{"id":122606,"date":"2024-12-19T15:35:44","date_gmt":"2024-12-19T14:35:44","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=122606"},"modified":"2024-12-19T15:51:15","modified_gmt":"2024-12-19T14:51:15","slug":"innovative-3d-printed-scaffolds-offer-new-hope-for-bone-healing","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/innovadores-bastides-impreses-en-3d-ofereixen-una-nova-esperanca-per-a-la-curacio-ossia","title":{"rendered":"Innovadores bastides impreses en 3D ofereixen una nova esperan\u00e7a per a la curaci\u00f3 \u00f2ssia"},"content":{"rendered":"\n

Els defectes ossis cr\u00edtics causats per traumatismes, extirpacions tumorals o malalties cong\u00e8nites representen un gran desafiament m\u00e8dic, ja que les taxes de frac\u00e0s en els empelts ossis s\u00f3n altes a causa de la insufici\u00e8ncia en el subministrament sanguini necessari per a la seva integraci\u00f3 i regeneraci\u00f3. Per a abordar aquest problema, investigadors de l’Institut de\u00a0Bioenginyeria\u00a0de Catalunya han desenvolupat noves bastides impreses en 3D fetes d’\u00e0cid\u00a0polil\u00e0ctic\u00a0i fosfat de calci. Aquestes innovadores bastides promouen la formaci\u00f3 de vasos sanguinis, garantint una millor cicatritzaci\u00f3 i regeneraci\u00f3 del teixit ossi.<\/strong><\/p>\n\n\n\n

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Elisabeth Engel (esquerra) i \u00d3scar Casta\u00f1o (dreta) als laboratoris de l’IBEC.<\/figcaption><\/figure>\n\n\n\n

L’os \u00e9s un teixit altament vascularitzat, i la relaci\u00f3 entre l’angiog\u00e8nesi -formaci\u00f3 de vasos sanguinis- i la cicatritzaci\u00f3 \u00f2ssia ha estat discutida durant molt de temps per la comunitat cient\u00edfica, amb diversos estudis que descriuen la deterioraci\u00f3 de la cicatritzaci\u00f3 \u00f2ssia a causa de la falta o disminuci\u00f3 de l’angiog\u00e8nesi. Els enfocaments tradicionals, com l’\u00fas d’empelts, sovint causen complicacions a causa d’un subministrament vascular inadequat als implants, la qual cosa condueix a una integraci\u00f3 deficient i a la formaci\u00f3 de teixit necr\u00f2tic.<\/p>\n\n\n\n

\n

Aquest innovador m\u00e8tode permet crear bastides personalitzables que imiten l’estructura de l’os natural, essencial per a potenciar la infiltraci\u00f3 cel\u00b7lular i l’intercanvi de nutrients durant el proc\u00e9s de cicatritzaci\u00f3<\/p>\n\n\n\n

Celia Ximenes-Carballo<\/p>\n<\/blockquote>\n\n\n\n

Per a fer front a aquest problema, investigadors de l’IBEC liderats per \u00d3scar Casta\u00f1o, investigador principal del grup de Biomaterials per a Ter\u00e0pies Regeneratives<\/a>, van desenvolupar un enfocament nou, publicat recentment en la revista Biomaterials Advances<\/a>. Van aplicar la t\u00e8cnica de bioimpressi\u00f3 3D per a construir bastides d’estructura v\u00edtria a base d’\u00e0cid polil\u00e0ctic i fosfat de calci, que afavoreixen l’angiog\u00e8nesi i la maduraci\u00f3 dels vasos sanguinis.<\/p>\n\n\n\n

L’os es compon tant d’una part org\u00e0nica no mineralitzada (principalment col\u00b7lagen) com d’una part inorg\u00e0nica mineralitzada (principalment hidroxiapatita). En aquesta estructura, la porositat 3D \u00e9s necess\u00e0ria per a assegurar el transport de nutrients i oxigen, aix\u00ed com per a permetre la vascularitzaci\u00f3, la infiltraci\u00f3 cel\u00b7lular i l’eliminaci\u00f3 de residus. L’enfocament dels investigadors es va basar en l’\u00fas de bastides d’estructura v\u00edtria a base de fosfat de calci (CaP) per a millorar les propietats de l’\u00e0cid polil\u00e0ctic (PLA) i obtenir un material que compleixi amb les necessitats qu\u00edmiques, mec\u00e0niques i biol\u00f2giques del teixit ossi.<\/p>\n\n\n\n

Les noves bastides de PLA-CaP permeten una adequada vascularitzaci\u00f3, que no nom\u00e9s cicatritza el teixit, sin\u00f3 que tamb\u00e9 permet una regeneraci\u00f3 eficient, la qual cosa es tradueix en la reducci\u00f3 o eliminaci\u00f3 de danys en l’os. Per a crear aquestes bastides, els investigadors van emprar la impressi\u00f3 3D per a aconseguir un control prec\u00eds sobre la geometria de la bastida, la porositat i les caracter\u00edstiques de la superf\u00edcie. “Aquest innovador m\u00e8tode permet crear bastides personalitzables que imiten l’estructura de l’os natural, essencial per a potenciar la infiltraci\u00f3 cel\u00b7lular i l’intercanvi de nutrients durant el proc\u00e9s de cicatritzaci\u00f3”, explica Celia Ximenes-Carballo, primera autora de l’estudi.<\/p>\n\n\n

\n
\"\"
La tinci\u00f3 amb vermell d’alitzarina, que ressalta els llocs de mineralitzaci\u00f3 en una bastida PLAG520%, evid\u00e8ncia la macroporositat tridimensional i la seva capacitat per a millorar l’osteog\u00e8nesi.
<\/figcaption><\/figure><\/div>\n\n\n

Les proves realitzades in vitro<\/em> van revelar que les bastides impreses en 3D van afavorir la proliferaci\u00f3 de c\u00e8l\u00b7lules mare mesenquim\u00e0tiques humanes i van estimular la secreci\u00f3 del factor de creixement de l’endoteli vascular, un factor cr\u00edtic que promou la formaci\u00f3 de vasos sanguinis. A m\u00e9s, les bastides van mantenir l’alliberament d’ions de calci a nivells fisiol\u00f2gics, un altre element vital per a estimular la vascularitzaci\u00f3.<\/p>\n\n\n\n

D’altra banda, les proves subcut\u00e0nies in vivo<\/em> en un model de ratol\u00ed tamb\u00e9 van mostrar resultats prometedors. Tan sols una setmana despr\u00e9s de la implantaci\u00f3, les bastides van mostrar una bona integraci\u00f3 i una notable infiltraci\u00f3 de vasos sanguinis. Les bastides de PLA-CaP van ser particularment efectives, mostrant una major maduraci\u00f3 dels vasos despr\u00e9s de quatre setmanes sense signes de regressi\u00f3 vascular. L’an\u00e0lisi dels vasos sanguinis va revelar que les seves parets eren inicialment fines, per\u00f2 es van tornar m\u00e9s s\u00f2lides i estables amb el temps. Aquesta progressi\u00f3 indica que les bastides no nom\u00e9s ofereixen un suport inicial per al creixement dels vasos sanguinis, sin\u00f3 que tamb\u00e9 fomenten un entorn propici per a una vascularitzaci\u00f3 persistent, essencial per a la regeneraci\u00f3 \u00f2ssia.<\/p>\n\n\n\n

\n

Creiem que les nostres bastides impreses en 3D podrien revolucionar la forma en qu\u00e8 abordem la regeneraci\u00f3 \u00f2ssia. En millorar la vascularitzaci\u00f3, podem millorar significativament els resultats de curaci\u00f3 i reduir les possibilitats de complicacions associades amb els m\u00e8todes d’empelt tradicionals\u201d<\/em><\/p>\n\n\n\n

\u00d3scar Casta\u00f1o, investigador s\u00e8nior de l’IBEC.<\/em><\/p>\n<\/blockquote>\n\n\n\n

El desenvolupament d’aquestes innovadores bastides posa de manifest els efectes sin\u00e8rgics de combinar la tecnologia d’impressi\u00f3 3D amb materials bioactius com les part\u00edcules alliberadores de calci. L’arquitectura de les bastides de PLA-CaP, a m\u00e9s de facilitar una millor vascularitzaci\u00f3, tamb\u00e9 dona suport a l’osteog\u00e8nesi, obrint el cam\u00ed per a estrat\u00e8gies de curaci\u00f3 \u00f2ssia m\u00e9s efectives amb el potencial de reduir les taxes de frac\u00e0s dels empelts.<\/p>\n\n\n\n

\n\n\n\n

Article referenciat:<\/strong><\/p>\n\n\n\n

Celia Ximenes-Carballo, Sergi Rey-Vi\u00f1olas, Barbara Blanco-Fernandez, Soledad P\u00e9rez-Amodio, Elisabeth Engel, Oscar Casta\u00f1o. Combining three-dimensionality and CaP glass-PLA composites: Towards an efficient vascularization in bone tissue healing.<\/strong> Biomaterials Advances<\/em>, 164 (2024) 213985. DOI: 10.1016\/j.bioadv.2024.213985<\/a><\/p>\n\n\n\n

\n\n\n\n

<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Els defectes ossis cr\u00edtics causats per traumatismes, extirpacions tumorals o malalties cong\u00e8nites representen un gran desafiament m\u00e8dic, ja que les taxes de frac\u00e0s en els empelts ossis s\u00f3n altes a causa de la insufici\u00e8ncia en el subministrament sanguini necessari per a la seva integraci\u00f3 i regeneraci\u00f3. Per a abordar aquest problema, investigadors de l’Institut de\u00a0Bioenginyeria\u00a0de Catalunya han desenvolupat noves bastides impreses en 3D fetes d’\u00e0cid\u00a0polil\u00e0ctic\u00a0i fosfat de calci. Aquestes innovadores bastides promouen la formaci\u00f3 de vasos sanguinis, garantint una millor cicatritzaci\u00f3 i regeneraci\u00f3 del teixit ossi.<\/p>\n","protected":false},"author":37,"featured_media":122592,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1605],"post_formats":[],"class_list":["post-122606","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-biomaterials-for-regenerative-therapies"],"yoast_head":"\nInnovadores bastides impreses en 3D ofereixen una nova esperan\u00e7a per a la curaci\u00f3 \u00f2ssia - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/innovadores-bastides-impreses-en-3d-ofereixen-una-nova-esperanca-per-a-la-curacio-ossia\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Innovadores bastides impreses en 3D ofereixen una nova esperan\u00e7a per a la curaci\u00f3 \u00f2ssia - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Els defectes ossis cr\u00edtics causats per traumatismes, extirpacions tumorals o malalties cong\u00e8nites representen un gran desafiament m\u00e8dic, ja que les taxes de frac\u00e0s en els empelts ossis s\u00f3n altes a causa de la insufici\u00e8ncia en el subministrament sanguini necessari per a la seva integraci\u00f3 i regeneraci\u00f3. Per a abordar aquest problema, investigadors de l'Institut de\u00a0Bioenginyeria\u00a0de Catalunya han desenvolupat noves bastides impreses en 3D fetes d'\u00e0cid\u00a0polil\u00e0ctic\u00a0i fosfat de calci. Aquestes innovadores bastides promouen la formaci\u00f3 de vasos sanguinis, garantint una millor cicatritzaci\u00f3 i regeneraci\u00f3 del teixit ossi.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/ca\/innovadores-bastides-impreses-en-3d-ofereixen-una-nova-esperanca-per-a-la-curacio-ossia\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2024-12-19T14:35:44+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-12-19T14:51:15+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2024\/12\/EEngel-noti-huesos-3_low.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"789\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Sarah Moreira\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrit per\" \/>\n\t<meta name=\"twitter:data1\" content=\"Sarah Moreira\" \/>\n\t<meta name=\"twitter:label2\" content=\"Temps estimat de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minuts\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/innovadores-bastides-impreses-en-3d-ofereixen-una-nova-esperanca-per-a-la-curacio-ossia\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/innovadores-bastides-impreses-en-3d-ofereixen-una-nova-esperanca-per-a-la-curacio-ossia\\\/\"},\"author\":{\"name\":\"Sarah Moreira\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/d3a158b8d448000777023ca1e3d71d34\"},\"headline\":\"Innovadores bastides impreses en 3D ofereixen una nova esperan\u00e7a per a la curaci\u00f3 \u00f2ssia\",\"datePublished\":\"2024-12-19T14:35:44+00:00\",\"dateModified\":\"2024-12-19T14:51:15+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/innovadores-bastides-impreses-en-3d-ofereixen-una-nova-esperanca-per-a-la-curacio-ossia\\\/\"},\"wordCount\":924,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/innovadores-bastides-impreses-en-3d-ofereixen-una-nova-esperanca-per-a-la-curacio-ossia\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2024\\\/12\\\/EEngel-noti-huesos-3_low.jpg\",\"keywords\":[\"Biomaterials for regenerative therapies\"],\"articleSection\":[\"Not\u00edcies de recerca\"],\"inLanguage\":\"ca\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/innovadores-bastides-impreses-en-3d-ofereixen-una-nova-esperanca-per-a-la-curacio-ossia\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/innovadores-bastides-impreses-en-3d-ofereixen-una-nova-esperanca-per-a-la-curacio-ossia\\\/\",\"name\":\"Innovadores bastides impreses en 3D ofereixen una nova esperan\u00e7a per a la curaci\u00f3 \u00f2ssia - 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