{"id":115734,"date":"2024-02-29T12:26:39","date_gmt":"2024-02-29T11:26:39","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/ibec-and-isglobal-scientists-develop-an-innovative-compound-effective-against-malaria-and-leishmaniasis\/"},"modified":"2024-02-29T14:49:33","modified_gmt":"2024-02-29T13:49:33","slug":"ibec-and-isglobal-scientists-develop-an-innovative-compound-effective-against-malaria-and-leishmaniasis","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/cientifics-de-ibec-i-isglobal-desenvolupen-un-compost-innovador-eficac-contra-malaria-i-la-leishmaniosi","title":{"rendered":"Cient\u00edfics de l&#8217;IBEC i ISGlobal desenvolupen un compost innovador efica\u00e7 contra mal\u00e0ria i la leishmaniosi"},"content":{"rendered":"\n<p><strong>Un estudi liderat per l&#8217;IBEC i ISGlobal ha demostrat el potencial antileishmanial d&#8217;un compost antimal\u00e0ric. Dissenyat inicialment per a la mal\u00e0ria, aquest f\u00e0rmac mostra una elevada efic\u00e0cia contra la leishmaniosi, marcant un aven\u00e7 \u00fanic i prometedor per al tractament d&#8217;ambdues infeccions.<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"576\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2024\/02\/IMG-5673-horizontal-1024x576.jpg\" alt=\"\" class=\"wp-image-115726 lazyload\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2024\/02\/IMG-5673-horizontal-1024x576.jpg 1024w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2024\/02\/IMG-5673-horizontal-300x169.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2024\/02\/IMG-5673-horizontal-768x432.jpg 768w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2024\/02\/IMG-5673-horizontal-1536x864.jpg 1536w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2024\/02\/IMG-5673-horizontal-2048x1152.jpg 2048w\" data-sizes=\"(max-width: 1024px) 100vw, 1024px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 1024px; --smush-placeholder-aspect-ratio: 1024\/576;\" \/><figcaption class=\"wp-element-caption\">D&#8217;esquerra a dreta: Yunuen Avalos-Padilla, Luc\u00eda Rom\u00e1n-\u00c1lamo i Xavier Fern\u00e0ndez-Busquets (IBEC \u2013 ISGlobal)<\/figcaption><\/figure>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>La leishmaniosi, una malaltia que afecta anualment entre 700.000 i 1 mili\u00f3 de persones a tot el m\u00f3n, \u00e9s especialment prevalent en poblacions desfavorides. Transmesa per par\u00e0sits del g\u00e8nere <em>Leishmania<\/em> a trav\u00e9s de la picada del fleb\u00f2tom, un insecte similar al mosquit, les formes cut\u00e0nia i visceral de la malaltia s\u00f3n end\u00e8miques a Europa, amb el 80% dels casos cutanis concentrats a la Mediterr\u00e0nia Oriental.<\/p>\n\n\n\n<p>Els medicaments actuals per tractar aquesta malaltia enfronten desafiaments com resist\u00e8ncia, toxicitat i costos elevats. Per aix\u00f2, \u00e9s urgent identificar nous agents terap\u00e8utics amb enfocaments innovadors per abordar aquestes dificultats.<\/p>\n\n\n\n<p>En aquest context, un equip liderat pel grup de recerca de <a href=\"https:\/\/ibecbarcelona.eu\/es\/nanomalaria\">Nanomal\u00e0ria<\/a> de l&#8217;IBEC i l&#8217;Institut de Salut Global de Barcelona (ISGlobal) ha explorat un enfocament innovador per tractar la leishmaniosi basat en les troballes recents en mal\u00e0ria.<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>Surprenentment, YAT2150 va resultar ser molt efectiu tamb\u00e9 contra la leishmaniosi, situant-nos en una posici\u00f3 \u00fanica, ja que ambdues malalties s\u00f3n les principals causes de mortalitat per par\u00e0sits en humans<\/p>\n<cite>Xavier Fern\u00e0ndez Busquets<\/cite><\/blockquote>\n\n\n\n<p>La investigaci\u00f3, publicada a la revista cient\u00edfica <a href=\"https:\/\/journals.asm.org\/doi\/full\/10.1128\/aac.01127-23\"><em>Antimicrobial Agents and Chemotherapy<\/em><\/a>, se centra en l&#8217;acci\u00f3 <em>in vitro <\/em>del compost YAT2150, originalment dissenyat com un potent medicament contra la mal\u00e0ria. &#8220;En el marc d&#8217;un projecte anterior centrat a millorar l&#8217;efic\u00e0cia de f\u00e0rmacs coneguts contra la mal\u00e0ria mitjan\u00e7ant encapsulaci\u00f3, va sorgir la idea de provar el compost YAT2150. Sorprenentment, va resultar ser molt efectiu tamb\u00e9 contra la leishmaniosi, situant-nos en una posici\u00f3 \u00fanica, ja que ambdues malalties s\u00f3n les principals causes de mortalitat per par\u00e0sits en humans.&#8221;, explica Xavier Fern\u00e0ndez Busquets, l\u00edder de l&#8217;estudi i investigador principal d&#8217;IBEC-ISGlobal<\/p>\n\n\n\n<p>Els resultats de l&#8217;estudi suggereixen que YAT2150 podria actuar inhibint l&#8217;agregaci\u00f3 de prote\u00efnes a les c\u00e8l\u00b7lules de <em>Leishmania<\/em>, el mateix mode d&#8217;acci\u00f3 que ja s&#8217;ha observat en el par\u00e0sit de la mal\u00e0ria. Aquesta capacitat d&#8217;actuar efica\u00e7ment contra ambd\u00f3s, <em>Plasmodium<\/em> i <em>Leishmania<\/em>, posiciona YAT2150 com un candidat prometedor per al tractament de coinfeccions d&#8217;ambd\u00f3s par\u00e0sits.<\/p>\n\n\n\n<p>Actualment, l&#8217;equip treballa per avan\u00e7ar cap a la seg\u00fcent fase de la investigaci\u00f3, que implica provar el f\u00e0rmac en models de leishmaniosi en ratol\u00ed. Un pas crucial cap al desenvolupament d&#8217;un tractament innovador.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong><strong>El poder de l&#8217;encapsulaci\u00f3<\/strong><\/strong><\/h4>\n\n\n\n<p>El treball tamb\u00e9 aborda els efectes d&#8217;encapsular el f\u00e0rmac dins de liposomes. Aquesta estrat\u00e8gia no nom\u00e9s amplia la seva finestra terap\u00e8utica, potenciant la seva letalitat contra el par\u00e0sit i reduint la toxicitat per a la resta de c\u00e8l\u00b7lules, sin\u00f3 que tamb\u00e9 permet dirigir el f\u00e0rmac espec\u00edficament a les zones del cos d&#8217;inter\u00e8s.<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>Hem donat amb alguns f\u00e0rmacs derivats del YAT2150 que mostren \u00edndexs de selectivitat per al par\u00e0sit de la mal\u00e0ria de 1.000, 2.000 o fins i tot 3.000.<\/p>\n<cite>Luc\u00eda Rom\u00e1n-\u00c1lamo<\/cite><\/blockquote>\n\n\n\n<p>D&#8217;altra banda, un indicador clau per con\u00e8ixer l&#8217;especificitat d&#8217;acci\u00f3 d&#8217;un f\u00e0rmac \u00e9s l&#8217;\u00edndex de selectivitat: &#8220;Perqu\u00e8 un f\u00e0rmac sigui considerat per arribar a fases de desenvolupament i assajos cl\u00ednics, el seu \u00edndex de selectivitat ha de ser major a 100. En el nostre cas, hem donat amb alguns f\u00e0rmacs derivats del YAT2150 que mostren \u00edndexs de selectivitat per al par\u00e0sit de la mal\u00e0ria de 1.000, 2.000 o fins i tot 3.000. S\u00f3n resultats molt prometedors.&#8221;, destaca Luc\u00eda Rom\u00e1n-\u00c1lamo, estudiant de doctorat en el grup de Nanomalaria i primera autora de l&#8217;estudi.<\/p>\n\n\n\n<p>El treball ha comptat tamb\u00e9 amb la col\u00b7laboraci\u00f3 del grup de recerca de Diego Mu\u00f1oz-Torrero a l&#8217;Institut de Biomedicina de la Universitat de Barcelona (IBUB) que es va encarregar del desenvolupament de la fam\u00edlia de f\u00e0rmacs derivats de la mol\u00e8cula mare YAT2150.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p><strong>Article referenciat:<\/strong><\/p>\n\n\n\n<p>Luc\u00eda Rom\u00e1n-\u00c1lamo, Yunuen Avalos-Padilla, In\u00e9s Bouz\u00f3n-Arn\u00e1iz, Valent\u00edn Iglesias, Jorge Fern\u00e1ndez-Lajo, Juan M. Monteiro, Luis Rivas, SHOW ALL (15 AUTHORS), Xavier Fern\u00e0ndez-Busquets. <a href=\"https:\/\/journals.asm.org\/doi\/full\/10.1128\/aac.01127-23\" target=\"_blank\" rel=\"noreferrer noopener\">Effect of the aggregated protein dye YAT2150 on <em>Leishmania<\/em> parasite viability.<\/a> <em>Antimicrobial Agents and Chemotherapy<\/em> (2024). DOI: 10.1128\/aac.01127-23<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n","protected":false},"excerpt":{"rendered":"<p>Un estudi liderat per l&#8217;IBEC i ISGlobal ha demostrat el potencial antileishmanial d&#8217;un compost antimal\u00e0ric. Dissenyat inicialment per a la mal\u00e0ria, aquest f\u00e0rmac mostra una elevada efic\u00e0cia contra la leishmaniosi, marcant un aven\u00e7 \u00fanic i prometedor per al tractament d&#8217;ambdues infeccions.<\/p>\n","protected":false},"author":37,"featured_media":115727,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[312,1112],"post_formats":[],"class_list":["post-115734","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-malaria-ca-2","tag-xavier-fernandez-busquets-ca"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Un compost innovador efica\u00e7 contra mal\u00e0ria i la leishmaniosi - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"description\" content=\"Dissenyat inicialment per a la mal\u00e0ria, 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