{"id":110558,"date":"2023-07-27T12:01:00","date_gmt":"2023-07-27T10:01:00","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=110558"},"modified":"2023-07-27T11:50:52","modified_gmt":"2023-07-27T09:50:52","slug":"samuel-sanchez-receives-erc-proof-of-concept-grant-to-target-mucinous-tumors-with-his-nanorobots","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/samuel-sanchez-aconsegueix-l-erc-proof-of-concept-per-portar-els-seus-nanorrobots-a-tumors-mucinosos","title":{"rendered":"Samuel S\u00e1nchez aconsegueix l&#8217;ERC Proof of Concept per portar els seus nanorrobots a tumors mucinosos"},"content":{"rendered":"\n<p>Samuel S\u00e1nchez ha obtingut una &#8220;ERC Proof of Concept&#8221; amb la qual explorar\u00e0 el potencial dels seus nanorrobots en el tractament de tumors secretors de moc. Aquest ajut l&#8217;atorga el Consell de Recerca Europeu (ERC) i <strong>permet als seus beneficiaris <\/strong>avaluar la viabilitat i el potencial de transfer\u00e8ncia de coneixement d&#8217;un projecte de recerca. <\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"2560\" height=\"1439\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2023\/07\/Samuel-Sanchez-IBEC-edited-scaled.jpg\" alt=\"\" class=\"wp-image-110554 lazyload\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2023\/07\/Samuel-Sanchez-IBEC-edited-scaled.jpg 2560w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2023\/07\/Samuel-Sanchez-IBEC-edited-300x169.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2023\/07\/Samuel-Sanchez-IBEC-edited-1024x576.jpg 1024w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2023\/07\/Samuel-Sanchez-IBEC-edited-768x432.jpg 768w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2023\/07\/Samuel-Sanchez-IBEC-edited-1536x864.jpg 1536w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2023\/07\/Samuel-Sanchez-IBEC-edited-2048x1151.jpg 2048w\" data-sizes=\"(max-width: 2560px) 100vw, 2560px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 2560px; --smush-placeholder-aspect-ratio: 2560\/1439;\" \/><figcaption class=\"wp-element-caption\">Samuel Sanchez al seu laboratori a l&#8217;IBEC.<\/figcaption><\/figure>\n\n\n\n<p>El projecte &#8220;MucOncoBots&#8221; t\u00e9 com a objectiu utilitzar nanobots per transportar un f\u00e0rmac destinat al tractament de la pseudomixoma peritoneal (PMP). Aquesta malaltia rara es caracteritza per formaci\u00f3 de tumors que generen una gran quantitat de mucositat en la cavitat peritoneal, la qual cosa la converteix en el tipus de tumor m\u00e9s mucin\u00f3s conegut.<\/p>\n\n\n\n<p>Samuel S\u00e1nchez \u00e9s professor de recerca ICREA a l&#8217;IBEC, on lidera el <a href=\"https:\/\/ibecbarcelona.eu\/es\/nanodevices\" target=\"_blank\" rel=\"noreferrer noopener\">grup de Nano-biodispositius Intel\u00b7ligents<\/a> dedicat a la recerca i desenvolupament de nanorrobots per a la seva aplicaci\u00f3 en l&#8217;\u00e0mbit biom\u00e8dic. En aquest projecte, compta amb la participaci\u00f3 de Meritxell Serra-Casablancas, una estudiant de doctorat enfocada en el desenvolupament de nanorrobots propulsats per enzims per al seu \u00fas en el tractament del c\u00e0ncer, amb un enfocament particular en tumors mucinosos. Meritxell ser\u00e0 la responsable del desenvolupament t\u00e8cnic dels nanobots i dur\u00e0 a terme les demostracions <em>in vitro de<\/em> l&#8217; efecte terap\u00e8utic.<\/p>\n\n\n\n<p> Aquesta investigaci\u00f3 es dur\u00e0 a terme en estreta col\u00b7laboraci\u00f3 amb l&#8217;equip de recerca del Dr. H\u00e9ctor G. Palmer, l\u00edder del grup de C\u00e8l\u00b7lules Mare i C\u00e0ncer de l&#8217;Institut de Recerca Oncol\u00f2gica de Vall d&#8217;Hebron (VHIO), i tamb\u00e9 comptar\u00e0 amb l&#8217;assessorament m\u00e8dic de la Dra. Elena \u00c9lez, cap del grup de C\u00e0ncer colorectal del VHIO i onc\u00f2loga de l\u2019Hospital Universitari Vall d&#8217;Hebron (VHUV).<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>Nanorobots per fer arribar un f\u00e0rmac a les c\u00e8l\u00b7lules tumorals<\/strong><\/h4>\n\n\n\n<p>El moc \u00e9s una barrera defensiva que protegeix les c\u00e8l\u00b7lules subjacents de pat\u00f2gens i compostos t\u00f2xics. Tanmateix, aquesta funci\u00f3 protectora tamb\u00e9 dificulta l&#8217;acc\u00e9s de f\u00e0rmacs quan s&#8217; administren localment. \u00c9s per aix\u00f2 que una administraci\u00f3 de f\u00e0rmacs transmucosa, com la proposta en aquest projecte, resultar\u00e0 m\u00e9s eficient. Els nanobots no nom\u00e9s actuaran com a transportadors del f\u00e0rmac, sin\u00f3 que tamb\u00e9 s&#8217;autopropulsaran cap al seu objectiu, superant la barrera de moc en el seu cam\u00ed.<\/p>\n\n\n\n<p>El desenvolupament d&#8217;aquesta nova ter\u00e0pia amb capacitat mucol\u00edtica i millor efic\u00e0cia en l&#8217;administraci\u00f3 de f\u00e0rmacs podria tenir un impacte benefici\u00f3s no nom\u00e9s en el tractament de la pseudomixoma peritoneal (PMP), sin\u00f3 tamb\u00e9 en altres patologies en qu\u00e8 la barrera mucosa dificulta l&#8217;activitat terap\u00e8utica efectiva. Entre aquestes patologies es troben aproximadament un 15% dels tumors colorrectals i el 5% dels tumors de pulm\u00f3, entre d&#8217;altres.<\/p>\n\n\n\n<p>A m\u00e9s, aquesta ter\u00e0pia podria tenir aplicacions en el tractament de malalties pulmonars inflamat\u00f2ries cr\u00f2niques, com la malaltia pulmonar obstructiva cr\u00f2nica (EPOC) i la fibrosi qu\u00edstica, on la barrera de moc tamb\u00e9 representa un desafiament per a l&#8217;administraci\u00f3 adequada dels f\u00e0rmacs.<\/p>\n\n\n\n<p>Aquest projecte sorgeix de la col\u00b7laboraci\u00f3 establerta entre Meritxell Serra-Casablancas, de l&#8217;equip de Samuel S\u00e1nchez, i un grup d&#8217;investigadors i investigadores del VHIO, aix\u00ed com cl\u00ednics del VHUV. Aquesta col\u00b7laboraci\u00f3 va tenir el seu origen durant el programa d&#8217;immersi\u00f3 cl\u00ednica per a estudiants de doctorat en el qual Meritxell participa, dut a terme conjuntament entre l&#8217;IBEC i el Col\u00b7legi de Metges de Barcelona (CoMB).<\/p>\n\n\n\n<p>L&#8217; objectiu d&#8217;aquest programa d&#8217;immersi\u00f3 cl\u00ednica \u00e9s connectar doctorands de l&#8217;IBEC amb especialistes cl\u00ednics, per tal de fomentar la transfer\u00e8ncia de resultats de la recerca a la pr\u00e0ctica cl\u00ednica.<\/p>\n\n\n\n<p>&#8220;El programa de mentoria plantejat pel COMB respon a una necessitat fonamental en medicina com \u00e9s el desenvolupament d&#8217;investigaci\u00f3 multidisciplin\u00e0ria que permet la col\u00b7laboraci\u00f3 estreta entre cl\u00ednics i investigadors b\u00e0sics per garantir que es busca contestar preguntes amb rellev\u00e0ncia per als pacients i que suposen una necessitat m\u00e8dica no resolta&#8221; explica la Dra. &#8220;En aquest cas concret, ens va permetre redefinir un brillant projecte inicialment plantejat per a un altre tipus de tumor per\u00f2 que podia respondre en una important mesura a un altre tipus de tumor diferent com \u00e9s el pseudomixoma peritoneal. Aquestes iniciatives permeten guanyar efici\u00e8ncia en les l\u00ednies de recerca primerenques en ambdues disciplines, en aquest cas tecnologia i medicina.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Samuel S\u00e1nchez has successfully secured an &#8220;ERC Proof of Concept&#8221; grant, provided by the European Research Council (ERC), to explore the application of his nanorobots in the treatment of mucus-secreting tumors. This prestigious grant enables researchers to assess the feasibility and potential for knowledge transfer of their research projects.<\/p>\n","protected":false},"author":37,"featured_media":110552,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[98],"tags":[1774,1411,2009,1140,1818],"post_formats":[],"class_list":["post-110558","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-institucionals","tag-cancer-ca","tag-erc-grant","tag-nanobots-ca","tag-samuel-sanchez-ca","tag-smart-nano-bio-devices-ca"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Samuel S\u00e1nchez aconsegueix l&#039;ERC Proof of Concept per portar els seus nanorrobots a tumors mucinosos - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/samuel-sanchez-aconsegueix-l-erc-proof-of-concept-per-portar-els-seus-nanorrobots-a-tumors-mucinosos\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Samuel S\u00e1nchez aconsegueix l&#039;ERC Proof of Concept per portar els seus nanorrobots a tumors mucinosos - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Samuel S\u00e1nchez has successfully secured an &quot;ERC Proof of Concept&quot; grant, provided by the European Research Council (ERC), to explore the application of his nanorobots in the treatment of mucus-secreting tumors. 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