{"id":126073,"date":"2025-05-28T16:13:10","date_gmt":"2025-05-28T14:13:10","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/ibec-receives-funding-from-the-prestigious-human-frontier-science-program\/"},"modified":"2025-05-28T16:15:57","modified_gmt":"2025-05-28T14:15:57","slug":"ibec-receives-funding-from-the-prestigious-human-frontier-science-program","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/ibec-rep-financament-del-prestigios-human-frontier-science-program","title":{"rendered":"L’IBEC rep finan\u00e7ament del prestigi\u00f3s Human Frontier Science Program"},"content":{"rendered":"\n

L’Institut de Bioenginyeria de Catalunya participar\u00e0 com a soci en el projecte internacional SOLFEGE, que busca explorar com diferents tipus cel\u00b7lulars es coordinen a trav\u00e9s de factors solubles en el microambient tumoral. El projecte ser\u00e0 possible gr\u00e0cies al finan\u00e7ament del prestigi\u00f3s “Human Frontier Science Program”. SOLFEGE \u00e9s un consorci coordinat pel Centre Alemany d’Investigaci\u00f3 Oncol\u00f2gica (DKFZ), i compta tamb\u00e9 amb la participaci\u00f3 de la Universitat de Duke, als Estats Units.<\/strong><\/strong><\/p>\n\n\n\n

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<\/div>\n\n\n\n

L’Institut de Bioenginyeria de Catalunya (IBEC) participar\u00e0 com a soci en el projecte internacional SOLFEGE (acr\u00f2nim en angl\u00e8s de Soluble Factors and Cell Arrangements<\/em>) que t\u00e9 com a objectiu investigar com diferents tipus cel\u00b7lulars es coordinen mitjan\u00e7ant senyals secretats\u2014els anomenats factors solubles\u2014 en el microambient tumoral. Xavier Rovira Clav\u00e9, investigador principal del grup de Biotecnologia Espacial<\/a> de l’IBEC, liderar\u00e0 la participaci\u00f3 del centre en aquest ambici\u00f3s projecte.<\/p>\n\n\n\n

\n

\u00c9s un projecte ambici\u00f3s que ens pot contestar a preguntes fonamentals fins ara sense resposta sobre el c\u00e0ncer.<\/p>\n\n\n\n

Xavier Rovira Clav\u00e9<\/p>\n<\/blockquote>\n\n\n\n

SOLFEGE<\/a> ha estat finan\u00e7at pel Human Frontier Science Program (HFSP)<\/a>, un dels programes internacionals m\u00e9s prestigiosos i competitius de suport a la recerca. Aquest programa promou la col\u00b7laboraci\u00f3 interdisciplin\u00e0ria per explorar els complexos mecanismes dels organismes vius. El projecte est\u00e0 coordinat pel Centre Alemany de Recerca Oncol\u00f2gica (DKFZ) i compta amb la participaci\u00f3 de l’IBEC i de la Universitat de Duke, als Estats Units.<\/p>\n\n\n\n

“\u00c9s un projecte ambici\u00f3s que ens pot contestar a preguntes fonamentals fins ara sense resposta sobre el c\u00e0ncer”, comenta Xavier Rovira. \u201cGr\u00e0cies al suport de l’HFSP, durant els pr\u00f2xims tres anys treballarem al costat del grup de John Hickey a la Universitat de Duke i al grup de Franzi Blaeschke al DKFZ per explorar com es coordinen diferents tipus cel\u00b7lulars a trav\u00e9s de factors solubles dins del context del microambient tumoral.”<\/p>\n\n\n\n

Des de l’IBEC es valora especialment el reconeixement que suposa rebre aquest finan\u00e7ament internacional tan selectiu, ja que l’HFSP es tracta d’un programa molt prestigi\u00f3s i competitiu.<\/p>\n\n\n\n

Coordinaci\u00f3 cel\u00b7lular mitjan\u00e7ant factors solubles<\/strong><\/h4>\n\n\n\n

En el nostre organisme, les c\u00e8l\u00b7lules s’autoorganitzen per formar teixits i \u00f2rgans que permeten la vida. Aquest proc\u00e9s est\u00e0 guiat per factors solubles, com les citocines, quimiocines i factors de creixement, que ajuden les c\u00e8l\u00b7lules a saber qu\u00e8 fer i on ubicar-se. Tot i que a vegades un d’aquests factors pot induir una acci\u00f3 concreta en una c\u00e8l\u00b7lula, la majoria de les funcions biol\u00f2giques i malalties resulten de combinacions complexes d’aquests factors que interactuen entre si, moltes vegades de formes que encara no es comprenen del tot.<\/p>\n\n\n\n

El projecte SOLFEGE t\u00e9 com a objectiu desentranyar com actuen aquestes xarxes de senyals en conjunt, especialment en entorns tumorals. Per aconseguir-ho, els investigadors desenvoluparan noves eines experimentals, com codis de barres cel\u00b7lulars, part\u00edcules alliberadores de factors solubles i models computacionals, que permetran observar com els factors solubles influeixen en l’organitzaci\u00f3 de les c\u00e8l\u00b7lules immunit\u00e0ries i canceroses.<\/p>\n\n\n\n

Concretament, estudiaran com s’organitzen les c\u00e8l\u00b7lules immunit\u00e0ries en organoides tumorals de melanoma exposats a factors solubles espec\u00edfics; com actuen part\u00edcules dissenyades per alliberar aquests factors; i com els senyals emesos per c\u00e8l\u00b7lules T especialitzades coordinen els processos cel\u00b7lulars en el microambient tumoral.<\/p>\n\n\n\n

Gr\u00e0cies a la seva experi\u00e8ncia en t\u00e8cniques d’imatge avan\u00e7ada, an\u00e0lisi espacial, biomaterials i modelitzaci\u00f3, l’equip de l’IBEC contribuir\u00e0 a avan\u00e7ar en la comprensi\u00f3 de l’organitzaci\u00f3 cel\u00b7lular i del seu impacte en el desenvolupament de noves ter\u00e0pies enfront del c\u00e0ncer.<\/p>\n\n\n\n

Aquest projecte ha estat finan\u00e7at per Human Frontier Science Program amb una \"Research Grant \u2013 Early Career\" (RGEC26\/2025).<\/pre>\n\n\n\n
\"\"<\/figure>\n","protected":false},"excerpt":{"rendered":"
L’Institut de Bioenginyeria de Catalunya participar\u00e0 com a soci en el projecte internacional SOLFEGE, que busca explorar com diferents tipus cel\u00b7lulars es coordinen a trav\u00e9s de factors solubles en el microambient tumoral. El projecte ser\u00e0 possible gr\u00e0cies al finan\u00e7ament del prestigi\u00f3s “Human Frontier Science Program”. SOLFEGE \u00e9s un consorci coordinat pel Centre Alemany d’Investigaci\u00f3 Oncol\u00f2gica (DKFZ), i compta tamb\u00e9 amb la participaci\u00f3 de la Universitat de Duke, als Estats Units.<\/p>\n","protected":false},"author":37,"featured_media":126070,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[98],"tags":[1774,2134,2038,2095,2082],"post_formats":[],"class_list":["post-126073","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-institucionals","tag-cancer-ca","tag-eu-project-ca","tag-european-projects-ca","tag-spatial-biotechnology-ca","tag-xavier-rovira-ca"],"yoast_head":"\nL'IBEC rep finan\u00e7ament del prestigi\u00f3s Human Frontier Science Program - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/ibec-rep-financament-del-prestigios-human-frontier-science-program\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"L'IBEC rep finan\u00e7ament del prestigi\u00f3s Human Frontier Science Program - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"L'Institut de Bioenginyeria de Catalunya participar\u00e0 com a soci en el projecte internacional SOLFEGE, que busca explorar com diferents tipus cel\u00b7lulars es coordinen a trav\u00e9s de factors solubles en el microambient tumoral. 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