{"id":118766,"date":"2024-06-25T17:09:08","date_gmt":"2024-06-25T15:09:08","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=118766"},"modified":"2024-06-25T17:23:16","modified_gmt":"2024-06-25T15:23:16","slug":"spinal-cord-organoids-to-study-treatments-for-paraplegia","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/organoides-de-medul%C2%B7la-espinal-per-estudiar-tractaments-per-a-la-paraplegia","title":{"rendered":"Organoides de medul\u00b7la espinal per estudiar tractaments per a la paraplegia"},"content":{"rendered":"\n<p><strong>Es tracta d\u2019un projecte centrat en la creaci\u00f3 d\u2019un dispositiu impr\u00e8s en 3D on es cultivar\u00e0 un organoide de medul\u00b7la espinal humana per estudiar el dany medul\u00b7lar i el posterior testatge de f\u00e0rmacs. La recerca, liderada per la investigadora principal de l\u2019IBEC Zaida \u00c1lvarez, ha rebut finan\u00e7ament part de la Fundaci\u00f3 Internacional per a la Recerca de la Paraplegia.<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"778\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2024\/06\/Zaida-portrait-1-1024x778.jpg\" alt=\"\" class=\"wp-image-118763 lazyload\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2024\/06\/Zaida-portrait-1-1024x778.jpg 1024w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2024\/06\/Zaida-portrait-1-300x228.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2024\/06\/Zaida-portrait-1-768x583.jpg 768w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2024\/06\/Zaida-portrait-1.jpg 1500w\" data-sizes=\"(max-width: 1024px) 100vw, 1024px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 1024px; --smush-placeholder-aspect-ratio: 1024\/778;\" \/><\/figure>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Zaida \u00c1lvarez Pinto, investigadora principal de l\u2019Institut de Bioenginyeria de Catalunya (IBEC), liderar\u00e0 un dels dos projectes seleccionats per rebre l\u2019Ajuda a la Recerca IRP en la convocat\u00f2ria de 2024. Es tracta d\u2019un finan\u00e7ament atorgat per l<a>a <\/a><a href=\"https:\/\/www.irp.ch\/en\/\">Fundaci\u00f3 Internacional per a la Recerca de la Paraplegia<\/a> (IRP), que t\u00e9 com a objectiu donar suport a la recerca en el camp de la paraplegia a Su\u00efssa i arreu del m\u00f3n a projectes amb seu a Europa. Aquesta convocat\u00f2ria 2024 es focalitza en projectes de recerca que busquin una cura o tractament per els danys medul\u00b7lars o par\u00e0lisis.<\/p>\n\n\n\n<p>El projecte, que comptar\u00e0 amb un finan\u00e7ament de 155.000\u20ac, es centra en la creaci\u00f3 d\u2019un dispositiu en 3D dissenyat a mida en el que es cultivar\u00e0 un organoide de medul\u00b7la espinal que posteriorment es lesionar\u00e0 experimentalment. L\u2019objectiu del dispositiu \u00e9s estudiar l\u2019evoluci\u00f3 del dany medul\u00b7lar aix\u00ed com avaluar l\u2019efic\u00e0cia de certs f\u00e0rmacs per al tractament de lesions medul\u00b7lars humanes sense necessitat d\u2019experimentaci\u00f3 amb animals.<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>We have developed a 3D platform where we grow spinal cord organoids and promote a certain organisation for the organoid to mature. Once we have them, we create a contusive injury that mimics the type of damage suffered by paraplegic patients.<\/p>\n<cite>Zaida \u00c1lvarez Pinto<\/cite><\/blockquote>\n\n\n\n<p>\u201cHem dissenyat una plataforma en 3D on fem cr\u00e9ixer els organoides de medul\u00b7la espinal afavorint una certa organitzaci\u00f3 per a que l\u2019organoide maduri. Un cop el tenim, generem un dany compressiu que replica el tipus de dany que pateixen els pacients amb paraplegia.\u201d, explica Zaida \u00c1lvarez, l\u00edder del projecte.<\/p>\n\n\n\n<p>Gracies aquesta plataforma l\u2019equip de recerca podr\u00e0 estudiar com es comporten les c\u00e8l\u00b7lules neurals en aquest organoide i buscar noves estrat\u00e8gies terap\u00e8utiques per avan\u00e7ar en la comprensi\u00f3 de les lesions de medul\u00b7la espinal i millorar el desenvolupament d\u2019intervencions terap\u00e8utiques utilitzant organoides.<\/p>\n\n\n\n<p>La Fundaci\u00f3 IRP es va establir a Ginebra (Su\u00efssa) el 1995 ambla missi\u00f3 d\u2019aportar finan\u00e7ament a la recerca fonamental i cl\u00ednica en el camp de la paraplegia. Gr\u00e0cies al suport dels seus donants i socis la fundaci\u00f3 treballa dia rere dia per recaptar fons, seleccionar i finan\u00e7ar els millors projectes de recerca amb l&#8217;ajuda d&#8217;un Comit\u00e8 Cient\u00edfic especialitzat per tal de contribuir a millorar la vida de les persones afectades per lesions de la medul\u00b7la espinal.<\/p>\n\n\n\n<p>La Dra. Zaida \u00c1lvarez Pinto va realitzar la seva tesi doctoral en biomaterials per a la reparaci\u00f3 de danys cerebrals a la UPC\/IBEC 2009-2014. Durant el per\u00edode 2015-2019, va fer una estada postdoctoral en el Simpson Querrey Institute for BioNanotechnology de la Northwestern University en Chicago. Del 2019-2021 va ser Research Assistant Professor a la Facultat de Medicina Feinberg Medical School a la Northwestern University.\u00a0 Actualment, \u00e9s investigadora principal del grup de Biomaterials per a regeneraci\u00f3 Neural de l\u2019IBEC i centra la seva recerca a desentranyar els processos moleculars subjacents a la regeneraci\u00f3 neuronal i utilitzar aquest coneixement per desenvolupar noves estrat\u00e8gies utilitzant biomaterials destinats a reparar els circuits danyats del sistema nervi\u00f3s central.<\/p>\n\n\n\n<p><a id=\"_msocom_1\"><\/a><\/p>\n\n\n\n<p><a id=\"_msocom_1\"><\/a><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Es tracta d\u2019un projecte centrat en la creaci\u00f3 d\u2019un dispositiu impr\u00e8s en 3D on es cultivar\u00e0 un organoide de medul\u00b7la espinal humana per estudiar el dany medul\u00b7lar i el posterior testatge de f\u00e0rmacs. La recerca, liderada per la investigadora principal de l\u2019IBEC Zaida \u00c1lvarez, ha rebut finan\u00e7ament part de la Fundaci\u00f3 Internacional per a la Recerca de la Paraplegia.<\/p>\n","protected":false},"author":37,"featured_media":118764,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[98],"tags":[1965,1970],"post_formats":[],"class_list":["post-118766","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-institucionals","tag-biomaterials-for-neural-regeneration-group-ca","tag-zaida-alvarez-ca"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Organoides de medul\u00b7la espinal per estudiar tractaments per a la paraplegia - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/organoides-de-medul\u00b7la-espinal-per-estudiar-tractaments-per-a-la-paraplegia\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Organoides de medul\u00b7la espinal per estudiar tractaments per a la paraplegia - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Es tracta d\u2019un projecte centrat en la creaci\u00f3 d\u2019un dispositiu impr\u00e8s en 3D on es cultivar\u00e0 un organoide de medul\u00b7la espinal humana per estudiar el dany medul\u00b7lar i el posterior testatge de f\u00e0rmacs. La recerca, liderada per la investigadora principal de l\u2019IBEC Zaida \u00c1lvarez, ha rebut finan\u00e7ament part de la Fundaci\u00f3 Internacional per a la Recerca de la Paraplegia.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/ca\/organoides-de-medul\u00b7la-espinal-per-estudiar-tractaments-per-a-la-paraplegia\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2024-06-25T15:09:08+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-06-25T15:23:16+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2024\/06\/Zaida-portrait-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1500\" \/>\n\t<meta property=\"og:image:height\" content=\"1139\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Sarah Moreira\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrit per\" \/>\n\t<meta name=\"twitter:data1\" content=\"Sarah Moreira\" \/>\n\t<meta name=\"twitter:label2\" content=\"Temps estimat de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minuts\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/organoides-de-medul%C2%B7la-espinal-per-estudiar-tractaments-per-a-la-paraplegia\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/organoides-de-medul%C2%B7la-espinal-per-estudiar-tractaments-per-a-la-paraplegia\\\/\"},\"author\":{\"name\":\"Sarah Moreira\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/d3a158b8d448000777023ca1e3d71d34\"},\"headline\":\"Organoides de medul\u00b7la espinal per estudiar tractaments per a la paraplegia\",\"datePublished\":\"2024-06-25T15:09:08+00:00\",\"dateModified\":\"2024-06-25T15:23:16+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/organoides-de-medul%C2%B7la-espinal-per-estudiar-tractaments-per-a-la-paraplegia\\\/\"},\"wordCount\":606,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/organoides-de-medul%C2%B7la-espinal-per-estudiar-tractaments-per-a-la-paraplegia\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2024\\\/06\\\/Zaida-portrait-1.jpg\",\"keywords\":[\"Biomaterials for Neural regeneration group\",\"Zaida \u00c1lvarez\"],\"articleSection\":[\"Not\u00edcies institucionals\"],\"inLanguage\":\"ca\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/organoides-de-medul%C2%B7la-espinal-per-estudiar-tractaments-per-a-la-paraplegia\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/organoides-de-medul%C2%B7la-espinal-per-estudiar-tractaments-per-a-la-paraplegia\\\/\",\"name\":\"Organoides de medul\u00b7la espinal per estudiar tractaments per a la paraplegia - 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