{"id":128477,"date":"2025-09-25T14:41:47","date_gmt":"2025-09-25T12:41:47","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/high-fat-diets-alter-genes-differently-in-males-and-females\/"},"modified":"2025-09-25T15:39:18","modified_gmt":"2025-09-25T13:39:18","slug":"high-fat-diets-alter-genes-differently-in-males-and-females","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/les-dietes-riques-en-greix-alteren-de-forma-diferent-els-gens-en-mascles-i-femelles","title":{"rendered":"Les dietes riques en greix alteren de forma diferent els gens en mascles i femelles"},"content":{"rendered":"\n<p><strong>Un estudi liderat per l&#8217;\u00e0rea de Diabetis i Malalties Metab\u00f2liques Associades del CIBER (CIBERDEM) en col\u00b7laboraci\u00f3 amb l&#8217;institut de Bioenginyeria de Catalunya (IBEC) ha demostrat que les dietes riques en greixos modifiquen, de manera distinta en funci\u00f3 del sexe, l&#8217;expressi\u00f3 de gens en teixits clau per al control metab\u00f2lic. Aquests resultats aporten una nova perspectiva sobre com l&#8217;obesitat impacta de manera distinta en funci\u00f3 del sexe.<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/09\/joan-marc-1024x683.jpg\" alt=\"\" class=\"wp-image-128472 lazyload\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/09\/joan-marc-1024x683.jpg 1024w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/09\/joan-marc-300x200.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/09\/joan-marc-768x512.jpg 768w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/09\/joan-marc-1536x1024.jpg 1536w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/09\/joan-marc-2048x1365.jpg 2048w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/09\/joan-marc-1200x800.jpg 1200w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/09\/joan-marc-600x400.jpg 600w\" data-sizes=\"(max-width: 1024px) 100vw, 1024px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 1024px; --smush-placeholder-aspect-ratio: 1024\/683;\" \/><figcaption class=\"wp-element-caption\">Equip del CIBERDEM<\/figcaption><\/figure>\n\n\n\n<p>Diversos grups de l&#8217;\u00e0rea de Diabetis i Malalties Metab\u00f2liques Associades del CIBER (CIBERDEM) han demostrat, en models murins, que les dietes riques en greixos modifiquen, de manera profunda i de forma diferent en funci\u00f3 del sexe, l&#8217;expressi\u00f3 de gens en teixits clau per al control metab\u00f2lic, sent els gens que normalment marquen difer\u00e8ncies entre sexes els m\u00e9s sensibles als efectes de l&#8217;obesitat.<\/p>\n\n\n\n<p>El treball, publicat recentment a la revista <em>American Journal of Physiology \u2013 Cell Physiology<\/em>, ha comptat amb la participaci\u00f3 de personal investigador de l&#8217;Institut d&#8217;Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) i de l&#8217;Institut de Bioenginyeria de Catalunya (IBEC).<\/p>\n\n\n\n<p>Van observar que, en ratolins sotmesos a dietes riques en greixos, els mascles van presentar un deteriorament metab\u00f2lic m\u00e9s sever, tot i que ambd\u00f3s sexes van desenvolupar una quantitat similar de greix corporal. En analitzar els canvis en l&#8217;expressi\u00f3 g\u00e8nica del fetge i el teixit adip\u00f3s, van comprovar que l&#8217;obesitat alterava de forma molt diferent l&#8217;expressi\u00f3 dels gens segons el sexe<em>. &#8220;La troballa m\u00e9s sorprenent va ser descobrir que els gens que marquen difer\u00e8ncies entre sexes en condicions normals, anomenats gens &#8216;sexualment dom\u00f2rfics&#8217;, s\u00f3n precisament els m\u00e9s sensibles a les dietes obesog\u00e8niques&#8221;<\/em><a><\/a> indica Joan-Marc Servitja, investigador CIBERDEM i col\u00edder de l&#8217;estudi. Com a conseq\u00fc\u00e8ncia, es produeix una p\u00e8rdua de les difer\u00e8ncies naturals en l&#8217;expressi\u00f3 g\u00e8nica entre sexes, la qual cosa indica que l&#8217;obesitat pot esborrar patrons espec\u00edfics de cada sexe fonamentals per a l&#8217;equilibri metab\u00f2lic.<\/p>\n\n\n\n<p>Aquests resultats aporten <em>&#8220;una nova perspectiva sobre com l&#8217;obesitat impacta de forma diferent en funci\u00f3 del sexe i posen en relleu que les difer\u00e8ncies d&#8217;expressi\u00f3 g\u00e8nica entre sexes exerceixen un paper clau en la salut metab\u00f2lica&#8221;,<\/em> conclou Vicent Ribas investigador CIBERDEM i col\u00edder de l&#8217;estudi. L&#8217;estudi subratlla la import\u00e0ncia d&#8217;analitzar ambd\u00f3s sexes en la investigaci\u00f3 sobre malalties metab\u00f2liques, ja que aquest enfocament pot ser decisiu per dissenyar estrat\u00e8gies de prevenci\u00f3 i tractament m\u00e9s efica\u00e7os.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p><strong><strong>Article de refer\u00e8ncia:<\/strong><\/strong><\/p>\n\n\n\n<p>Vicent Ribas, Samantha Mor\u00f3n-Ros, Helena Mari, Albert Gracia-Batllori, Laura Brugnara, Alba Herrero-Gomez, Elena Eyre, Marc Claret, Irene Marco-Rius, Anna Novials, Joan-Marc Servitja. <strong>Diet-Induced Obesity Disrupts Sexually Dimorphic Gene Expression in Mice<\/strong>. <em>Am J Physiol Cell Physiol<\/em>. (2025). DOI: <a href=\"https:\/\/journals.physiology.org\/doi\/full\/10.1152\/ajpcell.00098.2025\">10.1152\/ajpcell.00098.2025<\/a>.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Un estudi liderat per l&#8217;\u00e0rea de Diabetis i Malalties Metab\u00f2liques Associades del CIBER (CIBERDEM) en col\u00b7laboraci\u00f3 amb l&#8217;institut de Bioenginyeria de Catalunya (IBEC) ha demostrat que les dietes riques en greixos modifiquen, de manera distinta en funci\u00f3 del sexe, l&#8217;expressi\u00f3 de gens en teixits clau per al control metab\u00f2lic. Aquests resultats aporten una nova perspectiva sobre com l&#8217;obesitat impacta de manera distinta en funci\u00f3 del sexe.<\/p>\n","protected":false},"author":37,"featured_media":128473,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1122,1736],"post_formats":[],"class_list":["post-128477","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-irene-marco-rius-ca","tag-molecular-imaging-for-precision-medicine-ca"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Les dietes riques en greix alteren de forma diferent els gens en mascles i femelles - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/les-dietes-riques-en-greix-alteren-de-forma-diferent-els-gens-en-mascles-i-femelles\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Les dietes riques en greix alteren de forma diferent els gens en mascles i femelles - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Un estudi liderat per l&#039;\u00e0rea de Diabetis i Malalties Metab\u00f2liques Associades del CIBER (CIBERDEM) en col\u00b7laboraci\u00f3 amb l&#039;institut de Bioenginyeria de Catalunya (IBEC) ha demostrat que les dietes riques en greixos modifiquen, de manera distinta en funci\u00f3 del sexe, l&#039;expressi\u00f3 de gens en teixits clau per al control metab\u00f2lic. 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