{"id":101054,"date":"2022-11-14T11:10:00","date_gmt":"2022-11-14T10:10:00","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=101054"},"modified":"2025-03-05T09:54:40","modified_gmt":"2025-03-05T08:54:40","slug":"creen-un-gimnas-en-un-xip-que-permetra-estudiar-la-diabetis-i-desenvolupar-nous-farmacs-per-al-seu-tractament","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/creen-un-gimnas-en-un-xip-que-permetra-estudiar-la-diabetis-i-desenvolupar-nous-farmacs-per-al-seu-tractament\/","title":{"rendered":"Creen un “gimn\u00e0s en un xip” que permetr\u00e0 estudiar la diabetis i desenvolupar nous f\u00e0rmacs per al seu tractament"},"content":{"rendered":"\n

Coincidint amb el dia mundial de la Diabetis, investigadors de l’IBEC fan p\u00fablic un estudi en qu\u00e8 combinen c\u00e8l\u00b7lules musculars i de p\u00e0ncrees en un mateix xip i demostren que la producci\u00f3 d’insulina pel p\u00e0ncrees durant l’exercici f\u00edsic s’indueix per la contracci\u00f3 de les c\u00e8l\u00b7lules musculars.<\/h4>\n\n\n\n

El nou xip \u00e9s una potent eina per desenvolupar i testejar nous f\u00e0rmacs contra la diabetis, i permet una modelitzaci\u00f3 personalitzada de la malaltia, ja que pot utilitzar c\u00e8l\u00b7lules del mateix pacient. Aquest model permetr\u00e0 estudiar detalladament perqu\u00e8 falla la producci\u00f3 d’insulina pel p\u00e0ncrees en les persones diab\u00e8tiques combinant diferents tipus cel\u00b7lulars.<\/p>\n\n\n\n

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Segons l’Organitzaci\u00f3 Mundial de la Salut<\/a>, 422 milions de persones al m\u00f3n pateixen diabetis mellitus, i 1,5 milions de morts cada any s’associen directament a aquesta malaltia. La diabetis \u00e9s una complexa malaltia metab\u00f2lica caracteritzada per una alta acumulaci\u00f3 de glucosa en la sang, com a resultat d’un defecte en la producci\u00f3 o en l’activitat de la insulina. La insulina \u00e9s una hormona produ\u00efda, emmagatzemada i alliberada pel p\u00e0ncrees, i \u00e9s la que possibilita que la glucosa entri en les diferents c\u00e8l\u00b7lules del cos per a proporcionar l’energia que necessiten per a funcionar correctament.<\/p>\n\n\n\n

Els m\u00fasculs s\u00f3n una de les principals dianes de la insulina i s\u00f3n crucials en el manteniment global dels nivells de glucosa en tot el cos. Els models fisiol\u00f2gics actuals d’estudi in vivo en humans o animals permeten estudiar l’efecte de l’exercici f\u00edsic sobre la secreci\u00f3 d’insulina, per\u00f2 no determinar si aquest efecte es deu a la contracci\u00f3 muscular o a algun altre \u00f2rgan mediador d’aquesta senyalitzaci\u00f3. D’altra banda, els estudis in vitro amb cultius tradicionals en 2D no permeten analitzar en temps real la interacci\u00f3 entre les c\u00e8l\u00b7lules musculars i les c\u00e8l\u00b7lules pancre\u00e0tiques, i tampoc recreen l’estructura 3D dels teixits i \u00f2rgans, molt rellevants en la seva fisiologia.
El desenvolupament de nous f\u00e0rmacs per a prevenir i tractar la diabetis ha d’estar basat en eines que tinguin en compte la comunicaci\u00f3 entre el p\u00e0ncrees i els altres \u00f2rgans perqu\u00e8 puguin recrear els detalls de la malaltia.<\/p>\n\n\n\n

En un recent estudi publicat a la revista Advanced Materials Technology<\/a>, investigadors de l’Institut de Bioenginyeria de Catalunya (IBEC), liderats per Juan M. Fern\u00e1ndez-Costa i Javier Ramon-Azcon, del laboratori “Biosensors per a Bioenginyeria<\/a>“, han desenvolupat un “multi-organ-on-xip” que permet, en un mateix dispositiu, estudiar la comunicaci\u00f3 entre les c\u00e8l\u00b7lules del p\u00e0ncrees que produeixen insulina i les c\u00e8l\u00b7lules musculars. En aquest innovador “gimn\u00e0s en un xip”, els investigadors han estimulat el\u00e8ctricament les c\u00e8l\u00b7lules musculars per a induir la seva contracci\u00f3, i han vist que aix\u00f2 indueix directament la producci\u00f3 d’insulina per les c\u00e8l\u00b7lules del p\u00e0ncrees.<\/p>\n\n\n\n

El “gimn\u00e0s en un xip”<\/strong>
En aquest nou dispositiu de bioenginyeria els investigadors de l’IBEC han posat, d’una banda, c\u00e8l\u00b7lules de m\u00fascul esquel\u00e8tic, els m\u00fasculs que estan units als ossos i que ens proporcionen mobilitat, i, d’altra banda, c\u00e8l\u00b7lules de p\u00e0ncrees, concretament illots pancre\u00e0tics formats per c\u00e8l\u00b7lules Beta, les que produeixen insulina.<\/p>\n\n\n\n

En cr\u00e9ixer i desenvolupar-se, aquestes c\u00e8l\u00b7lules formen estructures en 3D que simulen d’una certa forma un “mini-\u00f2rgan”, i encara que es troben en compartiments diferents, el “multi-organ-on-xip” t\u00e9 diminuts canals que permeten comunicar de manera controlada i monitorar, a demanda i en diferents situacions, l’intercanvi de senyals i de compostos entre ells.<\/p>\n\n\n\n

Les c\u00e8l\u00b7lules musculars del “multi-organ-on-xip” estan connectades a un estimulador el\u00e8ctric que indueix la seva contracci\u00f3 simulant l’exercici f\u00edsic. A m\u00e9s, el dispositiu tamb\u00e9 est\u00e0 integrat a una complexa plataforma de biosensors capa\u00e7 de monitorar, sense necessitat de marcatge extern, els nivells d’insulina produ\u00efts per les c\u00e8l\u00b7lules del p\u00e0ncrees i els nivells d’interleuquina 6 (IL-6). Aquesta prote\u00efna reguladora es produeix pel m\u00fascul i senyalitza al p\u00e0ncrees que augmenti la producci\u00f3 d’insulina. En altres paraules, durant l’exercici f\u00edsic, la IL-6 va del m\u00fascul cap al p\u00e0ncrees per a estimular la producci\u00f3 d’insulina.<\/p>\n\n\n\n

\n

“Amb el nostre “gimn\u00e0s en un xip” vam demostrar que la secreci\u00f3 d’insulina pels illots pancre\u00e0tics durant l’exercici est\u00e0 mediada din\u00e0micament per l’activitat contr\u00e0ctil de les c\u00e8l\u00b7lules musculars i no per altres intermediaris”.<\/em> Juan M. Fern\u00e1ndez-Costa, primer autor de l’estudi.<\/em><\/p>\n<\/blockquote>\n\n\n\n

El futur dels “multi-organ-on-xip”<\/strong><\/p>\n\n\n\n

La nova plataforma multiorg\u00e0nica in vitro<\/em> desenvolupada per l’IBEC est\u00e0 acoblada a una plataforma de detecci\u00f3 que presenta una s\u00e8rie d’avantatges respecte als sistemes de detecci\u00f3 actuals, ja que t\u00e9 un cost de fabricaci\u00f3 abordable i dispensa la utilitzaci\u00f3 d’anticossos marcats. A m\u00e9s, es connecta f\u00e0cilment a altres dispositius de “organ-on-xip” i permet un monitoratge en temps real i amb gran sensibilitat del metabolisme dels \u00f2rgans implicats.<\/p>\n\n\n\n

<\/div>\n\n\n\n
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“Els dispositius de “organ-on-xip” representen amb precisi\u00f3 la fisiologia dels \u00f2rgans in vivo i permeten estudiar la cin\u00e8tica dels f\u00e0rmacs mitjan\u00e7ant l’estudi de la funcionalitat i la comunicaci\u00f3 entre teixits”. Javier Ramon-Azcon, l\u00edder del grup Biosensors per a Bioenginyeria”<\/em><\/p>\n<\/blockquote>\n\n\n\n

En aquest estudi, la nova plataforma ha perm\u00e8s monitorar in situ<\/em> i en temps real, la comunicaci\u00f3 entre el p\u00e0ncrees i els m\u00fasculs en la diabetis, i estudiar la din\u00e0mica de secreci\u00f3 d’insulina per part dels illots pancre\u00e0tics en resposta a l’exercici muscular indu\u00eft per l’estimulaci\u00f3 el\u00e8ctrica. Representa un gran pas per a la modelitzaci\u00f3 de la diabetis, l’estudi de la resist\u00e8ncia a la insulina i la recerca de f\u00e0rmacs candidats a la ter\u00e0pia. A m\u00e9s, aquesta nova eina contribuir\u00e0 a reduir l’experimentaci\u00f3 amb animals, en general llarga en temps I molt costosa econ\u00f2micament, amb limitacions \u00e8tiques i que dificulta l’extrapolaci\u00f3 dels resultats als humans.
<\/p>\n\n\n\n

En un futur, el “muti-organ-on-xip” tamb\u00e9 es podr\u00e0 utilitzar per a estudiar la comunicaci\u00f3 entre altres \u00f2rgans en el context de diverses malalties metab\u00f2liques, sent una plataforma prometedora per la selecci\u00f3 de nous f\u00e0rmacs i per a la medicina personalitzada.<\/p>\n\n\n\n

<\/div>\n\n\n\n

Article de refer\u00e8ncia: <\/strong>Training-on-a-Chip: A Multi-Organ Device to Study the Effect of Muscle Exercise on Insulin Secretion in Vitro.<\/a> Juan M. Fern\u00e1ndez-Costa, Mar\u00eda A. Ortega, J\u00falia Rodr\u00edguez-Comas, Gerardo Lopez-Mu\u00f1oz, Jose Yeste, Llu\u00eds Mangas-Florencio, Miriam Fern\u00e1ndez-Gonz\u00e1lez, Eduard Martin-Lasierra, Ainoa Tejedera-Villafranca, and Javier Ramon-Azcon. Adv. Mater. Technol. 2022, 2200873.<\/p>\n\n\n\n

<\/p>\n\n\n\n

Ajut finan\u00e7at amb el suport del programa predoctoral AGAUR-FI ajuts (2022 FI_B 00386) Joan Or\u00f3 de la Generalitat de Catalunya i del Fons Europeu Social Plus<\/em><\/p>\n\n\n\n

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Coincidint amb el dia mundial de la Diabetis, investigadors de l’IBEC fan p\u00fablic un estudi en qu\u00e8 combinen c\u00e8l\u00b7lules musculars i de p\u00e0ncrees en un mateix xip i demostren que … Read more<\/a><\/p>\n","protected":false},"author":24,"featured_media":101047,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1999,1838,1131,1840],"post_formats":[],"class_list":["post-101054","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-biosensors-for-bioengineering-ca","tag-diabetis","tag-javier-ramon-ca","tag-organ-en-un-xip"],"yoast_head":"\nCreen un "gimn\u00e0s en un xip" que permetr\u00e0 estudiar la diabetis i desenvolupar nous f\u00e0rmacs per al seu tractament - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/creen-un-gimnas-en-un-xip-que-permetra-estudiar-la-diabetis-i-desenvolupar-nous-farmacs-per-al-seu-tractament\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Creen un "gimn\u00e0s en un xip" que permetr\u00e0 estudiar la diabetis i desenvolupar nous f\u00e0rmacs per al seu tractament - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Coincidint amb el dia mundial de la Diabetis, investigadors de l’IBEC fan p\u00fablic un estudi en qu\u00e8 combinen c\u00e8l\u00b7lules musculars i de p\u00e0ncrees en un mateix xip i demostren que ... 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