{"id":12166,"date":"2015-01-26T17:25:23","date_gmt":"2015-01-26T17:25:23","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new\/?p=12166"},"modified":"2015-02-03T16:05:05","modified_gmt":"2015-02-03T16:05:05","slug":"les-ferides-es-curen-mitjancant-un-estira-i-arronsa-cel%c2%b7lular","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/les-ferides-es-curen-mitjancant-un-estira-i-arronsa-cel%c2%b7lular\/","title":{"rendered":"Les ferides es curen mitjan\u00e7ant un “estira i arronsa” cel\u00b7lular"},"content":{"rendered":"
Peu de foto: Forces exercides per les c\u00e8l\u2022lules que rodegen l’escletxa (l\u00ednia blava puntejada) al principi s\u2019estenen lluny, despr\u00e9s es dirigeixen cap a l’escletxa durant la contracci\u00f3 del cable “en bossa de tabac” (vermell).<\/h6>\n

Normalment, les ferides petites o superficials, les c\u00e8l\u2022lules comencen a arrossegar-se cap endavant a trav\u00e9s del forat, es formen uns cables contr\u00e0ctils a les c\u00e8l\u2022lules que rodegen la ferida per ajudar a tancar-la. Aquest mecanisme es basa en una capa a sota sobre la que els c\u00e8l\u2022lules s’arrosseguen, la matriu extracel\u2022lular (ECM), que proporciona un suport per adherir-se i arrossegar-se per sobre.<\/p>\n

No obstant, en casos de ferides cr\u00f2niques o severes , les capes subjacents poden danyar-se tamb\u00e9, i les c\u00e8l\u2022lules circumdants poden no ser capaces de reempla\u00e7ar les prote\u00efnes de la matriu extracel\u2022lular. Els investigadors volien tribar com aquesta mena de ferides – conegudes com a bretxes no adherents – es tanquen i es curen, encara que a un ritme m\u00e9s lent i amb una major probabilitat d’infecci\u00f3.<\/p>\n

“Hem vist que el tancament d’aquesta mena de forats es dona exclusivament mitjan\u00e7ant el mecanisme conegut com “tancament en bossa de tabac”, explica Xavier Trepat, investigador principal del grup del IBEC Integraci\u00f3 Cel\u2022lular i Din\u00e0mica de Teixits. “Utilitzant una combinaci\u00f3 de cultius cel\u2022lulars, microfabricaic\u00f3 i mesures de for\u00e7a. Hem vist que les c\u00e8l\u2022lules a la vora de les bretxes no adherents estan encara unides per la matriu extracel\u2022lular. Llavors es propaguen tan lluny com els \u00e9s possible a trav\u00e9s del centre del forat – per\u00f2 mesurant la direcci\u00f3 de les forces ens vam adonar que en realitat el que fan \u00e9s emp\u00e8nyer lluny d’ell.”<\/p>\n

Malgrat que aix\u00f2 pugui semblar contra-intu\u00eftiu, en realitat estabilitza les c\u00e8l\u2022lules, una mica com un pont penjant, on cada extrem recolzat en una vora ancora l\u2019extensi\u00f3 del pont a l’espai fins que les dues parts s\u2019uneixen al centre. Una vegada que les c\u00e8l\u2022lules s’han disseminat el m\u00e9s lluny possible del forat, es dormen cables contr\u00e0ctils en “bossa de tabac” a trav\u00e9s de les c\u00e8l\u2022lules. La for\u00e7a exercida per aquestes c\u00e8l\u2022lules s’inverteix i les c\u00e8l\u2022lules comencen a estirar l’una de l’altre a traves del centre del forat, accelerant cont\u00ednuament la contracci\u00f3 de la prote\u00efna cable. “A mesura que les c\u00e8l\u2022lules es mouen cap a dins per a tancar l’espai buit, m\u00e9s cables contr\u00e0ctils poden arribar a la bretxa i connectar-se a l’altra banda,” diu Xavier. “Aquests cables poden contraure’s r\u00e0pidament, donant lloc a la formaci\u00f3 d’una l\u00e0mina de c\u00e8l\u2022lules suspeses sobre el forat, i el tancament complert de la ferida.”<\/p>\n

El mecanisme de “estira i arronsa” identificat en aquest estudi proporciona una demostraci\u00f3 s\u00f2lida de com les c\u00e8l\u2022lules exerceixen forces direccionals per potenciar processos biol\u00f2gics. Aquests nous coneixements de les propietats mec\u00e0niques de la pell i les c\u00e8l\u2022lules internes epitelials poden conduir a aven\u00e7os en la reparaci\u00f3 de ferides, especialment en els casos en que es veu compromesa la matriu extracel\u2022lular. Amb les ferides cr\u00f2niques, llagues i \u00falceres – una complicaci\u00f3 com\u00ed en diverses malalties, particularment aquelles associades amb l’envelliment – \u00e9s imperatiu que els investigadors comprenguin millor els mecanismes que intervenen en la seva reparaci\u00f3.<\/p>\n

—<\/p>\n

Art\u00edculo de referencia: <\/strong><\/em>Vedula SR, Peyret G, Cheddadi I, Chen T, Brugu\u00e9s A, Hirata H, Lopez-Menendez H, Toyama Y, Neves de Almeida L, Trepat X, Lim CT & Ladoux B. (2015). Mechanics of epithelial closure over non-adherent environments.<\/a> Nat Commun.,<\/em> 6:6111<\/p>\n","protected":false},"excerpt":{"rendered":"

Investigadors del IBEC desvetllen a un article de Nature Communications alguns mecanismes sorprenents que condueixen a tancar el forat epitelial en l’abs\u00e8ncia de capes subjacents<\/h3>\n

En col\u2022laboraci\u00f3 amb els seus companys del Mechanobiology Institut a Singapur, els investigadors del IBEC han demostrar que una esp\u00e8cie de “estira i arronsa” t\u00e9 lloc despr\u00e9s del dany de la nostra pell o altres capes epitelials, particularment en aquells casos en els que el teixit es trobi cr\u00f2nica i profundament danyat.<\/p>\n","protected":false},"author":4,"featured_media":11880,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-12166","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca"],"yoast_head":"\nLes ferides es curen mitjan\u00e7ant un "estira i arronsa" cel\u00b7lular - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link 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