{"id":123016,"date":"2025-01-20T14:38:52","date_gmt":"2025-01-20T13:38:52","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=123016"},"modified":"2025-01-20T14:49:40","modified_gmt":"2025-01-20T13:49:40","slug":"printing-proteins-to-recreate-the-gut-in-the-lab","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/impressio-de-proteines-per-recrear-intesti-al-laboratori","title":{"rendered":"Impressi\u00f3 de prote\u00efnes per recrear l’intest\u00ed al laboratori"},"content":{"rendered":"\n

Un estudi liderat per l’IBEC descriu el desenvolupament d’un m\u00e8tode innovador per controlar la formaci\u00f3 d’estructures similars a les criptes i vellositats de l’intest\u00ed mitjan\u00e7ant una t\u00e8cnica d’impressi\u00f3 de prote\u00efnes per contacte. Aquest model permetr\u00e0 estudiar en detall processos clau com la regeneraci\u00f3 cel\u00b7lular o les alteracions vinculades a malalties com el c\u00e0ncer i els trastorns inflamatoris cr\u00f2nics.<\/strong><\/p>\n\n\n\n

\"\"
Elena Mart\u00ednez (esquerra) i Jordi Comelles (dreta) als laboratoris de l’IBEC.<\/figcaption><\/figure>\n\n\n\n

El m\u00e8tode desenvolupat pel grup de Sistemes Biomim\u00e8tics per a Enginyeria Cel\u00b7lular<\/a> de l’IBEC es basa en la impressi\u00f3 de patrons definits de prote\u00efnes clau, com Wnt3a i EphrinB1, sobre una membrana basal. Aquestes prote\u00efnes s\u00f3n essencials per a l’organitzaci\u00f3 i diferenciaci\u00f3 del teixit epitelial intestinal. Gr\u00e0cies a aquesta t\u00e8cnica, els investigadors van aconseguir controlar com i on es formen estructures com les criptes i vellositats intestinals. A m\u00e9s, el sistema permet estudiar el paper de cadascuna d’aquestes prote\u00efnes de manera individual i controlada.<\/p>\n\n\n\n

\n

El que aconseguim amb el nostre m\u00e8tode, basat en la d’impressi\u00f3 de prote\u00efnes per contacte, \u00e9s controlar com i on es formen aquestes estructures intestinals.<\/p>\n\n\n\n

Jordi Comelles<\/p>\n<\/blockquote>\n\n\n\n

“Les c\u00e8l\u00b7lules amb qu\u00e8 treballem s’autoorganitzen en compartiments diferenciats que repliquen amb precisi\u00f3 les estructures intestinals. El que aconseguim amb el nostre m\u00e8tode, basat en la d’impressi\u00f3 de prote\u00efnes per contacte, \u00e9s controlar com i on es formen aquestes estructures. Ho fem disposant aquestes prote\u00efnes en patrons espec\u00edfics, com cercles o forats”, explica Jordi Comelles, investigador s\u00e8nior de l’IBEC, professor associat a la Universitat de Barcelona (UB) i coautor de l’estudi.<\/p>\n\n\n\n

Aquesta innovadora metodologia permet, a m\u00e9s, analitzar individualment els factors implicats en l’organitzaci\u00f3 i funcionament de l’intest\u00ed, desvetllant el seu paper en processos clau com la proliferaci\u00f3 i diferenciaci\u00f3 cel\u00b7lular. “Hem observat, per exemple, que el Wnt3a pot reduir la producci\u00f3 del mateix factor end\u00f2genament cosa que obre noves possibilitats per manipular aquestes vies de senyalitzaci\u00f3”, afegeix Comelles.<\/p>\n\n\n\n

\n

Aquest model ens permetr\u00e0 estudiar en detall processos clau com la regeneraci\u00f3 cel\u00b7lular o les alteracions vinculades a malalties com el c\u00e0ncer i els trastorns inflamatoris cr\u00f2nics.<\/p>\n\n\n\n

Elena Mart\u00ednez<\/p>\n<\/blockquote>\n\n\n\n

Aquest enfocament permet controlar com les c\u00e8l\u00b7lules intestinals s’agrupen, depenent de la mida i la disposici\u00f3 dels patrons de Wnt3a. “El nostre objectiu era crear un sistema que reflecteixi de forma m\u00e9s fidel les condicions del teixit intestinal hum\u00e0. Aquest model ens permetr\u00e0 estudiar en detall processos clau com la regeneraci\u00f3 cel\u00b7lular o les alteracions vinculades a malalties com el c\u00e0ncer i els trastorns inflamatoris cr\u00f2nics”, assenyala Elena Mart\u00ednez Fraiz, investigadora principal de l’IBEC, professora agregada de la UB i l\u00edder de l’estudi.<\/p>\n\n\n\n

D’altra banda, l’equip va utilitzar models computacionals per simular les interaccions entre les vies de senyalitzaci\u00f3, obtenint una visi\u00f3 m\u00e9s detallada dels processos implicats en l’organitzaci\u00f3 cel\u00b7lular. Aquest aven\u00e7 no nom\u00e9s millora la nostra comprensi\u00f3 de la biologia intestinal, sin\u00f3 que tamb\u00e9 ofereix noves oportunitats per provar medicaments, estudiar malalties en un entorn controlat i desenvolupar tractaments m\u00e9s efectius.<\/p>\n\n\n\n

Aquest treball forma part de la tesi doctoral desenvolupada per Enara Larra\u00f1aga en el grup de Mart\u00ednez a l’IBEC. La investigaci\u00f3 ha comptat a m\u00e9s amb la col\u00b7laboraci\u00f3 del grup de Bioenginyeria en Salut Reproductiva<\/a> de l’IBEC, liderat per Samuel Ojosnegros; el Centre de Recerca Biom\u00e8dica en Xarxa \u2013 Bioenginyeria, Biomaterials i nanomedicina (CIBER-BBN), el Laboratori Europeu de Biologia Molecular (EMBL) de Barcelona i l’Institut de Recerca Biom\u00e8dica (IRB Barcelona).<\/p>\n\n\n\n

\n\n\n\n

Articel referenciat:<\/strong><\/p>\n\n\n\n

Enara Larra\u00f1aga, Miquel Marin-Riera, Aina Abad-L\u00e1zaro, David Bartolom\u00e9-Catal\u00e0, Aitor Otero, Vanesa Fern\u00e1ndez-Majada, Eduard Batlle, James Sharpe, Samuel Ojosnegros, Jordi Comelles & Elena Mart\u00ednez. Long-range organization of intestinal 2D-crypts using exogenous Wnt3a micropatterning<\/strong>. Nature Communications<\/em> (2025). DOI: https:\/\/doi.org\/10.1038\/s41467-024-55651-7<\/a><\/p>\n\n\n\n

\n","protected":false},"excerpt":{"rendered":"

Un estudi liderat per l’IBEC descriu el desenvolupament d’un m\u00e8tode innovador per controlar la formaci\u00f3 d’estructures similars a les criptes i vellositats de l’intest\u00ed mitjan\u00e7ant una t\u00e8cnica d’impressi\u00f3 de prote\u00efnes per contacte. Aquest model permetr\u00e0 estudiar en detall processos clau com la regeneraci\u00f3 cel\u00b7lular o les alteracions vinculades a malalties com el c\u00e0ncer i els trastorns inflamatoris cr\u00f2nics.<\/p>\n","protected":false},"author":37,"featured_media":123012,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1783,1826,820,1071],"post_formats":[],"class_list":["post-123016","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-bioengineering-in-reproductive-health-ca","tag-biomimetic-systems-for-cell-engineering-ca","tag-elena-martinez-ca","tag-samuel-ojosnegros-ca"],"yoast_head":"\nImpressi\u00f3 de prote\u00efnes per recrear l'intest\u00ed al laboratori - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/impressio-de-proteines-per-recrear-intesti-al-laboratori\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Impressi\u00f3 de prote\u00efnes per recrear l'intest\u00ed al laboratori - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Un estudi liderat per l'IBEC descriu el desenvolupament d'un m\u00e8tode innovador per controlar la formaci\u00f3 d'estructures similars a les criptes i vellositats de l'intest\u00ed mitjan\u00e7ant una t\u00e8cnica d'impressi\u00f3 de prote\u00efnes per contacte. 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