{"id":108839,"date":"2023-06-20T17:12:06","date_gmt":"2023-06-20T15:12:06","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=108839"},"modified":"2023-06-20T17:30:26","modified_gmt":"2023-06-20T15:30:26","slug":"researchers-identify-new-biomarkers-of-the-most-frequent-lung-cancer","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/identificats-nous-biomarcadors-del-cancer-de-pulmo-mes-frequent","title":{"rendered":"Identificats nous biomarcadors del c\u00e0ncer de pulm\u00f3 m\u00e9s freq\u00fcent"},"content":{"rendered":"\n

Investigadors de l’l\u2019IBEC i la Universitat de Barcelona han identificat nous biomarcadors del c\u00e0ncer de pulm\u00f3 de c\u00e8l\u00b7lules no petites, el c\u00e0ncer de pulm\u00f3 m\u00e9s freq\u00fcent. Aquests resultats, publicats a la revista\u00a0Modern Pathology<\/em>, s\u2019han aconseguit gr\u00e0cies a una nova t\u00e8cnica que permet analitzar quantitativament les mostres de teixits de pacients. Es tracta d\u2019una metodologia pionera, m\u00e9s econ\u00f2mica i f\u00e0cil d\u2019aplicar que les tradicionals en hospitals i altres entorns cl\u00ednics.\u00a0\u00a0<\/strong><\/p>\n\n\n\n

\"\"
D\u2019esquerra a dreta: Marselina Arshakyan (co primera autora del treball), Rafael Ikemori, Paula Duch, Jordi Alcaraz i Marta Gabasa. \/ Cr\u00e8dit: Universitat de Barcelona.<\/figcaption><\/figure>\n\n\n\n

L\u2019estudi constata que determinades caracter\u00edstiques de les fibres de col\u00b7lagen \u2014un dels components m\u00e9s abundants a l\u2019entorn de les c\u00e8l\u00b7lules cancer\u00edgenes\u2014 serien potencials indicadors per diagnosticar i pronosticar l\u2019evoluci\u00f3 de la malaltia.  <\/p>\n\n\n\n

\u00abLa nostra nova eina pot millorar la gesti\u00f3 cl\u00ednica dels pacients quir\u00fargics amb aquest tipus de c\u00e0ncer, ja que pot identificar quins tenen m\u00e9s risc de recaiguda i poden beneficiar-se, per tant, d\u2019un seguiment m\u00e9s exhaustiu i, fins i tot, de ter\u00e0pies neoadjuvants [complement\u00e0ries al tractament principal]\u00bb, explica Jordi Alcaraz, professor de la Facultat de Medicina i Ci\u00e8ncies de la Salut de la UB i investigador associat de l\u2019IBEC, que ha liderat l\u2019estudi juntament amb l\u2019investigador de la mateixa facultat Joan Montero, investigador del grup de Nanobioenginyeria<\/a> de l’IBEC en el moment de l’estudi, i el catedr\u00e0tic de la Facultat de F\u00edsica i director de l\u2019IBEC, Josep Samitier. <\/p>\n\n\n\n

En el treball tamb\u00e9 hi han participat investigadors de l\u2019Hospital Cl\u00ednic, el Centre d\u2019Investigaci\u00f3 Biom\u00e8dica en Xarxa de Malalties Respirat\u00f2ries (CIBERES), el Centre d\u2019Investigaci\u00f3 Biom\u00e8dica en Xarxa de Bioenginyeria, Biomaterials i Nanomedicina (CIBER-BBN), l\u2019Hospital 12 d\u2019Octubre i l\u2019Hospital Universitari Parc Taul\u00ed. <\/p>\n\n\n\n

Quin \u00e9s el paper de les fibres de col\u00b7lagen en la progressi\u00f3 dels tumors?  <\/strong><\/h4>\n\n\n\n

El c\u00e0ncer de pulm\u00f3 \u00e9s la principal causa de mort relacionada amb el c\u00e0ncer tant en homes com en dones a tot el m\u00f3n, amb una taxa de superviv\u00e8ncia a 5 anys del 18\u202f%. La majoria d\u2019aquests pacients s\u00f3n diagnosticats de c\u00e0ncer de pulm\u00f3 de c\u00e8l\u00b7lules no petites, que es subdivideix en adenocarcinoma, carcinoma de c\u00e8l\u00b7lules escamoses i altres subtipus menys freq\u00fcents. Cada vegada hi ha m\u00e9s evid\u00e8ncies del paper essencial de l\u2019ambient ric en fibres de col\u00b7lagen que envolta les c\u00e8l\u00b7lules canceroses en la progressi\u00f3 d\u2019aquest tipus de c\u00e0ncers i altres tumors s\u00f2lids. <\/p>\n\n\n\n

En aquest entorn tumoral, una alta expressi\u00f3 del col\u00b7lagen de tipus I s\u2019ha associat amb un mal pron\u00f2stic i amb un augment del risc de met\u00e0stasi. \u00abAquestes evid\u00e8ncies han assenyalat els col\u00b7l\u00e0gens fibril\u00b7lars com una font potencial important de biomarcadors rellevants per al c\u00e0ncer i ha despertat l\u2019inter\u00e8s terap\u00e8utic per comprendre les seves funcions en el desenvolupament de tumors\u00bb, explica Jordi Alcaraz, tamb\u00e9 investigador de l\u2019Hospital Cl\u00ednic. <\/p>\n\n\n\n

Davant aquest repte, els investigadors han desenvolupat i validat un nou enfocament de patologia digital \u2014\u00e9s a dir, l\u2019estudi de la malaltia amb eines digitals\u2014 per analitzar quantitativament les fibres de col\u00b7lagen en mostres de teixits de pacients amb c\u00e0ncer de pulm\u00f3 de c\u00e8l\u00b7lules no petites.<\/p>\n\n\n\n

Una t\u00e8cnica m\u00e9s accessible per a les unitats de patologia dels hospitals<\/strong><\/strong><\/h4>\n\n\n\n

La nova metodologia es basa en imatges digitalitzades de bi\u00f2psies de pacients tenyides amb un colorant anomenat picrosirius red (PSR) i visualitzades amb llum polaritzada. Despr\u00e9s, els investigadors utilitzen el programari de codi obert CT-FIRE per segmentar autom\u00e0ticament les fibres individuals que apareixen a les imatges i, aix\u00ed, poder quantificar-ne caracter\u00edstiques rellevants, com ara la longitud, l\u2019amplada o la rectitud.  <\/p>\n\n\n\n

\u00abLa metodologia est\u00e0ndard per analitzar les fibres de col\u00b7lagen es basa en una t\u00e8cnica de microsc\u00f2pia avan\u00e7ada anomenada second harmonic generation<\/em>, que requereix un microscopi confocal de doble fot\u00f3, un tipus de microscopi car i que necessita un operari expert\u00bb, detalla. \u00abPer contra \u2014continua\u2014, la nostra eina \u00e9s una aproximaci\u00f3 m\u00e9s barata i f\u00e0cil d\u2019incorporar per a les unitats de patologia, ja que fa servir una tinci\u00f3 econ\u00f2mica, el PSR; un programari gratu\u00eft com CT-FIRE, i una t\u00e8cnica de microsc\u00f2pia accessible per a la majoria d\u2019hospitals com \u00e9s la llum polaritzada\u00bb.  <\/p>\n\n\n\n

La densitat del col\u00b7lagen, un indicador de mal pron\u00f2stic<\/strong><\/strong><\/h4>\n\n\n\n

Els investigadors han aplicat aquesta metodologia per analitzar 195 mostres de pacients amb adenocarcinoma i carcinoma de c\u00e8l\u00b7lules escamoses. Els resultats mostren que la rectitud de les fibres seria un potencial biomarcador per diagnosticar la malaltia, mentre que la densitat seria un indicador de mal pron\u00f2stic. A m\u00e9s, el valor pron\u00f2stic de la densitat del col\u00b7lagen seria \u00abindependent de l\u2019estadi cl\u00ednic del tumor, i demostraria que analitzar les fibres de col\u00b7lagen aporta informaci\u00f3 addicional rellevant\u00bb, destaca Jordi Alcaraz.<\/p>\n\n\n\n

Enduriment an\u00f2mal dels teixits en els pacients amb adenocarcinoma<\/strong><\/strong><\/h4>\n\n\n\n

La nova metodologia tamb\u00e9 ha perm\u00e8s comparar les caracter\u00edstiques de les fibres de col\u00b7lagen dels pacients amb mostres de teixits no cancer\u00edgenes. D\u2019aquesta manera, per primera vegada han pogut descriure quantitativament els canvis que tenen lloc en l\u2019organitzaci\u00f3 del col\u00b7lagen en el c\u00e0ncer de pulm\u00f3 de c\u00e8l\u00b7lules no petites.  <\/p>\n\n\n\n

Els resultats mostren que, en les mostres de teixits tumorals, es produeix un augment de la rectitud, la longitud i l\u2019amplada d\u2019aquestes fibres, cosa que indica un enduriment an\u00f2mal del teixit, especialment en els pacients amb adenocarcinoma. Segons els investigadors, aquest enduriment estaria relacionat amb diversos mecanismes per evitar la resposta del sistema immunitari i, conseg\u00fcentment, amb la progressi\u00f3 del tumor en aquest tipus de c\u00e0ncer. \u00abAix\u00f2 obre les portes a identificar noves ter\u00e0pies dirigides contra l\u2019enduriment an\u00f2mal\u00bb, conclou l\u2019investigador. <\/p>\n\n\n\n

Han finan\u00e7at aquesta recerca l\u2019Ag\u00e8ncia Estatal de Recerca del Ministeri de Ci\u00e8ncia i Innovaci\u00f3, La Caixa i la Fundaci\u00f3 Cellex.<\/p>\n\n\n\n

\u200b\u200b\u200b\u200b\u200b\u200b\u200bEnlla\u00e7 al v\u00eddeo de l’investigador.<\/strong><\/a><\/p>\n\n\n\n

\n\n\n\n

Article referenciat:<\/strong><\/p>\n\n\n\n

Enrico Almici, Marselina Arshakyan, Josep Llu\u00eds Carrasco, Andrea Mart\u00ednez, Josep Ram\u00edrez, Ana Bel\u00e9n Enguita, Eduard Mons\u00f3, Joan Montero, Josep Samitiera, Jordi Alcaraz.  \u00abQuantitative Image Analysis of Fibrillar Collagens Reveals Novel Diagnostic and Prognostic Biomarkers and Histotype-dependent Aberrant Mechanobiology in Lung Cancer\u00bb<\/a>, Modern Pathology<\/em>, march 2023. DOI: https:\/\/doi.org\/10.1016\/j.modpat.2023.100155<\/a>.<\/p>\n\n\n\n

\n\n\n\n

Via Universitat de Barcelona<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

Investigadors de l’l\u2019IBEC i la Universitat de Barcelona han identificat nous biomarcadors del c\u00e0ncer de pulm\u00f3 de c\u00e8l\u00b7lules no petites, el c\u00e0ncer de pulm\u00f3 m\u00e9s freq\u00fcent. Aquests resultats, publicats a … Read more<\/a><\/p>\n","protected":false},"author":37,"featured_media":108836,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1774,1919,745,1914,1136,1878],"post_formats":[],"class_list":["post-108839","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-cancer-ca","tag-cancer-de-pulmo","tag-joan-montero-ca","tag-jordi-alcaraz-5-ca","tag-josep-samitier-ca","tag-nanobioengineering-ca"],"yoast_head":"\nIdentificats nous biomarcadors del c\u00e0ncer de pulm\u00f3 m\u00e9s freq\u00fcent - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/identificats-nous-biomarcadors-del-cancer-de-pulmo-mes-frequent\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Identificats nous biomarcadors del c\u00e0ncer de pulm\u00f3 m\u00e9s freq\u00fcent - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Investigadors de l’l\u2019IBEC i la Universitat de Barcelona han identificat nous biomarcadors del c\u00e0ncer de pulm\u00f3 de c\u00e8l\u00b7lules no petites, el c\u00e0ncer de pulm\u00f3 m\u00e9s freq\u00fcent. 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