{"id":100122,"date":"2022-10-26T11:37:20","date_gmt":"2022-10-26T09:37:20","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=100122"},"modified":"2022-10-27T11:46:18","modified_gmt":"2022-10-27T09:46:18","slug":"projecte-theracat-donant-a-la-diana-del-cancer","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/projecte-theracat-donant-a-la-diana-del-cancer\/","title":{"rendered":"Projecte THERACAT: donant a la diana del c\u00e0ncer\u00a0"},"content":{"rendered":"\n

Els investigadors del projecte europeu THERACAT, coordinat per l’Institut de Bioenginyeria de Catalunya (IBEC), fa quatre anys que treballen en el desenvolupament de noves estrat\u00e8gies per tractar el c\u00e0ncer de forma local. Mitjan\u00e7ant l’\u00fas de nanopart\u00edcules capaces de transformar un prof\u00e0rmac no actiu en un f\u00e0rmac actiu, han fet un pas m\u00e9s en el desenvolupament d’un tractament efectiu. Com que el f\u00e0rmac nom\u00e9s funciona al lloc del tumor, els forts efectes secundaris indesitjables dels tractaments actuals es reduirien dr\u00e0sticament, augmentant la qualitat de vida dels pacients. El projecte THERACAT va abordar aquest repte amb un enfocament multidisciplinari, combinant la s\u00edntesi de noves nanopart\u00edcules i catalitzadors, el desenvolupament d’eines de caracteritzaci\u00f3 per microsc\u00f2pia i la realitzaci\u00f3 d’assajos in vitro<\/em> i in vivo<\/em> per avaluar-ne la cat\u00e0lisi terap\u00e8utica.\u00a0<\/h4>\n\n\n\n
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El 2020 es van perdre prop de 10 milions de vides, \u00e9s a dir, gaireb\u00e9 una de cada sis morts, a causa dels m\u00e9s de 100 tipus diferents de c\u00e0ncer descrits fins ara, segons l’Organitzaci\u00f3 Mundial de la Salut<\/a>. Aquestes malalties es caracteritzen per c\u00e8l\u00b7lules que presenten un creixement anormal i tenen el potencial d’estendre’s i de colonitzar altres parts del cos, a causa de factors com les mutacions gen\u00e8tiques, l’her\u00e8ncia i els carcin\u00f2gens ambientals. <\/p>\n\n\n\n

Els tractaments disponibles per al c\u00e0ncer es basen principalment en quimioter\u00e0pia, radioter\u00e0pia i ter\u00e0pies hormonals. No obstant aix\u00f2, aquests enfocaments no s\u00f3n espec\u00edfics i afecten els teixits i els \u00f2rgans sans. Causen forts efectes secundaris que s\u00f3n perjudicials per a la salut f\u00edsica i mental global dels pacients, per la qual cosa \u00e9s urgent trobar nous enfocaments per tractar el c\u00e0ncer. <\/p>\n\n\n\n

El projecte europeu\u202f<\/strong>THERACAT<\/strong><\/a>\u202fha proposat solucions a aquest problema mitjan\u00e7ant el desenvolupament de noves estrat\u00e8gies per administrar espec\u00edficament els f\u00e0rmacs nom\u00e9s al lloc del tumor<\/strong>. El projecte \u00e9s una Xarxa Europea de Formaci\u00f3\u202fMarie\u202fSk\u0142odowska-Curie (MSCA-ITN-ETN) que va formar 13 joves en diferents aspectes del nou camp de la cat\u00e0lisi\u202fbioortogonal\u202fper a la ter\u00e0pia del c\u00e0ncer. Cal destacar aqu\u00ed que, encara que la pand\u00e8mia de COVID-19 va impedir que es produ\u00efssin gaireb\u00e9 totes les estades previstes entre investigadors, els estudiants i els laboratoris van intercanviar material, informaci\u00f3 i coneixements de manera molt intensa al llarg del projecte, mantenint viu l’esperit\u202fdels\u202fprojectes de la Xarxa Europea de Formaci\u00f3. El projecte\u202fTHERACAT\u202fva ser coordinat per\u202fLorenzo\u202fAlbertazzi, l\u00edder del grup de\u202fNanosc\u00f2pia\u202fper a Nanomedicina<\/a> de l’Institut de Bioenginyeria de Catalunya (IBEC). 
 
Aquesta nova generaci\u00f3 de joves cient\u00edfics ha estat formada per abordar els reptes de la cat\u00e0lisi\u202fbioortogonal\u202fper tractar el c\u00e0ncer des d’una perspectiva\u202fmultidisciplin\u00e0ria\u202fi col\u00b7laborativa, un punt de partida prometedor per trobar nous tractaments m\u00e9s efica\u00e7os contra el c\u00e0ncer i amb menys efectes secundaris. <\/p>\n\n\n\n

Qu\u00e8 \u00e9s la cat\u00e0lisi bioortogonal?<\/strong>\u00a0<\/p>\n\n\n\n

La qu\u00edmica bioortogonal fa refer\u00e8ncia a les reaccions que poden tenir lloc dins del nostre cos sense interferir amb les reaccions bioqu\u00edmiques natives que es produeixen normalment. Es tracta d’un camp de recerca cada cop m\u00e9s ampli, la pionera del qual va ser Carolyn Bertozzi<\/a>, guardonada amb el Premi Nobel de Qu\u00edmica el 2022. i pot tenir aplicacions en salut, agricultura i ind\u00fastria. <\/p>\n\n\n\n

Aquestes reaccions inclouen dos passos principals: en primer lloc, es dipositen al lloc del tumor, micro i nanodispositius amb una unitat catalitzadora, i despr\u00e9s s’administren al pacient f\u00e0rmacs no actius (coneguts com a prof\u00e0rmacs). Aquests prof\u00e0rmacs entren al torrent sanguini i, quan arriben al tumor, les unitats catal\u00edtiques dels micro i nanodispositius duen a terme una reacci\u00f3, una reacci\u00f3 bioortogonal, i converteixen el prof\u00e0rmac inactiu en un f\u00e0rmac actiu, que ara pot exercir la seva funci\u00f3 localment nom\u00e9s al tumor. De manera metaf\u00f2rica, podr\u00edem dir que el prof\u00e0rmac \u00e9s un pany i el catalitzador bioortogonal \u00e9s la clau. Les cat\u00e0lisis bioortogonals s\u00f3n, per tant, molt espec\u00edfiques, i cada prof\u00e0rmac necessita una unitat catal\u00edtica concreta per ser activat. <\/p>\n\n\n\n

Nanopart\u00edcules amb metalls com a catalitzadors<\/strong><\/strong><\/p>\n\n\n\n

L’objectiu de\u202fTHERACAT\u202f\u00e9s utilitzar les reaccions\u202fbioortogonals\u202fper activar els f\u00e0rmacs nom\u00e9s al lloc del tumor, evitant una acci\u00f3 sist\u00e8mica. Els joves investigadors del projecte van seguir diferents enfocaments per assolir aquest mateix\u202fprop\u00f2sit: estudiar, desenvolupar i optimitzar les nanopart\u00edcules que porten una unitat catalitzadora, en aquest cas diferents metalls, per convertir efica\u00e7ment els prof\u00e0rmacs en f\u00e0rmacs actius al lloc del tumor. En concret, els seus treballs es van centrar en quatre aspectes principals: i) s\u00edntesi i caracteritzaci\u00f3 de materials catal\u00edtics\u202fbioortogonals; ii) disseny de nous prof\u00e0rmacs anticancerosos i estrat\u00e8gies catal\u00edtiques per activar-los; iii) desenvolupament\u202fd’estrat\u00e8gies\u202fd’administraci\u00f3\u202fdels materials catal\u00edtics in vitro<\/em> i in vivo<\/em>; i iv) avaluaci\u00f3 de les activitats in vitro<\/em> i in vivo<\/em> per a la ter\u00e0pia del c\u00e0ncer. <\/p>\n\n\n\n

Un dels diversos estudis va ser realitzat per\u202fAnjana\u202fSathyan\u202fal laboratori de la professora\u202fAnja\u202fPalmans\u202fa la Universitat Tecnol\u00f2gica d’Eindhoven (Pa\u00efsos Baixos), en col\u00b7laboraci\u00f3 amb altres laboratoris del consorci\u202fTHERACAT. Els resultats del treball s’han publicat recentment a la revista Molecular\u202fSystems\u202fDesign\u202f&\u202fEngineering\u202fJournal<\/a>\u202fde la Royal Society\u202fof\u202fChemistry\u202fi posen de manifest la import\u00e0ncia de combinar el catalitzador amb el prof\u00e0rmac adequat per aconseguir una activaci\u00f3 satisfact\u00f2ria del f\u00e0rmac. <\/p>\n\n\n\n

Les reaccions\u202fbioortogonals\u202fintervingudes per metalls de transici\u00f3 per sintetitzar f\u00e0rmacs in situ dirigits a les c\u00e8l\u00b7lules tumorals poden ajudar a desenvolupar ter\u00e0pies contra el c\u00e0ncer sense efectes secundaris<\/em><\/em><\/p>

<\/p>Anjana\u202fSathyan, primera autora del treball a dalt esmentat<\/em>\u00a0<\/em><\/em><\/cite><\/blockquote>\n\n\n\n

Els investigadors van desenvolupar nanopart\u00edcules de mida petita (5-6 nm) formades per pol\u00edmers que s’autopleguen de manera que originen un domini intern que repel\u00b7leix l’aigua, necessari per albergar la unitat catal\u00edtica. En aquest cas, van utilitzar nanopart\u00edcules amb el metall pal\u00b7ladi per activar els prof\u00e0rmacs. La capacitat d’aquestes nanopart\u00edcules per alliberar efica\u00e7ment els f\u00e0rmacs actius es va provar en medis complexos que imiten els entorns cel\u00b7lulars. Per aix\u00f2, els investigadors van fer servir tres dels principals f\u00e0rmacs contra el c\u00e0ncer\u202fusats\u202factualment i van\u202fassolir\u202ftransformar-los d’inactius a actius.\u00a0<\/p>\n\n\n\n

\"\"<\/figure>
\n

A m\u00e9s dels resultats obtinguts amb el pal\u00b7ladi, els investigadors del projecte\u202fTHERACAT\u202fhan estudiat les nanopart\u00edcules amb altres metalls com a catalitzadors, com el ruteni, l’or i el coure, i el seu possible \u00fas com a catalitzadors. De moment, han obert noves vies amb resultats molt encoratjadors, activant prof\u00e0rmacs amb alta especificitat, m\u00ednima toxicitat i de forma controlada. En un\u202ffutur pr\u00f2xim, alguns dels laboratoris que participen\u202fen el\u202fprojecte\u202fTHERACAT\u202fcontinuaran publicant\u202fresultats interessants que ens aproparan a una nova generaci\u00f3 de tractaments dirigits contra el c\u00e0ncer.<\/p>\n<\/div><\/div>\n\n\n\n

Created with BioRender.com.<\/em> <\/p>\n\n\n\n


Els resultats del projecte\u202fTHERACAT\u202fi altres aven\u00e7os al camp de la qu\u00edmica\u202fbioortogonal\u202fobren noves vies per trobar tractaments locals contra el c\u00e0ncer que limitin els efectes secundaris dels tractaments cl\u00e0ssics i presentin una efic\u00e0cia prolongada del f\u00e0rmac.<\/p>\n\n\n\n

Article de refer\u00e8ncia<\/strong>: Developing Pd(II) based amphiphilic polymeric nanoparticles for pro-drug activation in complex media.<\/a> Anjana Sathyan, Stephen Croke, Ana M. P\u00e9rez-L\u00f3pez, Bas de Waal, Asier Unciti-Broceta, Anja R.A Palmans. Mol. Syst. Des. Eng.<\/em>, 2022, Advance Article. DOI: 10.1039\/d2me00173j.\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"

Els investigadors del projecte europeu THERACAT, coordinat per l’Institut de Bioenginyeria de Catalunya (IBEC), fa quatre anys que treballen en el desenvolupament de noves estrat\u00e8gies per tractar el c\u00e0ncer de … Read more<\/a><\/p>\n","protected":false},"author":4,"featured_media":100118,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[98],"tags":[1052,1732],"post_formats":[],"class_list":["post-100122","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-institucionals","tag-lorenzo-albertazzi-ca","tag-theracat-2-ca"],"yoast_head":"\nProjecte THERACAT: donant a la diana del c\u00e0ncer\u00a0 - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/projecte-theracat-donant-a-la-diana-del-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Projecte THERACAT: donant a la diana del c\u00e0ncer\u00a0 - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Els investigadors del projecte europeu THERACAT, coordinat per l’Institut de Bioenginyeria de Catalunya (IBEC), fa quatre anys que treballen en el desenvolupament de noves estrat\u00e8gies per tractar el c\u00e0ncer de ... 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