{"id":112688,"date":"2023-11-21T10:14:53","date_gmt":"2023-11-21T09:14:53","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/luminescent-nanoparticle-based-implants-for-pain-and-epilepsy-treatment\/"},"modified":"2023-11-21T10:41:33","modified_gmt":"2023-11-21T09:41:33","slug":"luminescent-nanoparticle-based-implants-for-pain-and-epilepsy-treatment","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/implants-amb-nanoparticules-luminescents-per-tractar-el-dolor-i-epilepsia","title":{"rendered":"Implants amb nanopart\u00edcules luminescents per tractar el dolor i l’epil\u00e8psia"},"content":{"rendered":"\n

L’IBEC coordinar\u00e0 el projecte PHOTOTHERAPORT que es desenvolupar\u00e0 amb el finan\u00e7ament del programa Pathfinder Open del Consell d’Innovaci\u00f3 Europeu.<\/strong> El projecte se centra en el desenvolupament d’implants luminescents i f\u00e0rmacs activats amb llum per a innovadores ter\u00e0pies de neuromodulaci\u00f3.<\/strong> Phototheraport ser\u00e0 un consorci internacional de 8 institucions i rebr\u00e0 3 milions d’euros en 3 anys per a l’estudi precl\u00ednic d’aquests implants.<\/strong><\/p>\n\n\n\n

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Pau Gorostiza, professor de recerca ICREA i investigador principal del grup de Nanosondas i Nanocommutadors<\/a> de l’Institut de Bioenginyeria de Catalunya (IBEC) i del CIBER-BBN, coordinar\u00e0 el projecte PHOTOTHERAPORT finan\u00e7at pel prestigi\u00f3s programa Pathfinder Open del Consell d’Innovaci\u00f3 Europeu (EIC, per les seves sigles en angl\u00e8s). Amb aquesta iniciativa l’EIC impulsa l’exploraci\u00f3 d’idees atrevides per a tecnologies radicalment noves, donant suport a col\u00b7laboracions cient\u00edfiques d’avantguarda, interdisciplin\u00e0ries i d’alt risc\/alta recompensa que sustenten aven\u00e7os tecnol\u00f2gics.<\/p>\n\n\n\n

PHOTOTHERAPORT se centra en el desenvolupament d’implants luminescents com ports per a ter\u00e0pies de llum, en analogia als que s’empren en quimioter\u00e0pia per administrar f\u00e0rmacs. Un consorci de 8 institucions de 4 pa\u00efsos, coordinat per l’IBEC, dur\u00e0 a terme el projecte amb un finan\u00e7ament de 3 milions d’euros durant els pr\u00f2xims 3 anys.<\/a><\/p>\n\n\n\n

Les ter\u00e0pies basades en la llum estan cobrant import\u00e0ncia en medicina a causa de la seva capacitat per dirigir-se a regions espec\u00edfiques del cos. Malgrat el seu demostrat potencial terap\u00e8utic, aquestes ter\u00e0pies s’enfronten a un desafiament com\u00fa: l’atenuaci\u00f3 de la llum visible a trav\u00e9s de teixits tous i ossos abans que arribi de manera efectiva al lloc d’inter\u00e8s. Aquesta atenuaci\u00f3 \u00e9s m\u00e9s gran com m\u00e9s profunds s\u00f3n els teixits i \u00f2rgans als quals es vol arribar.<\/p>\n\n\n\n

La plataforma PhotoTheraPort ofereix una soluci\u00f3 a aquest desafiament. Es tracta d’uns implants dissenyats perqu\u00e8 emetin llum localment en il\u00b7luminar-los amb una font de llum externa. Aquests dispositius incorporen nanopart\u00edcules d‘upconversion<\/em> (conversi\u00f3 ascendent, en angl\u00e8s), que en il\u00b7luminar-les amb llum infraroja emeten fotons de major energia (llum visible o ultraviolada). D’aquesta manera, l’emissi\u00f3 de llum per part de les nanopart\u00edcules es pot controlar de forma remota i no invasiva, aplicant externament llum infraroja, que s\u00ed que penetra a trav\u00e9s del teixit i l’os. La forma i el color d’emissi\u00f3 dels PhotoTheraPorts podran ajustar-se a diversos prop\u00f2sits terap\u00e8utics. El consorci d’investigaci\u00f3 emprar\u00e0 inicialment aquesta plataforma per produir efectes analg\u00e8sics \u00fanicament mitjan\u00e7ant llum, la qual cosa es coneix com a fotobiomodulaci\u00f3 contra el dolor, i el compararan amb l\u00e0mpades que ja s’utilitzen cl\u00ednicament. El prop\u00f2sit \u00e9s tractar el dolor inflamatori de manera m\u00e9s efectiva en regions ocultes de la columna vertebral.<\/p>\n\n\n\n

A continuaci\u00f3, els PhotoTheraPort s’aplicaran a ter\u00e0pies de neuromodulaci\u00f3 fotofarmacol\u00f2gica. Per a aix\u00f2 es desenvoluparan fotof\u00e0rmacs dissenyats per treballar conjuntament amb la plataforma d’emissors de llum. Aquests f\u00e0rmacs s’activen \u00fanicament quan s’exposen a un color de llum espec\u00edfic. Aquesta segona tecnologia es provar\u00e0 per reduir el dolor neurop\u00e0tic il\u00b7luminant en certes regions de la columna vertebral. Tamb\u00e9 s’intentar\u00e0 inhibir la hiperactivitat neuronal caracter\u00edstica de l’epil\u00e8psia focal, que afecta una zona limitada del cervell i \u00e9s intractable en el 30% dels pacients epil\u00e8ptics.<\/p>\n\n\n\n

\n

“La nostra meta \u00e9s demostrar, d\u2019aqu\u00ed a cinc anys, la seguretat i no toxicitat de la plataforma i acostar aquesta nova ter\u00e0pia de fotobiomodulaci\u00f3 a l’\u00fas cl\u00ednic. Els terminis de desenvolupament dels fotof\u00e0rmacs s\u00f3n impredictibles, per\u00f2 es preveuen m\u00e9s llargs. Si obtenim bons resultats precl\u00ednics per a la neuromodulaci\u00f3, seria la primera mol\u00e8cula d’aquest tipus que compleixi amb els requisits reguladors.” Explica Gorostiza.<\/p>\n<\/blockquote>\n\n\n\n

Un cop provada l’efic\u00e0cia dels PhotoTheraPort per a aquestes patologies, la plataforma t\u00e9 el potencial de poder aplicar-se a altres condicions que requereixen tractaments amb acci\u00f3 localitzada, com s\u00f3n l’artritis, les malalties autoimmunes, les infeccions o els trasplantaments. La simplicitat i versatilitat d’aquesta innovadora plataforma pret\u00e9n millorar el tractament del dolor i la qualitat de vida dels pacients, a m\u00e9s d’oferir al sistema sanitari formes d’optimitzar costos m\u00e8dics i ampliar els seus beneficis.<\/p>\n\n\n\n

El consorci PHOTOTHERAPORT est\u00e0 format per l’Institut Let\u00f3 de S\u00edntesi Org\u00e0nica, la Universitat de Tampere (Finl\u00e0ndia), l’Institut de Tecnologia Technion (Israel), la Universitat Stradins de Riga (Let\u00f2nia), la Universitat de Cadis, l’Institut d’Investigacions Biom\u00e8diques de Barcelona (IIBB-CSIC) i l’Institut Teamit, tamb\u00e9 a Barcelona, i est\u00e0 coordinat per l’IBEC.<\/p>\n\n\n\n

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L’IBEC coordinar\u00e0 el projecte PHOTOTHERAPORT que es desenvolupar\u00e0 amb el finan\u00e7ament del programa Pathfinder Open del Consell d’Innovaci\u00f3 Europeu. El projecte se centra en el desenvolupament d’implants luminescents i f\u00e0rmacs activats amb llum per a innovadores ter\u00e0pies de neuromodulaci\u00f3. Phototheraport ser\u00e0 un consorci internacional de 8 institucions i rebr\u00e0 3 milions d’euros en 3 anys per a l’estudi precl\u00ednic d’aquests implants.<\/p>\n","protected":false},"author":37,"featured_media":112679,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[98],"tags":[2073,1879,1883],"post_formats":[],"class_list":["post-112688","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-institucionals","tag-epilepsy-ca","tag-nanoprobes-and-nanoswitches-ca","tag-pau-gorostiza-ca-2"],"yoast_head":"\nImplants luminescents per tractar el dolor i l'epil\u00e8psia - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"description\" content=\"L'IBEC coordinar\u00e0 el projecte PHOTOTHERAPORT finan\u00e7at pel programa Pathfinder Open del Consell d'Innovaci\u00f3 Europeu.\" \/>\n<meta name=\"robots\" content=\"index, follow, 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