{"id":11843,"date":"2015-01-23T11:08:56","date_gmt":"2015-01-23T11:08:56","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new\/?p=11843"},"modified":"2015-09-28T12:40:46","modified_gmt":"2015-09-28T12:40:46","slug":"un-nou-pas-cap-als-farmacs-controlats-per-llum","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/un-nou-pas-cap-als-farmacs-controlats-per-llum\/","title":{"rendered":"Un nou pas cap als f\u00e0rmacs controlats per llum"},"content":{"rendered":"
Imatge: Esquema de la interacci\u00f3 prote\u00efna-prote\u00efna<\/h6>\n

El descobriment va significar un gran pas cap al desenvolupament de f\u00e0rmacs dirigits i controlats per llum, ja que els efectes del f\u00e0rmac es limitarien a un \u00e0rea i a un temps espec\u00edfic, reduint aix\u00ed els efectes secundaris.<\/p>\n

Ara, en experiments recents, els mateixos investigadors han estat emprant les seves mol\u00e8cules foto sensibles per a controlar l’endocitosi -el proc\u00e9s mitjan\u00e7ant el qual les c\u00e8l\u00b7lules absorbeixen certes subst\u00e0ncies que necessiten per a funcionar correctament-, intervinguda per clatrina, amb el que han descobert que s’amplia el camp dels inhibidors potencials.<\/p>\n

“Com moltes de les interaccions prote\u00efna-prote\u00efna estan intervingudes per p\u00e8ptids linears petits, sovint helico\u00efdals (prote\u00efnes petites), nosaltres pens\u00e0vem que les nostres mol\u00e8cules foto commutables havien de ser dissenyades per imitar aquests p\u00e8ptids r\u00edgids per a qu\u00e8 fossin capaces d’inhibir el PPI,” explica Pau Gorostiza del grup de Nanosondes i Nanocommutadors del IBEC. “Per\u00f2 ara hem trobat que no necessiten tenir la mateixa estructura r\u00edgida, i que les mol\u00e8cules amb estructures flexibles mostren una gran capacitat inhibit\u00f2ria, aix\u00ed com una major capacitat foto commutadora”.<\/p>\n

L’abs\u00e8ncia d’una estructura r\u00edgida i helico\u00efdal, per tant, no \u00e9s una limitaci\u00f3 per a seleccionar candidats per ser inhibidors foto commutables del PPI, el que significa que quan s\u2019estan desenvolupant potencials addicionals inhibitoris, els investigadors poden mirar entre l’ampli grup de p\u00e8ptids m\u00e9s flexibles per trobar el seu candidat.<\/p>\n

\u201cAquests resultats s\u00f3n un avan\u00e7 rellevant de les interaccions intracel\u00b7lulars prote\u00efna-prote\u00efna cap a futures ter\u00e0pies controlades per llum\u201d diu Ernest Giralt, investigador principal del grup de P\u00e8ptids i Prote\u00efnes de l’IRB Barcelona. \u201cEl comportament que mostren aquests p\u00e8ptids ressalta l’avantatge que pot procedir de la flexibilitat parcial d’alguns inhibidors de la interacci\u00f3 prote\u00efna-prote\u00efna, la qual cosa permet al p\u00e8ptid \u2018adaptar-se\u2019 estructuralment a la prote\u00efna diana,\u201d afegeix Laura Nevola, co- autora de l’article de l’IRB Barcelona.<\/p>\n

Les aplicacions terap\u00e8utiques m\u00e9s immediates dels inhibidors foto commutables s\u00f3n dirigides a malalties que afecten al teixit superficial com per exemple la pell, la retina o les membranes mucoses externes. En el futur, les mol\u00e8cules fotosensibles es podran utilitzar per estudiar, per exemple, l\u2019endocitosi in vitro de les c\u00e8l\u00b7lules cancer\u00edgenes -en les que aquest \u00e9s un proc\u00e9s incontrolat\u00a0 el que podr\u00e0 permetre la inhibici\u00f3 selectiva de la proliferaci\u00f3 cel\u00b7lular.<\/p>\n

Una altra \u00e0ria d\u2019aplicaci\u00f3 per a aquestes mol\u00e8cules pot trobar-se a la biologia del desenvolupament, on les c\u00e8l\u00b7lules requereixen de la endocitosi per a canviar de forma i de funci\u00f3. El seu desenvolupament tamb\u00e9 obre les portes a un nou camp de recerca com la optofarmacologia o la optogen\u00e8tica.<\/p>\n

—<\/p>\n

Article de refer\u00e8ncia:<\/strong> <\/em>Andr\u00e9 Martin-Quiro, Laura Nevola, Kay Eckelt, Sergio Madurga, Pau Gorostiza and Ernest Giralt (2015). \u201cAbsence of a Stable Secondary Structure is not a Limitation for Photoswitchable Inhibitors of b-Arrestin\/b-Adaptin 2 Protein-Protein Interaction\u201d<\/a>. Chemistry & Biology<\/em>, http:\/\/dx.doi.org\/10.1016\/j.chembiol.2014.10.022<\/p>\n","protected":false},"excerpt":{"rendered":"

\"MVI_4165_\"Investigadors de l’IBEC i de l’IRB descobreixen m\u00e9s opcions potencials cap a les ter\u00e0pies foto-commutables al refutar la limitaci\u00f3 del disseny<\/h3>\n

L’any passat, un grup de cient\u00edfics de l\u2019Institut de Bioenginyeria de Catalunya (IBEC), de l\u2019Institut de Recerca Biom\u00e8dica (IRB) i de la Universitat de Barcelona (UB) van anunciar que havien aconseguit mol\u00e8cules foto commutables, o regulades per llum, per controlar interaccions prote\u00efna-prote\u00efna -interaccions clau en els processos biol\u00f2gics i, per tant, dianes terap\u00e8utiques altament prometedores- de manera remota i no invasiva. <\/p>\n","protected":false},"author":4,"featured_media":11813,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-11843","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca"],"yoast_head":"\nUn nou pas cap als f\u00e0rmacs controlats per llum - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" 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