{"id":106474,"date":"2023-03-24T10:32:39","date_gmt":"2023-03-24T09:32:39","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=106474"},"modified":"2023-03-24T11:21:36","modified_gmt":"2023-03-24T10:21:36","slug":"the-movement-of-cancer-cells-depends-on-the-topography-and-stiffness-of-their-environment","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/el-moviment-de-les-cel%C2%B7lules-canceroses-depen-de-la-topografia-i-la-rigidesa-de-l-entorn","title":{"rendered":"El moviment de les c\u00e8l\u00b7lules canceroses dep\u00e8n de la topografia i la rigidesa de l’entorn"},"content":{"rendered":"\n

Un estudi recent de l’IBEC ha descrit com l’orientaci\u00f3 per contacte de les c\u00e8l\u00b7lules no nom\u00e9s dep\u00e8n de la topografia, sin\u00f3 que tamb\u00e9 es veu afectada per la rigidesa de l’entorn. El treball ressalta la import\u00e0ncia de tenir en compte la rigidesa del substrat com una variable m\u00e9s a l’hora d’estudiar i comprendre en profunditat el despla\u00e7ament cel\u00b7lular en l’organisme. Aquesta informaci\u00f3 \u00e9s cabdal per entendre multitud de processos fisiol\u00f2gics i patol\u00f2gics associats a la migraci\u00f3 cel\u00b7lular.<\/strong> <\/p>\n\n\n\n

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Se sap que, per orientar-se, les c\u00e8l\u00b7lules poden detectar senyals qu\u00edmics, mec\u00e0nics, o fins i tot la topografia del seu entorn. A aquest \u00faltim cas, se’ l coneix com a orientaci\u00f3 per contacte i pot estar determinada per la pres\u00e8ncia de solcs, crestes o altres patrons de superf\u00edcie. <\/p>\n\n\n\n

Una investigaci\u00f3 recent del grup de Sistemes biomim\u00e8tics per a enginyeria cel\u00b7lular de l’IBEC, liderat per Elena Mart\u00ednez, ha descrit com l’orientaci\u00f3 per contacte de les c\u00e8l\u00b7lules tamb\u00e9 es veu afectada per la rigidesa de l’entorn. El treball, publicat recentment a la revista cient\u00edfica Materials Today Bio,<\/em> ressalta la import\u00e0ncia de tenir en compte la rigidesa del substrat com una variable m\u00e9s a l’hora d’estudiar els efectes de la topografia en el comportament de les c\u00e8l\u00b7lules. Aquesta informaci\u00f3 \u00e9s cabdal per entendre m\u00faltiples processos fisiol\u00f2gics i patol\u00f2gics associats a la migraci\u00f3 cel\u00b7lular, com s\u00f3n la creaci\u00f3 de nous \u00f2rgans durant el desenvolupament embrionari, la resposta immunit\u00e0ria o la propagaci\u00f3 de tumors durant la met\u00e0stasi. <\/p>\n\n\n\n

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“Les c\u00e8l\u00b7lules s’orienten a trav\u00e9s de fibres alineades de prote\u00efnes, una mena de ra\u00efls que les fan moure en una direcci\u00f3 concreta, com les vies del tren.”<\/p>\nElena Mart\u00ednez<\/cite><\/blockquote>\n\n\n\n

“Les c\u00e8l\u00b7lules s’orienten a trav\u00e9s de fibres alineades de prote\u00efnes, una mena de ra\u00efls que les fan moure en una direcci\u00f3 concreta, com les vies del tren. Utilitzant aquest tipus de substrats microestructurats podem simular aquests ra\u00efls que les c\u00e8l\u00b7lules utilitzen per migrar en molts processos tant fisiol\u00f2gics com patol\u00f2gics.” Explica Elena Mart\u00ednez, investigadora principal de l’IBEC i professora de la Universitat de Barcelona. <\/p>\n\n\n\n

L’equip d’investigaci\u00f3 va comparar el comportament de dues l\u00ednies cel\u00b7lulars de c\u00e0ncer de mama. Una considerada metast\u00e0tica -\u00e9s a dir, que migra- i una altra que no. En el cas de substrats amb una rigidesa elevada, van observar que tots dos tipus de c\u00e8l\u00b7lules a penes migraven. No obstant, en utilitzar substrats amb una rigidesa menor, m\u00e9s similar a la fisiol\u00f2gica, el comportament de les c\u00e8l\u00b7lules canviava. <\/p>\n\n\n\n

“El que hem vist, \u00e9s que quan posem les c\u00e8l\u00b7lules sobre substrats m\u00e9s tous, amb una rigidesa similar a la de teixit sa, no migren. No obstant aix\u00f2, quan augmentem aquesta rigidesa a un punt intermedi, equivalent a la d’un teixit patol\u00f2gic com el que es pot trobar en els tumors, les c\u00e8l\u00b7lules comencen a migrar de manera molt m\u00e9s eficient, fins i tot aquelles considerades no metast\u00e0tiques.”  detalla Jordi Comelles, investigador de l’IBEC i primer autor de l’article. <\/p>\n\n\n\n

\n

Quan posem les c\u00e8l\u00b7lules sobre substrats amb una rigidesa equivalent a la d’un teixit patol\u00f2gic, com el que es pot trobar en els tumors, les c\u00e8l\u00b7lules comencen a migrar de manera molt m\u00e9s eficient, fins i tot aquelles considerades no metast\u00e0tiques.”<\/p>\nJordi Comelles<\/cite><\/blockquote>\n\n\n\n

La majoria dels estudis ja publicats sobre l’orientaci\u00f3 per contacte s’havien dut a terme utilitzant materials molt m\u00e9s r\u00edgids que els teixits que es troben a l’organisme. Aquesta limitaci\u00f3 venia donada per la manca de m\u00e8todes de microfabricaci\u00f3 que permetessin crear patrons topogr\u00e0fics en materials tous, amb una rigidesa similar a la dels teixits org\u00e0nics. No obstant aix\u00f2, el grup de Mart\u00ednez va ser capa\u00e7 de produir un patr\u00f3 de solcs microm\u00e8trics en un substrat tou \u2013 un gel polim\u00e8ric- utilitzant un m\u00e8tode avan\u00e7at de microfabricaci\u00f3 desenvolupat pel mateix grup de recerca.  <\/p>\n\n\n\n

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Article referenciat:<\/strong> <\/p>\n\n\n\n

Jordi Comelles, Vanesa Fern\u00e1ndez-Majada, Ver\u00f3nica Acevedo, Beatriz Rebollo-Calderon y Elena Mart\u00ednez.  Soft topographical patterns trigger a stiffness-dependent cellular response to contact guidance<\/a>. Materials Today Bio<\/em> (2023). DOI: 10.1016\/j.mtbio.2023.100593 <\/p>\n\n\n\n

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Un estudi recent de l’IBEC ha descrit com l’orientaci\u00f3 per contacte de les c\u00e8l\u00b7lules no nom\u00e9s dep\u00e8n de la topografia, sin\u00f3 que tamb\u00e9 es veu afectada per la rigidesa de … Read more<\/a><\/p>\n","protected":false},"author":37,"featured_media":106471,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1826,1774,820,436],"post_formats":[],"class_list":["post-106474","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-biomimetic-systems-for-cell-engineering-ca","tag-cancer-ca","tag-elena-martinez-ca","tag-migracio-cellular"],"yoast_head":"\nEl moviment de les c\u00e8l\u00b7lules canceroses dep\u00e8n de la topografia i la rigidesa de l'entorn - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/el-moviment-de-les-cel\u00b7lules-canceroses-depen-de-la-topografia-i-la-rigidesa-de-l-entorn\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"El moviment de les c\u00e8l\u00b7lules canceroses dep\u00e8n de la topografia i la rigidesa de l'entorn - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Un estudi recent de l’IBEC ha descrit com l’orientaci\u00f3 per contacte de les c\u00e8l\u00b7lules no nom\u00e9s dep\u00e8n de la topografia, sin\u00f3 que tamb\u00e9 es veu afectada per la rigidesa de ... 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