{"id":120738,"date":"2024-10-15T12:05:44","date_gmt":"2024-10-15T10:05:44","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/ibec-receives-funding-from-the-us-national-institutes-of-health-to-advance-neural-regeneration\/"},"modified":"2024-10-15T12:16:50","modified_gmt":"2024-10-15T10:16:50","slug":"ibec-receives-funding-from-the-us-national-institutes-of-health-to-advance-neural-regeneration","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/l%27ibec-rep-financament-dels-instituts-nacionals-de-salut-dels-estats-units-per-avancar-en-la-regeneracio-neural","title":{"rendered":"L&#8217;IBEC rep finan\u00e7ament dels Instituts Nacionals de Salut dels Estats Units per avan\u00e7ar en la regeneraci\u00f3 neural"},"content":{"rendered":"\n<p><strong>La investigadora principal de l&#8217;IBEC, Zaida \u00c1lvarez, ha rebut finan\u00e7ament els Instituts Nacionals de Salut (NIH) dels Estats Units per desenvolupar models de medul\u00b7la espinal basats en c\u00e8l\u00b7lules mare. El projecte, coordinat per la Northwestern University amb la participaci\u00f3 de l&#8217;IBEC i l&#8217;IDIBELL, permetr\u00e0 estudiar malalties neurodegeneratives i desenvolupar nous tractaments per a lesions medul\u00b7lars i altres patologies neurodegeneratives.<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2024\/10\/Zaida-Avarez-2024_edit_low-1024x683.jpg\" alt=\"\" class=\"wp-image-120713 lazyload\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2024\/10\/Zaida-Avarez-2024_edit_low-1024x683.jpg 1024w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2024\/10\/Zaida-Avarez-2024_edit_low-300x200.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2024\/10\/Zaida-Avarez-2024_edit_low-768x512.jpg 768w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2024\/10\/Zaida-Avarez-2024_edit_low-600x400.jpg 600w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2024\/10\/Zaida-Avarez-2024_edit_low.jpg 1200w\" data-sizes=\"(max-width: 1024px) 100vw, 1024px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 1024px; --smush-placeholder-aspect-ratio: 1024\/683;\" \/><\/figure>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>La investigadora de l&#8217;IBEC, Zaida \u00c1lvarez, participar\u00e0 com a investigadora principal en un projecte finan\u00e7at pels <a href=\"https:\/\/salud.nih.gov\/\">Instituts Nacionals de Salut<\/a> (NIH, per les seves sigles en angl\u00e8s) dels Estats Units. Coordinat pel professor Evangelos Kiskinis de la Northwestern University a Chicago, el projecte tamb\u00e9 compta amb la participaci\u00f3 del Dr. Alberto Ortega, de l&#8217;Institut d&#8217;Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL). El seu objectiu \u00e9s investigar com canvia la matriu extracel\u00b7lular de les neurones en diferents etapes del desenvolupament per avan\u00e7ar en la comprensi\u00f3 de malalties neurodegeneratives.<\/p>\n\n\n\n<p>El projecte, que porta per nom &#8220;Refinant els sistemes model de medul\u00b7la espinal basats en c\u00e8l\u00b7lules mare pluripotents indu\u00efdes (iPSC) mitjan\u00e7ant la fabricaci\u00f3 de senyals de matriu extracel\u00b7lular programades segons el desenvolupament&#8221;, durar\u00e0 cinc anys i compta amb un pressupost de m\u00e9s de 2,7 milions de d\u00f2lars, dels quals l&#8217;IBEC rebr\u00e0 m\u00e9s de 600.000.<\/p>\n\n\n\n<p>Les tecnologies de reprogramaci\u00f3 cel\u00b7lular i les c\u00e8l\u00b7lules mare pluripotents indu\u00efdes (iPSC) han revolucionat l&#8217;estudi del sistema nervi\u00f3s central hum\u00e0, fet que permet crear models per investigar el desenvolupament neuronal i les malalties neurol\u00f2giques. No obstant aix\u00f2, cultivar neurones derivades d&#8217;iPSC <em>in vitro<\/em> continua sent un desafiament, ja que no assoleixen la maduresa necess\u00e0ria per estudiar patologies neurodegeneratives. Aix\u00f2 es deu, en part, a la falta d&#8217;una matriu extracel\u00b7lular (ECM) adequada, que \u00e9s l&#8217;estructura que suporta i regula les c\u00e8l\u00b7lules al cos.<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>A llarg termini, els aven\u00e7os obtinguts en la funcionalitzaci\u00f3 de matrius i construccions tissulars podrien establir noves bases per a tractaments efectius de lesions medul\u00b7lars i altres patologies neurodegeneratives.<\/p>\n\n\n\n<p>Zaida \u00c1lvarez Pinto<\/p>\n<\/blockquote>\n\n\n\n<p>El\u00a0projecte en q\u00fcesti\u00f3 proposa superar aquest repte investigant com canvia l&#8217;ECM en diferents etapes de desenvolupament, des de la infantesa fins a la vellesa, utilitzant la medul\u00b7la espinal de ratolins i humans. A partir d&#8217;aquestes troballes, els investigadors dissenyaran matrius artificials que imitin l&#8217;ECM natural per millorar la maduraci\u00f3 i l&#8217;envelliment de les neurones al laboratori. Aquests aven\u00e7os permetran desenvolupar millors models de medul\u00b7les espinal basats en iPSC, amb aplicacions en l&#8217;estudi de malalties i en el desenvolupament de ter\u00e0pies.<\/p>\n\n\n\n<p>L&#8217;equip d&#8217;\u00c1lvarez a l&#8217;IBEC, el <a href=\"https:\/\/ibecbarcelona.eu\/biomaterial-for-neural-regeneration\/\">grup de Biomaterials per a la Regeneraci\u00f3 Neural<\/a>, tindr\u00e0 un paper clau en el projecte. Desenvoluparan matrius funcionalitzades amb prote\u00efnes de l&#8217;ECM per millorar la maduraci\u00f3 de neurones motores humanes en cultius 2D i dissenyaran plataformes 3D per madurar organoides de medul\u00b7la espinal. Tamb\u00e9 duran a terme estudis sobre la morfologia, mec\u00e0nica i degradaci\u00f3 dels hidrogels que actuaran com a substrats, a m\u00e9s d&#8217;analitzar els senyals alliberats per l&#8217;ECM.<\/p>\n\n\n\n<p>Segons \u00c1lvarez: &#8220;Aquesta oportunitat ens permetr\u00e0 aprofundir en l&#8217;estudi de la matriu extracel\u00b7lular de la medul\u00b7la espinal i la seva influ\u00e8ncia en la maduraci\u00f3 neural. A llarg termini, els aven\u00e7os obtinguts en la funcionalitzaci\u00f3 de matrius i construccions tissulars podrien establir noves bases per a tractaments efectius de lesions medul\u00b7lars i altres patologies neurodegeneratives&#8221;.<\/p>\n\n\n\n<p>El projecte ha estat finan\u00e7at sota el programa R01 dels NIH, un dels majors finan\u00e7adors p\u00fablics de recerca biom\u00e8dica al m\u00f3n, que dona suport a investigacions independents d&#8217;alt impacte en \u00e0rees espec\u00edfiques d&#8217;inter\u00e8s cient\u00edfic. Aquest tipus de finan\u00e7ament permet a investigadors que es troben en etapes primerenques de la seva carrera investigadora explorar solucions innovadores per abordar desafiaments en la biomedicina.<\/p>\n\n\n\n<p><a id=\"_msocom_1\"><\/a><\/p>\n\n\n\n<pre class=\"wp-block-verse\">La investigaci\u00f3 esmentada en aquesta publicaci\u00f3 ha estat recolzada per l'Institut Nacional sobre l'Envelliment dels Instituts Nacionals de Salut (National Institutes of Health - NIH) sota el n\u00famero de concessi\u00f3 R01AG086270. <em>Aquest contingut \u00e9s responsabilitat exclusiva dels autors i no necess\u00e0riament representa les opinions oficials de l'Institut Nacional sobre l'Envelliment dels Instituts Nacionals de Salut.<\/em><br><\/pre>\n\n\n\n<div class=\"wp-block-columns are-vertically-aligned-top is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-top is-layout-flow wp-block-column-is-layout-flow\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" width=\"413\" height=\"146\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2024\/10\/NIAFundLogo_rounded-e1611596621168-1.png\" alt=\"\" class=\"wp-image-120727 lazyload\" style=\"--smush-placeholder-width: 413px; --smush-placeholder-aspect-ratio: 413\/146;width:auto;height:80px\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2024\/10\/NIAFundLogo_rounded-e1611596621168-1.png 413w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2024\/10\/NIAFundLogo_rounded-e1611596621168-1-300x106.png 300w\" data-sizes=\"(max-width: 413px) 100vw, 413px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" \/><\/figure><\/div><\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-top is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full is-resized\"><img decoding=\"async\" width=\"374\" height=\"329\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2024\/10\/NIH_Master_Logo_Vertical_2Color.png\" alt=\"\" class=\"wp-image-120717 lazyload\" style=\"--smush-placeholder-width: 374px; --smush-placeholder-aspect-ratio: 374\/329;width:100px\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2024\/10\/NIH_Master_Logo_Vertical_2Color.png 374w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2024\/10\/NIH_Master_Logo_Vertical_2Color-300x264.png 300w\" data-sizes=\"(max-width: 374px) 100vw, 374px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" \/><\/figure>\n<\/div>\n<\/div>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>La investigadora principal de l&#8217;IBEC, Zaida \u00c1lvarez, ha rebut finan\u00e7ament els Instituts Nacionals de Salut (NIH) dels Estats Units per desenvolupar models de medul\u00b7la espinal basats en c\u00e8l\u00b7lules mare. El projecte, coordinat per la Northwestern University amb la participaci\u00f3 de l&#8217;IBEC i l&#8217;IDIBELL, permetr\u00e0 estudiar malalties neurodegeneratives i desenvolupar nous tractaments per a lesions medul\u00b7lars i altres patologies neurodegeneratives.<\/p>\n","protected":false},"author":37,"featured_media":120714,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[98],"tags":[1965,1970],"post_formats":[],"class_list":["post-120738","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-institucionals","tag-biomaterials-for-neural-regeneration-group-ca","tag-zaida-alvarez-ca"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>L&#039;IBEC rep finan\u00e7ament dels Instituts Nacionals de Salut dels Estats Units per avan\u00e7ar en la regeneraci\u00f3 neural - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/l'ibec-rep-financament-dels-instituts-nacionals-de-salut-dels-estats-units-per-avancar-en-la-regeneracio-neural\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"L&#039;IBEC rep finan\u00e7ament dels Instituts Nacionals de Salut dels Estats Units per avan\u00e7ar en la regeneraci\u00f3 neural - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"La investigadora principal de l&#039;IBEC, Zaida \u00c1lvarez, ha rebut finan\u00e7ament els Instituts Nacionals de Salut (NIH) dels Estats Units per desenvolupar models de medul\u00b7la espinal basats en c\u00e8l\u00b7lules mare. El projecte, coordinat per la Northwestern University amb la participaci\u00f3 de l&#039;IBEC i l&#039;IDIBELL, permetr\u00e0 estudiar malalties neurodegeneratives i desenvolupar nous tractaments per a lesions medul\u00b7lars i altres patologies neurodegeneratives.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/ca\/l&#039;ibec-rep-financament-dels-instituts-nacionals-de-salut-dels-estats-units-per-avancar-en-la-regeneracio-neural\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2024-10-15T10:05:44+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-10-15T10:16:50+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2024\/10\/Zaida-Avarez-2024_edit_low.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"800\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Sarah Moreira\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrit per\" \/>\n\t<meta name=\"twitter:data1\" content=\"Sarah Moreira\" \/>\n\t<meta name=\"twitter:label2\" content=\"Temps estimat de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minuts\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/l%27ibec-rep-financament-dels-instituts-nacionals-de-salut-dels-estats-units-per-avancar-en-la-regeneracio-neural\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/l%27ibec-rep-financament-dels-instituts-nacionals-de-salut-dels-estats-units-per-avancar-en-la-regeneracio-neural\\\/\"},\"author\":{\"name\":\"Sarah Moreira\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/d3a158b8d448000777023ca1e3d71d34\"},\"headline\":\"L&#8217;IBEC rep finan\u00e7ament dels Instituts Nacionals de Salut dels Estats Units per avan\u00e7ar en la regeneraci\u00f3 neural\",\"datePublished\":\"2024-10-15T10:05:44+00:00\",\"dateModified\":\"2024-10-15T10:16:50+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/l%27ibec-rep-financament-dels-instituts-nacionals-de-salut-dels-estats-units-per-avancar-en-la-regeneracio-neural\\\/\"},\"wordCount\":654,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/l%27ibec-rep-financament-dels-instituts-nacionals-de-salut-dels-estats-units-per-avancar-en-la-regeneracio-neural\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2024\\\/10\\\/Zaida-Avarez-2024_edit_low.jpg\",\"keywords\":[\"Biomaterials for Neural regeneration group\",\"Zaida \u00c1lvarez\"],\"articleSection\":[\"Not\u00edcies institucionals\"],\"inLanguage\":\"ca\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/l%27ibec-rep-financament-dels-instituts-nacionals-de-salut-dels-estats-units-per-avancar-en-la-regeneracio-neural\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/l%27ibec-rep-financament-dels-instituts-nacionals-de-salut-dels-estats-units-per-avancar-en-la-regeneracio-neural\\\/\",\"name\":\"L'IBEC rep finan\u00e7ament dels Instituts Nacionals de Salut dels Estats Units per avan\u00e7ar en la regeneraci\u00f3 neural - 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