{"id":119383,"date":"2024-07-12T09:53:13","date_gmt":"2024-07-12T07:53:13","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=119383"},"modified":"2024-07-12T10:10:28","modified_gmt":"2024-07-12T08:10:28","slug":"light-activated-drugs-against-neuropathic-pain","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/medicaments-activats-per-llum-per-tractar-el-dolor-neuropatic","title":{"rendered":"Medicaments activats per llum per tractar el dolor neurop\u00e0tic"},"content":{"rendered":"\n

Un equip de recerca dirigit per l’Institut de Bioenginyeria de Catalunya (IBEC) ha desenvolupat derivats de la carbamazepina, un medicament antiepil\u00e8ptic, per tractar el dolor neurop\u00e0tic. Aquests compostos, que mostren efectes analg\u00e8sics en activar-los per llum, poden inhibir els senyals nerviosos de manera localitzada i sota demanda. Els tractaments fotofarmacol\u00f2gics ofereixen una acci\u00f3 precisa en el lloc d’aplicaci\u00f3, reduint aix\u00ed els efectes adversos a escala sist\u00e8mica.<\/strong><\/a><\/p>\n\n\n\n

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La llum es pot utilitzar per activar f\u00e0rmacs en \u00e0rees espec\u00edfiques del cos mitjan\u00e7ant la fotofarmacologia. Aquest enfocament innovador implica modificar l’estructura qu\u00edmica d’un f\u00e0rmac agregant-li un commutador molecular activat per la llum, com l’azobenz\u00e8. D’aquesta manera es pot aconseguir que el f\u00e0rmac s’activi nom\u00e9s quan s’exposa a un color de llum particular, i no en la foscor.<\/p>\n\n\n\n

Basant-se en aquests principis, un equip de recerca liderat per l’Institut de Bioenginyeria de Catalunya (IBEC) ha desenvolupat derivats fotocommutables de la carbamazepina, un medicament antiepil\u00e8ptic \u00e0mpliament usat en medicina, per combatre alguns tipus de dolor neurop\u00e0tic, com la neur\u00e0lgia del nervi trigemin. Aquests compostos, que tenen un efecte analg\u00e8sic despr\u00e9s d\u2019activar-los amb llum, s\u00f3n capa\u00e7os d’inhibir els senyals nerviosos de forma local i sota demanda. Els derivats sintetitzats pels investigadors s’activen en longituds d’ona corresponents al color ambre, la qual cosa permet travessar teixit i ossos usant l\u00e0mpades hal\u00f2genes convencionals.<\/p>\n\n\n\n

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Quan il\u00b7luminem les larves que han absorbit aquests compostos amb una longitud d’ona espec\u00edfica, el f\u00e0rmac s’activa i les larves es mouen m\u00e9s r\u00e0pidament. En canviar la longitud d’ona, el seu moviment es redueix novament, cosa que demostra l’efecte reversible del compost sobre el sistema nervi\u00f3s.<\/p>\nLuisa Camerin<\/cite><\/blockquote>\n\n\n\n

Els dos compostos sintetitzats, carbazopine-1 i carbadiazocine, mostren activitat fotofarmacol\u00f2gica, permetent controlar amb llum de forma reversible l’activitat de les neurones de l’hipocamp i la locomoci\u00f3 de larves de peix zebra. Aquests experiments in vivo<\/em> permeten observar comportaments relacionats amb l’ansietat, que es reflecteixen en moviments de nataci\u00f3 sobtats. Tal com explica Luisa Camerin, investigadora de l’IBEC i primera autora de l’estudi: “Quan il\u00b7luminem les larves que han absorbit aquests compostos amb una longitud d’ona espec\u00edfica, el f\u00e0rmac s’activa i les larves es mouen m\u00e9s r\u00e0pidament. En canviar la longitud d’ona, el seu moviment es redueix novament, cosa que demostra l’efecte reversible del compost sobre el sistema nervi\u00f3s.”<\/p>\n\n\n\n

<\/a><\/p>\n\n\n\n

V\u00eddeo representatiu del moviment fotocontrolat en peixos zebra. Els animals tractats amb el vehicle (l\u00ednia negra) mostren menor activitat de nataci\u00f3 i gaireb\u00e9 cap resposta a la llum en comparaci\u00f3 amb els animals no tractats. En els peixos tractats amb Carbadiazocina, s’observen respostes comportamentals a la llum, on la llum de 420 nm augmenta la locomoci\u00f3 i la llum de 500 nm la disminueix.<\/em><\/figcaption><\/figure>\n\n\n\n

A m\u00e9s, la carbadiazocine ha demostrat tamb\u00e9 propietats analg\u00e8siques: “Hem observat, en models de rata desenvolupats al laboratori d’Esther Berrocoso a la Universitat de Cadis, que la carbadiazocine t\u00e9 un efecte analg\u00e8sic contra el dolor neurop\u00e0tic sense signes d’anest\u00e8sia, sedaci\u00f3 o toxicitat. Aquests resultats s\u00f3n una demostraci\u00f3 d’un tractament simple i convincent amb il\u00b7luminaci\u00f3 no invasiva,” detalla Pau Gorostiza, professor de recerca ICREA, investigador principal a l’IBEC i membre del CIBER-BBN.<\/p>\n\n\n\n

El dolor neurop\u00e0tic \u00e9s causat per lesions o malalties del sistema somatosensorial, com la radiculopatia lumbar (“ci\u00e0tica”), la neuropatia diab\u00e8tica i el dolor cr\u00f2nic postquir\u00fargic. El tractament d’aquest tipus de dolor sovint requereix opioides, analg\u00e8sics m\u00e9s potents que els antiinflamatoris no esteroidals habituals – com el paracetamol i l’ibuprof\u00e8n-. Tanmateix, el seu \u00fas \u00e9s controvertit a causa de la seva efic\u00e0cia inconsistent, la necessitat de dosis altes que poden causar toler\u00e0ncia i addicci\u00f3, i efectes secundaris sist\u00e8mics com estrenyiment, n\u00e0usees, marejos i somnol\u00e8ncia.<\/a><\/p>\n\n\n\n

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Hem observat, en models de rata desenvolupats al laboratori d’Esther Berrocoso a la Universitat de Cadis, que la carbadiazocine t\u00e9 un efecte analg\u00e8sic contra el dolor neurop\u00e0tic sense signes d’anest\u00e8sia, sedaci\u00f3 o toxicitat. Aquests resultats s\u00f3n una demostraci\u00f3 d’un tractament simple i convincent amb il\u00b7luminaci\u00f3 no invasiva.<\/p>\nPau Gorostiza<\/cite><\/blockquote>\n\n\n\n

En aquest context, les ter\u00e0pies basades en la llum estan guanyant import\u00e0ncia en medicina per la seva capacitat de dirigir-se a regions espec\u00edfiques del cos, augmentant l’efic\u00e0cia del tractament i reduint els efectes secundaris dels f\u00e0rmacs sist\u00e8mics.<\/p>\n\n\n\n

L’equip ja est\u00e0 treballant en el pr\u00f2xim pas previst per a aquest projecte, que \u00e9s activar els f\u00e0rmacs mitjan\u00e7ant llum infraroja, que penetra encara amb m\u00e9s profunditat en els teixits, i utilitzar fonts de llum infraroja port\u00e0tils com l\u00e0sers o d\u00edodes electroluminescents (LEDs).<\/p>\n\n\n\n

Aquest estudi forma part del projecte PHOTOTHERAPORT<\/a>, coordinat per l’Institut de Bioenginyeria de Catalunya (IBEC). El projecte est\u00e0 finan\u00e7at pel prestigi\u00f3s programa Pathfinder Open del Consell d’Innovaci\u00f3 Europeu (EIC, per les seves sigles en angl\u00e8s) i se centra en el desenvolupament d’implants luminescents i f\u00e0rmacs activats amb llum per a innovadores ter\u00e0pies de neuromodulaci\u00f3 (Programa HORIZON-EIC-2023 PATHFINDEROPEN-01, n\u00fam. 101130883). PHOTOTHERAPORT \u00e9s un consorci de 8 institucions de 4 pa\u00efsos que compta amb un finan\u00e7ament de 3 milions d’euros durant tres anys per dur a terme el projecte.<\/p>\n\n\n\n

\n\n\n\n

Article referenciat:<\/strong><\/p>\n\n\n\n

Luisa Camerin, Galyna Maleeva, Alexandre M. J. Gomila, Irene Su\u00e1rez-Pereira, Carlo Matera, Davia Prischich, Ekin Opar, Fabio Riefolo, Esther Berrocoso, and Pau Gorostiza. Photoswitchable Carbamazepine Analogs for Non-Invasive Neuroinhibition In Vivo. Angewandte Chemie (2024). DOI: https:\/\/doi.org\/10.1002\/anie.202403636<\/a><\/p>\n\n\n\n

\n","protected":false},"excerpt":{"rendered":"

Un equip de recerca dirigit per l’Institut de Bioenginyeria de Catalunya (IBEC) ha desenvolupat derivats de la carbamazepina, un medicament antiepil\u00e8ptic, per tractar el dolor neurop\u00e0tic. Aquests compostos, que mostren efectes analg\u00e8sics en activar-los per llum, poden inhibir els senyals nerviosos de manera localitzada i sota demanda. Els tractaments fotofarmacol\u00f2gics ofereixen una acci\u00f3 precisa en el lloc d’aplicaci\u00f3, reduint aix\u00ed els efectes adversos a escala sist\u00e8mica.<\/p>\n","protected":false},"author":37,"featured_media":119360,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1879,1883,2129,2130],"post_formats":[],"class_list":["post-119383","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-nanoprobes-and-nanoswitches-ca","tag-pau-gorostiza-ca-2","tag-photomedicine-ca","tag-photopharmacology-ca"],"yoast_head":"\nMedicaments activats per llum per tractar el dolor neurop\u00e0tic - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/medicaments-activats-per-llum-per-tractar-el-dolor-neuropatic\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Medicaments activats per llum per tractar el dolor neurop\u00e0tic - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Un equip de recerca dirigit per l'Institut de Bioenginyeria de Catalunya (IBEC) ha desenvolupat derivats de la carbamazepina, un medicament antiepil\u00e8ptic, per tractar el dolor neurop\u00e0tic. 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