{"id":101292,"date":"2022-11-17T18:21:33","date_gmt":"2022-11-17T17:21:33","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=101292"},"modified":"2022-11-17T18:48:50","modified_gmt":"2022-11-17T17:48:50","slug":"mini-intestinos-en-3d-para-estudiar-infecciones-bacterianas","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/mini-intestins-en-3d-per-a-estudiar-infeccions-bacterianes","title":{"rendered":"Mini-intestins en 3D per a estudiar infeccions bacterianes"},"content":{"rendered":"\n

Investigadors de l’Institut de Bioenginyeria de Catalunya desenvolupen un model d’intest\u00ed hum\u00e0 en 3D que simula les caracter\u00edstiques de la mucosa intestinal i el seu relleu. Aquest mini-intest\u00ed ha perm\u00e8s recrear infeccions bacterianes com la que caracteritza la malaltia de Crohn i servir\u00e0 per a estudiar el funcionament de l’intest\u00ed i la seva resposta a diferents pat\u00f2gens.<\/h4>\n\n\n\n
\"\"<\/figure>\n\n\n\n

Les principals funcions del nostre intest\u00ed s\u00f3n absorbir els nutrients de la digesti\u00f3 i actuar com a barrera protectora enfront de pat\u00f2gens. La paret interna de l’intest\u00ed, l’epiteli intestinal, t\u00e9 una peculiar estructura 3D organitzada en forma de dits o de \u201cvalls i cims\u201d, i se sap que aquesta estructura 3D \u00e9s fonamental per al seu correcte funcionament. D’altra banda, aquestes valls i cims estan recoberts per una mucosa, que entre altres funcions abriga a la nostra microbiota intestinal, formada entre 500 i 1000 esp\u00e8cies diferents de microorganismes.<\/p>\n\n\n\n

Aquesta mateixa mucosa \u00e9s tamb\u00e9 la primera barrera de protecci\u00f3 justament per a impedir que altres microorganismes potencialment patog\u00e8nics, o subst\u00e0ncies qu\u00edmiques nocives, puguin entrar en el nostre organisme i causar malalties. Aquests dos factors, estructura 3D + mucosa, s\u00f3n essencials en la fisiologia intestinal, no obstant aix\u00f2, els models d’intest\u00ed desenvolupats fins avui per al seu estudi en laboratori es basen en estructures en 2D que no produeixen mucositat, la qual cosa limita molt la seva rellev\u00e0ncia i utilitzaci\u00f3. <\/p>\n\n\n\n

Ara, investigadors de l’Institut de Bioenginyeria de Catalunya (IBEC) han creat un model d’intest\u00ed que presenta la caracter\u00edstica estructura 3D de valls i cims, i a m\u00e9s pot generar la mucosa. Han utilitzat aquest nou model per a estudiar la interacci\u00f3 amb pat\u00f2gens intestinals. Concretament han pogut simular amb \u00e8xit la infecci\u00f3 bacteriana produ\u00efda per un cep d’E. coli <\/em>que caracteritza la malaltia de Crohn. El treball ha estat liderat per Elena Mart\u00ednez, investigadora principal del grup \u201cSistemes Biomim\u00e8tics per a Enginyeria Cel\u00b7lular\u201d en col\u00b7laboraci\u00f3 amb el grup \u201cInfeccions Bacterianes i Ter\u00e0pies Antomicrobianes\u201d liderat per Eduard Torrents. Els resultats s’han publicat recentment en la revista Pharmaceutics.<\/p>\n\n\n\n

Fabricant mini-intestins 3D<\/strong><\/p>\n\n\n\n

Per a construir l’estructura 3D de valls i cims de l’intest\u00ed, els investigadors han utilitzat el m\u00e8tode de la fotopolimerizaci\u00f3, \u00e9s a dir, han usat un material que adquireix la seva forma i consist\u00e8ncia finals en ser il\u00b7luminat amb un tipus concret de llum UV. Amb aquest sistema han constru\u00eft una estructura 3D similar a l’intest\u00ed, en forma de dits, i els diferents tipus de c\u00e8l\u00b7lules que formen aquest \u00f2rgan han crescut, s’han posicionat de manera similar al que ocorre en l’intest\u00ed, i m\u00e9s important, han estat capa\u00e7os de produir mucositat intestinal. Utilitzant aquesta tecnologia els investigadors han pogut crear al detall una estructura 3D similar a l’intest\u00ed.<\/p>\n\n\n\n

\u201cLes c\u00e8l\u00b7lules han colonitzat la nostra estructura de mini-intest\u00ed 3D i han estat capa\u00e7os de secretar la mucositat i respondre al fluid intestinal que caracteritza l’intest\u00ed, dos aspectes essencials per al seu correcte funcionament\u201d.\u00a0<\/em>\u00a0Mar\u00eda Garc\u00eda-D\u00edaz (IBEC), primera autora de l’estudi<\/em><\/p><\/blockquote>\n\n\n\n

Un nou model per a estudiar infeccions intestinals<\/strong><\/p>\n\n\n\n

Els mini-intestins desenvolupats pels investigadors de l’IBEC presenten tant l’estructura 3D caracter\u00edstica de valls i cims, com la capacitat de produir la mucositat intestinal, sent per tant un model molt \u00fatil per a estudis d’intest\u00ed en el laboratori.<\/p>\n\n\n\n

Per a analitzar l’efic\u00e0cia d’aquest model en estudis d’infeccions bacterianes, els investigadors s’han centrat en la malaltia de Crohn. Aquesta malaltia pertany al grup de malalties inflamat\u00f2ries intestinals, i fins avui es desconeixen les seves causes. Afecta el tracte intestinal i es creu que aquest trastorn est\u00e0 relacionat amb un atac del sistema immune a alguns components bacterians presents en l’intest\u00ed. Actualment no existeix cura per a aquesta malaltia i els tractaments es limiten a pal\u00b7liar els s\u00edmptomes.  <\/p>\n\n\n\n

En inocular en els mini-intestins 3D un cep del bacteri E. coli<\/em> relacionada amb la malaltia de Crohn, els investigadors han observat una resposta inflamat\u00f2ria similar a la que ocorre en pacients, posant de manifest la import\u00e0ncia de recrear un ambient el m\u00e9s fidedigne possible per a simular en laboratori el comportament dels bacteris. En altres paraules, aquests prometedors resultats reforcen la utilitat i validesa d’aquest nou model per a l’estudi d’aquesta, i possiblement d’altres malalties intestinals causades per pat\u00f2gens. Aquest treball mostra a m\u00e9s que la mucositat intestinal juga un paper protector clau en les infeccions.\u00a0\u00a0<\/p>\n\n\n\n

\u201cHem demostrat que el nostre model imita de manera rigorosa les caracter\u00edstiques clau de la mucosa intestinal necess\u00e0ries per a estudiar les interaccions amb els pat\u00f2gens\u201d. Elena Mart\u00ednez (IBEC), investigadora principal de l’estudi.<\/em> <\/p><\/blockquote>\n\n\n\n

<\/div>\n\n\n\n

Article de refer\u00e8ncia:<\/strong> Mimicking the Intestinal Host\u2013Pathogen Interactions in a 3D In Vitro Model: The Role of the Mucus Layer<\/a>. Mar\u00eda Garc\u00eda-D\u00edaz, Maria del Mar Cendra, Raquel Alonso-Roman, Mar\u00eda Urd\u00e1niz, Eduard Torrents, Elena Mart\u00ednez. Pharmaceutics<\/em> 2022, 14(8).  <\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Investigadors de l’Institut de Bioenginyeria de Catalunya desenvolupen un model d’intest\u00ed hum\u00e0 en 3D que simula les caracter\u00edstiques de la mucosa intestinal i el seu relleu. Aquest mini-intest\u00ed ha perm\u00e8s recrear infeccions bacterianes … Read more<\/a><\/p>\n","protected":false},"author":4,"featured_media":101290,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1826,1846,820,1847],"post_formats":[],"class_list":["post-101292","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-biomimetic-systems-for-cell-engineering-ca","tag-e-coli-2-ca","tag-elena-martinez-ca","tag-mini-intestine-ca"],"yoast_head":"\nMini-intestins en 3D per a estudiar infeccions bacterianes - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/mini-intestins-en-3d-per-a-estudiar-infeccions-bacterianes\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mini-intestins en 3D per a estudiar infeccions bacterianes - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Investigadors de l’Institut de Bioenginyeria de Catalunya desenvolupen un model d’intest\u00ed hum\u00e0 en 3D que simula les caracter\u00edstiques de la mucosa intestinal i el seu relleu. Aquest mini-intest\u00ed ha perm\u00e8s recrear infeccions bacterianes ... 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