{"id":111134,"date":"2023-09-18T09:00:00","date_gmt":"2023-09-18T07:00:00","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=111134"},"modified":"2023-09-14T16:47:36","modified_gmt":"2023-09-14T14:47:36","slug":"european-funding-for-the-treatment-of-type-1-diabetes-using-3d-bioprinting","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/financament-europeu-per-al-tractament-de-la-diabetis-tipus-1","title":{"rendered":"Finan\u00e7ament europeu per al tractament de la diabetis tipus 1 mitjan\u00e7ant bioimpressi\u00f3 3D"},"content":{"rendered":"\n

L’investigador de l’IBEC Javier Ram\u00f3n Azc\u00f3n ha rebut una “ERC Proof of Concept Grant”. Es tracta d’ un prestigi\u00f3s finan\u00e7ament que concedeix el Consell Europeu de Recerca per explorar el potencial comercial i social de projectes de recerca duts a terme en institucions europees. El projecte de Ramon, Uniink, s’enfoca en el tractament de la diabetis tipus 1 amb ter\u00e0pia cel\u00b7lular i bioimpressi\u00f3 3D.<\/strong><\/p>\n\n\n\n

\"\"
Javier Ram\u00f3n Azc\u00f3n al seu laboratori de l’IBEC.<\/figcaption><\/figure>\n\n\n\n

Javier Ram\u00f3n Azc\u00f3n, professor de recerca ICREA i l\u00edder del grup de Biosensors per a Bioenginyeria<\/a> a l’IBEC, ha estat guardonat amb una “ERC Proof of Concept Grant”. Es tracta d’una prestigiosa subvenci\u00f3 que concedeix el Consell Europeu de Recerca (ERC, per les seves sigles en angl\u00e8s) i t\u00e9 com a objectiu explorar el potencial comercial i social de projectes de recerca que estan o han estat finan\u00e7ats pr\u00e8viament per l’ERC. Els i les sol\u00b7licitants utilitzen aquest tipus de finan\u00e7ament per verificar la viabilitat de conceptes cient\u00edfics, explorar oportunitats de negoci o preparar sol\u00b7licituds de patents.<\/p>\n\n\n\n

El projecte de Ramon ha estat batejat com a Uniink i s’enfoca en el tractament de la diabetis tipus 1 amb ter\u00e0pia cel\u00b7lular i bioimpressi\u00f3 3D.<\/p>\n\n\n\n

La diabetis tipus 1 \u00e9s una afecci\u00f3 en la qual el mateix sistema immune destrueix les c\u00e8l\u00b7lules \u03b2 del p\u00e0ncrees, encarregades de produir insulina, una hormona que interv\u00e9 en el control de la glucosa en sang.<\/p>\n\n\n\n

Una alternativa a les famoses injeccions d’insulina, que no permeten una resposta tan din\u00e0mica als canvis de glucosa, \u00e9s la ter\u00e0pia cel\u00b7lular. Concretament, el trasplantament d’illots de Langerhans (pancre\u00e0tics) de donants morts.  Els  illots s\u00f3n grups de c\u00e8l\u00b7lules del p\u00e0ncrees que contenen, entre d’altres, c\u00e8l\u00b7lules \u03b2 productores d’insulina. Tot i ser un tractament efectiu amb m\u00faltiples beneficis, no \u00e9s possible aplicar-lo de forma generalitzada a causa de la dificultat de trobar donants compatibles i a la necessitat d’immunosuprimir la persona receptora. Aix\u00f2 \u00faltim \u00e9s necessari perqu\u00e8 el sistema immune de l’hoste reconeix els illots trasplantats com a estranys i els ataca.<\/p>\n\n\n\n

Uniink es presenta com una evoluci\u00f3 a aquest tipus de ter\u00e0pia. El projecte proposa un nou procediment de bioimpressi\u00f3 3D per fabricar grans quantitats de microesferes biocompatibles carregades de c\u00e8l\u00b7lules que s\u00f3n capaces de secretar insulina en resposta a est\u00edmuls de glucosa extracel\u00b7lular. La creaci\u00f3 de barreres f\u00edsiques, com l’encapsulaci\u00f3, pot protegir les c\u00e8l\u00b7lules trasplantades del sistema immunitari de l’hoste. Aix\u00f2 permetria la recuperaci\u00f3 de l’empelt, restaurant la regulaci\u00f3 fisiol\u00f2gica de la glucosa.<\/p>\n\n\n

\n
\"\"
Representaci\u00f3 esquem\u00e0tica de les microesferes biocompatibles del projecte Uniink.<\/figcaption><\/figure><\/div>\n\n\n

quest innovador sistema va ser desenvolupat per Laura Clua Ferr\u00e9 durant la seva tesi doctoral en el grup de Ramon. Per al nou projecte, que recull el testimoni de Clua, l’equip de l’IBEC provar\u00e0 l’efic\u00e0cia d’Uniink en models de ratol\u00ed i col\u00b7laborar\u00e0 amb el grup d’Anna Novials de l’Institut d’Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) per obtenir les c\u00e8l\u00b7lules de donants.<\/p>\n\n\n\n

Pel moment, ja s’ha sol\u00b7licitat una patent per al sistema d’encapsulaci\u00f3 i, tal com explica Javier Ram\u00f3n: “Al llarg del projecte, explorarem la possibilitat d’establir una nova empresa i col\u00b7laboracions amb socis privats, amb l’objectiu de portar aquesta tecnologia cap a la seva aplicaci\u00f3 cl\u00ednica. En resum, Uniink t\u00e9 el potencial de transformar el tractament de la diabetis tipus 1 de manera significativa, brindant noves esperances als pacients afectats per aquesta condici\u00f3.”<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

L’investigador de l’IBEC Javier Ram\u00f3n Azc\u00f3n ha rebut una “ERC Proof of Concept Grant”. Es tracta d’ un prestigi\u00f3s finan\u00e7ament que concedeix el Consell Europeu de Recerca per explorar el potencial comercial i social de projectes de recerca duts a terme en institucions europees. El projecte de Ramon, Uniink, s’enfoca en el tractament de la diabetis tipus 1 amb ter\u00e0pia cel\u00b7lular i bioimpressi\u00f3 3D. <\/p>\n","protected":false},"author":37,"featured_media":111122,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[98],"tags":[1999,1838,1131],"post_formats":[],"class_list":["post-111134","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-institucionals","tag-biosensors-for-bioengineering-ca","tag-diabetis","tag-javier-ramon-ca"],"yoast_head":"\nTractament de la diabetis tipus 1 mitjan\u00e7ant bioimpressi\u00f3 3D - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"description\" content=\"Javier Ram\u00f3n Azc\u00f3n rep finan\u00e7ament per al seu projecte Uniink, enfocat en el tractament de la diabetis tipus 1 amb ter\u00e0pia cel\u00b7lular i bioimpressi\u00f3 3D.\" \/>\n<meta name=\"robots\" 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