{"id":116424,"date":"2024-03-25T12:51:02","date_gmt":"2024-03-25T11:51:02","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/a-study-led-by-ibec-successfully-mimics-the-complex-neuroblastoma-vasculature-on-a-chip-to-explore-treatments-for-this-pediatric-cancer\/"},"modified":"2024-03-25T13:32:58","modified_gmt":"2024-03-25T12:32:58","slug":"a-study-led-by-ibec-successfully-mimics-the-complex-neuroblastoma-vasculature-on-a-chip-to-explore-treatments-for-this-pediatric-cancer","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/un-estudi-liderat-per-ibec-aconsegueix-imitar-la-complexa-vasculatura-del-neuroblastoma-en-un-xip","title":{"rendered":"Un estudi liderat per l’IBEC aconsegueix imitar la complexa vasculatura del neuroblastoma en un xip per estudiar f\u00e0rmacs contra aquest c\u00e0ncer pedi\u00e0tric"},"content":{"rendered":"\n

Dos estudis liderats per l’IBEC han aconseguit recrear el proc\u00e9s de transdiferenciaci\u00f3 de la vasculatura del neuroblastoma en models fabricats in vitro. Aquests models, un en 2D i un altre en un xip microflu\u00eddic, proporcionen plataformes per buscar nous biomarcadors i dissenyar ter\u00e0pies efectives contra aquest tipus de c\u00e0ncer.<\/strong><\/p>\n\n\n\n

\"\"
La Dra. Aranzazu Villasante als laboratoris de l’IBEC.<\/figcaption><\/figure>\n\n\n\n

El neuroblastoma, un dels c\u00e0ncers pedi\u00e0trics m\u00e9s comuns, es classifica com un c\u00e0ncer del desenvolupament, ja que sorgeix abans del naixement, durant la formaci\u00f3 d’\u00f2rgans i teixits. S’origina a partir de c\u00e8l\u00b7lules canceroses que es desenvolupen en els neuroblastos, un tipus de teixit nervi\u00f3s immadur, i sol afectar principalment les gl\u00e0ndules suprarenals.<\/p>\n\n\n\n

Una de les l\u00ednies de recerca del grup del Dr. Josep Samitier (Grup de Nanobioenginyeria<\/a> de l’IBEC) liderada per la Dra. Villasante, \u00e9s el desenvolupament de models in vitro<\/em> de neuroblastoma que permeten replicar la seva caracter\u00edstica vasculatura per buscar nous biomarcadors i dissenyar ter\u00e0pies efectives contra aquest tipus de c\u00e0ncer.<\/p>\n\n\n\n

Aix\u00f2 \u00e9s rellevant perqu\u00e8 una de les caracter\u00edstiques del neuroblastoma \u00e9s la seva elevada vascularitzaci\u00f3, que pot ser mediada per un proc\u00e9s anomenat transdiferenciaci\u00f3, on les c\u00e8l\u00b7lules canceroses es transformen en c\u00e8l\u00b7lules endotelials que formen els vasos sanguinis del tumor. Aquest proc\u00e9s s’ha associat amb la resist\u00e8ncia als tractaments i la recurr\u00e8ncia del c\u00e0ncer.<\/p>\n\n\n\n

\n

Vam descobrir que, en modificar el substrat de la placa simulant la rigidesa de les art\u00e8ries i venes humanes, les c\u00e8l\u00b7lules comen\u00e7aven a formar la vasculatura alternativa caracter\u00edstica del neuroblastoma que busc\u00e0vem.<\/p>\nDr. Aranzazu Villasante<\/cite><\/blockquote>\n\n\n\n

La Dra. Villasante, investigadora s\u00e8nior del grup, \u00e9s l’autora principal dels \u00faltims dos estudis en aquesta l\u00ednia, publicats a les revistes cient\u00edfiques in vitro models<\/em><\/a> i cancers<\/em><\/a>, respectivament. Aquests treballs detallen com l’equip de recerca ha aconseguit reproduir el proc\u00e9s de transdiferenciaci\u00f3 de la vasculatura del neuroblastoma en models fabricats in vitro<\/em>. Ho han fet en dos sistemes f\u00e0cilment reprodu\u00efbles: Un d’ells \u00e9s un model m\u00e9s simple, en 2D, utilitzat per investigar possibles dianes terap\u00e8utiques; mentre que l’altre \u00e9s un xip microflu\u00eddic, m\u00e9s complex, dissenyat per al cribratge de f\u00e0rmacs. A m\u00e9s, han identificat el biomarcador GB3 com una possible diana terap\u00e8utica per a futures nanoter\u00e0pies contra el neuroblastoma.<\/p>\n\n\n\n

“Quan poses c\u00e8l\u00b7lules de neuroblastoma en una placa de cultiu en 2D, no duen a terme el proc\u00e9s de transdiferenciaci\u00f3 com ho farien en condicions fisiol\u00f2giques. Tanmateix, descobrim que, en modificar el substrat de la placa simulant la rigidesa de les art\u00e8ries i venes humanes, les c\u00e8l\u00b7lules comen\u00e7aven a formar la vasculatura alternativa caracter\u00edstica del neuroblastoma que busc\u00e0vem.” Explica la Dra. Villasante, investigadora de l’IBEC, la Universitat de Barcelona i el CIBER-BBN.<\/p>\n\n\n\n

Aquest model va servir als investigadors per confirmar que les c\u00e8l\u00b7lules tumorals expressaven el biomarcador GB3, un receptor cel\u00b7lular implicat en la formaci\u00f3 de vasos sanguinis, la met\u00e0stasi i la resist\u00e8ncia a f\u00e0rmacs.<\/p>\n\n\n\n

\n

Vam decorar la superf\u00edcie de les nanopart\u00edcules amb una toxina que sabem que s’uneix a GB3 i vam observar que aquestes anaven directes a les c\u00e8l\u00b7lules de neuroblastoma.<\/p>\nDr. Aranzazu Villasante<\/cite><\/blockquote>\n\n\n\n

Tal com assenyala la Dra. Villasante, el seg\u00fcent pas va consistir a realitzar un estudi pilot amb nanopart\u00edcules: “Vam decorar la superf\u00edcie de les nanopart\u00edcules amb una toxina que sabem que s’uneix a GB3 i vam observar que aquestes anaven directes a les c\u00e8l\u00b7lules de neuroblastoma.” Aquests resultats posen de manifest el potencial de GB3 com a diana terap\u00e8utica per al disseny de futures nanoter\u00e0pies dirigides.<\/p>\n\n\n\n

El seg\u00fcent pas ser\u00e0 traslladar aquests estudis al model microflu\u00eddic, m\u00e9s complex, que els permetr\u00e0 fer un cribratge de f\u00e0rmacs i seleccionar els de m\u00e9s potencial abans d’iniciar estudis in vivo<\/em>.<\/p>\n\n\n\n

Aquesta recerca ha comptat amb la col\u00b7laboraci\u00f3 del Pediatric Cancer Center Barcelona de l’Hospital Sant Joan de D\u00e9u i l’Institut de Recerca Sanit\u00e0ria (IDIVAL) de la Universitat de Cant\u00e0bria.<\/p>\n\n\n\n

\n\n\n\n

Referenced papers:<\/strong><\/p>\n\n\n\n

Aranzazu Villasante, Maria Jose Lopez\u2011Martinez, Gema Qui\u00f1onero, Andrea Garcia\u2011Lizarribar, Xiaofeng Peng, Josep Samitier. Microfluidic model of the alternative vasculature in neuroblastoma.<\/strong> In vitro models<\/em> (2024). DOI: https:\/\/doi.org\/10.1007\/s44164-023-00064-x<\/a><\/p>\n\n\n\n

Aranzazu Villasante, Josep Corominas, Clara Alcon, Andrea Garcia-Lizarribar, Jaume Mora, Monica Lopez-Fanarraga, Josep Samitier. Identification of GB3 as a Novel Biomarker of Tumor-Derived Vasculature in Neuroblastoma Using a Stiffness-Based Model.<\/strong> Cancers<\/em> (2024). DOI: https:\/\/doi.org\/10.3390\/cancers16051060<\/a><\/p>\n\n\n\n

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