{"id":126178,"date":"2025-06-05T12:21:54","date_gmt":"2025-06-05T10:21:54","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/new-technology-for-mass-serological-analysis\/"},"modified":"2025-06-05T12:27:05","modified_gmt":"2025-06-05T10:27:05","slug":"new-technology-for-mass-serological-analysis","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/nova-tecnologia-per-a-analisi-serologica-massiva","title":{"rendered":"Nova tecnologia per a l’an\u00e0lisi serol\u00f2gica massiva"},"content":{"rendered":"\n

Un estudi de la Universitat de Stanford i l’Institut de Bioenginyeria de Catalunya descriu el desenvolupament d’una innovadora tecnologia que permet analitzar de forma massiva la pres\u00e8ncia d’anticossos en mostres biol\u00f2giques. Gr\u00e0cies a l’\u00fas de part\u00edcules microsc\u00f2piques marcades amb is\u00f2tops estables, aquest aven\u00e7 supera les t\u00e8cniques tradicionals, accelerant l’estudi de respostes immunit\u00e0ries i obrint noves possibilitats per a la recerca biom\u00e8dica.<\/strong><\/p>\n\n\n\n

\"\"
Xavier Rovira-Clav\u00e9 als laboratoris de l’IBEC.<\/figcaption><\/figure>\n\n\n\n

Els m\u00e8todes actuals per detectar anticossos, com els assajos serol\u00f2gics convencionals, tenen limitacions quant a la quantitat d’informaci\u00f3 que poden processar en una sola prova. Tot i que t\u00e8cniques m\u00e9s recents han perm\u00e8s ampliar el nombre de mesuraments simultanis, continuen enfrontant restriccions a causa d’interfer\u00e8ncies en els senyals de detecci\u00f3. La nova tecnologia desenvolupada per la Universitat de Stanford i l’Institut de Bioenginyeria de Catalunya (IBEC) supera aquestes barreres mitjan\u00e7ant l’\u00fas de part\u00edcules de poliestir\u00e8 marcades amb combinacions \u00faniques d’is\u00f2tops estables- no radioactius-, que poden ser identificades de manera precisa mitjan\u00e7ant espectrometria de masses, una t\u00e8cnica \u00e0mpliament utilitzada en recerca biom\u00e8dica per analitzar la composici\u00f3 qu\u00edmica d’una mostra.<\/p>\n\n\n\n

\n

Hem aconseguit ampliar enormement la capacitat d’an\u00e0lisi serol\u00f2gica, cosa que permet detectar de manera simult\u00e0nia la pres\u00e8ncia de desenes d’anticossos diferents en centenars de mostres. Aix\u00f2 es pot traduir en una eina clau per a la recerca biom\u00e8dica, el desenvolupament de vacunes i els estudis epidemiol\u00f2gics.<\/p>\n\n\n\n

Xavier Rovira<\/p>\n<\/blockquote>\n\n\n\n

“Hem aconseguit ampliar enormement la capacitat d’an\u00e0lisi serol\u00f2gica, cosa que permet detectar de manera simult\u00e0nia la pres\u00e8ncia de desenes d’anticossos diferents en centenars de mostres. Aix\u00f2 es pot traduir en una eina clau per a la recerca biom\u00e8dica, el desenvolupament de vacunes i els estudis epidemiol\u00f2gics”, explica Xavier Rovira Clav\u00e9, l\u00edder de l’estudi, investigador principal de l’IBEC i pr\u00e8viament investigador a la Universitat de Stanford.<\/p>\n\n\n\n

La clau d’aquesta tecnologia \u00e9s que permet analitzar molts m\u00e9s par\u00e0metres alhora, una cosa que abans no era possible. “En lloc de dependre de senyals fluorescents, que poden superposar-se entre si i limiten el nombre de mesuraments simultanis a un m\u00e0xim de 500, utilitzem is\u00f2tops, la qual cosa elimina aquest problema permetent la detecci\u00f3 simult\u00e0nia de m\u00e9s de 18.000 mesuraments en una sola reacci\u00f3, i amb un horitz\u00f3 molt ampli de millora”, afegeix Rovira.<\/p>\n\n\n\n

En les proves realitzades, l’equip va aplicar aquesta metodologia per analitzar mostres serol\u00f2giques de pacients amb COVID-19, mesurant la pres\u00e8ncia d’anticossos contra diverses variants del virus SARS-CoV-2. La capacitat d’avaluar simult\u00e0niament milers de mostres amb diferents variants v\u00edriques podria millorar la resposta davant futures pand\u00e8mies i la investigaci\u00f3 sobre immunitat adquirida. A m\u00e9s, la versatilitat d’aquesta t\u00e8cnica obre noves possibilitats en l’estudi de malalties autoimmunes i altres patologies. “Poder analitzar un gran nombre de dades immunol\u00f2giques en paral\u00b7lel ens podria permetre identificar biomarcadors per a diferents tipus de patologies, millorant el diagn\u00f2stic i el desenvolupament de noves ter\u00e0pies”, apunta Rovira.<\/p>\n\n\n\n

Aquest treball representa un important pas endavant en la recerca biom\u00e8dica i la salut p\u00fablica, en proporcionar una eina m\u00e9s eficient per a l’an\u00e0lisi d’anticossos i la detecci\u00f3 de respostes immunit\u00e0ries. Els professors Julien Sage i Garry Nolan de Stanford, el professor David McIlwain de la Universitat de Nevada a Reno, l’investigador Alexandros Drainas i Xavier Rovira a l’IBEC continuen millorant l’efici\u00e8ncia de la t\u00e8cnica i reduint el cost de les proves perqu\u00e8, en un futur, puguin arribar m\u00e9s f\u00e0cilment a la pr\u00e0ctica cl\u00ednica.<\/p>\n\n\n\n

\n\n\n\n

Article de refer\u00e8ncia:<\/strong><\/p>\n\n\n\n

Alexandros P. Drainas, David R. McIlwain, Alec Dallas, Theresa Chu, Antonio Delgado-Gonz\u00e1lez, Maya Baron, Maria Angulo-Ib\u00e1\u00f1ez, Angelica Trejo, Yunhao Bai, John W. Hickey, Guolan Lu, Scott Lu, Jesus Pineda-Ramirez, Khamal Anglin, Eugene T. Richardson, John C. Prostko, Edwin Frias, Venice Servellita, Noah Brazer, Charles Y. Chiu, Michael J. Peluso, Jeffrey N. Martin, Oliver F. Wirz, Tho D. Pham, Scott D. Boyd, J. Daniel Kelly, Julien Sage, <\/ins>Garry P. Nolan & Xavier Rovira-Clav\u00e9. High-throughput multiplexed serology via the mass-spectrometric analysis of isotopically barcoded beads<\/strong>. Nature Biomedical Engineering<\/em> (2025). DOI: 10.1038\/s41551-025-01349-0<\/a><\/p>\n\n\n\n

\n","protected":false},"excerpt":{"rendered":"

Un estudi de la Universitat de Stanford i l’Institut de Bioenginyeria de Catalunya descriu el desenvolupament d’una innovadora tecnologia que permet analitzar de forma massiva la pres\u00e8ncia d’anticossos en mostres biol\u00f2giques. Gr\u00e0cies a l’\u00fas de part\u00edcules microsc\u00f2piques marcades amb is\u00f2tops estables, aquest aven\u00e7 supera les t\u00e8cniques tradicionals, accelerant l’estudi de respostes immunit\u00e0ries i obrint noves possibilitats per a la recerca biom\u00e8dica.<\/p>\n","protected":false},"author":37,"featured_media":126174,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[923,2095,2082],"post_formats":[],"class_list":["post-126178","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-covid-ca","tag-spatial-biotechnology-ca","tag-xavier-rovira-ca"],"yoast_head":"\nNova tecnologia per a l'an\u00e0lisi serol\u00f2gica massiva - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/nova-tecnologia-per-a-analisi-serologica-massiva\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nova tecnologia per a l'an\u00e0lisi serol\u00f2gica massiva - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Un estudi de la Universitat de Stanford i l'Institut de Bioenginyeria de Catalunya descriu el desenvolupament d'una innovadora tecnologia que permet analitzar de forma massiva la pres\u00e8ncia d'anticossos en mostres biol\u00f2giques. 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