{"id":123188,"date":"2025-01-23T16:13:16","date_gmt":"2025-01-23T15:13:16","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=123188"},"modified":"2025-01-23T16:18:23","modified_gmt":"2025-01-23T15:18:23","slug":"intropy-a-new-approach-to-cancer-therapy-by-inhibiting-mechanotransduction","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/intropy%3A-un-nou-enfocament-en-la-terapia-contra-el-cancer-mitjancant-la-inhibicio-de-la-mecanotransduccio","title":{"rendered":"INTROPY: Un nou enfocament en la ter\u00e0pia contra el c\u00e0ncer mitjan\u00e7ant la inhibici\u00f3 de la mecanotransducci\u00f3"},"content":{"rendered":"\n<p><strong>L&#8217;investigador principal de l&#8217;IBEC Pere Roca-Cusachs ha obtingut una &#8220;ERC Proof of Concept Grant&#8221;. Es tracta d&#8217;un prestigi\u00f3s finan\u00e7ament que concedeix el Consell Europeu de Recerca per explorar el potencial comercial i social de projectes de recerca duts a terme en institucions europees. El projecte de Roca-Cusachs, INTROPY, s&#8217;enfoca en la inhibici\u00f3 de la mecanotransducci\u00f3 com a potencial ter\u00e0pia contra el c\u00e0ncer o la fibrosi.<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/01\/PRoca_IBEC_low-1024x683.png\" alt=\"\" class=\"wp-image-123184 lazyload\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/01\/PRoca_IBEC_low-1024x683.png 1024w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/01\/PRoca_IBEC_low-300x200.png 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/01\/PRoca_IBEC_low-768x512.png 768w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/01\/PRoca_IBEC_low-600x400.png 600w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/01\/PRoca_IBEC_low.png 1200w\" data-sizes=\"(max-width: 1024px) 100vw, 1024px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 1024px; --smush-placeholder-aspect-ratio: 1024\/683;\" \/><\/figure>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Pere Roca-Cusachs Soulere, professor catedr\u00e0tic de la Facultat de Medicina i Ci\u00e8ncies de la Salut de la Universitat de Barcelona (UB) i l\u00edder del grup <a href=\"https:\/\/ibecbarcelona.eu\/es\/cellmolmech\">Mecanobiologia cel\u00b7lular i molecular<\/a> a l&#8217;IBEC, ha estat guardonat amb una &#8220;ERC Proof of Concept Grant&#8221;. Es tracta d&#8217;una prestigiosa subvenci\u00f3 que concedeix el Consell Europeu de Recerca (ERC, per les seves sigles en angl\u00e8s) i t\u00e9 com a objectiu explorar el potencial comercial i social de projectes de recerca que estan o han estat finan\u00e7ats pr\u00e8viament per l&#8217;ERC. Els i les sol\u00b7licitants utilitzen aquest tipus de finan\u00e7ament per verificar la viabilitat de conceptes cient\u00edfics, explorar oportunitats de negoci o preparar sol\u00b7licituds de patents.<\/p>\n\n\n\n<p>El projecte de Roca-Cusachs i la investigadora postdoctoral Mamatha Nijaguna, anomenat INTROPY, es centra en la inhibici\u00f3 de la mecanotransducci\u00f3 com una nova estrat\u00e8gia per a la ter\u00e0pia oncol\u00f2gica. La mecanotransducci\u00f3 \u00e9s el proc\u00e9s mitjan\u00e7ant el qual les c\u00e8l\u00b7lules converteixen canvis mec\u00e0nics en respostes biol\u00f2giques, regulant processos com el desenvolupament embrionari, la progressi\u00f3 tumoral i la curaci\u00f3 de ferides.<\/p>\n\n\n\n<p>Un canvi mec\u00e0nic com\u00fa \u00e9s l&#8217;enduriment dels teixits, que passa, per exemple, en el c\u00e0ncer i facilita el creixement m\u00e9s r\u00e0pid dels tumors. En aquest context, l&#8217;equip de Roca-Cusachs ha identificat una interacci\u00f3 clau entre dues prote\u00efnes essencials per a la mecanotransducci\u00f3 i proposa un enfocament terap\u00e8utic que inhibeix aquest proc\u00e9s mitjan\u00e7ant la inhibici\u00f3 d&#8217;aquestes prote\u00efnes diana.<\/p>\n\n\n\n<p>A trav\u00e9s de diverses proves de cribratge, els investigadors han trobat sis mol\u00e8cules amb gran potencial per actuar sobre aquestes prote\u00efnes. Amb el projecte INTROPY, s&#8217;espera validar aquests resultats i aportar proves de concepte del seu potencial per al tractament del c\u00e0ncer, tan <em>in vitro<\/em> com en models de ratol\u00ed.<\/p>\n\n\n\n<p>Aquest enfocament innovador t\u00e9 el potencial de transformar la ter\u00e0pia contra el c\u00e0ncer i proporcionar nous coneixements sobre el paper dels senyals mec\u00e0nics en la progressi\u00f3 de la malaltia.<\/p>\n\n\n\n<p>Si el projecte t\u00e9 \u00e8xit, els investigadors esperen poder establir una <em>spin-off<\/em> per portar el desenvolupament d&#8217;aquests f\u00e0rmacs a fases cl\u00edniques. Aix\u00f2 podria donar lloc al primer f\u00e0rmac mecanoinhibidor de la seva classe, amb aplicacions potencials en el tractament del c\u00e0ncer (enfocat en el c\u00e0ncer de mama i de p\u00e0ncrees) i altres malalties caracteritzades per estr\u00e8s mec\u00e0nic, com la fibrosi.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>L&#8217;investigador principal de l&#8217;IBEC Pere Roca-Cusachs ha obtingut una &#8220;ERC Proof of Concept Grant&#8221;. Es tracta d&#8217;un prestigi\u00f3s finan\u00e7ament que concedeix el Consell Europeu de Recerca per explorar el potencial comercial i social de projectes de recerca duts a terme en institucions europees. El projecte de Roca-Cusachs, INTROPY, s&#8217;enfoca en la inhibici\u00f3 de la mecanotransducci\u00f3 com a potencial ter\u00e0pia contra el c\u00e0ncer o la fibrosi.<\/p>\n","protected":false},"author":37,"featured_media":123185,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[98],"tags":[1812,2061,1412,1134,1817],"post_formats":[],"class_list":["post-123188","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-institucionals","tag-cellular-and-molecular-mechanobiology-ca","tag-erc-ca","tag-erc-grant-ca","tag-pere-roca-cusachs-ca","tag-premi"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>INTROPY: Un nou enfocament en la ter\u00e0pia contra el c\u00e0ncer mitjan\u00e7ant la inhibici\u00f3 de la mecanotransducci\u00f3 - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/intropy:-un-nou-enfocament-en-la-terapia-contra-el-cancer-mitjancant-la-inhibicio-de-la-mecanotransduccio\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"INTROPY: Un nou enfocament en la ter\u00e0pia contra el c\u00e0ncer mitjan\u00e7ant la inhibici\u00f3 de la mecanotransducci\u00f3 - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"L&#039;investigador principal de l&#039;IBEC Pere Roca-Cusachs ha obtingut una &quot;ERC Proof of Concept Grant&quot;. 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