{"id":127384,"date":"2025-07-14T12:02:00","date_gmt":"2025-07-14T10:02:00","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=127384"},"modified":"2025-07-10T15:13:01","modified_gmt":"2025-07-10T13:13:01","slug":"two-ibec-projects-receive-erc-funding-to-advance-bioinks-for-3d-printing-and-cancer-therapies","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/dos-projectes-de-ibec-reben-financament-erc-per-avancar-en-biotintes-per-a-impressio-3d-i-terapies-contra-el-cancer","title":{"rendered":"Dos projectes de l’IBEC reben finan\u00e7ament ERC per avan\u00e7ar en biotintes per a impressi\u00f3 3D i ter\u00e0pies contra el c\u00e0ncer"},"content":{"rendered":"\n

Manuel Salmeron i Xavier Rovira, ambd\u00f3s investigadors principals de l’IBEC, han obtingut sengles “ERC Proof of Concept Grant”. Es tracta d’ un prestigi\u00f3s finan\u00e7ament que concedeix el Consell Europeu de Recerca per explorar el potencial comercial i social de projectes de recerca duts a terme en institucions europees. El projecte de Salmeron, FACTORINK, s’enfoca en el disseny de biotintes funcionals amb activitat biol\u00f2gica per a la impressi\u00f3 de teixits artificials. Per la seva banda, el de Rovira, busca desenvolupar la plataforma EVOaware, dissenyada per abordar la resist\u00e8ncia dels tumors a les ter\u00e0pies i accelerar el descobriment i desenvolupament de nous tractaments contra el c\u00e0ncer.<\/strong><\/p>\n\n\n\n

\"\"
Manuel Salmeron (esquerra) and Xavier Rovira (dreta).<\/figcaption><\/figure>\n\n\n\n

Manuel Salmeron, professor de recerca ICREA a l’IBEC i investigador principal del grup de Microambients per a Medicina<\/a>, i Xavier Rovira, investigador principal del grup de Biotecnologia Espacial de<\/a> l’IBEC, han estat guardonats amb una “ERC Proof of Concept Grant” cadascun. Es tracta d’una prestigiosa subvenci\u00f3 que concedeix el Consell Europeu de Recerca (ERC, per les seves sigles en angl\u00e8s) i t\u00e9 com a objectiu explorar el potencial comercial i social de projectes de recerca que estan o han estat finan\u00e7ats pr\u00e8viament per l’ERC. Els i les sol\u00b7licitants utilitzen aquest tipus de finan\u00e7ament per verificar la viabilitat de conceptes cient\u00edfics, explorar oportunitats de negoci o preparar sol\u00b7licituds de patents.<\/p>\n\n\n\n

FACTORINK: Noves biotintes per a la impressi\u00f3 de teixits artificials<\/strong><\/h4>\n\n\n\n

El projecte de Manuel Salmeron, anomenat FACTORINK, se centra en la fabricaci\u00f3 de biotintes amb funcionalitat biol\u00f2gica per a la impressi\u00f3 de teixits in vitro<\/em>. Les biotintes s\u00f3n materials basats en hidrogels que contenen c\u00e8l\u00b7lules vives i altres biomaterials, com prote\u00efnes. S’utilitzen en bioimpressi\u00f3 3D, per\u00f2 perqu\u00e8 aquesta t\u00e8cnica funcioni correctament, les biotintes han de ser biocompatibles i recrear un entorn que permeti a les c\u00e8l\u00b7lules sobreviure i comportar-se com ho farien en el cos hum\u00e0. Aix\u00f2 \u00e9s fonamental per fabricar models de teixits in vitro<\/em> que resultin \u00fatils en recerca biom\u00e8dica i en el desenvolupament de f\u00e0rmacs. Per a aix\u00f2, les biotintes han d’imitar la matriu extracel\u00b7lular, oferint propietats mec\u00e0niques i senyals bioqu\u00edmics ben definits, com una rigidesa controlada i la pres\u00e8ncia de prote\u00efnes d’adhesi\u00f3 i factors de creixement. No obstant aix\u00f2, les biotintes comercials actuals s\u00f3n limitades, ja que no retenen efica\u00e7ment els factors de creixement, que es dispersen r\u00e0pidament despr\u00e9s de la impressi\u00f3.<\/p>\n\n\n\n

\n

Aquest finan\u00e7ament \u00e9s una gran oportunitat que ens permetr\u00e0 continuar desenvolupant aquestes biotintes en aplicacions m\u00e9s sofisticades, incloent-hi models multicel\u00b7lulars que incorporen el sistema immunitari.<\/p>\n\n\n\n

Manuel Salmeron<\/p>\n<\/blockquote>\n\n\n\n

En aquest context, els investigadors de l’IBEC han dissenyat una nova classe de biotintes que incorporen prote\u00efnes de la matriu extracel\u00b7lular, cosa que conserva la seva funci\u00f3 biol\u00f2gica i els permet actuar com a dip\u00f2sit de factors de creixement.<\/p>\n\n\n\n

“Hem demostrat el potencial d’aquesta tecnologia utilitzant models cel\u00b7lulars simples.  Aquest finan\u00e7ament \u00e9s una gran oportunitat que ens permetr\u00e0 continuar desenvolupant aquestes biotintes en aplicacions m\u00e9s sofisticades, incloent-hi models multicel\u00b7lulars que incorporen el sistema immunitari. Els resultats permetran consolidar la tecnologia i obrir oportunitats de comercialitzaci\u00f3”, detalla Salmeron.<\/p>\n\n\n\n

Amb el projecte FACTORINK, l’equip de l’IBEC busca desencadenar el potencial de les biotintes demostrant la seva capacitat per contenir models multif\u00e0sics que inclouen c\u00e8l\u00b7lules mare, c\u00e8l\u00b7lules endotelials i el sistema immunitari. S’espera que les dades recopilades a trav\u00e9s d’aquest projecte ajudin a definir la ruta comercial dels productes, conduint a la creaci\u00f3 de noves propietats intel\u00b7lectuals.<\/p>\n\n\n\n

EVOaware: Entendre l’evoluci\u00f3 dels tumors per v\u00e8ncer el c\u00e0ncer<\/strong><\/h4>\n\n\n\n

El projecte EVOaware, liderat per Xavier Rovira, t\u00e9 com a objectiu desenvolupar una plataforma innovadora per abordar un dels principals reptes en el tractament del c\u00e0ncer, la resist\u00e8ncia a les ter\u00e0pies- des d’una perspectiva evolutiva dels tumors.<\/p>\n\n\n\n

En molts casos, els tumors s\u00f2lids acaben desenvolupant resist\u00e8ncia als tractaments, cosa que provoca que aquests deixin de ser efectius. Aquesta resist\u00e8ncia no \u00e9s aleat\u00f2ria: sorgeix de la complexa interacci\u00f3 entre diferents tipus de c\u00e8l\u00b7lules canceroses i el seu entorn, cosa que impulsa el tumor a adaptar-se i evolucionar. Les estrat\u00e8gies actuals de descobriment de f\u00e0rmacs no aconsegueixen abordar adequadament aquesta complexitat.<\/p>\n\n\n\n

Per fer front a aquest desafiament, EVOaware proposa una plataforma basada en tecnologies d’imatge avan\u00e7ada per a teixits capa\u00e7 d’anticipar com evolucionen els tumors i com podrien tornar-se resistents, tant a ter\u00e0pies ja conegudes com a tractaments experimentals.<\/p>\n\n\n\n

\n

Estem molt il\u00b7lusionats amb aquest projecte. Amb les dades que obtinguem, esperem demostrar el potencial de la nostra plataforma i posicionar-nos estrat\u00e8gicament per portar la nostra tecnologia al mercat.<\/p>\n\n\n\n

Xavier Rovira<\/p>\n<\/blockquote>\n\n\n\n

Es tracta d’una soluci\u00f3 pionera que integra diverses tecnologies capdavanteres: cribratges gen\u00e8tics i rastreig de llinatges per analitzar la diversitat cel\u00b7lular dins del tumor, codificaci\u00f3 espacial en organoides per identificar amb precisi\u00f3 l’efecte dels f\u00e0rmacs, t\u00e8cniques d’\u00f2mica espacial per seguir els canvis moleculars en el seu context, i, en el futur, models d’IA multimodals que simulen el microambient tumoral i prediuen la seva evoluci\u00f3.<\/p>\n\n\n\n

“Estem molt il\u00b7lusionats amb aquest projecte. Amb les dades que obtinguem, esperem demostrar el potencial de la nostra plataforma i posicionar-nos estrat\u00e8gicament per portar la nostra tecnologia al mercat”, explica Rovira.<\/p>\n\n\n\n

En \u00faltima inst\u00e0ncia, aquesta innovadora plataforma, busca accelerar el descobriment i desenvolupament de noves ter\u00e0pies contra el c\u00e0ncer, millorant el pron\u00f2stic dels i les pacients.<\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Manuel Salmeron i Xavier Rovira, ambd\u00f3s investigadors principals de l’IBEC, han obtingut sengles “ERC Proof of Concept Grant”. Es tracta d’ un prestigi\u00f3s finan\u00e7ament que concedeix el Consell Europeu de Recerca per explorar el potencial comercial i social de projectes de recerca duts a terme en institucions europees. El projecte de Salmeron, FACTORINK, s’enfoca en el disseny de biotintes funcionals amb activitat biol\u00f2gica per a la impressi\u00f3 de teixits artificials. Per la seva banda, el de Rovira, busca desenvolupar la plataforma EVOaware, dissenyada per abordar la resist\u00e8ncia dels tumors a les ter\u00e0pies i accelerar el descobriment i desenvolupament de nous tractaments contra el c\u00e0ncer.<\/p>\n","protected":false},"author":37,"featured_media":127375,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[98],"tags":[1767,1774,2061,1412,2085,2098,823,2095,2082],"post_formats":[],"class_list":["post-127384","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-institucionals","tag-bioimpressio-3d-ca","tag-cancer-ca","tag-erc-ca","tag-erc-grant-ca","tag-manuel-salmeron-ca","tag-microenvironments-for-medicine-ca","tag-proof-of-concept-ca","tag-spatial-biotechnology-ca","tag-xavier-rovira-ca"],"yoast_head":"\nDos projectes de l'IBEC reben finan\u00e7ament ERC per avan\u00e7ar en biotintes per a impressi\u00f3 3D i ter\u00e0pies contra el c\u00e0ncer - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/dos-projectes-de-ibec-reben-financament-erc-per-avancar-en-biotintes-per-a-impressio-3d-i-terapies-contra-el-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Dos projectes de l'IBEC reben finan\u00e7ament ERC per avan\u00e7ar en biotintes per a impressi\u00f3 3D i ter\u00e0pies contra el c\u00e0ncer - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Manuel Salmeron i Xavier Rovira, ambd\u00f3s investigadors principals de l'IBEC, han obtingut sengles "ERC Proof of Concept Grant". 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