{"id":118713,"date":"2024-06-19T14:58:56","date_gmt":"2024-06-19T12:58:56","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=118713"},"modified":"2024-06-19T15:09:41","modified_gmt":"2024-06-19T13:09:41","slug":"for-the-first-time-scientists-managed-to-generate-kidney-organoids-with-a-complex-vascular-system","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/aconsegueixen-generar-per-primera-vegada-organoides-de-ronyo-amb-un-complex-sistema-vascular","title":{"rendered":"Aconsegueixen generar per primera vegada organoides de rony\u00f3 amb un complex sistema vascular \u00a0"},"content":{"rendered":"\n

Es tracta d’asembloides, organoides microm\u00e8trics formats per la uni\u00f3 d’organoides de rony\u00f3 amb organoides vasculars en 3D.<\/strong>\u00a0 Aquests petits sistemes de cultiu s\u00f3n \u00fatils per al modelatge de malalties i el cribratge de f\u00e0rmacs.<\/strong>\u00a0L’estudi, liderat per l’IBEC, descriu un abordatge que no s’havia provat abans.<\/strong>\u00a0<\/p>\n\n\n\n

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Assembloide de rony\u00f3.<\/figcaption><\/figure>\n<\/figure>\n\n\n\n
<\/div>\n\n\n\n

Un estudi liderat per l’Institut de Bioenginyeria de Catalunya (IBEC) descriu un nou abordatge per produir mini ronyons al laboratori que repliquen una vasculatura complexa, similar en algunes caracter\u00edstiques a la dels ronyons humans. Aquests “assembloides” es creen mitjan\u00e7ant la uni\u00f3 d’organoides de rony\u00f3 en 3D amb organoides endotelials. <\/p>\n\n\n\n

Els organoides s\u00f3n estructures tridimensionals cultivades in vitro<\/em> que imiten les funcions dels \u00f2rgans i s\u00f3n una eina prometedora per al modelatge de malalties i el cribratge de f\u00e0rmacs. Tanmateix, aquests petits \u00f2rgans sovint no tenen sistemes nervi\u00f3s, immunol\u00f2gic o vascular a causa de la seva complexitat. <\/p>\n\n\n\n

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Quan aquests dos tipus d’organoides estan junts, inicien un proc\u00e9s d’interacci\u00f3 en a penes tres hores. El resultat d’aquest procediment \u00e9s veritablement espectacular.<\/p>\nN\u00faria Montserrat Pulido<\/cite><\/blockquote>\n\n\n\n

Reproduir al laboratori el complex sistema de vascularitzaci\u00f3 dels ronyons, un teixit altament irrigat, ha estat un desafiament per als cient\u00edfics durant m\u00e9s d’una d\u00e8cada. Ara, aquest treball publicat a la prestigiosa revista cient\u00edfica Advanced Materials<\/em><\/a>, descriu una aproximaci\u00f3 que no s’havia provat abans: <\/p>\n\n\n\n

“Hem acoblat organoides de rony\u00f3 amb organoides vasculars. Per dur a terme amb \u00e8xit aquest proc\u00e9s, \u00e9s essencial identificar el moment idoni per unir-los, tenint en compte el moment de desenvolupament de cadascun dels organoides”, explica N\u00faria Montserrat Pulido, professora de recerca ICREA, investigadora principal de l’IBEC i l\u00edder de l’estudi. “Quan aquests dos tipus d’organoides estan junts, inicien un proc\u00e9s d’interacci\u00f3 en a penes tres hores. El resultat d’aquest procediment \u00e9s veritablement espectacular”, destaca. <\/p>\n\n\n\n

Aquestes troballes no nom\u00e9s proporcionen informaci\u00f3 valuosa sobre el desenvolupament dels organoides renals, sin\u00f3 que tamb\u00e9 estableixin les bases per dissenyar nous procediments de vascularitzaci\u00f3 d’aquests organoides. Aix\u00f2 podria tenir aplicacions en trasplantaments d’organoides en entorns cl\u00ednics i en investigacions sobre disfuncions vasculars en malalties humanes.  <\/p>\n\n\n\n

“Necessitem tenir aquest sistema vascular en els nostres organoides si volem modelar patologies sist\u00e8miques que afecten el rony\u00f3 a trav\u00e9s del torrent sanguini, com pot ser una malaltia autoimmune o una diabetis, per exemple. Creiem, a m\u00e9s, que l’abordatge que hem utilitzat en aquest estudi es podria aplicar tamb\u00e9 a altres models d’organoide.”, detalla Elena Garreta Bahima, investigadora al grup de Montserrat a l’IBEC i primera autora de l’estudi. <\/p>\n\n\n\n

El seg\u00fcent pas, comenta Montserrat, ser\u00e0 introduir aquests organoides vascularitzats en un xip microflu\u00eddic per poder fer estudis encara m\u00e9s especialitzats per tal de mimetitzar condicions que s’esdevenen en malalties complexes aix\u00ed com permetre la connexi\u00f3 vascular amb altres organoides, com els organoides card\u00edacs, treball que avui dia estan desenvolupant al laboratori a IBEC.<\/p>\n\n\n\n

Imprimir amb c\u00e8l\u00b7lules<\/strong>\u00a0<\/h4>\n\n\n\n

L’equip d’investigaci\u00f3 ja havia vist en estudis anteriors que els organoides de rony\u00f3 que generaven contenien un component vascular: c\u00e8l\u00b7lules d’endoteli, que s\u00f3n les que acaben donant lloc als vasos sanguinis. Utilitzant teixit renal d’origen porc\u00ed o hum\u00e0, van crear un hidrogel biocompatible, que podria ser utilitzat com a tinta per a impressi\u00f3 3D.\u00a0<\/p>\n\n\n\n

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Necessitem tenir aquest sistema vascular en els nostres organoides si volem modelar patologies sist\u00e8miques que afecten el rony\u00f3 a trav\u00e9s del torrent sanguini, com pot ser una malaltia autoimmune o una diabetis, per exemple.<\/p>\nElena Garreta Bahima<\/cite><\/blockquote>\n\n\n\n

Amb aquesta base, van decidir simplificar el sistema per fer-lo m\u00e9s accessible i econ\u00f2mic. D’entre totes les prote\u00efnes que conformen l’hidrogel, van seleccionar el col\u00b7lagen I, una de les prote\u00efnes m\u00e9s abundants en la matriu extracel\u00b7lular del teixit renal, i van generar un gel biocompatible amb el qual van validar els seus resultats experimentals. <\/p>\n\n\n\n

Aquest treball representa una fita significativa en el camp de les ter\u00e0pies emergents i avan\u00e7ades, una de les principals \u00e0rees de recerca de l’IBEC. Aquestes ter\u00e0pies s\u00f3n tractaments m\u00e8dics innovadors que empren tecnologies d’avantguarda per abordar malalties i condicions complexes. <\/p>\n\n\n\n

L’estudi a m\u00e9s ha aglutinat investigadors d’altres centres que formen part de la Plataforma Nacional de Biomodals i Biobancs de l’Institut de Salut Carles III (PISCIII-BB), posant en relleu la import\u00e0ncia de la col\u00b7laboraci\u00f3 en xarxa per a la definici\u00f3 de solucions en biomedicina basades en bioenginyeria. Aquesta Plataforma, coordinada per N\u00faria Montserrat, subdirectora d’iniciatives de translaci\u00f3 cl\u00ednica de l’IBEC, proporciona serveis d’alt nivell cient\u00edfic i tecnol\u00f2gic en integrar i coordinar les activitats de totes les seves unitats en resposta a les necessitats del Sistema Nacional de Salut, a m\u00e9s, maneja m\u00e9s de 500.000 mostres biol\u00f2giques i dades cl\u00edniques relacionades.  <\/p>\n\n\n\n

A m\u00e9s de l’IBEC, van participar en l’estudi el Centre d’Investigaci\u00f3 M\u00e8dica Aplicada (CIMA) de la Universitat de Navarra, l’Institut d’Investigaci\u00f3 Biom\u00e8dica d’A Coru\u00f1a (INIBIC), el centre tecnol\u00f2gic Leartiker (Pa\u00eds Basc), l’Hospital Cl\u00ednic de Barcelona i l’Hospital General Universitari Gregorio Mara\u00f1\u00f3n (Madrid). <\/p>\n\n\n\n

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Article Referenciat:<\/strong>\u00a0<\/p>\n\n\n\n

Elena Garreta, Daniel Moya-Rull, Andr\u00e9s Marco, Gaia Amato, Asier Ullate-Agote, Carolina Tarantino, Maria Gallo, David Esporr\u00edn-Ubieto, Alberto Centeno, Amaia Vilas-Zornoza, Rafael Mestre, Mar\u00eda Kalil, Izar Gorro\u00f1ogoitia, Ane Miren Zaldua, Samuel S\u00e1nchez, Laura Izquierdo Reyes, Mar\u00eda Eugenia Fern\u00e1ndez-Santos, Felipe Prosper, and Nuria Montserrat. Natural Hydrogels Support Kidney Organoid Generation and Promote In Vitro Angiogenesis<\/strong>. Advanced Materials<\/em> (2024). DOI: https:\/\/doi.org\/10.1002\/adma.202400306<\/a>  <\/p>\n\n\n\n

\n","protected":false},"excerpt":{"rendered":"

These are asembloids, micrometric organoids formed by the union of kidney organoids with vascular organoids in 3D.\u00a0 These small culture systems are useful for disease modelling and drug screening.\u00a0 The study, led by IBEC, describes an approach that has not been tried before.\u00a0<\/p>\n","protected":false},"author":37,"featured_media":118710,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1123,1831,1780],"post_formats":[],"class_list":["post-118713","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-nuria-montserrat-ca-2","tag-organoides-ca","tag-pluripotency-for-organ-regeneration-ca"],"yoast_head":"\nGeneren organoides de rony\u00f3 amb un complex sistema vascular - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"description\" content=\"Es tracta d'asembloides, organoides microm\u00e8trics 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