{"id":109333,"date":"2023-06-29T12:25:03","date_gmt":"2023-06-29T10:25:03","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=109333"},"modified":"2023-06-29T18:11:44","modified_gmt":"2023-06-29T16:11:44","slug":"the-internal-clock-of-our-cells-is-influenced-by-mechanical-forces","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/el-rellotge-intern-de-les-nostres-cellules-es-veu-afectat-per-les-forces-mecaniques","title":{"rendered":"El rellotge intern de les nostres c\u00e8l\u00b7lules es veu afectat per les forces mec\u00e0niques"},"content":{"rendered":"\n

Investigadors de l’IBEC demostren com les forces f\u00edsiques desregulen el rellotge circadiari de les c\u00e8l\u00b7lules, el mecanisme que controla els canvis fisiol\u00f2gics cada 24h.<\/strong> La troballa pot ajudar a entendre millor l’envelliment i certes malalties, com alguns tipus de c\u00e0ncer, en qu\u00e8 el rellotge circadiari deixa de funcionar correctament. <\/strong><\/p>\n\n\n\n

\"A<\/figure>\n\n\n\n
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Els \u00e9ssers vius posseeixen un cicle biol\u00f2gic intern, conegut com a rellotge circadiari, que els permet adaptar-se a les modificacions ambientals derivades de la rotaci\u00f3 de la Terra. Activitats fisiol\u00f2giques crucials com el son, el metabolisme, les variacions hormonals, de temperatura corporal i de tensi\u00f3 arterial estan regulades per aquest rellotge intern. El 2017 el Premi Nobel de Medicina<\/a> es va concedir als investigadors que van realitzar importants troballes sobre els mecanismes que el controlen.<\/p>\n\n\n\n

El correcte funcionament del rellotge \u00e9s fonamental perqu\u00e8 els \u00e9ssers vius es puguin anticipar als canvis entre el dia i la nit, i adaptar la seva fisiologia per fer-hi front. Un exemple del desajust entre el rellotge circadiari i l’ambient extern \u00e9s el trastorn conegut com a “jet lag”, que es tradueix en canvis fisiol\u00f2gics en les persones que viatgen per diferents fusos horaris en poques hores.<\/p>\n\n\n\n

Ara, un grup d’investigadors liderats pel professor de recerca ICREA i l\u00edder del grup Din\u00e0mica Integrativa de c\u00e8l\u00b7lules i teixits<\/a> de l’IBEC, Xavier Trepat, han fet un pas m\u00e9s per desxifrar el seu funcionament i han descrit el mecanisme pel qual el rellotge circadiari de les c\u00e8l\u00b7lules es desregula en resposta a forces f\u00edsiques externes. <\/strong>El treball, fruit d’una col\u00b7laboraci\u00f3 entre l’IBEC i la Universitat Pompeu Fabra a Barcelona, es va publicar ahir a la revista Journal of Cell Biology<\/em>.<\/p>\n\n\n\n

Prote\u00efna YAP: clau en la desregulaci\u00f3 del rellotge intern en resposta a forces f\u00edsiques<\/strong><\/h4>\n\n\n\n

En els mam\u00edfers, el rellotge circadiari central es localitza al cervell i es regula principalment per la llum. No obstant aix\u00f2, cada c\u00e8l\u00b7lula t\u00e9 el seu petit rellotge intern que percep i s’adapta al microambient que l’envolta.<\/p>\n\n\n\n

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“Recentment s’ha descrit que les forces mec\u00e0niques s\u00f3n capaces de desregular el rellotge circadiari. El que mostrem ara \u00e9s el mecanisme molecular pel qual aix\u00f2 succeeix”.<\/em><\/p>\nJuan F. Abenza, investigador de l’ IBEC i co-primer autor de<\/em> l’estudi.<\/cite><\/blockquote>\n\n\n\n

A trav\u00e9s d’experiments in vitro <\/em>utilitzant fibroblasts de ratol\u00ed, c\u00e8l\u00b7lules del teixit connectiu encarregades entre altres coses de mantenir la seva estructura, han vist que la prote\u00efna YAP (de l’angl\u00e8s Yes-Associated Protein<\/em>), \u00e9s la clau en la desregulaci\u00f3 del rellotge circadiari. Aquesta mateixa prote\u00efna tamb\u00e9 controla la proliferaci\u00f3 cel\u00b7lular i est\u00e0 relacionada amb el desenvolupament de met\u00e0stasi en diferents tipus de c\u00e0ncer.<\/p>\n\n\n\n

La prote\u00efna YAP \u00e9s el punt cap a on conflueixen els senyals mec\u00e0nics externs i que fa que les c\u00e8l\u00b7lules siguin capaces de percebre la rigidesa del seu entorn. YAP es troba en una forma inactiva en el citoplasma de les c\u00e8l\u00b7lules, i en resposta a est\u00edmuls mec\u00e0nics, s’activa i entra en el nucli, on actua concretament sobre alguns gens “diana” iniciant una resposta a l’est\u00edmul inicial.<\/p>\n\n\n\n

Els investigadors han utilitzat t\u00e8cniques avan\u00e7ades de microsc\u00f2pia confocal, microfabricaci\u00f3 i an\u00e0lisis customitzades per ordinador per estudiar el funcionament del rellotge circadiari en c\u00e8l\u00b7lules individuals. Han aplicat pertorbacions mec\u00e0niques, bioqu\u00edmiques i gen\u00e8tiques de manera controlada sobre les c\u00e8l\u00b7lules i han vist que un d’aquests gens “diana” de YAP \u00e9s Rev- erb\u03b1<\/em>, un gen clau en el control del rellotge circadiari.<\/p>\n\n\n\n

\n

“Quan una for\u00e7a f\u00edsica afecta la c\u00e8l\u00b7lula, la prote\u00efna YAP se’n va del citoplasma al nucli i afecta el gen Rev-erb\u03b1, pertorbant les oscil\u00b7lacions circadi\u00e0ries”.<\/em><\/em><\/p>\nLeone Rossetti, investigador de l’IBEC i co-primer autor de l’estudi.<\/em><\/cite><\/blockquote>\n\n\n\n

L’observaci\u00f3 que YAP altera el ritme de les c\u00e8l\u00b7lules afegeix una nova dimensi\u00f3 a la regulaci\u00f3 del rellotge circadiari i aporta elements que poden contribuir a explicar perqu\u00e8 deixa de funcionar correctament en c\u00e8l\u00b7lules canceroses i en proc\u00e9s d’envelliment.<\/p>\n\n\n\n

Xavier Trepat, l\u00edder de l’estudi, \u00e9s tamb\u00e9 professor a la Universitat de Barcelona (UB) i membre del Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER-BBN).<\/p>\n\n\n\n

\n\n\n\n

Article referenciat:<\/strong><\/p>\n\n\n\n

Juan F. Abenza, Leone Rossetti, Mal\u00e8ke Mouelhi, Javier Burgu\u00e9s, Ion Andreu, Keith Kennedy, Pere Roca-Cusachs, Santiago Marco, Jordi Garc\u00eda-Ojalvo, Xavier Trepat. Mechanical control of the mammalian circadian clock via YAP\/TAZ and TEAD<\/a>. J Cell Biol<\/em> (2023). DOI: 10.1083\/jcb.202209120<\/p>\n\n\n\n

\n","protected":false},"excerpt":{"rendered":"

Investigadors de l’IBEC demostren com les forces f\u00edsiques desregulen el rellotge circadiari de les c\u00e8l\u00b7lules, el mecanisme que controla els canvis fisiol\u00f2gics cada 24h. La troballa pot ajudar a entendre … Read more<\/a><\/p>\n","protected":false},"author":37,"featured_media":109328,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1774,1842,1143],"post_formats":[],"class_list":["post-109333","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-cancer-ca","tag-integrative-cell-and-tissue-dynamics-ca","tag-xavier-trepat-ca"],"yoast_head":"\nLes forces mec\u00e0niques afecten el rellotge intern de les c\u00e8l\u00b7lules<\/title>\n<meta name=\"description\" content=\"La prote\u00efna YAP \u00e9s clau en la desregulaci\u00f3 del rellotge intern de les c\u00e8l\u00b7lules. 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