{"id":128767,"date":"2025-10-07T03:00:00","date_gmt":"2025-10-07T01:00:00","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=128767"},"modified":"2025-10-06T17:37:31","modified_gmt":"2025-10-06T15:37:31","slug":"scientists-reverse-alzheimers-in-mice-using-nanoparticles","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/consiguen-revertir-el-alzheimer-en-ratones-con-el-uso-de-nanoparticulas","title":{"rendered":"Aconsegueixen revertir l\u2019alzheimer en ratolins amb l’\u00fas de nanopart\u00edcules"},"content":{"rendered":"\n

Un equip internacional codirigit per l’Institut de Bioenginyeria de Catalunya (IBEC) i l’Hospital West China de la Universitat de Sichuan (WCHSU) va poder revertir l’Alzheimer en ratolins despr\u00e9s de nom\u00e9s 3 injeccions amb nanopart\u00edcules.<\/strong> L’enfocament innovador per tractar la malaltia se centra a restaurar la funci\u00f3 normal del sistema vascular, en lloc d’actuar sobre les neurones o altres c\u00e8l\u00b7lules cerebrals, com s’ha fet habitualment fins ara.<\/strong> Aquest assoliment, publicat a la revista Signal Transduction and Targeted Therapy, \u00e9s un pas prometedor cap a un tractament efica\u00e7 per a la malaltia d’Alzheimer.<\/strong><\/p>\n\n\n\n

\"\"
Giuseppe Battaglia (esquerra) i Lorena Ruiz P\u00e9rez (dreta).<\/figcaption><\/figure>\n\n\n\n

Un equip de recerca codirigit per l’Institut de Bioenginyeria de Catalunya (IBEC) i l’Hospital West China de la Universitat de Sichuan (WCHSU) en col\u00b7laboraci\u00f3 amb investigadors del Regne Unit, ha demostrat una estrat\u00e8gia basada en nanotecnologia que reverteix la malaltia d’Alzheimer<\/strong> en ratolins. A difer\u00e8ncia de la nanomedicina tradicional, que es basa en nanopart\u00edcules com a portadores de mol\u00e8cules terap\u00e8utiques, aquest enfocament utilitza nanopart\u00edcules que s\u00f3n bioactives per si soles: “f\u00e0rmacs supramoleculars”. En lloc de dirigir-se directament a les neurones, la ter\u00e0pia restaura la funci\u00f3 adequada de la barrera hematoencef\u00e0lica (BBB per les seves sigles en angl\u00e8s)<\/strong>, el “guardi\u00e0 vascular” que regula l’entorn del cervell. En reparar aquesta interf\u00edcie cr\u00edtica, els investigadors van aconseguir revertir la patologia de l’Alzheimer en models animals.<\/p>\n\n\n\n

\n

Nom\u00e9s 1 hora despr\u00e9s de la injecci\u00f3 observem una reducci\u00f3 del 50-60% en la quantitat d’A\u03b2 dins del cervell.<\/p>\n\n\n\n

Junyang Chen<\/p>\n<\/blockquote>\n\n\n\n

El cervell \u00e9s l’\u00f2rgan m\u00e9s car del cos, consumint el 20% de l’energia en adults i fins al 60% en nens. Aquesta energia arriba a trav\u00e9s d’un vast subministrament de sang, assegurat per un sistema vascular \u00fanic i dens on cada neurona es nodreix d’un capil\u00b7lar. El nostre cervell cont\u00e9 aproximadament mil milions de capil\u00b7lars, cosa que destaca el paper vital del sistema vascular cerebral en el manteniment de la salut i la lluita contra les malalties. Aquestes troballes ressalten el paper crucial de la salut vascular, especialment en malalties com la dem\u00e8ncia i l’Alzheimer, que es relacionen amb un sistema vascular comprom\u00e8s.<\/p>\n\n\n\n

La BBB \u00e9s una barrera cel\u00b7lular i fisiol\u00f2gica que separa el cervell del flux sanguini per protegir-lo de perills externs com pat\u00f2gens o toxines. L’equip d’investigadors va demostrar que enfocar a un mecanisme espec\u00edfic permet que les “prote\u00efnes de rebuig” indesitjades produ\u00efdes al cervell travessin aquesta barrera i s’eliminin en el flux sanguini correctament. En la malaltia d’Alzheimer, la principal prote\u00efna “de rebuig” \u00e9s l’amiloide-\u03b2 (A\u03b2), l’acumulaci\u00f3 de la qual perjudica el funcionament normal de les neurones.<\/p>\n\n\n\n

Els investigadors van utilitzar models de ratol\u00ed que estan programats gen\u00e8ticament per produir majors quantitats de prote\u00efna A\u03b2 i desenvolupar un deteriorament cognitiu significatiu que imita la patologia de l’Alzheimer. Van administrar nom\u00e9s 3 dosis dels f\u00e0rmacs supramoleculars i posteriorment van monitorar regularment l’evoluci\u00f3 de la malaltia. “Nom\u00e9s 1 hora despr\u00e9s de la injecci\u00f3 observem una reducci\u00f3 del 50-60% en la quantitat d’A\u03b2 dins del cervell<\/strong>“, explica Junyang Chen, primer coautor de l’estudi, investigador de l’Hospital West China de la Universitat de Sichuan i estudiant de doctorat del University College London (UCL).<\/p>\n\n\n\n

\n

L’efecte a llarg termini prov\u00e9 de la restauraci\u00f3 del sistema vascular del cervell. El m\u00e9s rellevant \u00e9s que les nostres nanopart\u00edcules actuen com un f\u00e0rmac i semblen activar un mecanisme de retroalimentaci\u00f3 que retorna aquesta via d’eliminaci\u00f3 a nivells normals.<\/em><\/em><\/p>\n\n\n\n

Giuseppe Battaglia<\/p>\n<\/blockquote>\n\n\n\n

Les dades m\u00e9s destacades van ser els efectes terap\u00e8utics. Els investigadors van realitzar diversos experiments per analitzar el comportament dels animals i mesurar el deteriorament de la mem\u00f2ria durant diversos mesos, cobrint totes les etapes de la malaltia. En un dels experiments, van tractar un ratol\u00ed de 12 mesos (equivalent a un hum\u00e0 de 60 anys) amb les nanopart\u00edcules i van analitzar el seu comportament despr\u00e9s de 6 mesos. El resultat va ser impressionant: l’animal, de 18 mesos (comparable a un hum\u00e0 de 90 anys), havia recuperat el comportament d’un ratol\u00ed sa.<\/strong><\/p>\n\n\n\n

“L’efecte a llarg termini prov\u00e9 de la restauraci\u00f3 del sistema vascular del cervell. Creiem que funciona com una cascada: quan s’acumulen esp\u00e8cies t\u00f2xiques com la beta amiloide (A\u03b2), la malaltia progressa. Per\u00f2 una vegada que la vascularitzaci\u00f3 pot funcionar novament, comen\u00e7a a eliminar A\u03b2 i altres mol\u00e8cules perjudicioses, cosa que permet que tot el sistema recuperi el seu equilibri. El m\u00e9s rellevant \u00e9s que les nostres nanopart\u00edcules actuen com un f\u00e0rmac i semblen activar un mecanisme de retroalimentaci\u00f3 que retorna aquesta via d’eliminaci\u00f3 a nivells normals.<\/em>“<\/p>\n\n\n\n

Giuseppe Battaglia, professor de recerca ICREA a l’IBEC, investigador principal del <\/em>Grup de Bi\u00f2nica Molecular<\/em><\/a> i l\u00edder de l’estudi.<\/em><\/p>\n\n\n\n

\"\"
Imatges de microsc\u00f2pia de fluoresc\u00e8ncia basada en fulla de llum del cervell d’un ratol\u00ed 12 hores despr\u00e9s d\u2019haver estat tractat (esquerra) o no (dreta) amb nanopart\u00edcules. Es van analitzar els cervells per a veure la quantitat d’acumulaci\u00f3 de plaques A\u03b2. Vermell: plaques A\u03b2. Verd: vasos sanguinis de la barrera hematoencef\u00e0lica.<\/figcaption><\/figure>\n\n\n\n

Eliminaci\u00f3 d’amiloide-\u03b2 del cervell<\/strong><\/h4>\n\n\n\n

En la malaltia d’Alzheimer, un dels problemes clau \u00e9s que el sistema natural d’eliminaci\u00f3 del cervell per a toxines com la prote\u00efna amiloide-\u03b2 deixa de funcionar correctament. Normalment, la prote\u00efna LRP1 actua com un guardi\u00e0 molecular: reconeix A\u03b2, s’hi uneix per lligands i la transporta a trav\u00e9s de la barrera hematoencef\u00e0lica cap al torrent sanguini, on es pot eliminar. Per\u00f2 aquest sistema \u00e9s fr\u00e0gil. Si LRP1 s’uneix a massa A\u03b2 i amb massa for\u00e7a, el transport s’obstrueix i la prote\u00efna mateixa es degrada dins de les c\u00e8l\u00b7lules de barrera hematoencef\u00e0lica, deixant menys LRP1 “portadors” disponibles. En contra, si s’uneix a molt poca A\u03b2, el senyal \u00e9s massa feble per activar el transport. En tots dos casos, el resultat \u00e9s el mateix: A\u03b2 s’acumula dins del cervell.<\/p>\n\n\n\n

Els f\u00e0rmacs supramoleculars desenvolupats en aquest treball actuen com un interruptor que restableix el sistema. En imitar els lligands de LRP1, poden unir-se a A\u03b2, creuar la barrera hematoencef\u00e0lica i iniciar el proc\u00e9s d’eliminaci\u00f3 d’esp\u00e8cies t\u00f2xiques del cervell. D\u2019aquesta manera ajuden a restaurar el paper natural del sistema vascular com a via de neteja de residus i restableixen la seva funci\u00f3 adequada.<\/p>\n\n\n\n

\"\"
Xiaohe Tian (esquerra) i Giuseppe Battaglia (dreta).<\/figcaption><\/figure>\n\n\n\n

Nanopart\u00edcules per tractar l’Alzheimer<\/strong><\/h4>\n\n\n\n

En aquest estudi, els investigadors introdueixen nanopart\u00edcules que actuen com a f\u00e0rmacs supramoleculars<\/strong>, agents terap\u00e8utics per si sols en lloc de portadors de medicaments. Dissenyades amb un enfocament d’enginyeria molecular bottom-up<\/em> (de baix a dalt)<\/strong>, aquestes nanopart\u00edcules combinen un control de mida prec\u00eds amb un nombre definit de lligands a la superf\u00edcie, creant una plataforma multivalent capa\u00e7 d’interactuar amb els receptors cel\u00b7lulars d’una manera molt espec\u00edfica. En participar en el tr\u00e0fic de receptors en la membrana cel\u00b7lular, obren una forma \u00fanica i innovadora de modular la funci\u00f3 del receptor<\/strong>. Aquesta precisi\u00f3 no nom\u00e9s permet l’eliminaci\u00f3 efectiva de la prote\u00efna amiloide-\u03b2 del cervell, sin\u00f3 que tamb\u00e9 restaura l’equilibri del sistema vascular que mant\u00e9 una funci\u00f3 cerebral saludable.<\/p>\n\n\n\n

\n

El nostre estudi va demostrar una notable efic\u00e0cia per aconseguir una r\u00e0pida eliminaci\u00f3 d’A\u03b2, restaurar la funci\u00f3 saludable en la barrera hematoencef\u00e0lica i conduir a una sorprenent reversi\u00f3 de la patologia de l’Alzheimer.<\/p>\n\n\n\n

Lorena Ruiz P\u00e9rez<\/p>\n<\/blockquote>\n\n\n\n

Aquesta innovadora proposta de ter\u00e0pia ofereix una via prometedora per desenvolupar intervencions cl\u00edniques efectives, abordar les contribucions vasculars a la malaltia d’Alzheimer i, en \u00faltima inst\u00e0ncia, millorar els resultats dels pacients. \u00abEl nostre estudi va demostrar una notable efic\u00e0cia per aconseguir una r\u00e0pida eliminaci\u00f3 d’A\u03b2, restaurar la funci\u00f3 saludable en la barrera hematoencef\u00e0lica i conduir a una sorprenent reversi\u00f3 de la patologia de l’Alzheimer\u00bb, conclou Lorena Ruiz P\u00e9rez, investigadora del grup de Bi\u00f2nica Molecular de l’Institut de Bioenginyeria de Catalunya (IBEC) i professora adjunta Serra Hunter a la Facultat de F\u00edsica de la Universitat de Barcelona (UB).<\/p>\n\n\n\n

L’estudi \u00e9s fruit d’una col\u00b7laboraci\u00f3 entre l’Institut de Bioenginyeria de Catalunya (IBEC), l’Hospital West China de la Universitat de Sichuan, l\u2019Hospital Xiamen West China de la Universitat de Sichuan, el University College de Londres, el Xiamen Key Laboratory of Psychoradiology and Neuromodulation, la Universitat de Barcelona, l’Acad\u00e8mia Xinesa de Ci\u00e8ncies M\u00e8diques i la Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats (ICREA).<\/p>\n\n\n\n

\n\n\n\n

Article de refer\u00e8ncia:<\/strong><\/p>\n\n\n\n

Junyang Chen, Pan Xiang, Aroa Duro-Castano, Huawei Cai, Bin Guo, Xiqin Liu, Yifan Yu, Su Lui, Kui Luo, Bowen Ke, Lorena Ruiz Perez, Xiawei Wei, Qiyong Gong, Xiaohe Tian, Giuseppe Battaglia. Multivalent modulation of endothelial LRP1 induces fast neurovascular amyloid-\u03b2 clearance and cognitive function improvement in Alzheimer\u2019s disease models<\/strong>. Signal Transduction and Targeted Therapy<\/em> (2025). DOI: 10.1038\/s41392-025-02426-1<\/a><\/p>\n\n\n\n

\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Un equip internacional codirigit per l’Institut de Bioenginyeria de Catalunya (IBEC) i l’Hospital West China de la Universitat de Sichuan (WCHSU) va poder revertir l’Alzheimer en ratolins despr\u00e9s de nom\u00e9s 3 injeccions amb nanopart\u00edcules. L’enfocament innovador per tractar la malaltia se centra a restaurar la funci\u00f3 normal del sistema vascular, en lloc d’actuar sobre les neurones o altres c\u00e8l\u00b7lules cerebrals, com s’ha fet habitualment fins ara. Aquest assoliment, publicat a la revista Signal Transduction and Targeted Therapy, \u00e9s un pas prometedor cap a un tractament efica\u00e7 per a la malaltia d’Alzheimer.<\/p>\n","protected":false},"author":37,"featured_media":128764,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1627,1104,2000],"post_formats":[],"class_list":["post-128767","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-alzheimer-ca-2","tag-giuseppe-battaglia-ca","tag-molecular-bionics-ca"],"yoast_head":"\nAconsegueixen revertir l\u2019alzheimer en ratolins amb l'\u00fas de nanopart\u00edcules - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/consiguen-revertir-el-alzheimer-en-ratones-con-el-uso-de-nanoparticulas\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Aconsegueixen revertir l\u2019alzheimer en ratolins amb l'\u00fas de nanopart\u00edcules - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Un equip internacional codirigit per l'Institut de Bioenginyeria de Catalunya (IBEC) i l'Hospital West China de la Universitat de Sichuan (WCHSU) va poder revertir l'Alzheimer en ratolins despr\u00e9s de nom\u00e9s 3 injeccions amb nanopart\u00edcules. L'enfocament innovador per tractar la malaltia se centra a restaurar la funci\u00f3 normal del sistema vascular, en lloc d'actuar sobre les neurones o altres c\u00e8l\u00b7lules cerebrals, com s'ha fet habitualment fins ara. Aquest assoliment, publicat a la revista Signal Transduction and Targeted Therapy, \u00e9s un pas prometedor cap a un tractament efica\u00e7 per a la malaltia d'Alzheimer.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/ca\/consiguen-revertir-el-alzheimer-en-ratones-con-el-uso-de-nanoparticulas\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2025-10-07T01:00:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/10\/Giuseppe-Battaglia-and-Lorena-Ruiz-scaled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"1707\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Sarah Moreira\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrit per\" \/>\n\t<meta name=\"twitter:data1\" content=\"Sarah Moreira\" \/>\n\t<meta name=\"twitter:label2\" content=\"Temps estimat de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"7 minuts\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/consiguen-revertir-el-alzheimer-en-ratones-con-el-uso-de-nanoparticulas\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/consiguen-revertir-el-alzheimer-en-ratones-con-el-uso-de-nanoparticulas\\\/\"},\"author\":{\"name\":\"Sarah Moreira\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/d3a158b8d448000777023ca1e3d71d34\"},\"headline\":\"Aconsegueixen revertir l\u2019alzheimer en ratolins amb l’\u00fas de nanopart\u00edcules\",\"datePublished\":\"2025-10-07T01:00:00+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/consiguen-revertir-el-alzheimer-en-ratones-con-el-uso-de-nanoparticulas\\\/\"},\"wordCount\":1493,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/consiguen-revertir-el-alzheimer-en-ratones-con-el-uso-de-nanoparticulas\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2025\\\/10\\\/Giuseppe-Battaglia-and-Lorena-Ruiz-scaled.jpg\",\"keywords\":[\"Alzheimer\",\"Giuseppe Battaglia\",\"Molecular Bionics\"],\"articleSection\":[\"Not\u00edcies de recerca\"],\"inLanguage\":\"ca\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/consiguen-revertir-el-alzheimer-en-ratones-con-el-uso-de-nanoparticulas\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/consiguen-revertir-el-alzheimer-en-ratones-con-el-uso-de-nanoparticulas\\\/\",\"name\":\"Aconsegueixen revertir l\u2019alzheimer en ratolins amb l'\u00fas de nanopart\u00edcules - Institute for Bioengineering of Catalonia\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/consiguen-revertir-el-alzheimer-en-ratones-con-el-uso-de-nanoparticulas\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/consiguen-revertir-el-alzheimer-en-ratones-con-el-uso-de-nanoparticulas\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2025\\\/10\\\/Giuseppe-Battaglia-and-Lorena-Ruiz-scaled.jpg\",\"datePublished\":\"2025-10-07T01:00:00+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/consiguen-revertir-el-alzheimer-en-ratones-con-el-uso-de-nanoparticulas\\\/#breadcrumb\"},\"inLanguage\":\"ca\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/consiguen-revertir-el-alzheimer-en-ratones-con-el-uso-de-nanoparticulas\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"ca\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/consiguen-revertir-el-alzheimer-en-ratones-con-el-uso-de-nanoparticulas\\\/#primaryimage\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2025\\\/10\\\/Giuseppe-Battaglia-and-Lorena-Ruiz-scaled.jpg\",\"contentUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2025\\\/10\\\/Giuseppe-Battaglia-and-Lorena-Ruiz-scaled.jpg\",\"width\":2560,\"height\":1707},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/consiguen-revertir-el-alzheimer-en-ratones-con-el-uso-de-nanoparticulas\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Aconsegueixen revertir l\u2019alzheimer en ratolins amb l’\u00fas de nanopart\u00edcules\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#website\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/\",\"name\":\"Institute for Bioengineering of Catalonia\",\"description\":\"Bioengineering Solutions for Health\",\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/ibecbarcelona.eu\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"ca\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\",\"name\":\"Institute for Bioengineering of Catalonia\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"ca\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2026\\\/01\\\/cropped-IBEC_20ANYS_GRIS.png\",\"contentUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2026\\\/01\\\/cropped-IBEC_20ANYS_GRIS.png\",\"width\":696,\"height\":257,\"caption\":\"Institute for Bioengineering of Catalonia\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/d3a158b8d448000777023ca1e3d71d34\",\"name\":\"Sarah Moreira\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"ca\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/37385a1f83bdef106d1b89522da4c620ee48ba2eb0662dbc73ba05b7f3fbdf89?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/37385a1f83bdef106d1b89522da4c620ee48ba2eb0662dbc73ba05b7f3fbdf89?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/37385a1f83bdef106d1b89522da4c620ee48ba2eb0662dbc73ba05b7f3fbdf89?s=96&d=mm&r=g\",\"caption\":\"Sarah Moreira\"},\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/author\\\/smoreira\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Aconsegueixen revertir l\u2019alzheimer en ratolins amb l'\u00fas de nanopart\u00edcules - Institute for Bioengineering of Catalonia","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/ibecbarcelona.eu\/ca\/consiguen-revertir-el-alzheimer-en-ratones-con-el-uso-de-nanoparticulas\/","og_locale":"ca_ES","og_type":"article","og_title":"Aconsegueixen revertir l\u2019alzheimer en ratolins amb l'\u00fas de nanopart\u00edcules - Institute for Bioengineering of Catalonia","og_description":"Un equip internacional codirigit per l'Institut de Bioenginyeria de Catalunya (IBEC) i l'Hospital West China de la Universitat de Sichuan (WCHSU) va poder revertir l'Alzheimer en ratolins despr\u00e9s de nom\u00e9s 3 injeccions amb nanopart\u00edcules. L'enfocament innovador per tractar la malaltia se centra a restaurar la funci\u00f3 normal del sistema vascular, en lloc d'actuar sobre les neurones o altres c\u00e8l\u00b7lules cerebrals, com s'ha fet habitualment fins ara. Aquest assoliment, publicat a la revista Signal Transduction and Targeted Therapy, \u00e9s un pas prometedor cap a un tractament efica\u00e7 per a la malaltia d'Alzheimer.","og_url":"https:\/\/ibecbarcelona.eu\/ca\/consiguen-revertir-el-alzheimer-en-ratones-con-el-uso-de-nanoparticulas\/","og_site_name":"Institute for Bioengineering of Catalonia","article_published_time":"2025-10-07T01:00:00+00:00","og_image":[{"width":2560,"height":1707,"url":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/10\/Giuseppe-Battaglia-and-Lorena-Ruiz-scaled.jpg","type":"image\/jpeg"}],"author":"Sarah Moreira","twitter_card":"summary_large_image","twitter_misc":{"Escrit per":"Sarah Moreira","Temps estimat de lectura":"7 minuts"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/ibecbarcelona.eu\/ca\/consiguen-revertir-el-alzheimer-en-ratones-con-el-uso-de-nanoparticulas\/#article","isPartOf":{"@id":"https:\/\/ibecbarcelona.eu\/ca\/consiguen-revertir-el-alzheimer-en-ratones-con-el-uso-de-nanoparticulas\/"},"author":{"name":"Sarah Moreira","@id":"https:\/\/ibecbarcelona.eu\/#\/schema\/person\/d3a158b8d448000777023ca1e3d71d34"},"headline":"Aconsegueixen revertir l\u2019alzheimer en ratolins amb l’\u00fas de nanopart\u00edcules","datePublished":"2025-10-07T01:00:00+00:00","mainEntityOfPage":{"@id":"https:\/\/ibecbarcelona.eu\/ca\/consiguen-revertir-el-alzheimer-en-ratones-con-el-uso-de-nanoparticulas\/"},"wordCount":1493,"publisher":{"@id":"https:\/\/ibecbarcelona.eu\/#organization"},"image":{"@id":"https:\/\/ibecbarcelona.eu\/ca\/consiguen-revertir-el-alzheimer-en-ratones-con-el-uso-de-nanoparticulas\/#primaryimage"},"thumbnailUrl":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/10\/Giuseppe-Battaglia-and-Lorena-Ruiz-scaled.jpg","keywords":["Alzheimer","Giuseppe Battaglia","Molecular Bionics"],"articleSection":["Not\u00edcies de recerca"],"inLanguage":"ca"},{"@type":"WebPage","@id":"https:\/\/ibecbarcelona.eu\/ca\/consiguen-revertir-el-alzheimer-en-ratones-con-el-uso-de-nanoparticulas\/","url":"https:\/\/ibecbarcelona.eu\/ca\/consiguen-revertir-el-alzheimer-en-ratones-con-el-uso-de-nanoparticulas\/","name":"Aconsegueixen revertir l\u2019alzheimer en ratolins amb l'\u00fas de nanopart\u00edcules - Institute for Bioengineering of Catalonia","isPartOf":{"@id":"https:\/\/ibecbarcelona.eu\/#website"},"primaryImageOfPage":{"@id":"https:\/\/ibecbarcelona.eu\/ca\/consiguen-revertir-el-alzheimer-en-ratones-con-el-uso-de-nanoparticulas\/#primaryimage"},"image":{"@id":"https:\/\/ibecbarcelona.eu\/ca\/consiguen-revertir-el-alzheimer-en-ratones-con-el-uso-de-nanoparticulas\/#primaryimage"},"thumbnailUrl":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/10\/Giuseppe-Battaglia-and-Lorena-Ruiz-scaled.jpg","datePublished":"2025-10-07T01:00:00+00:00","breadcrumb":{"@id":"https:\/\/ibecbarcelona.eu\/ca\/consiguen-revertir-el-alzheimer-en-ratones-con-el-uso-de-nanoparticulas\/#breadcrumb"},"inLanguage":"ca","potentialAction":[{"@type":"ReadAction","target":["https:\/\/ibecbarcelona.eu\/ca\/consiguen-revertir-el-alzheimer-en-ratones-con-el-uso-de-nanoparticulas\/"]}]},{"@type":"ImageObject","inLanguage":"ca","@id":"https:\/\/ibecbarcelona.eu\/ca\/consiguen-revertir-el-alzheimer-en-ratones-con-el-uso-de-nanoparticulas\/#primaryimage","url":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/10\/Giuseppe-Battaglia-and-Lorena-Ruiz-scaled.jpg","contentUrl":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/10\/Giuseppe-Battaglia-and-Lorena-Ruiz-scaled.jpg","width":2560,"height":1707},{"@type":"BreadcrumbList","@id":"https:\/\/ibecbarcelona.eu\/ca\/consiguen-revertir-el-alzheimer-en-ratones-con-el-uso-de-nanoparticulas\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/ibecbarcelona.eu\/ca\/"},{"@type":"ListItem","position":2,"name":"Aconsegueixen revertir l\u2019alzheimer en ratolins amb l’\u00fas de nanopart\u00edcules"}]},{"@type":"WebSite","@id":"https:\/\/ibecbarcelona.eu\/#website","url":"https:\/\/ibecbarcelona.eu\/","name":"Institute for Bioengineering of Catalonia","description":"Bioengineering Solutions for Health","publisher":{"@id":"https:\/\/ibecbarcelona.eu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/ibecbarcelona.eu\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"ca"},{"@type":"Organization","@id":"https:\/\/ibecbarcelona.eu\/#organization","name":"Institute for Bioengineering of Catalonia","url":"https:\/\/ibecbarcelona.eu\/","logo":{"@type":"ImageObject","inLanguage":"ca","@id":"https:\/\/ibecbarcelona.eu\/#\/schema\/logo\/image\/","url":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2026\/01\/cropped-IBEC_20ANYS_GRIS.png","contentUrl":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2026\/01\/cropped-IBEC_20ANYS_GRIS.png","width":696,"height":257,"caption":"Institute for Bioengineering of Catalonia"},"image":{"@id":"https:\/\/ibecbarcelona.eu\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/ibecbarcelona.eu\/#\/schema\/person\/d3a158b8d448000777023ca1e3d71d34","name":"Sarah Moreira","image":{"@type":"ImageObject","inLanguage":"ca","@id":"https:\/\/secure.gravatar.com\/avatar\/37385a1f83bdef106d1b89522da4c620ee48ba2eb0662dbc73ba05b7f3fbdf89?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/37385a1f83bdef106d1b89522da4c620ee48ba2eb0662dbc73ba05b7f3fbdf89?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/37385a1f83bdef106d1b89522da4c620ee48ba2eb0662dbc73ba05b7f3fbdf89?s=96&d=mm&r=g","caption":"Sarah Moreira"},"url":"https:\/\/ibecbarcelona.eu\/ca\/author\/smoreira\/"}]}},"AFP_featured_media_urls":{"full":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/10\/Giuseppe-Battaglia-and-Lorena-Ruiz-scaled.jpg",2560,1707,false],"thumbnail":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/10\/Giuseppe-Battaglia-and-Lorena-Ruiz-150x150.jpg",150,150,true],"medium":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/10\/Giuseppe-Battaglia-and-Lorena-Ruiz-300x200.jpg",300,200,true],"medium_large":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/10\/Giuseppe-Battaglia-and-Lorena-Ruiz-768x512.jpg",768,512,true],"large":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/10\/Giuseppe-Battaglia-and-Lorena-Ruiz-1024x683.jpg",1024,683,true]},"AFP_attachments":{"full":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/10\/Imagen-horizontal-3.jpg",1920,1080,false],"thumbnail":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/10\/Imagen-horizontal-3-150x150.jpg",150,150,true],"medium":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/10\/Imagen-horizontal-3-300x169.jpg",300,169,true],"medium_large":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/10\/Imagen-horizontal-3-768x432.jpg",768,432,true],"large":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/10\/Imagen-horizontal-3-1024x576.jpg",1024,576,true]},"AFP_videos":[],"AFP_video_blocks":"","AFP_category_names":["Not\u00edcies de recerca"],"_links":{"self":[{"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/posts\/128767","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/users\/37"}],"replies":[{"embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/comments?post=128767"}],"version-history":[{"count":4,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/posts\/128767\/revisions"}],"predecessor-version":[{"id":128860,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/posts\/128767\/revisions\/128860"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/media\/128764"}],"wp:attachment":[{"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/media?parent=128767"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/categories?post=128767"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/tags?post=128767"},{"taxonomy":"post_format","embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/post_formats?post=128767"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}