{"id":12178,"date":"2015-01-21T16:15:15","date_gmt":"2015-01-21T16:15:15","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new\/?p=12178"},"modified":"2015-02-03T16:26:43","modified_gmt":"2015-02-03T16:26:43","slug":"sidentifica-un-actor-clau-en-les-infeccions-e-coli","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/sidentifica-un-actor-clau-en-les-infeccions-e-coli\/","title":{"rendered":"S\u2019identifica un actor clau en les infeccions E.coli"},"content":{"rendered":"
Peu de foto: Microscopia electr\u00f2nica del cep LF82 de l\u2019adherent i invasiva E. coli (esquerra) i els mutants nrdR (dreta) (ampliaci\u00f3 \u00c5~ 10,000).<\/h6>\n

En un article publicat recentment en la revista American Society for Microbiology\u2019s Infection and Immunity, el grup \u201cInfeccions Bacterianes: ter\u00e0pies antimicrobianes\u201d de l\u2019IBEC ha descobert que la ribonucle\u00f2tid reductasa (RNRs) \u2013enzim que proporciona els blocs de construcci\u00f3 per a la replicaci\u00f3 de l\u2019ADN en les c\u00e8l\u00b7lules vives\u2013 juga un paper important en la virul\u00e8ncia i infecci\u00f3 de la Escherichia coli<\/em>.<\/p>\n

\u201cHem examinat els papers de diferents classes de RNR durant la infecci\u00f3 per la malaltia de Crohn \u2013associada a l\u2019adher\u00e8ncia i invasi\u00f3 del cep d\u2019E.coli<\/em> AIEX LF82\u2013\u201d diu Eduard Torrents, investigador principal j\u00fanior de l\u2019IBEC. Utilitzant c\u00e8l\u00b7lules intestinals en un model d\u2019infecci\u00f3 in vivo i treballant conjuntament amb un grup de la Universitat de Auverge a Clarmont, l\u00edders mundials en infeccions per E.coli, hem trobat que inactivant o anul\u00b7lant la prote\u00efna NrdD i el regulador transcripcional NrdR, disminueix l\u2019habilitat particular d\u2019aquest cep d\u2019E.coli de colonitzar la mucosa de l\u2019intest\u00ed. \u201cAix\u00f2 mostra que la RNRs, i en particular la prote\u00efna NrdR, regula la virul\u00e8ncia de la malaltia de Crohn associada a l\u2019E.coli<\/em> mitjan\u00e7ant la regulaci\u00f3 del moviment i la propagaci\u00f3 del bacteri\u201d, explica Eduard Torrents.<\/p>\n

\u00c9s essencial accedir a nous i m\u00e9s efectius antibi\u00f2tics ja que la resist\u00e8ncia antimicrobiana (AMR) \u00e9s un dels majors riscos socials que amenacen a la salut humana avui dia. L\u2019increment de la resist\u00e8ncia antibacteriana i la falta de nous antibi\u00f2tics en desenvolupament significa que \u00e9s crucial identificar noves alternatives per tractar les infeccions bacterianes.<\/p>\n

Gr\u00e0cies als nous descobriments, el desenvolupament de f\u00e0rmacs dirigits a la ribonucle\u00f2tid reductasa, en particular a les prote\u00efnes NrdD i NrdR, pot ser una nova estrat\u00e8gia prometedora per controlar infeccions bacterianes, i particularment per controlar la colonitzaci\u00f3 de l\u2019intest\u00ed per Escherichia coli<\/em>.<\/p>\n

—<\/p>\n

Article de refer\u00e8ncia:<\/strong> <\/em>Nicolas Dreux, Maria del Mar Cendra, S\u00e9bastien Massier, Arlette Darfeuille-Michaud, Nicolas Barnich & Eduard Torrents (2015). \u201cRibonucleotide reductase NrdR as a novel regulator for motility and chemotaxis during adherent-invasive Escherichia coli infection.\u201d<\/a> Infect. Immun.<\/em>, accepted manuscript posted online 20 January 2015, doi:10.1128\/IAI.02772-14<\/p>\n","protected":false},"excerpt":{"rendered":"

\"torrentsjan\"Un grup de l\u2019Institut de Bioenginyeria de Catalunya (IBEC) ha identificat un factor important en les infeccions produ\u00efdes per E.coli, obrint una nova via cap al desenvolupament de f\u00e0rmacs dirigits contra aquesta malaltia potencialment mortal.<\/h3>\n

La majoria de ceps bacterians d\u2019E.coli es troben de manera natural en l\u2019intest\u00ed hum\u00e0 i no representen cap dany per a la salut, a excepci\u00f3 d\u2019un serotipo particular que sempre apareix en les not\u00edcies, l\u2019O157:H7, que pot causar intoxicaci\u00f3 aliment\u00e0ria i la mort en alguns pacients.<\/p>\n","protected":false},"author":4,"featured_media":11799,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-12178","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca"],"yoast_head":"\nS\u2019identifica un actor clau en les infeccions E.coli - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/sidentifica-un-actor-clau-en-les-infeccions-e-coli\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"S\u2019identifica un actor clau en les infeccions E.coli - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Un grup de l\u2019Institut de Bioenginyeria de Catalunya (IBEC) ha identificat un factor important en les infeccions produ\u00efdes per E.coli, obrint una nova via cap al desenvolupament de f\u00e0rmacs dirigits contra aquesta malaltia potencialment mortal. La majoria de ceps bacterians d\u2019E.coli es troben de manera natural en l\u2019intest\u00ed hum\u00e0 i no representen cap dany per a la salut, a excepci\u00f3 d\u2019un serotipo particular que sempre apareix en les not\u00edcies, l\u2019O157:H7, que pot causar intoxicaci\u00f3 aliment\u00e0ria i la mort en alguns pacients.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/ca\/sidentifica-un-actor-clau-en-les-infeccions-e-coli\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2015-01-21T16:15:15+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2015-02-03T16:26:43+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2015\/01\/torrentsjan1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"425\" \/>\n\t<meta property=\"og:image:height\" content=\"210\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrit per\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Temps estimat de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minuts\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/sidentifica-un-actor-clau-en-les-infeccions-e-coli\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/sidentifica-un-actor-clau-en-les-infeccions-e-coli\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"S\u2019identifica un actor clau en les infeccions E.coli\",\"datePublished\":\"2015-01-21T16:15:15+00:00\",\"dateModified\":\"2015-02-03T16:26:43+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/sidentifica-un-actor-clau-en-les-infeccions-e-coli\\\/\"},\"wordCount\":403,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/sidentifica-un-actor-clau-en-les-infeccions-e-coli\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2015\\\/01\\\/torrentsjan1.jpg\",\"articleSection\":[\"Not\u00edcies de recerca\"],\"inLanguage\":\"ca\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/sidentifica-un-actor-clau-en-les-infeccions-e-coli\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/sidentifica-un-actor-clau-en-les-infeccions-e-coli\\\/\",\"name\":\"S\u2019identifica un actor clau en les infeccions E.coli - 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