{"id":117682,"date":"2024-05-15T11:00:00","date_gmt":"2024-05-15T09:00:00","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=117682"},"modified":"2024-05-14T13:28:58","modified_gmt":"2024-05-14T11:28:58","slug":"new-biomarker-to-diagnose-alzheimers-in-asymptomatic-stages","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/nou-biomarcador-per-diagnosticar-alzheimer-en-etapes-asimptomatiques","title":{"rendered":"Nou biomarcador per diagnosticar l’alzheimer en etapes asimptom\u00e0tiques"},"content":{"rendered":"\n

Es tracta d’una mol\u00e8cula que est\u00e0 directament relacionada amb l’expressi\u00f3 de la prote\u00efna pri\u00f2nica cel\u00b7lular, present a la superf\u00edcie de les c\u00e8l\u00b7lules neurals.<\/strong> L’estudi, liderat per l’IBEC, obre la porta a la detecci\u00f3 primerenca de la malaltia d’Alzheimer en etapes asimptom\u00e0tiques en mostres de sang, afavorint el seu diagn\u00f2stic i tractament.<\/strong><\/p>\n\n\n\n

\"\"
D’esquerra a dreta: Rosalina Gav\u00edn, Jos\u00e9 Antonio del R\u00edo i Dayaneth J\u00e1come.<\/figcaption><\/figure>\n\n\n\n
<\/div>\n\n\n\n

Un estudi recent, liderat pel grup de Neurobiotecnologia Molecular i Cel\u00b7lular<\/a> de l’IBEC i de la Universitat de Barcelona, ha identificat un nou biomarcador d’alzheimer en estadis asimptom\u00e0tics de la malaltia. Es tracta de la mol\u00e8cula miR-519a-3p, un microARN que est\u00e0 directament relacionat amb l’expressi\u00f3 de la prote\u00efna pri\u00f2nica cel\u00b7lular (PrPC<\/sup>), la qual es troba desregulada en persones que pateixen algunes malalties neurodegeneratives com l’alzheimer.<\/p>\n\n\n\n

La recerca de biomarcadors que siguin estables i f\u00e0cilment detectables en biofluids, com els microARN, brinda esperances per a la detecci\u00f3 primerenca de l’alzheimer en les seves etapes asimptom\u00e0tiques inicials, cosa que podria ajudar en el diagn\u00f2stic i tractament primerenc d’aquesta malaltia que afecta m\u00e9s de 35 milions de persones a tot el m\u00f3n.<\/p>\n\n\n\n

Primera vegada que es relacionen miR-519a-3p i PrPC<\/sup> en alzheimer<\/strong><\/strong><\/h4>\n\n\n\n

Se sap que l’expressi\u00f3 d’alguns microARN est\u00e0 desregulada en pacients amb alzheimer. No obstant aix\u00f2, \u00e9s la primera vegada que aquest microARN s’ha relacionat espec\u00edficament amb la disminuci\u00f3 en la producci\u00f3 de la prote\u00efna pri\u00f2nica cel\u00b7lular durant la progressi\u00f3 de la malaltia.<\/p>\n\n\n\n

“Actualment, les proves per diagnosticar la malaltia d’Alzheimer solen dur-se a terme despr\u00e9s de l’aparici\u00f3 dels primers s\u00edmptomes, quan ja hi ha un deteriorament cognitiu subjacent. Creiem que la detecci\u00f3 d’aquest microARN pot ajudar a establir criteris addicionals per a un diagn\u00f2stic m\u00e9s prec\u00eds en les fases inicials de la malaltia.”,\u00a0explica Jos\u00e9 Antonio del R\u00edo, investigador principal de l’IBEC, catedr\u00e0tic de la Facultat de Biologia y de l\u2019Institut de Neuroci\u00e8ncies (UBneuro) de la Universitat de Barcelona (UB) i col\u00edder de l’estudi.<\/p>\n\n\n\n

\n

Creiem que la detecci\u00f3 d’aquest microARN pot ajudar a establir criteris addicionals per a un diagn\u00f2stic m\u00e9s prec\u00eds en les fases inicials de la malaltia.<\/p>\nJos\u00e9 Antonio del R\u00edo<\/cite><\/blockquote>\n\n\n\n

A m\u00e9s, el treball analitza de forma comparativa la pres\u00e8ncia del biomarcador en mostres d’altres malalties neurodegeneratives:<\/p>\n\n\n\n

“Si el nostre objectiu \u00e9s utilitzar miR-519a-3p com a biomarcador per detectar dem\u00e8ncia de tipus alzheimer en persones hipot\u00e8ticament sanes, \u00e9s clau assegurar-se que els seus nivells no estiguin alterats en altres malalties neurodegeneratives. En el nostre estudi, comparem els nivells d’aquest biomarcador en mostres d’altres taupaties i Parkinson, confirmant que els canvis del miR-519a-3p s\u00f3n espec\u00edfics de la malaltia d’Alzheimer”, detalla Rosalina Gav\u00edn, investigadora s\u00e8nior de l’IBEC, professora agregada de la UB i l\u2019UBneuro i col\u00edder de l’estudi.<\/p>\n\n\n\n

L’equip avan\u00e7a en la seva investigaci\u00f3, com indica Dayaneth J\u00e1come, investigadora en el grup de del R\u00edo i primera autora de l’estudi “el seg\u00fcent pas \u00e9s la validaci\u00f3 del miR-519a-3p com a biomarcador en mostres de sang de diferents cohorts de pacients, per comen\u00e7ar a emprar-lo en el diagn\u00f2stic cl\u00ednic d’alzheimer en mostres perif\u00e8riques”.<\/p>\n\n\n\n

\n

El seg\u00fcent pas \u00e9s la validaci\u00f3 del miR-519a-3p com a biomarcador en mostres de sang de diferents cohorts de pacients.<\/p>\nDayaneth J\u00e1come<\/cite><\/blockquote>\n\n\n\n

Els investigadors s\u00f3n membres del Centre de recerca en Xarxa de Malalties Neurodegeneratives, CIBERNED.<\/p>\n\n\n\n

<\/div>\n\n\n\n

Els microARNs: silenciadors de gens<\/strong><\/strong><\/h4>\n\n\n\n
\"\"
Fotografia al microscopi \u00f2ptic d’una secci\u00f3 d’escor\u00e7a frontal humana post mortem d’un pacient amb malaltia d’Alzheimer escala o grau VI de Braak (el m\u00e9s avan\u00e7at). S’aprecien neurones amb elevat contingut de prote\u00efna tau.<\/figcaption><\/figure>\n\n\n\n

La quantitat de prote\u00efna pri\u00f2nica cel\u00b7lular canvia durant la progressi\u00f3 de l’alzheimer, mostrant nivells m\u00e9s alts en les primeres etapes de la malaltia i disminuint a mesura que avan\u00e7a la mateixa. Tot i que no es coneix en detall el mecanisme responsable d’aquests canvis, s’ha observat que certs microARN s’uneixen a una regi\u00f3 espec\u00edfica del gen PRNP<\/em>, que controla l’expressi\u00f3 de PrPC<\/sup>, disminuint-la. Per aix\u00f2, i basant-se en comparacions d’estudis previs i an\u00e0lisi computacional en diverses bases de dades gen\u00f2miques, els investigadors van seleccionar el microARN miR-519a-3p per al seu estudi.<\/p>\n\n\n\n

\n\n\n\n

Article referenciat:<\/strong><\/p>\n\n\n\n

Dayaneth J\u00e1come, Tiziana Cotrufo, Pol Andr\u00e9s-Benito, Laia Lid\u00f3n, Eul\u00e0lia Mart\u00ed, Isidre Ferrer, Jos\u00e9 Antonio del R\u00edo, Rosalina Gav\u00edn. miR-519a-3p, found to regulate cellular prion protein during Alzheimer\u2019s disease pathogenesis, as a biomarker of asymptomatic stages<\/strong>. BBA – Molecular Basis of Disease<\/em> (2024). DOI: https:\/\/doi.org\/10.1016\/j.bbadis.2024.167187<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Es tracta d’una mol\u00e8cula que est\u00e0 directament relacionada amb l’expressi\u00f3 de la prote\u00efna pri\u00f2nica cel\u00b7lular, present a la superf\u00edcie de les c\u00e8l\u00b7lules neurals. L’estudi, liderat per l’IBEC, obre la porta a la detecci\u00f3 primerenca de la malaltia d’Alzheimer en etapes asimptom\u00e0tiques en mostres de sang, afavorint el seu diagn\u00f2stic i tractament.<\/p>\n","protected":false},"author":37,"featured_media":117664,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1627,2119,1132,1581],"post_formats":[],"class_list":["post-117682","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-alzheimer-ca-2","tag-dementia-ca","tag-jose-antonio-del-rio-ca","tag-molecular-and-cellular-neurobiotechnology-group-ca"],"yoast_head":"\nNou biomarcador per diagnosticar l'alzheimer en etapes asimptom\u00e0tiques - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/nou-biomarcador-per-diagnosticar-alzheimer-en-etapes-asimptomatiques\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nou biomarcador per diagnosticar l'alzheimer en etapes asimptom\u00e0tiques - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Es tracta d'una mol\u00e8cula que est\u00e0 directament relacionada amb l'expressi\u00f3 de la prote\u00efna pri\u00f2nica cel\u00b7lular, present a la superf\u00edcie de les c\u00e8l\u00b7lules neurals. 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