{"id":128282,"date":"2025-09-04T14:39:36","date_gmt":"2025-09-04T12:39:36","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/chemtubio-a-new-erc-project-at-ibec-to-study-enzymes-with-therapeutic-potential\/"},"modified":"2025-09-04T14:56:07","modified_gmt":"2025-09-04T12:56:07","slug":"chemtubio-a-new-erc-project-at-ibec-to-study-enzymes-with-therapeutic-potential","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/chemtubio-un-nou-projecte-erc-a-ibec-per-estudiar-enzims-amb-potencial-terapeutic","title":{"rendered":"CHEMTUBIO, un nou projecte ERC a l&#8217;IBEC per estudiar enzims amb potencial terap\u00e8utic"},"content":{"rendered":"\n<p><strong>Carlos Moreno Yruela, actualment investigador a l&#8217;Escola Polit\u00e8cnica Federal de Lausana (Su\u00efssa), ha estat seleccionat en la convocat\u00f2ria &#8220;Starting Grant&#8221; del Consell Europeu de Recerca (ERC) per desenvolupar el seu projecte \u00abCHEMTUBIO\u00bb a l&#8217;Institut de Bioenginyeria de Catalunya (IBEC). Aquest projecte t\u00e9 com a objectiu l&#8217;estudi qu\u00edmic dels enzims esborradors de modificacions de microt\u00fabuls. Es tracta d&#8217;un tipus d&#8217;enzims fonamentals per al funcionament de les nostres c\u00e8l\u00b7lules que han mostrat un prometedor potencial com a dianes terap\u00e8utiques per al tractament del c\u00e0ncer, aix\u00ed com de malalties card\u00edaques i neuronals.<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"819\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/09\/CMY3-Editada-1024x819.png\" alt=\"\" class=\"wp-image-128278 lazyload\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/09\/CMY3-Editada-1024x819.png 1024w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/09\/CMY3-Editada-300x240.png 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/09\/CMY3-Editada-768x614.png 768w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/09\/CMY3-Editada-1536x1229.png 1536w\" data-sizes=\"(max-width: 1024px) 100vw, 1024px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 1024px; --smush-placeholder-aspect-ratio: 1024\/819;\" \/><\/figure>\n\n\n\n<p>Hi ha un tipus d&#8217;enzims poc coneguts per\u00f2 fonamentals per al funcionament de les nostres c\u00e8l\u00b7lules: les anomenats &#8220;esborradors&#8221; de modificacions qu\u00edmiques en prote\u00efnes. Aquests enzims regulen processos essencials de la vida cel\u00b7lular i alguns ja serveixen de diana terap\u00e8utica de f\u00e0rmacs utilitzats contra el c\u00e0ncer. No obstant aix\u00f2, encara n&#8217;hi ha moltes altres de les quals amb prou feines es coneix informaci\u00f3, en part perqu\u00e8 resulten molt dif\u00edcils d&#8217;analitzar amb les t\u00e8cniques convencionals.<\/p>\n\n\n\n<p>El projecte CHEMTUBIO, que liderar\u00e0 Carlos Moreno Yruela a l&#8217;Institut de Bioenginyeria de Catalunya (IBEC), busca superar aquesta limitaci\u00f3 mitjan\u00e7ant una estrat\u00e8gia innovadora que permet observar l&#8217;activitat d&#8217;aquests enzims directament sobre prote\u00efnes completes, i no nom\u00e9s en fragments artificials com es fa habitualment. Aquesta aproximaci\u00f3 no nom\u00e9s facilitar\u00e0 el desenvolupament de nous medicaments, sin\u00f3 que tamb\u00e9 permetr\u00e0 cartografiar l&#8217;acci\u00f3 dels enzims dins de les c\u00e8l\u00b7lules vives.<\/p>\n\n\n\n<p>En particular, el projecte se centra en els enzims que actuen sobre la prote\u00efna tubulina, que forma els microt\u00fabuls, un component clau de l&#8217;esquelet cel\u00b7lular. Aquests enzims actuen generant patrons qu\u00edmics i se sap que inhibir la seva acci\u00f3 podria resultar \u00fatil per tractar malalties card\u00edaques i neuronals. No obstant aix\u00f2, els mecanismes d&#8217;acci\u00f3 d&#8217;aquests enzims s\u00f3n encara desconeguts a causa de la falta de m\u00e8todes adequats per estudiar-los. En aquest context, el projecte CHEMTUBIO pret\u00e9n crear sondes i sensors qu\u00edmics per desxifrar aquests processos i obrir noves vies terap\u00e8utiques.<\/p>\n\n\n\n<p>A m\u00e9s, Moreno i el seu equip desenvoluparan t\u00e8cniques pioneres per estudiar modificacions que ocorren a l&#8217;interior dels microt\u00fabuls. Comprendre aquests mecanismes podria impulsar aven\u00e7os en el tractament de malalties neuromusculars i en la lluita contra el c\u00e0ncer.<\/p>\n\n\n\n<p>La &#8220;Starting Grant&#8221; de l&#8217;ERC (Consell Europeu de Recerca) \u00e9s una prestigiosa subvenci\u00f3 destinada a investigadors joves i talentosos en les primeres etapes de les seves carreres cient\u00edfiques independents. Est\u00e0 dissenyada per finan\u00e7ar projectes de recerca innovadors i ambiciosos que abordin preguntes cient\u00edfiques d&#8217;avantguarda. Els beneficiaris reben fons significatius per establir els seus propis grups de recerca i dur a terme investigacions d&#8217;alt nivell durant un per\u00edode de fins a cinc anys. Aquesta subvenci\u00f3 s&#8217;atorga en funci\u00f3 de l&#8217;excel\u00b7l\u00e8ncia cient\u00edfica i l&#8217;originalitat del projecte proposat i \u00e9s altament competitiva en l&#8217;\u00e0mbit europeu.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Carlos Moreno Yruela, actualment investigador a l&#8217;Escola Polit\u00e8cnica Federal de Lausana (Su\u00efssa), ha estat seleccionat en la convocat\u00f2ria &#8220;Starting Grant&#8221; del Consell Europeu de Recerca (ERC) per desenvolupar el seu projecte \u00abCHEMTUBIO\u00bb a l&#8217;Institut de Bioenginyeria de Catalunya (IBEC). Aquest projecte t\u00e9 com a objectiu l&#8217;estudi qu\u00edmic dels enzims esborradors de modificacions de microt\u00fabuls. Es tracta d&#8217;un tipus d&#8217;enzims fonamentals per al funcionament de les nostres c\u00e8l\u00b7lules que han mostrat un prometedor potencial com a dianes terap\u00e8utiques per al tractament del c\u00e0ncer, aix\u00ed com de malalties card\u00edaques i neuronals.<\/p>\n","protected":false},"author":37,"featured_media":128279,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[98],"tags":[2061,1412],"post_formats":[],"class_list":["post-128282","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-institucionals","tag-erc-ca","tag-erc-grant-ca"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>CHEMTUBIO, un nou projecte ERC a l&#039;IBEC per estudiar enzims amb potencial terap\u00e8utic - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/chemtubio-un-nou-projecte-erc-a-ibec-per-estudiar-enzims-amb-potencial-terapeutic\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"CHEMTUBIO, un nou projecte ERC a l&#039;IBEC per estudiar enzims amb potencial terap\u00e8utic - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Carlos Moreno Yruela, actualment investigador a l&#039;Escola Polit\u00e8cnica Federal de Lausana (Su\u00efssa), ha estat seleccionat en la convocat\u00f2ria &quot;Starting Grant&quot; del Consell Europeu de Recerca (ERC) per desenvolupar el seu projecte \u00abCHEMTUBIO\u00bb a l&#039;Institut de Bioenginyeria de Catalunya (IBEC). Aquest projecte t\u00e9 com a objectiu l&#039;estudi qu\u00edmic dels enzims esborradors de modificacions de microt\u00fabuls. Es tracta d&#039;un tipus d&#039;enzims fonamentals per al funcionament de les nostres c\u00e8l\u00b7lules que han mostrat un prometedor potencial com a dianes terap\u00e8utiques per al tractament del c\u00e0ncer, aix\u00ed com de malalties card\u00edaques i neuronals.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/ca\/chemtubio-un-nou-projecte-erc-a-ibec-per-estudiar-enzims-amb-potencial-terapeutic\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2025-09-04T12:39:36+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-09-04T12:56:07+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/09\/CMY3-Editada.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1\" \/>\n\t<meta property=\"og:image:height\" content=\"1\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Sarah Moreira\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrit per\" \/>\n\t<meta name=\"twitter:data1\" content=\"Sarah Moreira\" \/>\n\t<meta name=\"twitter:label2\" content=\"Temps estimat de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minuts\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/chemtubio-un-nou-projecte-erc-a-ibec-per-estudiar-enzims-amb-potencial-terapeutic\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/chemtubio-un-nou-projecte-erc-a-ibec-per-estudiar-enzims-amb-potencial-terapeutic\\\/\"},\"author\":{\"name\":\"Sarah Moreira\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/d3a158b8d448000777023ca1e3d71d34\"},\"headline\":\"CHEMTUBIO, un nou projecte ERC a l&#8217;IBEC per estudiar enzims amb potencial terap\u00e8utic\",\"datePublished\":\"2025-09-04T12:39:36+00:00\",\"dateModified\":\"2025-09-04T12:56:07+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/chemtubio-un-nou-projecte-erc-a-ibec-per-estudiar-enzims-amb-potencial-terapeutic\\\/\"},\"wordCount\":513,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/chemtubio-un-nou-projecte-erc-a-ibec-per-estudiar-enzims-amb-potencial-terapeutic\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2025\\\/09\\\/CMY3-Editada.png\",\"keywords\":[\"ERC\",\"ERC Grant\"],\"articleSection\":[\"Not\u00edcies institucionals\"],\"inLanguage\":\"ca\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/chemtubio-un-nou-projecte-erc-a-ibec-per-estudiar-enzims-amb-potencial-terapeutic\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/chemtubio-un-nou-projecte-erc-a-ibec-per-estudiar-enzims-amb-potencial-terapeutic\\\/\",\"name\":\"CHEMTUBIO, un nou projecte ERC a l'IBEC per estudiar enzims amb potencial terap\u00e8utic - 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