{"id":103724,"date":"2023-01-25T12:43:37","date_gmt":"2023-01-25T11:43:37","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/ibec-researchers-discover-how-to-improve-the-existed-antibiotics-and-develop-new-antimicrobial-treatments\/"},"modified":"2023-01-25T13:19:40","modified_gmt":"2023-01-25T12:19:40","slug":"ibec-researchers-discover-how-to-improve-the-existed-antibiotics-and-develop-new-antimicrobial-treatments","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/millorar-els-antibiotics-existents-i-desenvolupar-nous-tractaments-antimicrobians","title":{"rendered":"Investigadors de l’IBEC descobreixen com millorar els antibi\u00f2tics existents i desenvolupar nous tractaments antimicrobians"},"content":{"rendered":"\n

En un estudi dut a terme per investigadors de l’Institut de Bioenginyeria de Catalunya (IBEC), s’ha aconseguit millorar antibi\u00f2tics coneguts perqu\u00e8 siguin m\u00e9s efica\u00e7os en dosis molt m\u00e9s petites, la qual cosa obre la possibilitat de desenvolupar nous tractaments antimicrobians de manera innovadora i assequible. L’estudi, publicat recentment en la revista Communications Biology<\/em> del grup Nature<\/em>, ha estat liderat per Eduard Torrents, investigador principal de l’IBEC i professor de la Universitat de Barcelona (UB).<\/h4>\n\n\n\n

La falta d’antibi\u00f2tics efectius \u00e9s una amena\u00e7a cada vegada m\u00e9s greu per a la salut mundial. En les \u00faltimes d\u00e8cades, nom\u00e9s uns pocs agents antimicrobians nous han arribat al mercat. Una opci\u00f3 prometedora i assequible per a suplir aquesta escassetat \u00e9s el disseny de noves funcionalitats per a antibi\u00f2tics ja coneguts o en des\u00fas per la seva toxicitat. Un estudi recentment publicat en la revista Communications Biology del grup Nature liderat per l’investigador Eduard Torrents de l’IBEC i de la Universitat de Barcelona, juntament amb investigadors de l’Institut Jozef Stefan d’Eslov\u00e8nia, explora aquesta opci\u00f3 a trav\u00e9s del disseny i desenvolupament d’un complex format per tres mol\u00e8cules, incloent-hi l’antimicrobi\u00e0 ciprofloxacina. En aquest nou format, el f\u00e0rmac augmenta la seva efic\u00e0cia, la seva estabilitat i redueix la seva toxicitat, millorant el seu \u00fas com a antibi\u00f2tic.<\/p>\n\n\n\n

Reutilitzaci\u00f3 d’antibi\u00f2tics per a solucionar un problema mundial<\/strong><\/p>\n\n\n\n

Una forma senzilla i econ\u00f2mica de redissenyar vells antibi\u00f2tics \u00e9s incloure’ls en complexos capa\u00e7os de modificar algunes de les seves propietats, com la solubilitat, l’estabilitat, la biodisponibilitat i la permeabilitat, que s\u00f3n fonamentals perqu\u00e8 siguin efectius contra els bacteris. En aquest context, els investigadors han aconseguit crear un nou complex ternari en el qual l’antibi\u00f2tic ciprofloxacina s’uneix a la superf\u00edcie hidrof\u00edlica de la ciclodextrina a trav\u00e9s d’un amino\u00e0cid, l’arginina, que actua com a enlla\u00e7 entre totes dues mol\u00e8cules. En comparaci\u00f3 amb altres complexos d’inclusi\u00f3 cl\u00e0ssics menys estable, que nom\u00e9s modifiquen la solubilitat de l’antibi\u00f2tic, el complex ternari sintetitzat en aquest estudi \u00e9s tamb\u00e9 m\u00e9s estable i efica\u00e7.<\/p>\n\n\n\n

\"\"
Descomposici\u00f3 de la membrana en una estructura similar a una ves\u00edcula en Pseudomonas aeruginosa<\/em> tractada amb el complex de ciprofloxacina<\/figcaption><\/figure>\n\n\n\n

Durant la recerca, s’ha comprovat que aquest nou complex intensifica la interacci\u00f3 del f\u00e0rmac amb les membranes dels bacteris i augmenta la seva biodisponibilitat a l’interior cel\u00b7lular, millorant aix\u00ed la seva efic\u00e0cia antimicrobiana i el seu perfil de seguretat. \u201cEl seu alliberament es produeix de forma m\u00e9s controlada i permet que, amb menys quantitat, tingui major efectivitat. Per tant, el tractament resulta menys t\u00f2xic per a l’organisme\u201d, explica Torrents.<\/p>\n\n\n\n

\n

\u201c<\/em>El nostre sistema de redisseny podria reduir la toxicitat o augmentar la capacitat de penetraci\u00f3 de molts f\u00e0rmacs antibi\u00f2tics que s’han usat durant d\u00e8cades i que estan en des\u00fas.\u201d<\/em><\/p>\nEduard Torrents<\/cite><\/blockquote>\n\n\n\n

La s\u00edntesi d’aquesta mena de complexos a partir de la ciclodextrina i en els quals s’utilitzen mol\u00e8cules com a enlla\u00e7 amb el f\u00e0rmac, t\u00e9 un gran potencial per a millorar l’efic\u00e0cia d’antibi\u00f2tics pr\u00e8viament aprovats i utilitzats cl\u00ednicament durant anys. \u201cD’aquesta manera, podr\u00edem aprofitar el que ja tenim i donar-li un nou \u00fas, millorar-lo, per a aconseguir els tractaments antimicrobians efica\u00e7os que necessitem amb urg\u00e8ncia\u201d, explica Torrents.<\/p>\n\n\n\n

M\u00e9s estudis en aquesta \u00e0rea servirien per a explorar totes les possibilitats disponibles per a aconseguir un augment de la biodisponibilitat de f\u00e0rmacs ja coneguts, incloent-hi la seva capacitat per a desenvolupar efectes en ceps que actualment s\u00f3n resistents als antibi\u00f2tics tradicionals. Produ\u00efts a trav\u00e9s d’una qu\u00edmica simple, que no requereix un alt nivell de tecnologia i que \u00e9s altament econ\u00f2mica, aquest tipus de complexos podrien convertir-se en eines molt prometedores, capaces d’animar a la ind\u00fastria farmac\u00e8utica a dedicar esfor\u00e7os en aquest \u00e0mbit, ja que la falta d’antibi\u00f2tics efectius a nivell global cada vegada \u00e9s m\u00e9s preocupant.<\/p>\n\n\n\n

\n\n\n\n

Article referenciat:<\/strong><\/p>\n\n\n\n

Marija Vukomanovic, Lea Gazvoda, Mario Kurtjak, Jitka Hrescak, Blaz Jaklic, Laura Moya-And\u00e9rico, Maria del Mar Centra y Eduard Torrents.  Development of a ternary cyclodextrin-arginine-ciprofloxacin antimicrobial complex with enhanced stability<\/a>. Commun Biol<\/em> 5<\/strong>, 1234 (2022). https:\/\/doi.org\/10.1038\/s42003-022-04197-9<\/a><\/p>\n\n\n\n

\n","protected":false},"excerpt":{"rendered":"

En un estudi dut a terme per investigadors de l’Institut de Bioenginyeria de Catalunya (IBEC), s’ha aconseguit millorar antibi\u00f2tics coneguts perqu\u00e8 siguin m\u00e9s efica\u00e7os en dosis molt m\u00e9s petites, la … Read more<\/a><\/p>\n","protected":false},"author":4,"featured_media":103716,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1905,1141,1629,1906],"post_formats":[],"class_list":["post-103724","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-bacterial-infections-and-antimicrobial-therapies-ca-2","tag-eduard-torrents-ca","tag-resistencia-antibiotica-ca","tag-resistencia-bacteriana-ca"],"yoast_head":"\nInvestigadors de l'IBEC descobreixen com millorar els antibi\u00f2tics existents i desenvolupar nous tractaments antimicrobians - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/millorar-els-antibiotics-existents-i-desenvolupar-nous-tractaments-antimicrobians\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Investigadors de l'IBEC descobreixen com millorar els antibi\u00f2tics existents i desenvolupar nous tractaments antimicrobians - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"En un estudi dut a terme per investigadors de l’Institut de Bioenginyeria de Catalunya (IBEC), s’ha aconseguit millorar antibi\u00f2tics coneguts perqu\u00e8 siguin m\u00e9s efica\u00e7os en dosis molt m\u00e9s petites, la ... 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