{"id":107006,"date":"2023-03-31T12:30:00","date_gmt":"2023-03-31T10:30:00","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=107006"},"modified":"2023-04-24T12:55:50","modified_gmt":"2023-04-24T10:55:50","slug":"researchers-design-a-microfluidics-device-to-predict-cancer-therapy-response","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/researchers-design-a-microfluidics-device-to-predict-cancer-therapy-response\/","title":{"rendered":"Dissenyat un dispositiu per predir la resposta de f\u00e0rmacs contra el c\u00e0ncer"},"content":{"rendered":"\n

Un dels grans desafiaments en la lluita contra el c\u00e0ncer \u00e9s el disseny de noves tecnologies per al tractament personalitzat. En funci\u00f3 de les caracter\u00edstiques moleculars de cada tumor \u2014mutacions en l\u2019ADN i d\u2019altres\u2014, la medicina de precisi\u00f3 vol facilitar que els pacients oncol\u00f2gics, tant adults com pedi\u00e0trics, puguin rebre un tractament personalitzat i adequat a la seva patologia. Per\u00f2, \u00e9s possible saber si un pacient pot beneficiar-se o no d\u2019un tractament, abans d\u2019iniciar-lo?<\/strong><\/p>\n\n\n\n

\"\"
Els experts Albert Manzano i Joan Montero a la Facultat de Medicina i Ci\u00e8ncies de la Salut de la UB. \/Cr\u00e8dit: Universitat de Barcelona (UB).<\/figcaption><\/figure>\n\n\n\n

Un equip d\u2019experts de l\u2019Institut de Bioenginyeria de Catalunya (IBEC) i de la Facultat de Medicina i Ci\u00e8ncies de la Salut de la Universitat de Barcelona ha dissenyat un dispositiu microflu\u00eddic anomenat microfluidic dynamic BH3 profiling<\/em> (\u03bcDBP<\/strong>) que prediu l\u2019efic\u00e0cia del tractament del c\u00e0ncer de manera r\u00e0pida i automatitzada, utilitzant un nombre redu\u00eft de c\u00e8l\u00b7lules procedents de bi\u00f2psies i sense requerir personal t\u00e8cnic especialitzat.<\/p>\n\n\n\n

El treball, publicat a la revista npj Precision Oncology<\/em><\/a>, l\u2019han dirigit Joan Montero, professor del Departament de Biomedicina de la UB i l\u2019IBEC, i Javier Ram\u00f3n Azc\u00f3n, professor de recerca ICREA a l\u2019IBEC. En l\u2019estudi, que t\u00e9 com a primer autor Albert Manzano (UB-IBEC), que es va doctorar a la UB el 2022 amb una tesi sobre medicina de precisi\u00f3 en la lluita contra el c\u00e0ncer, tamb\u00e9 hi han participat experts de la Facultat de F\u00edsica de la UB, l\u2019Institut d\u2019Oncologia Vall d\u2019Hebron (VHIO) i el Centre de Recerca Biom\u00e8dica en Xarxa de Bioenginyeria, Biomaterials i Nanomedicina (CIBER-BBN).   <\/p>\n\n\n\n

Medicina de precisi\u00f3 en la lluita contra el c\u00e0ncer<\/strong><\/h4>\n\n\n\n

La medicina personalitzada ha revolucionat la manera de dissenyar tractaments contra el c\u00e0ncer, que cada vegada s\u00f3n m\u00e9s efica\u00e7os. Si considerem que cada tumor \u00e9s \u00fanic i t\u00e9 caracter\u00edstiques pr\u00f2pies, poder disposar d\u2019indicadors predictius de la resposta de cada pacient al tractament \u00e9s un gran pas endavant en oncologia. El dynamic BH3 profiling<\/em> (DBP) es va desenvolupar inicialment al laboratori del professor Anthony Letai \u2014el professor Montero en va ser coinventor\u2014 i el va patentar l\u2019Institut Oncol\u00f2gic Dana-Farber (Estats Units) l\u2019any 2015. Va ser un dels primers assajos funcionals provat amb \u00e8xit per predir el tractament en diversos tipus de c\u00e0ncer.<\/p>\n\n\n\n

Aquest sistema posa en contacte les c\u00e8l\u00b7lules canceroses amb diferents opcions terap\u00e8utiques per identificar ex vivo<\/em> i de manera r\u00e0pida les que podrien ser m\u00e9s efectives per eliminar el tumor. Conceptualment, \u00e9s molt similar als antibiogrames que s\u2019utilitzen per identificar antibi\u00f2tics per tractar infeccions bacterianes.<\/p>\n\n\n\n

\u00abEl DBP s\u2019ha utilitzat per identificar l\u2019efic\u00e0cia de tractaments a escala precl\u00ednica i cl\u00ednica en molts tipus de c\u00e0ncer diferents, tant s\u00f2lids com l\u00edquids. Aquests estudis han fet servir l\u00ednies cel\u00b7lulars, models animals i mostres prim\u00e0ries amb una gran capacitat predictiva en tots els casos. Tot i aix\u00ed, aquest assaig encara no s\u2019ha aplicat de manera generalitzada als hospitals\u00bb, detalla el professor Montero.<\/p>\n\n\n\n

\u00abDe moment \u2014afegeix\u2014 diversos estudis han trobat una bona correlaci\u00f3 entre els resultats del DBP i la resposta cl\u00ednica en mostres prim\u00e0ries de leuc\u00e8mia. Actualment hi ha diversos assajos cl\u00ednics oberts, amb els quals esperem que aquesta tecnologia es pugui implementar als hospitals en els propers anys per millorar les ter\u00e0pies oncol\u00f2giques\u00bb.<\/p>\n\n\n\n

Predir la resposta terap\u00e8utica amb poques c\u00e8l\u00b7lules canceroses<\/strong><\/h4>\n\n\n
\n
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Dispositiu microflu\u00eddic. \/ Cr\u00e8dit: Universitat de Barcelona (UB)<\/figcaption><\/figure><\/div>\n\n\n

Ara, el nou dispositiu microflu\u00eddic de DBP \u2014conegut com \u03bcDBP<\/strong>\u2014 resol diversos reptes dels assajos funcionals: redueix el nombre de c\u00e8l\u00b7lules canceroses necess\u00e0ries per provar possibles ter\u00e0pies ex vivo<\/em> i automatitza el proc\u00e9s per tal de facilitar-ne l\u2019aplicaci\u00f3 cl\u00ednica sense personal t\u00e8cnic especialitzat.<\/p>\n\n\n\n

\u00abUna de les principals limitacions del DBP \u00e9s el nombre de c\u00e8l\u00b7lules necess\u00e0ries per poder fer l\u2019assaig. Quan es fa una bi\u00f2psia a un pacient, el nombre de c\u00e8l\u00b7lules tumorals obtingudes \u00e9s molt limitat, cosa que no permet fer un estudi amb gaire tractaments diferents i limita la capacitat d\u2019identificar-ne un d\u2019efica\u00e7\u00bb, explica l\u2019expert Albert Manzano.<\/p>\n\n\n\n

Quan es rep la mostra d\u2019una bi\u00f2psia, es dissocia per poder obtenir-ne c\u00e8l\u00b7lules individuals fent servir un tractament mec\u00e0nic i enzim\u00e0tic. Un cop processada, la mostra es filtra per obtenir-ne c\u00e8l\u00b7lules individuals que, despr\u00e9s, se sotmeten als tractaments pertinents i se sembren en el dispositiu microflu\u00eddic.<\/p>\n\n\n\n

\u00abGr\u00e0cies a la nostra plataforma microflu\u00eddica \u03bcDBP<\/strong>, que est\u00e0 dotada de petits pous per sembrar les c\u00e8l\u00b7lules, podem reduir el nombre c\u00e8l\u00b7lules requerides per provar un tractament. Es tracta d\u2019una innovaci\u00f3 decisiva per augmentar el nombre de f\u00e0rmacs que es poden avaluar\u00bb, afegeix Manzano.<\/p>\n\n\n\n

Un sistema r\u00e0pid i completament automatitzat<\/strong><\/strong><\/h4>\n\n\n\n

Aquest \u00e9s el primer treball en qu\u00e8 s\u2019aplica la microflu\u00eddica per fer l\u2019assaig funcional del DBP. A difer\u00e8ncia d\u2019altres versions desenvolupades fins ara, com el high-throughput<\/em> DBP (Bhola et al., Science Signaling<\/em>, 2020), amb plaques i dispensadors autom\u00e0tics per provar centenars de tractaments, el nou dispositiu \u03bcDBP<\/strong> est\u00e0 orientat a provar tractaments in situ<\/em> de manera molt r\u00e0pida \u2014cosa que evita el deteriorament de les mostres\u2014, senzilla i automatitzada, sense la necessitat de maquin\u00e0ria costosa o personal especialitzat.<\/p>\n\n\n\n

\u00abEl m\u00e0xim avantatge del dispositiu \u03bcDBP<\/strong> \u00e9s tamb\u00e9 l\u2019automatitzaci\u00f3 de tot el proc\u00e9s, que ajudaria a implementar aquesta metodologia funcional a escala cl\u00ednica. En conjunt, tots aquests avantatges facilitarien l\u2019adopci\u00f3 del DBP als hospitals com a assaig rutinari\u00bb, detallen els experts.<\/p>\n\n\n\n

\u00abHem desenvolupat aquesta nova eina amb la idea de posar-la a l\u2019abast dels onc\u00f2legs. Aquest sistema automatitzat permet obtenir informaci\u00f3 personalitzada del pacient i del tractament\u00bb, detalla Javier Ram\u00f3n Azc\u00f3n (IBEC).<\/p>\n\n\n\n

Nanotecnologies: una revoluci\u00f3 en biomedicina<\/strong><\/h4>\n\n\n\n

La nanotecnologia \u2014en especial l\u2019aplicaci\u00f3 de la microflu\u00eddica a diferents processos\u2014 est\u00e0 impulsant diverses millores en el disseny d\u2019aquests dispositius per reduir la quantitat de reactius, abaratir els costos econ\u00f2mics, automatitzar processos o b\u00e9 augmentar la capacitat d\u2019an\u00e0lisi de certes metodologies, com ara el DBP.<\/p>\n\n\n\n

Actualment, l\u2019equip treballa en el disseny d\u2019un nou prototip amb m\u00e9s millores t\u00e8cniques per facilitar l\u2019an\u00e0lisi per DBP i obtenir m\u00e9s evid\u00e8ncies experimentals amb mostres prim\u00e0ries que en demostrin la utilitat cl\u00ednica per millorar el tractament de diversos  c\u00e0ncers, tant pedi\u00e0trics com d\u2019adults.<\/p>\n\n\n\n

L\u2019equip detalla: \u00abContinuarem treballant amb els nostres col\u00b7laboradors cl\u00ednics per tal d\u2019analitzar mostres de pacients i adaptar aquesta metodologia per millorar el tractament personalitzat de m\u00faltiples tipus de c\u00e0ncer, en benefici de tots els pacients oncol\u00f2gics\u00bb.<\/p>\n\n\n\n

\n\n\n\n

Article referenciat:<\/strong><\/p>\n\n\n\n

Manzano-Mu\u00f1oz, A.; Yeste, J.; Ortega, M.A.; Mart\u00edn, F.; L\u00f3pez, A.; Rosell, J.; Castro, S.; Serrano, C.; Samitier, J.; Ram\u00f3n-Azc\u00f3n, J.; Montero, J. \u201cMicrofluidic-based dynamic BH3 profiling predicts anticancer treatment efficacy\u201d<\/a>. npj Precision Oncology<\/em>, December 2022. Doi: 10.1038\/s41698-022-00333-0<\/p>\n\n\n\n

\n\n\n\n

Via Universitat de Barcelona<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Un dels grans desafiaments en la lluita contra el c\u00e0ncer \u00e9s el disseny de noves tecnologies per al tractament personalitzat. En funci\u00f3 de les caracter\u00edstiques moleculars de cada tumor \u2014mutacions … Read more<\/a><\/p>\n","protected":false},"author":37,"featured_media":106995,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[745,1878],"post_formats":[],"class_list":["post-107006","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-joan-montero-ca","tag-nanobioengineering-ca"],"yoast_head":"\nDissenyat un dispositiu per predir la resposta de f\u00e0rmacs contra el c\u00e0ncer - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/researchers-design-a-microfluidics-device-to-predict-cancer-therapy-response\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Dissenyat un dispositiu per predir la resposta de f\u00e0rmacs contra el c\u00e0ncer - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Un dels grans desafiaments en la lluita contra el c\u00e0ncer \u00e9s el disseny de noves tecnologies per al tractament personalitzat. 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