{"id":112800,"date":"2023-11-23T12:00:00","date_gmt":"2023-11-23T11:00:00","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=112800"},"modified":"2023-11-23T10:55:24","modified_gmt":"2023-11-23T09:55:24","slug":"benedetta-bolognesi-awarded-a-prestigious-european-erc-consolidator-grant","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/benedetta-bolognesi-guardonada-amb-una-prestigiosa-beca-europea-erc-consolidator-grant","title":{"rendered":"La investigadora Benedetta Bolognesi guardonada amb una prestigiosa beca europea ERC Consolidator Grant"},"content":{"rendered":"\n<p><strong>La investigadora de l&#8217;IBEC ha estat guardonada amb una \u00abERC Consolidator Grant\u00bb. Aquest prestigi\u00f3s finan\u00e7ament europeu dona suport a cient\u00edfics en l&#8217;etapa de consolidaci\u00f3 dels seus equips de recerca, permetent-los perseguir idees cient\u00edfiques innovadores. 2 milions d&#8217;euros durant 5 anys permetran a Bolognesi i el seu equip desenvolupar un nou m\u00e8tode per identificar les mutacions que condueixen a la formaci\u00f3 d&#8217;amiloides, agregats de prote\u00efnes que causen multitud de malalties, incloent-hi l&#8217;Alzheimer o el Parkinson.<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2023\/11\/0M0A7151-low-1024x683.jpg\" alt=\"\" class=\"wp-image-112809 lazyload\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2023\/11\/0M0A7151-low-1024x683.jpg 1024w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2023\/11\/0M0A7151-low-300x200.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2023\/11\/0M0A7151-low-768x512.jpg 768w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2023\/11\/0M0A7151-low-600x400.jpg 600w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2023\/11\/0M0A7151-low.jpg 1200w\" data-sizes=\"(max-width: 1024px) 100vw, 1024px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 1024px; --smush-placeholder-aspect-ratio: 1024\/683;\" \/><\/figure>\n\n\n\n<p>Benedetta Bolognesi, investigadora principal a l&#8217;IBEC ha estat guardonada amb una \u00abERC Consolidator Grant\u00bb, una de les fonts de finan\u00e7ament m\u00e9s prestigioses i competitives de la Uni\u00f3 Europea. Es tracta d&#8217;una ajuda a la investigaci\u00f3 atorgada pel Consell de Recerca Europeu (ERC) que dona suport a personal cient\u00edfic i acad\u00e8mic destacat en l&#8217;etapa de les seves carreres en la qual encara estan consolidant els seus propis equips d&#8217;investigaci\u00f3 independents perqu\u00e8 puguin perseguir les seves idees cient\u00edfiques m\u00e9s prometedores.<\/p>\n\n\n\n<p>Bolognesi forma part del selecte 14,5% de candidats guardonats a tot Europa d&#8217;entre les 2.130 sol\u00b7licituds que es van rebre en aquesta convocat\u00f2ria.<\/p>\n\n\n\n<p>La investigadora va iniciar el seu cam\u00ed com a l\u00edder de grup a finals del 2018, amb la creaci\u00f3 del grup de <a href=\"https:\/\/ibecbarcelona.eu\/protein-phase-transitions-in-health-and-disease\/\">Transicions de Fase de Prote\u00efnes en la Salut i la Malaltia<\/a> de l&#8217;IBEC. Despr\u00e9s de quatre anys com a l\u00edder de grup j\u00fanior, va estabilitzar la seva pla\u00e7a com a l\u00edder de grup consolidada.<\/p>\n\n\n\n<p>El projecte que desenvolupar\u00e0 gr\u00e0cies a aquest nou finan\u00e7ament porta per nom Mapatge Global d&#8217;Amiloides: Resolent la Nucleaci\u00f3 Amiloide mitjan\u00e7ant Mutag\u00e8nesi Profunda (GLAM-Map, per les seves sigles en angl\u00e8s).<\/p>\n\n\n\n<p>Els amiloides s\u00f3n prote\u00efnes que formen agregats o fibril\u00b7les que s&#8217;acumulen en l&#8217;organisme, sense que aquest sigui capa\u00e7 de descompondre-les. La seva pres\u00e8ncia i proc\u00e9s de formaci\u00f3 semblen ser la causa de m\u00e9s de 50 malalties humanes, incloses la malaltia d&#8217;Alzheimer, la malaltia de Parkinson, la dem\u00e8ncia frontotemporal, l&#8217;esclerosi lateral amiotr\u00f2fica (ELA) i la diabetis tipus II.<\/p>\n\n\n\n<p>En el proc\u00e9s de formaci\u00f3 d&#8217;amiloides, les prote\u00efnes travessen un estat de transici\u00f3 abans d&#8217;adoptar la seva conformaci\u00f3 final, en la qual acaben formant agregats. Aquest estat intermedi \u00e9s crucial per comprendre l&#8217;evoluci\u00f3 de la prote\u00efna cap a la seva estructura amiloide. No obstant aix\u00f2, estudiar aquest estat \u00e9s particularment desafiant amb els m\u00e8todes convencionals a causa de la seva breu durada.<\/p>\n\n\n\n<p>Com a alternativa per estudiar aquest proc\u00e9s, Benedetta i el seu equip han desenvolupat una nova metodologia basada en la t\u00e8cnica d&#8217;escaneig mutacional profund. Amb ella, s&#8217;introdueixen mutacions en milers de seq\u00fc\u00e8ncies de prote\u00efnes per estudiar els seus efectes en la taxa d&#8217;agregaci\u00f3.<\/p>\n\n\n\n<p>El projecte t\u00e9 tres objectius principals: mapar l&#8217;impacte de mutacions en m\u00e9s de 60 amiloides, construir models d&#8217;estats de transici\u00f3 d&#8217;amiloides associats a malalties, i descobrir seq\u00fc\u00e8ncies gen\u00e8tiques que inicien la formaci\u00f3 d&#8217;amiloides en resposta a l&#8217;estr\u00e8s ambiental.<\/p>\n\n\n\n<p>Aquest projecte busca desentranyar les regles que regeixen la formaci\u00f3 d&#8217;amiloides, identificar mutacions que acceleren l&#8217;agregaci\u00f3 i causen malalties, i comprendre els estats de transici\u00f3 d&#8217;aquest proc\u00e9s.<\/p>\n\n\n\n<p>S&#8217;espera que els resultats contribueixin al desenvolupament de nous enfocaments terap\u00e8utics per a malalties amiloides, incloses dem\u00e8ncies greus. M\u00e9s encara, els resultats podran alimentar nous models i predictors d&#8217;agregaci\u00f3 de prote\u00efnes per interpretar variants gen\u00e8tiques de les malalties i dissenyar prote\u00efnes sint\u00e8tiques innovadores.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>La investigadora de l&#8217;Institut de Bioenginyeria de Catalunya ha estat guardonada amb una \u00abERC Consolidator Grant\u00bb. Aquest prestigi\u00f3s finan\u00e7ament europeu dona suport a cient\u00edfics en l&#8217;etapa de consolidaci\u00f3 dels seus equips de recerca, permetent-los perseguir idees cient\u00edfiques innovadores. 2 milions d&#8217;euros durant 5 anys permetran a Bolognesi i el seu equip desenvolupar un nou m\u00e8tode per identificar les mutacions que condueixen a la formaci\u00f3 d&#8217;amiloides, agregats de prote\u00efnes que causen multitud de malalties, incloent-hi l&#8217;Alzheimer o La investigadora de l&#8217;Institut de Bioenginyeria de Catalunya ha estat guardonada amb una \u00abERC Consolidator Grant\u00bb. Aquest prestigi\u00f3s finan\u00e7ament europeu dona suport a cient\u00edfics en l&#8217;etapa de consolidaci\u00f3 dels seus equips de recerca, permetent-los perseguir idees cient\u00edfiques innovadores. 2 milions d&#8217;euros durant 5 anys permetran a Bolognesi i el seu equip desenvolupar un nou m\u00e8tode per identificar les mutacions que condueixen a la formaci\u00f3 d&#8217;amiloides, agregats de prote\u00efnes que causen multitud de malalties, incloent-hi l&#8217;Alzheimer o el Parkinson.<\/p>\n","protected":false},"author":37,"featured_media":112809,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[98],"tags":[1627,1107,2061,1817,1776],"post_formats":[],"class_list":["post-112800","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-institucionals","tag-alzheimer-ca-2","tag-benedetta-bolognesi-ca","tag-erc-ca","tag-premi","tag-protein-phase-transitions-in-health-and-disease-ca"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Benedetta Bolognesi awarded an ERC Consolidator Grant - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"description\" content=\"Bolognesi will develop a new method for identifying mutations that lead to the formation of amyloids.\" \/>\n<meta name=\"robots\" content=\"index, follow, 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