{"id":129498,"date":"2025-10-31T17:10:00","date_gmt":"2025-10-31T16:10:00","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=129498"},"modified":"2025-10-31T15:39:15","modified_gmt":"2025-10-31T14:39:15","slug":"first-transplant-in-pigs-of-modified-porcine-kidneys-with-human-renal-organoids","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/primer-trasplantament-en-porcs-de-ronyons-porcins-modificats-amb-organoides-renals-humans","title":{"rendered":"Primer trasplantament en porcs de ronyons porcins modificats amb organoides renals humans"},"content":{"rendered":"\n

Un equip de recerca ha desenvolupat una tecnologia pionera que permet produir organoides renals humans de manera escalable, combinar-los amb ronyons de porc fora del cos i trasplantar-los de nou al mateix animal de manera viable.<\/strong> L\u2019experiment,<\/strong> liderat per l\u2019Institut de Bioenginyeria de Catalunya (IBEC), es troba en fase precl\u00ednica i confirma la seguretat i viabilitat del procediment, obrint la porta a futurs assajos en contextos m\u00e9s propers a l\u2019hum\u00e0.<\/strong> A llarg termini, aquesta aproximaci\u00f3 podria contribuir a allargar la vida \u00fatil dels \u00f2rgans destinats al trasplantament i oferir una alternativa terap\u00e8utica per a malalts renals cr\u00f2nics.<\/strong><\/p>\n\n\n\n

\"\"
Elena Garreta Bahima (esquerra) i Daniel Moya Rull (dreta) als laboratoris de l’IBEC.<\/figcaption><\/figure>\n\n\n\n

Un equip de recerca liderat per l\u2019Institut de Bioenginyeria de Catalunya (IBEC), en col\u00b7laboraci\u00f3 amb l\u2019Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a (INIBIC) i grups de recerca internacionals, ha desenvolupat una tecnologia pionera que permet produir organoides renals humans de manera escalable, combinar-los amb ronyons de porc fora del cos i trasplantar-los de nou al mateix animal, tot avaluant la seva viabilitat despr\u00e9s del trasplantament. L\u2019estudi, publicat a la revista Nature Biomedical Engineering<\/em>, representa una fita en el camp de la medicina regenerativa i personalitzada, establint les bases per a la utilitzaci\u00f3 d\u2019organoides  de rony\u00f3 derivats de c\u00e8l\u00b7lules mare humanes per a ter\u00e0pia cel\u00b7lular en assajos cl\u00ednics.<\/p>\n\n\n\n

\n

L\u2019objectiu a llarg termini \u00e9s poder regenerar o reparar un \u00f2rgan abans del trasplantament. Aix\u00f2 podria reduir el temps d\u2019espera dels pacients cr\u00f2nics i augmentar el nombre d\u2019\u00f2rgans viables per al trasplantament<\/em>.<\/p>\n\n\n\n

N\u00faria Montserrat<\/p>\n<\/blockquote>\n\n\n\n

Aquest treball, liderat per la Dra. N\u00faria Montserrat,<\/strong> investigadora ICREA a l\u2019IBEC en el moment de l\u2019estudi i actual consellera del Departament de Recerca i Universitats de la Generalitat de Catalunya, \u00e9s el resultat d\u2019una traject\u00f2ria cient\u00edfica de m\u00e9s d\u2019una d\u00e8cada dedicada a la medicina regenerativa i a la bioenginyeria d\u2019\u00f2rgans. Fruit d\u2019aquesta l\u00ednia de recerca sostinguda, l\u2019equip d\u2019investigaci\u00f3 ha aconseguit combinar per primera vegada organoides renals humans amb ronyons porcins vius, connectats a m\u00e0quines de perfusi\u00f3 normot\u00e8rmica. L\u2019\u00fas d\u2019aquests dispositius, utilitzats habitualment en el quir\u00f2fan per mantenir l\u2019\u00f2rgan viu i oxigenat fora del cos abans d\u2019un transplantament, ha perm\u00e8s inserir organoides humans dins els ronyons porcins i monitorar en temps real la seva integraci\u00f3 i funci\u00f3.<\/p>\n\n\n\n

\u201cLa nostra recerca demostra que la combinaci\u00f3 de tecnologies d\u2019organoides i perfusi\u00f3 ex vivo pot permetre intervencions cel\u00b7lulars en condicions totalment controlades.<\/em>\u201d explica la Dra. Montserrat. \u201cL\u2019objectiu a llarg termini \u00e9s poder regenerar o reparar un \u00f2rgan abans del trasplantament. Aix\u00f2 podria reduir el temps d\u2019espera dels pacients cr\u00f2nics i augmentar el nombre d\u2019\u00f2rgans viables per al trasplantament<\/em>.\u201d
<\/strong><\/p>\n\n\n\n

Una tecnologia escalable i segura<\/strong><\/h4>\n\n\n\n

Un organoide de rony\u00f3 \u00e9s una estructura tridimensional, d\u2019unes micres de mida, cultivada al laboratori a partir de c\u00e8l\u00b7lules mare humanes. Tot i que no \u00e9s un \u00f2rgan complet, reprodueix moltes de les seves estructures i funcions principals. Gr\u00e0cies a aquestes caracter\u00edstiques, els organoides permeten estudiar com es desenvolupa el rony\u00f3, provar nous f\u00e0rmacs i, en el futur, s\u2019espera que puguin ser utilitzats per a reparar teixits renals danyats o millorar \u00f2rgans destinats al trasplantament.<\/p>\n\n\n\n

\n

Ara, amb el nostre nou m\u00e8tode, podem generar milers d\u2019organoides renals en condicions controlades i en poc temps, amb una gran precisi\u00f3 i sense necessitat de components complexos. Aix\u00f2 obre la porta a aplicacions com la detecci\u00f3 de f\u00e0rmacs o l\u2019estudi de malalties.<\/em><\/em><\/p>\n\n\n\n

Elena Garreta<\/p>\n<\/blockquote>\n\n\n\n

L\u2019estudi descriu, per primera vegada, un m\u00e8tode sistem\u00e0tic i escalable per produir milers d\u2019aquests organoides renals humans, utilitzant t\u00e8cniques de microagregaci\u00f3 i enginyeria gen\u00e8tica.<\/p>\n\n\n\n

“Tot i el gran potencial cl\u00ednic dels organoides, fins ara un dels grans reptes per aplicar aquesta tecnologia en tractaments m\u00e8dics reals era aconseguir produir aquests organoides de manera escalable, uniforme i assequible. Ara, amb el nostre nou m\u00e8tode, podem generar milers d\u2019organoides renals en condicions controlades i en poc temps, amb una gran precisi\u00f3 i sense necessitat de components complexos. Aix\u00f2 obre la porta a aplicacions com la detecci\u00f3 de f\u00e0rmacs o l\u2019estudi de malalties.”, <\/em>afegeix la Dra. Elena Garreta<\/strong>, investigadora s\u00e8nior del grup de Puripot\u00e8ncia per a la regeneraci\u00f3 d\u2019\u00f2rgans<\/a> de l\u2019IBEC i co-primera autora de l\u2019estudi.<\/p>\n\n\n\n

D\u2019altra banda, la utilitzaci\u00f3 de les m\u00e0quines mencionades, per portar a terme la perfusi\u00f3 dels organoides dins els ronyons, ofereix un avantatge clau: permet mesurar par\u00e0metres fisiol\u00f2gics de l\u2019\u00f2rgan en temps real i detectar de manera immediata qualsevol signe de dany o rebuig. Els experiments es van realitzar tant ex vivo<\/em> (fora de l\u2019organisme) com in vivo<\/em> (en el mateix animal), utilitzant un model porc\u00ed de trasplantament molt similar al rony\u00f3 hum\u00e0.<\/p>\n\n\n\n

L\u2019equip de recerca va observar que, despr\u00e9s de 24 i 48 hores del trasplantament, els organoides humans persistien integrats en el teixit renal porc\u00ed, mantenien la seva viabilitat i no desencadenaven cap resposta immune significativa. El rony\u00f3 trasplantat continuava funcionant amb normalitat, i no es van detectar signes de dany ni toxicitat.<\/p>\n\n\n\n

Cap a la regeneraci\u00f3 d\u2019\u00f2rgans abans del trasplantament<\/strong><\/h4>\n\n\n\n

Segons els autors i les autores, aquesta metodologia permet imaginar un escenari cl\u00ednic en qu\u00e8 els \u00f2rgans destinats al trasplantament puguin ser tractats i condicionats abans d\u2019implantar-los. En aquest context, la col\u00b7laboraci\u00f3 amb l\u2019Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a (INIBIC), l\u2019Organizaci\u00f3n Nacional de Trasplantes (ONT) i altres institucions, com l\u2019Instituto de Salud Carlos III (ISCIII), ha estat essencial per traslladar la recerca a un entorn quir\u00fargic realista i precl\u00ednic.<\/p>\n\n\n\n

Imatges tridimensionals (Z-stack) d\u2019organoides de rony\u00f3 al dia 16 de diferenciaci\u00f3 obtingudes per microsc\u00f2pia confocal.\u00a0Les c\u00e8l\u00b7lules han estat marcades amb diferents colors mitjan\u00e7ant la t\u00e8cnica d\u2019immunofluoresc\u00e8ncia per identificar components espec\u00edfics:\u00a0MEIS (verd: c\u00e8l\u00b7lules de l\u2019espai intersticial),\u00a0CD31\u00a0(vermell: c\u00e8l\u00b7lules endotelials),\u00a0LTL\u00a0(magenta: t\u00fabuls renals) i\u00a0DAPI\u00a0(blau: nuclis cel\u00b7lulars). Aquesta imatge permet observar com s\u2019organitzen els diferents tipus de c\u00e8l\u00b7lules dins l\u2019organoide renal. Organoides generats a partir de l\u2019agregaci\u00f3 de 250,000 (esquerra) i 500 (dreta) c\u00e8l\u00b7lules progenitores renals obtingudes de c\u00e8l\u00b7lules mare pluripotents humanes seguint un proc\u00e9s de diferenciaci\u00f3<\/figcaption><\/figure>\n\n\n\n

Un treball col\u00b7laboratiu i de gran impacte<\/strong><\/h4>\n\n\n\n

L\u2019article, titulat \u201cSystematic production of human kidney organoids for transplantation in porcine kidneys during ex vivo machine perfusion\u201d, ha estat fruit de la col\u00b7laboraci\u00f3 entre l\u2019IBEC, el INIBIC, el CIBER-BBN, la ONT, la UB, l\u2019Instituto de Investigaci\u00f3n Sanitaria de Navarra, l\u2019Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga, la Universitat de California, el Center for Bioengineering and Tissue Regeneration de California, l\u2019Instituto de Investigaci\u00f3n en Ciencias de la Alimentaci\u00f3n (CSIC-UAM), el University Medical Center Groningen, University Hospitals Leuven, National Center of Microbiology (ISCIII), l\u2019Instituto de investigaci\u00f3n Sanitaria HM Hospitales, la University of Leuven, el CIBERONC i el Networking Biomedical Research Center in Bioengineering El treball tamb\u00e9 ha comptat amb la participaci\u00f3 de EBERS Medical Technology SL, l\u2019empresa desenvolupadora de les m\u00e0quines de perfusi\u00f3 utilitzades.<\/p>\n\n\n\n

La Dra. Elena Garreta \u00e9s tamb\u00e9 professora associada al Departament de Biologia Cel\u00b7lular, Fisiologia i Immunologia de la Universitat de Barcelona (UB) i coordinadora de la Plataforma ISCIII Biomodelos y Biobancos (PISCIIIBB) de l\u2019Instituto de Salud Carlos III.<\/p>\n\n\n\n

\n\n\n\n

Article de refer\u00e8ncia<\/strong><\/p>\n\n\n\n

Elena Garreta, Daniel Moya-Rull, Alberto Centeno, Andr\u00e9s Marco, Asier Ullate-Agote, Gaia Amato, Carlos J. Aranda, Roger Oria, Daniel Lozano-Ojalvo, Merel B. F. Pool, Tim L. Hamelink, Idoia Luc\u00eda Selfa, Federico Gonz\u00e1lez, Carolina Tarantino, Alejandro Montero Salinas, Patricia L\u00f3pez San Mart\u00edn, Priyanka Koshy, Aleix Gavald\u00e0-Navarro, Amaia Vilas-Zornoza, Juan R. Rodr\u00edguez-Madoz, Ant\u00f3n Fern\u00e1ndez Garc\u00eda, Inmaculada Marquez-Leiva, Henri G. D. Leuvenink,  Cristobal Belda-Iniesta, Maarten Naesens, Beatriz Dominguez-Gil, Marcelino Gonz\u00e1lez-Mart\u00edn, Javier Rodr\u00edguez-Rivera, Jordi Ochando, Felipe Prosper, Cyril Moers & Nuria Montserrat. Systematic production of human kidney organoids for transplantation in porcine kidneys during ex vivo<\/em> machine perfusion<\/strong>. Nature Biomedical Engineering<\/em> (2025). DOI: 10.1038\/s41551-025-01542-1<\/a><\/p>\n\n\n\n

\n","protected":false},"excerpt":{"rendered":"

Un equip de recerca ha desenvolupat una tecnologia pionera que permet produir organoides renals humans de manera escalable, combinar-los amb ronyons de porc fora del cos i trasplantar-los de nou al mateix animal de manera viable. L\u2019experiment, liderat per l\u2019Institut de Bioenginyeria de Catalunya (IBEC), es troba en fase precl\u00ednica i confirma la seguretat i viabilitat del procediment, obrint la porta a futurs assajos en contextos m\u00e9s propers a l\u2019hum\u00e0. A llarg termini, aquesta aproximaci\u00f3 podria contribuir a allargar la vida \u00fatil dels \u00f2rgans destinats al trasplantament i oferir una alternativa terap\u00e8utica per a malalts renals cr\u00f2nics.<\/p>\n","protected":false},"author":24,"featured_media":129493,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[2164,2165,1123,1780],"post_formats":[],"class_list":["post-129498","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-kidney","tag-mini-kidney","tag-nuria-montserrat-ca-2","tag-pluripotency-for-organ-regeneration-ca"],"yoast_head":"\nPrimer trasplantament en porcs de ronyons porcins modificats amb organoides renals humans - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/primer-trasplantament-en-porcs-de-ronyons-porcins-modificats-amb-organoides-renals-humans\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Primer trasplantament en porcs de ronyons porcins modificats amb organoides renals humans - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Un equip de recerca ha desenvolupat una tecnologia pionera que permet produir organoides renals humans de manera escalable, combinar-los amb ronyons de porc fora del cos i trasplantar-los de nou al mateix animal de manera viable. L\u2019experiment, liderat per l\u2019Institut de Bioenginyeria de Catalunya (IBEC), es troba en fase precl\u00ednica i confirma la seguretat i viabilitat del procediment, obrint la porta a futurs assajos en contextos m\u00e9s propers a l\u2019hum\u00e0. A llarg termini, aquesta aproximaci\u00f3 podria contribuir a allargar la vida \u00fatil dels \u00f2rgans destinats al trasplantament i oferir una alternativa terap\u00e8utica per a malalts renals cr\u00f2nics.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/ca\/primer-trasplantament-en-porcs-de-ronyons-porcins-modificats-amb-organoides-renals-humans\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2025-10-31T16:10:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/10\/EGarretaDMoya-scaled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"1707\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Bia Moreno\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrit per\" \/>\n\t<meta name=\"twitter:data1\" content=\"Bia Moreno\" \/>\n\t<meta name=\"twitter:label2\" content=\"Temps estimat de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minuts\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/primer-trasplantament-en-porcs-de-ronyons-porcins-modificats-amb-organoides-renals-humans\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/primer-trasplantament-en-porcs-de-ronyons-porcins-modificats-amb-organoides-renals-humans\\\/\"},\"author\":{\"name\":\"Bia Moreno\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/b553413d524d76a399e659509449f8ec\"},\"headline\":\"Primer trasplantament en porcs de ronyons porcins modificats amb organoides renals humans\",\"datePublished\":\"2025-10-31T16:10:00+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/primer-trasplantament-en-porcs-de-ronyons-porcins-modificats-amb-organoides-renals-humans\\\/\"},\"wordCount\":1408,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/primer-trasplantament-en-porcs-de-ronyons-porcins-modificats-amb-organoides-renals-humans\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2025\\\/10\\\/EGarretaDMoya-scaled.jpg\",\"keywords\":[\"kidney\",\"mini-kidney\",\"Nuria Montserrat\",\"Pluripotency for organ regeneration\"],\"articleSection\":[\"Not\u00edcies de recerca\"],\"inLanguage\":\"ca\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/primer-trasplantament-en-porcs-de-ronyons-porcins-modificats-amb-organoides-renals-humans\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/primer-trasplantament-en-porcs-de-ronyons-porcins-modificats-amb-organoides-renals-humans\\\/\",\"name\":\"Primer trasplantament en porcs de ronyons porcins modificats amb organoides renals humans - Institute for Bioengineering of Catalonia\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/primer-trasplantament-en-porcs-de-ronyons-porcins-modificats-amb-organoides-renals-humans\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/primer-trasplantament-en-porcs-de-ronyons-porcins-modificats-amb-organoides-renals-humans\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2025\\\/10\\\/EGarretaDMoya-scaled.jpg\",\"datePublished\":\"2025-10-31T16:10:00+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/primer-trasplantament-en-porcs-de-ronyons-porcins-modificats-amb-organoides-renals-humans\\\/#breadcrumb\"},\"inLanguage\":\"ca\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/primer-trasplantament-en-porcs-de-ronyons-porcins-modificats-amb-organoides-renals-humans\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"ca\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/primer-trasplantament-en-porcs-de-ronyons-porcins-modificats-amb-organoides-renals-humans\\\/#primaryimage\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2025\\\/10\\\/EGarretaDMoya-scaled.jpg\",\"contentUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2025\\\/10\\\/EGarretaDMoya-scaled.jpg\",\"width\":2560,\"height\":1707},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/primer-trasplantament-en-porcs-de-ronyons-porcins-modificats-amb-organoides-renals-humans\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Primer trasplantament en porcs de ronyons porcins modificats amb organoides renals humans\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#website\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/\",\"name\":\"Institute for Bioengineering of Catalonia\",\"description\":\"Bioengineering Solutions for Health\",\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/ibecbarcelona.eu\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"ca\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\",\"name\":\"Institute for Bioengineering of Catalonia\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"ca\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2026\\\/01\\\/cropped-IBEC_20ANYS_GRIS.png\",\"contentUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2026\\\/01\\\/cropped-IBEC_20ANYS_GRIS.png\",\"width\":696,\"height\":257,\"caption\":\"Institute for Bioengineering of Catalonia\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/b553413d524d76a399e659509449f8ec\",\"name\":\"Bia Moreno\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"ca\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/bb483bca1d652e4f51c1831a5fbd1448c61e5d11f6b6f74fc8efed0509d20438?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/bb483bca1d652e4f51c1831a5fbd1448c61e5d11f6b6f74fc8efed0509d20438?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/bb483bca1d652e4f51c1831a5fbd1448c61e5d11f6b6f74fc8efed0509d20438?s=96&d=mm&r=g\",\"caption\":\"Bia Moreno\"},\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/author\\\/bmoreno\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Primer trasplantament en porcs de ronyons porcins modificats amb organoides renals humans - Institute for Bioengineering of Catalonia","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/ibecbarcelona.eu\/ca\/primer-trasplantament-en-porcs-de-ronyons-porcins-modificats-amb-organoides-renals-humans\/","og_locale":"ca_ES","og_type":"article","og_title":"Primer trasplantament en porcs de ronyons porcins modificats amb organoides renals humans - Institute for Bioengineering of Catalonia","og_description":"Un equip de recerca ha desenvolupat una tecnologia pionera que permet produir organoides renals humans de manera escalable, combinar-los amb ronyons de porc fora del cos i trasplantar-los de nou al mateix animal de manera viable. L\u2019experiment, liderat per l\u2019Institut de Bioenginyeria de Catalunya (IBEC), es troba en fase precl\u00ednica i confirma la seguretat i viabilitat del procediment, obrint la porta a futurs assajos en contextos m\u00e9s propers a l\u2019hum\u00e0. A llarg termini, aquesta aproximaci\u00f3 podria contribuir a allargar la vida \u00fatil dels \u00f2rgans destinats al trasplantament i oferir una alternativa terap\u00e8utica per a malalts renals cr\u00f2nics.","og_url":"https:\/\/ibecbarcelona.eu\/ca\/primer-trasplantament-en-porcs-de-ronyons-porcins-modificats-amb-organoides-renals-humans\/","og_site_name":"Institute for Bioengineering of Catalonia","article_published_time":"2025-10-31T16:10:00+00:00","og_image":[{"width":2560,"height":1707,"url":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/10\/EGarretaDMoya-scaled.jpg","type":"image\/jpeg"}],"author":"Bia Moreno","twitter_card":"summary_large_image","twitter_misc":{"Escrit per":"Bia Moreno","Temps estimat de lectura":"6 minuts"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/ibecbarcelona.eu\/ca\/primer-trasplantament-en-porcs-de-ronyons-porcins-modificats-amb-organoides-renals-humans\/#article","isPartOf":{"@id":"https:\/\/ibecbarcelona.eu\/ca\/primer-trasplantament-en-porcs-de-ronyons-porcins-modificats-amb-organoides-renals-humans\/"},"author":{"name":"Bia Moreno","@id":"https:\/\/ibecbarcelona.eu\/#\/schema\/person\/b553413d524d76a399e659509449f8ec"},"headline":"Primer trasplantament en porcs de ronyons porcins modificats amb organoides renals humans","datePublished":"2025-10-31T16:10:00+00:00","mainEntityOfPage":{"@id":"https:\/\/ibecbarcelona.eu\/ca\/primer-trasplantament-en-porcs-de-ronyons-porcins-modificats-amb-organoides-renals-humans\/"},"wordCount":1408,"publisher":{"@id":"https:\/\/ibecbarcelona.eu\/#organization"},"image":{"@id":"https:\/\/ibecbarcelona.eu\/ca\/primer-trasplantament-en-porcs-de-ronyons-porcins-modificats-amb-organoides-renals-humans\/#primaryimage"},"thumbnailUrl":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/10\/EGarretaDMoya-scaled.jpg","keywords":["kidney","mini-kidney","Nuria Montserrat","Pluripotency for organ regeneration"],"articleSection":["Not\u00edcies de recerca"],"inLanguage":"ca"},{"@type":"WebPage","@id":"https:\/\/ibecbarcelona.eu\/ca\/primer-trasplantament-en-porcs-de-ronyons-porcins-modificats-amb-organoides-renals-humans\/","url":"https:\/\/ibecbarcelona.eu\/ca\/primer-trasplantament-en-porcs-de-ronyons-porcins-modificats-amb-organoides-renals-humans\/","name":"Primer trasplantament en porcs de ronyons porcins modificats amb organoides renals humans - Institute for Bioengineering of Catalonia","isPartOf":{"@id":"https:\/\/ibecbarcelona.eu\/#website"},"primaryImageOfPage":{"@id":"https:\/\/ibecbarcelona.eu\/ca\/primer-trasplantament-en-porcs-de-ronyons-porcins-modificats-amb-organoides-renals-humans\/#primaryimage"},"image":{"@id":"https:\/\/ibecbarcelona.eu\/ca\/primer-trasplantament-en-porcs-de-ronyons-porcins-modificats-amb-organoides-renals-humans\/#primaryimage"},"thumbnailUrl":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/10\/EGarretaDMoya-scaled.jpg","datePublished":"2025-10-31T16:10:00+00:00","breadcrumb":{"@id":"https:\/\/ibecbarcelona.eu\/ca\/primer-trasplantament-en-porcs-de-ronyons-porcins-modificats-amb-organoides-renals-humans\/#breadcrumb"},"inLanguage":"ca","potentialAction":[{"@type":"ReadAction","target":["https:\/\/ibecbarcelona.eu\/ca\/primer-trasplantament-en-porcs-de-ronyons-porcins-modificats-amb-organoides-renals-humans\/"]}]},{"@type":"ImageObject","inLanguage":"ca","@id":"https:\/\/ibecbarcelona.eu\/ca\/primer-trasplantament-en-porcs-de-ronyons-porcins-modificats-amb-organoides-renals-humans\/#primaryimage","url":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/10\/EGarretaDMoya-scaled.jpg","contentUrl":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/10\/EGarretaDMoya-scaled.jpg","width":2560,"height":1707},{"@type":"BreadcrumbList","@id":"https:\/\/ibecbarcelona.eu\/ca\/primer-trasplantament-en-porcs-de-ronyons-porcins-modificats-amb-organoides-renals-humans\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/ibecbarcelona.eu\/ca\/"},{"@type":"ListItem","position":2,"name":"Primer trasplantament en porcs de ronyons porcins modificats amb organoides renals humans"}]},{"@type":"WebSite","@id":"https:\/\/ibecbarcelona.eu\/#website","url":"https:\/\/ibecbarcelona.eu\/","name":"Institute for Bioengineering of Catalonia","description":"Bioengineering Solutions for Health","publisher":{"@id":"https:\/\/ibecbarcelona.eu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/ibecbarcelona.eu\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"ca"},{"@type":"Organization","@id":"https:\/\/ibecbarcelona.eu\/#organization","name":"Institute for Bioengineering of Catalonia","url":"https:\/\/ibecbarcelona.eu\/","logo":{"@type":"ImageObject","inLanguage":"ca","@id":"https:\/\/ibecbarcelona.eu\/#\/schema\/logo\/image\/","url":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2026\/01\/cropped-IBEC_20ANYS_GRIS.png","contentUrl":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2026\/01\/cropped-IBEC_20ANYS_GRIS.png","width":696,"height":257,"caption":"Institute for Bioengineering of Catalonia"},"image":{"@id":"https:\/\/ibecbarcelona.eu\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/ibecbarcelona.eu\/#\/schema\/person\/b553413d524d76a399e659509449f8ec","name":"Bia Moreno","image":{"@type":"ImageObject","inLanguage":"ca","@id":"https:\/\/secure.gravatar.com\/avatar\/bb483bca1d652e4f51c1831a5fbd1448c61e5d11f6b6f74fc8efed0509d20438?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/bb483bca1d652e4f51c1831a5fbd1448c61e5d11f6b6f74fc8efed0509d20438?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/bb483bca1d652e4f51c1831a5fbd1448c61e5d11f6b6f74fc8efed0509d20438?s=96&d=mm&r=g","caption":"Bia Moreno"},"url":"https:\/\/ibecbarcelona.eu\/ca\/author\/bmoreno\/"}]}},"AFP_featured_media_urls":{"full":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/10\/EGarretaDMoya-scaled.jpg",2560,1707,false],"thumbnail":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/10\/EGarretaDMoya-150x150.jpg",150,150,true],"medium":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/10\/EGarretaDMoya-300x200.jpg",300,200,true],"medium_large":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/10\/EGarretaDMoya-768x512.jpg",768,512,true],"large":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/10\/EGarretaDMoya-1024x683.jpg",1024,683,true]},"AFP_attachments":{"full":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/10\/EGarretaDMoya-scaled.jpg",2560,1707,false],"thumbnail":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/10\/EGarretaDMoya-150x150.jpg",150,150,true],"medium":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/10\/EGarretaDMoya-300x200.jpg",300,200,true],"medium_large":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/10\/EGarretaDMoya-768x512.jpg",768,512,true],"large":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/10\/EGarretaDMoya-1024x683.jpg",1024,683,true]},"AFP_videos":{"129504":{"ID":129504,"post_author":"37","post_date":"2025-10-31 15:27:53","post_date_gmt":"2025-10-31 14:27:53","post_content":"","post_title":"NMontserrat-Organoides_2025(1)","post_excerpt":"","post_status":"inherit","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"nmontserrat-organoides_20251-2","to_ping":"","pinged":"","post_modified":"2025-10-31 15:27:53","post_modified_gmt":"2025-10-31 14:27:53","post_content_filtered":"","post_parent":129498,"guid":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/10\/NMontserrat-Organoides_20251.mp4","menu_order":0,"post_type":"attachment","post_mime_type":"video\/mp4","comment_count":"0","filter":"raw"},"129505":129504},"AFP_video_blocks":"<figure class=\"wp-block-video\"><video autoplay controls loop muted src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/10\/NMontserrat-Organoides_20251.mp4\"><\/video><figcaption class=\"wp-element-caption\">Imatges tridimensionals (Z-stack) d\u2019organoides de rony\u00f3 al dia 16 de diferenciaci\u00f3 obtingudes per microsc\u00f2pia confocal.\u00a0Les c\u00e8l\u00b7lules han estat marcades amb diferents colors mitjan\u00e7ant la t\u00e8cnica d\u2019immunofluoresc\u00e8ncia per identificar components espec\u00edfics:\u00a0MEIS (verd: c\u00e8l\u00b7lules de l\u2019espai intersticial),\u00a0CD31\u00a0(vermell: c\u00e8l\u00b7lules endotelials),\u00a0LTL\u00a0(magenta: t\u00fabuls renals) i\u00a0DAPI\u00a0(blau: nuclis cel\u00b7lulars). Aquesta imatge permet observar com s\u2019organitzen els diferents tipus de c\u00e8l\u00b7lules dins l\u2019organoide renal. Organoides generats a partir de l\u2019agregaci\u00f3 de 250,000 (esquerra) i 500 (dreta) c\u00e8l\u00b7lules progenitores renals obtingudes de c\u00e8l\u00b7lules mare pluripotents humanes seguint un proc\u00e9s de diferenciaci\u00f3<\/figcaption><\/figure>\n","AFP_category_names":["Not\u00edcies de recerca"],"_links":{"self":[{"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/posts\/129498","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/users\/24"}],"replies":[{"embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/comments?post=129498"}],"version-history":[{"count":6,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/posts\/129498\/revisions"}],"predecessor-version":[{"id":129514,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/posts\/129498\/revisions\/129514"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/media\/129493"}],"wp:attachment":[{"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/media?parent=129498"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/categories?post=129498"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/tags?post=129498"},{"taxonomy":"post_format","embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/post_formats?post=129498"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}