and translational approaches in a multidisciplinary framework involving close cooperation with clinical groups.<\/p>\n\n\n\n

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Our current research interest is focused on the study of cell-matrix mechanical cross-talk for tissue engineering and regenerative medicine.<\/p>\n<\/blockquote>\n\n\n\n

Cells sense and actively respond to the biophysical features of their microenvironment. Mechanical properties of the extracellular matrix regulate critical cell processes such as contraction, migration, proliferation, gene expression and differentiation.
We use atomic force microscopy and other cutting-edge biophysical techniques to study the mechanical properties of the extracellular matrix and their impact in cell behavior. We have implemented protocols to decellularize different soft tissues. This innovative approach allowed us to reveal the local mechanical properties of the lung and heart extracellular matrix. By seeding cells in these scaffolds we study the impact of the mechanical features of the microenvironment on stem cell engraftment and differentiation onto lung and heart phenotypes. We produce lab-on-chip devices mimicking the native cell microenvironment to investigate mechanical signaling driving stem cell differentiation under precisely controlled conditions.<\/p>\n\n\n\n

Using 3D bioprinters we integrate stem cells into synthetic and extracellular matrix hydrogels to fabricate tissue patches as an innovative approach to regenerate ventricular scars resulting from heart infarct. Organ biofabrication reengineered from decellularized tissue scaffolds offers a promising alternative for transplantation. We develop improved bioreactors mimicking breathing and blood perfusion to biofabricate lungs by seeding stem cells into acellular lung scaffolds.<\/p>\n\n\n\n

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Figure 1. <\/em>Mechanical mapping and imaging of the extracellular matrix of a slice of decellularized mouse lung obtained by the combination of bright field (A), immunofluorescence microscopy (B), and atomic force microscopy (C \u2013 F).<\/figcaption><\/figure>\n<\/figure>\n\n\n\n<\/div>

Projects<\/h2>\n
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INTERNATIONAL PROJECTS<\/th>FINANCER<\/th>PI<\/th><\/tr><\/thead>
Phys2BioMed<\/strong> \u00b7 Biomechanics in health and disease: advanced physical tools for innovative early diagnosis (2019-2022)<\/td>European Commission, MARIE CURIE – ITN<\/td>Daniel Navajas<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n
FINISHED PROJECTS<\/th>FINANCER<\/th>PI<\/th><\/tr><\/thead>
MatriMec<\/strong> \u00b7 Estudio multiescala de la mec\u00e0nica no lineal de la matriz extracelular de pulm\u00f3n (2018-2020)<\/td>MINECO, Proyectos I+D Excelencia<\/td>Daniel Navajas<\/td><\/tr>
Cardiopoesi amb biomatrius per regenerar la cicatriu post infart: From bench to bedside (first-in-man trial)<\/td>Pla Estrat\u00e8gic de Recerca i Innovaci\u00f3 en Salut (PERIS)<\/td>Daniel Navajas<\/td><\/tr>
Se\u00f1alizaci\u00f3n m\u00e9canica en la diferenciaci\u00f3n de c\u00e9lulas madre en el pulm\u00f3n. Modelo pulm\u00f3n-en-un-chip<\/td>FIS-Proyectos de investigaci\u00f3n en salud<\/td>Daniel Navajas<\/td><\/tr>
Bench test on performance of portable automatic CPAP devices (2016-2017)<\/td>RESMED (FBG2016A)<\/td>Ramon Farr\u00e9 (UB)<\/td><\/tr>
Precondicionamento biof\u00edsico de c\u00e9lulas madre mesenquimales para el tratamiento de la lesi\u00f3n pulmonar aguda provocada por sobreventilaci\u00f3n en modelo animal 2015-2017)<\/td>FIS-MINECO (PI14\/00280)<\/td>Daniel Navajas<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<\/div>

Publications<\/h2>\n
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See full publication list in ResearcherID<\/a> (h-index 51), Google Scholar<\/a> (h-index 67) and ORCID<\/a><\/p>\n\n\n

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