{"id":123486,"date":"2025-02-06T10:00:00","date_gmt":"2025-02-06T09:00:00","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=123486"},"modified":"2025-02-05T15:27:51","modified_gmt":"2025-02-05T14:27:51","slug":"researchers-develop-a-device-that-replicates-tumours-to-study-the-efficacy-of-immunotherapy-treatments","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/desenvolupen-un-dispositiu-que-replica-els-tumors-per-estudiar-eficacia-de-tractaments-amb-immunoterapia","title":{"rendered":"Desenvolupen un dispositiu que replica els tumors per estudiar l\u2019efic\u00e0cia de tractaments amb immunoter\u00e0pia"},"content":{"rendered":"\n

El Micro Immune Response On chip (MIRO) permet replicar els tumors i el seu entorn, per con\u00e8ixer la seva resposta als tractaments basats en inmunoter\u00e0pia.<\/strong> El dispositiu, que ja s\u2019ha provat amb \u00e8xit en mostres de c\u00e0ncer de mama, pot ser clau per desenvolupar nous tractaments i determinar quina \u00e9s la ter\u00e0pia m\u00e9s adequada per a cada pacient de manera personalitzada.<\/strong> El treball, publica Nature Communications, \u00e9s fruit de la col\u00b7laboraci\u00f3 entre l\u2019Institut de Bioenginyeria de Catalunya i l\u2019Institut de Recerca de l\u2019Hospital del Mar. <\/strong><\/p>\n\n\n\n

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Alice Perucca (esquerra) i Xavier Trepat (dreta) als laboratoris de l’IBEC.<\/figcaption><\/figure>\n\n\n\n

Un equip liderat per l\u2019Institut de Bioenginyeria de Catalunya (IBEC) i l\u2019Institut de Recerca de l\u2019Hospital del Mar ha desenvolupat el MIRO (Micro Immune Response On chip<\/em>, les seves sigles en angl\u00e8s), un dispositiu \u00a0basat en microfluidica que permet replicar les caracter\u00edstiques dels tumors i del seu entorn a partir de c\u00e8l\u00b7lules de pacients. Es tracta d\u2019una eina que pot ajudar a agilitzar el desenvolupament de nous tractaments d\u2019immunoter\u00e0pia contra el c\u00e0ncer aix\u00ed com a seleccionar els m\u00e9s convenients per a cada persona. El treball s\u2019ha publicat a la revista Nature Communications<\/em>.<\/p>\n\n\n\n

\n

MIRO ens permet recrear no nom\u00e9s el tumor, sin\u00f3 el seu entorn i la interacci\u00f3 que tenen amb les c\u00e8l\u00b7lules del sistema immunitari. Aquesta relaci\u00f3 \u00e9s vital per a l\u2019\u00e8xit dels tractaments basats en la immunoter\u00e0pia<\/em>.<\/p>\n\n\n\n

Anne Labernadie<\/p>\n<\/blockquote>\n\n\n\n

El dispositiu MIRO permet omplir un buit en la creaci\u00f3 de tractaments contra les c\u00e8l\u00b7lules canceroses. Molts desenvolupaments ofereixen resultats prometedors al laboratori, in vitro<\/em> i en models de ratolins, per\u00f2 no funcionen tan b\u00e9 quan es traslladen als humans. \u201cMIRO ens permet recrear no nom\u00e9s el tumor, sin\u00f3 el seu entorn i la interacci\u00f3 que tenen amb les c\u00e8l\u00b7lules del sistema immunitari. Aquesta relaci\u00f3 \u00e9s vital per a l\u2019\u00e8xit dels tractaments basats en la immunoter\u00e0pia que, malgrat el seu potencial curatiu, actualment nom\u00e9s funcionen en entre el 20 i el 40% dels pacients\u201d<\/em><\/strong>, explica la Dra. Anna Labernadie, qui va dissenyar el sistema microflu\u00eddic durant la seva recerca postdoctoral a l\u2019IBEC i actualment lidera el laboratori de Comportament Cel\u00b7lular i Bioenginyeria de teixits al Centre de Recerca Pr\u00edncipe Felipe (CIPF) a Val\u00e8ncia.<\/p>\n\n\n\n

Els investigadors que han desenvolupat aquesta tecnologia ja l\u2019han provat amb mostres de c\u00e0ncer de mama conegudes com a HER2-positives. Aquest tipus de c\u00e8l\u00b7lules canceroses tenen nivells molt alts de la prote\u00efna HER2, que afavoreix el creixement r\u00e0pid del tumor, per\u00f2 que, alhora, es pot tractar amb ter\u00e0pies dirigides espec\u00edficament a aquesta prote\u00efna.<\/p>\n\n\n\n

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Placa de cultiu, cadascun dels pous cont\u00e9 un dispositiu MIRO.<\/figcaption><\/figure>\n\n\n\n
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Imatge representativa del dispositiu MIRO. Imatges confocals combinades que mostren l’organitzaci\u00f3 dels fibroblasts (verd), l’esferoide tumoral (vermell) i les c\u00e8l\u00b7lules immunit\u00e0ries (cian). Barra d’escala: 2 mm.<\/em><\/figcaption><\/figure>\n<\/figure>\n\n\n\n
<\/div>\n\n\n\n

Les proves realitzades han perm\u00e8s comprovar la import\u00e0ncia de l\u2019entorn que envolta els tumors de mama a l\u2019hora de protegir-lo del tractament m\u00e9s habitual en aquest tipus de c\u00e0ncer, l\u2019antic\u00f2s monoclonal trastuzumab. \u201cGr\u00e0cies a<\/em><\/strong> MIRO, hem pogut rastrejar les c\u00e8l\u00b7lules immunit\u00e0ries, veure com perden velocitat, moviment, en acostar-se al tumor, el que fa que el tractament no funcioni. Es troben una barrera formada per l\u2019entorn tumoral i queden bloquejades\u201d<\/em><\/strong>, explica el Dr. Alexandre Calon, responsable del Laboratori de Recerca Translacional en microambient tumoral de l\u2019Institut de Recerca de l\u2019Hospital del Mar.<\/p>\n\n\n\n

Avan\u00e7ar cap a un tractament personalitzat<\/strong><\/h4>\n\n\n\n

El dispositiu MIRO, que ja ha estat provat amb altres tipus de tumor s\u00f2lids, com ara tumors de pulm\u00f3 o colon, est\u00e0 fabricat amb t\u00e8cniques de microfluidica<\/strong>. Aquestes t\u00e8cniques permeten manipular fluids i c\u00e8l\u00b7lules a una escala molt petita. MIRO inclou cultius de c\u00e8l\u00b7lules de diferents tipus, separats en compartiments per tal de dirigir i observar la seva evoluci\u00f3. Aquest model, el primer del seu tipus creat amb aquestes t\u00e8cniques, permet recrear i estudiar amb detall la interacci\u00f3 entre les c\u00e8l\u00b7lules canceroses, el seu teixit connectiu i les respostes immunes. \u201cAquest model ens permet provar directament els tractaments que es farien servir amb els pacients\u201d<\/em><\/strong>, explica el Dr. Xavier Trepat, professor d\u2019investigaci\u00f3 ICREA a l\u2019IBEC, on lidera el grup de Din\u00e0mica integrativa de c\u00e8l\u00b7lules i teixits<\/a>, y membre de la Universitat de Barcelona UB).<\/p>\n\n\n\n

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Aquest model ens permet provar directament els tractaments que es farien servir amb els pacients<\/em>.<\/p>\n\n\n\n

Xavier Trepat<\/p>\n<\/blockquote>\n\n\n\n

La capacitat del dispositiu per analitzar el funcionament de diferents tractaments, l\u2019aparici\u00f3 de possibles resist\u00e8ncies i, fins i tot, identificar nous biomarcadors de manera individualitzada per a cada pacient, representa un gran aven\u00e7 en el disseny i  personalitzaci\u00f3 dels tractaments d\u2019immunoter\u00e0pia en oncologia.<\/p>\n\n\n\n

En aquest sentit, el Dr. Joan Albanell, cap del Servei d\u2019Oncologia M\u00e8dica de l\u2019Hospital del Mar i director del Programa de Recerca en C\u00e0ncer del seu institut de recerca, ha apuntat que \u201cMIRO \u00e9s un model precl\u00ednic innovador que pot ajudar a millorar la taxa d\u2019\u00e8xit i d\u2019efic\u00e0cia de noves estrat\u00e8gies amb immunoter\u00e0pia un cop les traslladem a assajos cl\u00ednics\u201d<\/em><\/strong>.<\/p>\n\n\n\n

Pel que fa a la feina futura, l\u2019IBEC, ICREA i l\u2019 Institut de Recerca de l\u2019Hospital del Mar ja han presentat una sol\u00b7licitud de patent conjunta per la tecnologia de MIRO. \u201cEl nostre objectiu es transferir aquesta tecnologia a la ind\u00fastria farmac\u00e8utica i hospitals per poder aplicar-la a pacients\u201d<\/em><\/strong>, explica la Dra. Anna Labernadie.<\/p>\n\n\n\n

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D’esquerra a dreta: Laura Comerma, Ann Sallent Aragay, Alexandre Calon, Alba Recort Bascuas, Jenniffer Linares i Joan Albanell, investigadors a l’Institut de Recerca de l’Hospital del Mar.<\/figcaption><\/figure>\n\n\n\n
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Xavier Trepat (esquerra) i Anna Labernadie (dreta) als laboratoris de l’IBEC.<\/figcaption><\/figure>\n<\/figure>\n\n\n\n
<\/div>\n\n\n\n

L’estudi descrit forma part de la tesi doctoral d’Alice Preucca a l’IBEC, el treball de la qual se centra a investigar el paper de l’ecosistema immunocompetent en la progressi\u00f3 del c\u00e0ncer.<\/p>\n\n\n\n

El treball ha comptat tamb\u00e9 amb la col\u00b7laboraci\u00f3 de l\u2019Institut de Recerca Biom\u00e8dica (IRB Barcelona), la Universitat de Barcelona (UB), el Centre de Recerca Biom\u00e8dica en Xarxa de Bioenginyeria, Biomaterials i Nanomedicina (CIBER-BBN), la Universitat Pompeu Fabra i el Centre de Recerca Biom\u00e8dica en Xarxa d\u2019Oncologia (CIBERONC -ISCIII); i ha rebut finan\u00e7ament parcial de la Fundaci\u00f3 \u201cla Caixa\u201d.<\/p>\n\n\n\n


V\u00eddeo on es mostra l’organitzaci\u00f3 dels fibroblasts (verd), l’esferoide tumoral (vermell) i les c\u00e8l\u00b7lules immunit\u00e0ries (cian). Comparativa d’una condici\u00f3 control (esquerra), amb condicions de tractament (dreta). En condicions de tractament s’observa com les c\u00e8l\u00b7lules immunit\u00e0ries (cian) s\u00f3n capaces de travessar els fibroblasts (verd) i arribar al tumor (vermell).<\/figcaption><\/figure>\n\n\n\n
\n\n\n\n

Article referenciat<\/strong><\/p>\n\n\n\n

Alice Perucca, Andrea G\u00f3mez Llonin, Oriol Ma\u00f1e Benach, Clement Hallopeau, Elisa I. Rivas, Jenniffer Linares, Marta Garrido, Anna Sallent-Aragay, Tom Golde, Julien Colombelli, Eleni Dalaka, Judith Linacero, Marina Cazorla, Teresa Galan, Jordi Pastor Viel, Xavier Badenas, Alba Recort-Bascuas, Laura Comerma, Patricia Fernandez-Nogueira, Ana Rovira, Pere Roca-Cusachs, Joan Albanell, Xavier Trepat, Alexandre Calon and Anna Labernadie. Micro Immune Response On-chip (MIRO) models the tumour-stroma interface for immunotherapy testing.<\/strong> Nature Communications<\/em> (2025). DOI: 10.1038\/s41467-025-56275-1<\/a><\/a><\/p>\n\n\n\n

\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

El Micro Immune Response On chip (MIRO) permet replicar els tumors i el seu entorn, per con\u00e8ixer la seva resposta als tractaments basats en inmunoter\u00e0pia. El dispositiu, que ja s\u2019ha provat amb \u00e8xit en mostres de c\u00e0ncer de mama, pot ser clau per desenvolupar nous tractaments i determinar quina \u00e9s la ter\u00e0pia m\u00e9s adequada per a cada pacient de manera personalitzada. El treball, publica Nature Communications, \u00e9s fruit de la col\u00b7laboraci\u00f3 entre l\u2019Institut de Bioenginyeria de Catalunya i l\u2019Institut de Recerca de l\u2019Hospital del Mar. <\/p>\n","protected":false},"author":37,"featured_media":123461,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1774,2064,1842,1840,1143],"post_formats":[],"class_list":["post-123486","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-cancer-ca","tag-cancer-de-mama","tag-integrative-cell-and-tissue-dynamics-ca","tag-organ-en-un-xip","tag-xavier-trepat-ca"],"yoast_head":"\nAquest dispositiu replica els tumors per estudiar tractaments amb immunoter\u00e0pia - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"description\" content=\"El Micro Immune Response On chip (MIRO) permet replicar els tumors i el seu entorn, 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