{"id":17124,"date":"2014-12-10T16:22:39","date_gmt":"2014-12-10T15:22:39","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?page_id=17124"},"modified":"2026-01-16T14:57:14","modified_gmt":"2026-01-16T13:57:14","slug":"nanobioengineering","status":"publish","type":"page","link":"https:\/\/ibecbarcelona.eu\/ca\/nanobioengineering","title":{"rendered":"Nanobioengineering"},"content":{"rendered":"
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About<\/h2>\n
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The Nanobioengineering group is a truly multidisciplinary team composed by researchers coming from very diverse backgrounds working together in applying nanotechnology for the development of new biomedical systems and devices, mainly for diagnostic purposes, and integrated microfluidic Organ-on-Chip devices for the study of organ physiology, disease etiology, or drug screening.<\/h4>\n\n\n\n
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The goal is to fabricate microsystems containing living cells that recapitulate tissue and organ level functions in vitro and new portable diagnosis devices that can be used as Point-of-Care systems.<\/p>\n<\/blockquote>\n\n\n\n

The main research activities of the group include the engineering and biochemical functionalization of biomaterials integrated with microfluidics systems. The bioengineered microdevices are used to study cell responses to biomolecular compounds applied to Organ-on-Chip devices, or for the development of new lab-on-a-chip based biosensors.<\/p>\n\n\n\n

The projects carried out by the group are focused on clinical and industrial problems and are related to three convergent research lines:<\/p>\n\n\n\n

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1. Biosensors and Lab-on-a-Chip devices for clinical diagnosis and monitoring<\/h5>\n\n\n\n
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  • DNA sensors-arrays integrated in lab-on-a-chip for portable point of care diagnosis<\/li>\n\n\n\n
  • Vascular implantable sensors for circular cancer biomarker detection.<\/li>\n\n\n\n
  • Antibody-based sensors for pathogenic microorganisms\u2019 detection and neurodegenerative early detection<\/li>\n\n\n\n
  • Implantable physiological sensors-array for tissue in vivo hypoxia and ischemia monitoring.<\/li>\n\n\n\n
  • 3D printing microfluidic technology.<\/li>\n\n\n\n
  • Microfluidic chip using hydrodynamic forces for cell counting and sorting. Application for detection of circulating tumours cells (CTCs).<\/li>\n<\/ul>\n\n\n\n
    2. Nanotechnology applied to biomolecule interaction studies and micro\/nano-environments for regenerative medicine applications<\/h5>\n\n\n\n
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    • Development of bioengineered 2D and 3D micro\/nanoenvironments with a topography and chemical composition controlled at the nanoscale for cell behavior studies (adhesion, proliferation, differentiation). Application to musculoskeletal system regeneration.<\/li>\n\n\n\n
    • Biophysical description of cellular phenomena (adhesion, cell migration, differentiation) using micro\/nanotechnologies, cell biology tools and soft matter physics.<\/li>\n\n\n\n
    • Study of biological mechanisms at single molecule level.<\/li>\n\n\n\n
    • Study of magnetite nanoparticles – Amyloid-Beta interaction in Alzheimer disease.<\/li>\n<\/ul>\n\n\n\n
      3. Microfluidic systems for biological studies and Organ-on-Chip devices<\/h5>\n\n\n\n
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      • Microfluidic chip for blood\/plasma filtering and anemia diseases characterization<\/li>\n\n\n\n
      • Spleen-on-a-chip development.<\/li>\n\n\n\n
      • Nanoporous-based systems for kidney-on\u2013a-chip developments.<\/li>\n\n\n\n
      • Engineering microfluidic platforms for neurobiological studies.<\/li>\n\n\n\n
      • Development of 3D neuromuscular tissue models for soft robotics and clinical applications<\/li>\n\n\n\n
      • Microfluidic system to monitor cancer therapy response. Tumor Cancer on a chip in vitro development.<\/li>\n\n\n\n
      • Microfluidic vessel on-a-chip for screening drug delivery systems.<\/li>\n<\/ul>\n\n\n\n
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        In vitro model of Blood Brain Barrier<\/em><\/figcaption><\/figure>\n\n\n\n
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        Microfluid System for Circulating Tumour Cells isolation in Blood.<\/em><\/figcaption><\/figure>\n<\/figure>\n\n\n\n

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        Staff<\/h2>\n
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