{"id":110979,"date":"2023-09-14T17:00:00","date_gmt":"2023-09-14T15:00:00","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=110979"},"modified":"2023-09-14T11:16:12","modified_gmt":"2023-09-14T09:16:12","slug":"stiffness-may-be-key-to-slowing-the-progression-of-breast-tumors","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/evitar-que-els-teixits-responguin-al-seu-enduriment-pot-ser-clau-per-frenar-l-avanc-dels-tumors-de-mama","title":{"rendered":"Evitar que els teixits responguin al seu enduriment pot ser clau per frenar l’avan\u00e7 dels tumors de mama"},"content":{"rendered":"\n

Un estudi liderat per l’IBEC demostra que la laminina, una prote\u00efna present en els teixits mamaris sans, evita els efectes de l\u2019enduriment, protegint les c\u00e8l\u00b7lules contra el creixement tumoral.<\/strong> El mecanisme s’ha demostrat in vitro<\/em>, per\u00f2 es creu que tamb\u00e9 podria funcionar in vivo<\/em> a partir de l’observat en mostres de pacients.<\/strong><\/p>\n\n\n\n

\"In<\/figure>\n\n\n\n
<\/div>\n\n\n\n

Les c\u00e8l\u00b7lules s\u00f3n capaces de transformar canvis mec\u00e0nics en respostes biol\u00f2giques. Aquest proc\u00e9s es coneix com a mecanotransducci\u00f3 i t\u00e9 un paper fonamental en l’evoluci\u00f3 dels tumors s\u00f2lids, com el c\u00e0ncer de mama.<\/p>\n\n\n\n

Se sap que un canvi mec\u00e0nic habitual en processos de c\u00e0ncer \u00e9s l’enduriment dels teixits. Aquesta rigidesa \u00e9s precisament el que es detecta en fer una autoexploraci\u00f3 o palpaci\u00f3 mam\u00e0ria, per detectar possibles tumors. La rigidesa del teixit mamari provoca una reacci\u00f3 en cadena, generant tensi\u00f3 a l’interior de les c\u00e8l\u00b7lules i deformant el seu nucli. En \u00faltima inst\u00e0ncia, la deformaci\u00f3 del nucli activa gens que controlen la proliferaci\u00f3 cel\u00b7lular i estan relacionats amb el creixement tumoral.<\/p>\n\n\n\n

Un estudi publicat avui a la revista Nature Materials<\/em> demostra un mecanisme cel\u00b7lular que podria ser clau per frenar l’avan\u00e7 dels tumors de mama. Els resultats del treball, liderat per Pere Roca-Cusachs, investigador principal de l’IBEC i de la Universitat de Barcelona, indiquen que la laminina, una prote\u00efna que dona consist\u00e8ncia i suport als teixits mamaris sans, dificulta el proc\u00e9s de mecanotransducci\u00f3 a les c\u00e8l\u00b7lules, protegint el nucli de ser deformat.<\/p>\n\n\n\n

“Els nostres resultats mostren que la pres\u00e8ncia de laminina evita els efectes de la rigidesa. \u00c9s a dir, que protegeix les c\u00e8l\u00b7lules contra el creixement tumoral. Demostrem aquest mecanisme in vitro<\/em>, per\u00f2 creiem que tamb\u00e9 podria funcionar in vivo <\/em>ja que existeix una concordan\u00e7a amb l’observat en mostres de pacients de c\u00e0ncer de mama”<\/strong>, explica Zanetta Kechagia, investigadora postdoctoral de l’IBEC i primera autora de l’estudi.<\/p>\n\n\n\n

“A partir d’aquest mecanisme, que hem demostrat que preveu la invasi\u00f3 de c\u00e8l\u00b7lules tumorals, es podrien dissenyar eines diagn\u00f2stiques m\u00e9s sensibles o noves ter\u00e0pies potencials contra el c\u00e0ncer de mama. Per a aix\u00f2, ser\u00e0 necessari seguir investigant”<\/strong>, afegeix Pere Roca-Cusachs, investigador de l’IBEC, professor agregat Serra-Hunter de la Universitat de Barcelona (UB) i l\u00edder de l’estudi.<\/p>\n\n\n

\n
\"\"
C\u00e8l\u00b7lules mam\u00e0ries actuant de forma no invasiva a causa de la pres\u00e8ncia de laminina.<\/figcaption><\/figure><\/div>\n\n\n

Ja s’ha demostrat que un increment en la rigidesa del teixit indueix respostes mec\u00e0niques a l’interior de les c\u00e8l\u00b7lules. Les m\u00e9s habituals estan relacionades amb canvis en el citoesquelet de les c\u00e8l\u00b7lules per interaccionar amb el teixit i migrar, aix\u00ed com amb l’activaci\u00f3 de la prote\u00efna YAP, que entra al nucli accionant gens relacionats amb la proliferaci\u00f3 cel\u00b7lular.<\/p>\n\n\n\n

Per estudiar el proc\u00e9s de mecanotransducci\u00f3, l’equip d’investigaci\u00f3 va sembrar c\u00e8l\u00b7lules de teixit mamari sobre gels amb rigidesa variable per simular teixits sans (tous) i malignes (r\u00edgids). Van comparar el comportament de les c\u00e8l\u00b7lules sobre gels coberts amb laminina i gels coberts amb col\u00b7lagen o fibronectina, altres prote\u00efnes de suport cel\u00b7lular que es produeixen en exc\u00e9s en processos cancer\u00edgens.<\/p>\n\n\n\n

Aix\u00ed, els investigadors van observar que les c\u00e8l\u00b7lules sembrades sobre el gel ric en laminina van tenir una resposta mec\u00e0nica molt lleu a la rigidesa del substrat, en comparaci\u00f3 a aquelles sembrades sobre els gels rics en col\u00b7lagen i fibronectina.<\/p>\n\n\n\n

Aquest treball forma part del projecte europeu MECHANO\u00b7CONTROL<\/a>, amb un finan\u00e7ament de m\u00e9s de 7 milions d’euros dins del marc dels projectes europeus FET (Tecnologies Futures i Emergents).<\/p>\n\n\n\n

\n

“Aquests resultats s\u00f3n la culminaci\u00f3 de m\u00e9s de 6 anys de treball, en els quals hem comptat amb el suport de la Comissi\u00f3 Europea i un equip d’institucions internacionals, amb l’IBEC al cap, per entendre com les forces mec\u00e0niques afecten el c\u00e0ncer de mama.” Daniel Caudep\u00f3n, gestor de projectes de l’IBEC encarregat del projecte MECHANO\u00b7CONTROL.<\/ins><\/p>\n<\/blockquote>\n\n\n\n

El treball inclou contribucions importants d’altres institucions involucrades en MECHANO\u00b7CONTROL, amb el treball de Pablo S\u00e1ez i Marino Arroyo (Universitat Polit\u00e8cnica de Catalunya), i Thijs Koorman i Patrick Derksen (University Medical Center Utrecht, Pa\u00efsos Baixos). <\/p>\n\n\n\n

\n\n\n\n

Article referenciat:<\/strong><\/p>\n\n\n\n

Zanetta Kechagia, Pablo S\u00e1ez, Manuel G\u00f3mez-Gonz\u00e1lez, Brenda Canales, Srivatsava Viswanadha, Mart\u00edn Zamarbide, Ion Andreu, Thijs Koorman, Amy E. M. Beedle, Alberto Elosegui-Artola, Patrick W. B. Derksen, Xavier Trepat, Marino Arroyo & Pere Roca-Cusachs. The laminin\u2013keratin link shields the nucleus from mechanical deformation and signalling<\/a>. Nature Materials (2023). DOI: 10.1038\/s41563-023-01657-3.<\/p>\n\n\n\n

\n","protected":false},"excerpt":{"rendered":"

Un estudi liderat per l’Institut de Bioenginyeria de Catalunya demostra que la laminina, una prote\u00efna present en els teixits mamaris, evita els efectes de l\u2019enduriment, protegint les c\u00e8l\u00b7lules contra el creixement tumoral. El mecanisme s’ha demostrat in vitro, per\u00f2 es creu que tamb\u00e9 podria funcionar in vivo a partir de l’observat en mostres de pacients.<\/p>\n","protected":false},"author":37,"featured_media":110934,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96,98],"tags":[1774,2064,1812,1134,1143],"post_formats":[],"class_list":["post-110979","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","category-noticies-institucionals","tag-cancer-ca","tag-cancer-de-mama","tag-cellular-and-molecular-mechanobiology-ca","tag-pere-roca-cusachs-ca","tag-xavier-trepat-ca"],"yoast_head":"\nL'enduriment pot ser clau per frenar l'avan\u00e7 dels tumors de mama - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"description\" content=\"La laminina, una prote\u00efna present en els teixits mamaris, evita els efectes de l\u2019enduriment, protegint les c\u00e8l\u00b7lules contra el creixement tumoral.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/evitar-que-els-teixits-responguin-al-seu-enduriment-pot-ser-clau-per-frenar-l-avanc-dels-tumors-de-mama\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"L'enduriment pot ser clau per frenar l'avan\u00e7 dels tumors de mama - 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