{"id":117999,"date":"2024-05-27T09:00:00","date_gmt":"2024-05-27T07:00:00","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=117999"},"modified":"2024-05-24T11:33:51","modified_gmt":"2024-05-24T09:33:51","slug":"3d-bioprinting-for-an-advanced-gut-on-chip-model","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/bioimpressio-3d-per-a-un-model-avancat-intesti-en-un-xip","title":{"rendered":"Bioimpressi\u00f3 3D per a un model avan\u00e7at d\u2019intest\u00ed en un xip"},"content":{"rendered":"\n

Es tracta d\u2019un dispositiu innovador que cont\u00e9 un canal bioimpr\u00e8s en 3D amb estructures que imiten les vellositats intestinals i reprodueix els compartiments de la mucosa intestinal. Per primer cop, s\u2019han incorporat al sistema el\u00e8ctrodes que permeten supervisar la formaci\u00f3 de la barrera intestinal en temps real. El dispositiu \u00e9s molt vers\u00e0til i te potencial per aplicar-se en el modelat de malalties i el cribratge de f\u00e0rmacs.<\/strong><\/p>\n\n\n\n

\"\"
D\u2019esquerra a dreta: N\u00faria Torras Andr\u00e9s i Mar\u00eda Garc\u00eda D\u00edaz als laboratoris de l\u2019IBEC.<\/figcaption><\/figure>\n\n\n\n
\n

El m\u00e9s innovador \u00e9s que combinem la bioimpressi\u00f3 directament sobre el xip flu\u00eddic.<\/p>\nElena Mart\u00ednez Fraiz<\/cite><\/blockquote>\n\n\n\n

El <\/a>grup de Sistemes biomim\u00e8tics per a enginyeria cel\u00b7lular<\/a> de l\u2019Institut de Bioenginyeria de Catalunya (IBEC) en col\u00b7laboraci\u00f3 amb el Grup d\u2019aplicacions biom\u00e8diques (GAB) de l\u2019Institut de Microelectr\u00f2nica de Barcelona (IMB-CNM) ha dissenyat un model avan\u00e7at d\u2019intest\u00ed en un xip. Es tracta d\u2019un dispositiu innovador que cont\u00e9 un canal bioimpr\u00e8s en 3D amb estructures que imiten les vellositats intestinals i reprodueix els compartiments epitelial i estromal de la mucosa intestinal. En aquest model s\u2019han incorporat el\u00e8ctrodes que permeten supervisar la formaci\u00f3 de la barrera intestinal en temps real. El dispositiu \u00e9s molt vers\u00e0til i te potencial per aplicar-se en el modelat de malalties el cribratge de f\u00e0rmacs.<\/p>\n\n\n\n

\u201cEn el nostre estudi, integrem la part tova, que consisteix en hidrogels amb c\u00e8l\u00b7lules, amb una morfologia adequada. El m\u00e9s innovador \u00e9s que ho fem combinant la bioimpressi\u00f3 directament sobre el xip flu\u00eddic\u201d, explica Elena Mart\u00ednez Fraiz, investigadora principal de l\u2019IBEC, professora agregada de la Universitat de Barcelona (UB) i l\u00edder de l\u2019estudi.<\/p>\n\n\n\n

\n

En un futur proper podriem desenvolupar un model per estudiar la malaltia inflamat\u00f2ria intestinal o trastorns relacionats amb una superpoblaci\u00f3 bacteriana.<\/p>\nN\u00faria Torras Andr\u00e9s<\/cite><\/blockquote>\n\n\n\n

L\u2019equip ja treballa en donar encara m\u00e9s complexitat al sistema. \u201cEl nostre objectiu \u00e9s poder simular condicions m\u00e9s properes a la realitat i, en un futur proper, desenvolupar un model per estudiar la malaltia inflamat\u00f2ria intestinal o trastorns relacionats amb una superpoblaci\u00f3 bacteriana, per exemple\u201d, detalla N\u00faria Torras Andr\u00e9s, investigadora postdoctoral del grup de Mart\u00ednez i autora de l\u2019estudi.<\/p>\n\n\n\n

\"\"
Esquerra: Xip microflu\u00eddic de tres canals amb el canal d’hidrogel encapsulat al centre (barra d’escala: 10 mm). Dreta: canal d’hidrogel amb parets laterals que reprodueixen la forma de les vellositats intestinals trobades in vivo (barra d’escala: 2 mm).<\/figcaption><\/figure>\n\n\n\n
\n

L\u2019objectiu a llarg termini \u00e9s obtenir models m\u00e9s realistes i propers a la fisiologia humana que reemplacin la experimentaci\u00f3 amb animals i poder fer medicina molt m\u00e9s personalitzada.<\/p>\nMar\u00eda Garc\u00eda D\u00edaz<\/cite><\/blockquote>\n\n\n\n

En el camp dels \u00f2rgans en un xip, els models convencionals d’intest\u00ed en un xip han tingut dificultats per reproduir la complexitat de l’intest\u00ed hum\u00e0, especialment en la representaci\u00f3 completa dels seus components essencials. L’intest\u00ed consta de diverses capes, incloent-hi l’epiteli que forma la superf\u00edcie interna i l’estroma, un teixit conjuntiu que dona suport a l’epiteli i mant\u00e9 la integritat de la barrera intestinal. La manca de representaci\u00f3 adequada d’aquests components ha limitat el desenvolupament de models efica\u00e7os. No obstant aix\u00f2, les noves tecnologies com la bioimpressi\u00f3 3D i l’\u00fas d’hidrogels com a an\u00e0legs de la matriu extracel\u00b7lular obren noves oportunitats en el camp dels \u00f2rgans en un xip.<\/p>\n\n\n\n

 \u201cL\u2019objectiu a llarg termini \u00e9s obtenir models m\u00e9s realistes i propers a la fisiologia humana que reemplacin la experimentaci\u00f3 amb animals i poder fer medicina molt m\u00e9s personalitzada\u201d, explica Mar\u00eda Garc\u00eda D\u00edaz, investigadora s\u00e8nior del grup de Mart\u00ednez i autora de l\u2019estudi.<\/p>\n\n\n\n

\n\n\n\n

Art\u00edculo referenciado:<\/strong><\/p>\n\n\n\n

Daniel Vera, Mar\u00eda Garc\u00eda-D\u00edaz, N\u00faria Torras, \u00d3scar Castillo, Xavi Illa, Rosa Villa, Mar Alvarez and Elena Martinez. A 3D bioprinted hydrogel gut-on-chip with integrated electrodes for transepithelial electrical resistance (TEER) measurements<\/strong>. Biofabrication<\/em> (2024). DOI: https:\/\/doi.org\/10.1088\/1758-5090\/ad3aa4<\/a><\/p>\n\n\n\n

\n","protected":false},"excerpt":{"rendered":"

Es tracta d\u2019un dispositiu innovador que cont\u00e9 un canal bioimpr\u00e8s en 3D amb estructures que imiten les vellositats intestinals i reprodueix els compartiments de la mucosa intestinal. Per primer cop, s\u2019han incorporat al sistema el\u00e8ctrodes que permeten supervisar la formaci\u00f3 de la barrera intestinal en temps real. El dispositiu \u00e9s molt vers\u00e0til i te potencial per aplicar-se en el modelat de malalties i el cribratge de f\u00e0rmacs.<\/p>\n","protected":false},"author":37,"featured_media":117989,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1826,820,2109,1840],"post_formats":[],"class_list":["post-117999","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-biomimetic-systems-for-cell-engineering-ca","tag-elena-martinez-ca","tag-lab-on-a-chip-ca","tag-organ-en-un-xip"],"yoast_head":"\nBioimpressi\u00f3 3D per a un model avan\u00e7at d\u2019intest\u00ed en un xip - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"description\" content=\"El dispositiu cont\u00e9 un canal bioimpr\u00e8s en 3D amb estructures que imiten les vellositats intestinals i reprodueix els compartiments de la mucosa intestinal.\" 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